A particle-based numerical method for modelling of fluid-structure interactions in biomanufacturing processes by Lee, Jia Min

“…The method is validated through comparison with experimental data on deformations and transport of a MCF7 cancerous cell through a microchannel. Upon validation, the method was applied on a model extrusion-based bioprinting configuration, considering in addition the use of cytoprotective gel particles to encapsulate the cells in the bioink, thereby maintaining a high cell viability. …”
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Robot-assisted endoscopic submucosal dissection is effective in treating patients with early-stage gastric neoplasia by Phee, Soo Jay, Reddy, Nageshwar, Chiu, Philip W. Y., Rebala, Pradeep, Rao, Guduru V., Wang, Zheng, Sun, Zhenglong, Wong, Jennie Y. Y., Ho, Khek–Yu

“…Background & Aims Endoscopic submucosal dissection (ESD) is a new technique for endoscopic resection of early-stage gastrointestinal cancers. Though ESD achieves high rate of en bloc resection, it is technically difficult to master. …”
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ANALISIS BIAYA TERAPI STROKE HEMORAGI PADA PASIEN RAWAT INAP DI RS PKU MUHAMMADIYAH YOGYAKARTA NOVEMBER 2011-2013 by , Niken Feladita, , Dr. Satibi, M.Si, Apt.

“…Stroke is the third death factors in the US after heart disease and cancers. It is suggested that the cost for dealing with stroke will be doubled in. …”

Identification of potential targets of the curcumin analog CCA‑1.1 for glioblastoma treatment: integrated computational analysis and in vitro study by Hermawan, Adam, Wulandari, Febri, Hanif, Naufa, Utomo, Rohmad Yudi, Jenie, Riris Istighfari, Ikawati, Muthi', Tafrihani, Ahmad Syauqy

“…Curcumin has anticancer activity against aggressive cancers, such as leukemia, and GBM; however, its application is limited by its low solubility and bioavailability. …”
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Studying protein interaction and glycosylation with chemical proteomics by Nadal, S

“…</p> <p>The second chapter demonstrates de novo determination of the sequence and protein N-glycosylation of the anti- H2AX monoclonal antibody, enabling structural modelling of the antigen recognition and laying the groundwork for further development of this diagnostic reagent for DNA damage in cancers. Chapter 3 focusses on improving analysis of protein O-glycosylation using tandem mass spectrometry. …”

Discovery of small molecule epigenetic modulators by Moustakim, M

“…Up to this date there have been no reported inhibitors or chemical probes for the YEATS domain containing proteins despite numerous links to cancers.</p> <p>The final chapter 5 describes the outputs from the industrial placement period of my doctoral training during which synthetic methodology and total synthesis research at Vertex Pharmaceuticals was carried out. …”

Melanomas in renal transplant recipients. by Le Mire, L, Hollowood, K, Gray, D, Bordea, C, Wojnarowska, F

“…BACKGROUND: It is well documented that renal transplant recipients are at increased risk of developing skin cancers, in particular squamous cell carcinomas. Less extensively reviewed in the literature is the increased incidence of malignant melanoma. …”

Molecular characteristics of serrated adenomas of the colorectum. by Sawyer, E, Cerar, A, Hanby, A, Gorman, P, Arends, M, Talbot, I, Tomlinson, I

“…Molecular studies comparing SAs and classical adenomas suggest that each may be a distinct entity; in particular, it has been proposed that microsatellite instability (MSI) distinguishes SAs from classical adenomas and that SAs and the colorectal cancers arising from them develop along a pathway driven by low level microsatellite instability (MSI-L). …”

Clinical intensity modulated proton therapy for Hodgkin lymphoma: which patients benefit the most? by Ntentas, G, Dedeckova, K, Andrlik, M, Aznar, M, George, B, Kubeš, J, Darby, S, Cutter, D

“…<p><strong>Purpose</strong></p> <p>Radiation therapy (RT) improves control of Hodgkin lymphoma (HL), but patients who undergo RT are at risk for late effects, including cardiovascular disease and second cancers, because of radiation doses to organs at risk (OARs). …”

Benzodiazepines and related drugs for insomnia in palliative care. by Hirst, A, Sloan, R

“…SELECTION CRITERIA: Studies considered for inclusion were randomized controlled trials of adult patients in any setting, receiving palliative care or suffering an incurable progressive medical condition. (For example, cancers, AIDS, Motor Neurone Disease, Multiple Sclerosis, Parkinson's Disease, Chronic Obstructive Pulmonary Disease). …”

Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients by Watling, C, Kelly, R, Tong, Y, Piernas, C, Watts, E, Tin Tin, S, Knuppel, A, Schmidt, J, Wrightson, R, Key, T, Travis, R

“…<p><strong>Background:</strong> Circulating insulin-like growth factor-I (IGF-I) is associated with the risk of several cancers. Dietary protein intake, particularly dairy protein, may increase circulating IGF-I; however, associations with different protein sources, other macronutrients, and fibre are inconclusive.…”

Randomized controlled trial of dietary fiber for the prevention of radiation-induced gastrointestinal toxicity during pelvic radiotherapy by Wedlake, L, Shaw, C, McNair, H, Lalji, A, Mohammed, K, Klopper, T, Allan, L, Tait, D, Hawkins, M, Somaiah, N, Lalondrelle, S, Taylor, A, VanAs, N, Stewart, A, Essapen, S, Gage, H, Whelan, K, Andreyev, H

“…Background: Therapeutic radiotherapy is an important treatment of pelvic cancers. Historically, low-fiber diets have been recommended despite a lack of evidence and potentially beneficial mechanisms of fiber.Objective: This randomized controlled trial compared low-, habitual-, and high-fiber diets for the prevention of gastrointestinal toxicity in patients undergoing pelvic radiotherapy.Design: Patients were randomly assigned to low-fiber [≤10 g nonstarch polysaccharide (NSP)/d], habitual-fiber (control), or high-fiber (≥18 g NSP/d) diets and received individualized counseling at the start of radiotherapy to achieve these targets. …”

Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication. by Farquhar, M, Humphreys, I, Rudge, S, Wilson, G, Bhattacharya, B, Ciaccia, M, Hu, K, Zhang, Q, Mailly, L, Reynolds, G, Aschcroft, M, Balfe, P, Baumert, T, Roessler, S, Wakelam, M, McKeating, J

“…Autotaxin generates the biologically active lipid lysophosphatidic acid that has been reported to play a tumorigenic role in a wide number of cancers. In this study we show that Hepatitis C virus infection increases autotaxin expression via hypoxia inducible transcription factor and provides an environment in the liver that promotes fibrosis and liver injury. …”

Understanding drug resistance through computational models of the genotype-phenotype mapping by Nichol, D

“…If we are to predict or reverse evolution, as we must to determine effective treatments for drug-resistant infections and cancers, then we must first understand the relationship between genetic and phenotypic change. …”

MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival. by Chi, J, Ballabio, E, Chen, X, Kušec, R, Taylor, S, Hay, D, Tramonti, D, Saunders, N, Littlewood, T, Pezzella, F, Boultwood, J, Wainscoat, J, Hatton, C, Lawrie, C

“… BACKGROUND: MicroRNAs are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many cancers including hematological malignancies. However, the role of microRNAs in the pathogenesis of multiple myeloma (MM) is only poorly understood. …”

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists by Ye, Y

“…Hence, selective blockage of Ins<em>P₃ </em>Rs will allow better understanding of Ca²⁺ signalling and might also unveil novel treatment for cancers, in the long term. There were no selective Ins<em>P₃ </em>Rs antagonists known at the start of these studies. …”

Synthesis of deuterated phosphatidylinositol phosphates by Saunders, A

“…Dysfunction of these processes has been implicated in numerous diseases including diabetes and many cancers. Some aspects of PtdInsP_n signalling have been heavily investigated; PTEN, PKC/Akt, PtdIns3K and PtdIns4K are all important therapeutic targets that have seen much attention in industrial endeavours. …”

Radionuclide imaging of angiogenesis by Patel, N

“…<p>Angiogenesis is a fundamental process in the survival, growth and spread of cancers. In recent years several therapies have been developed to interfere with this process. …”

Presentation of B-cell lymphoma in childhood and adolescence: a systematic review and meta-analysis by Saatci, D, Zhu, C, Harnden, A, Hippisley-Cox, J

“…Background: The diagnosis of B-cell lymphoma, one of the commonest cancers seen in childhood and adolescence, is challenging. …”

Unravelling the molecular and cellular mechanisms of fetal B cell lymphopoiesis to help understand childhood leukaemia by Green, J

“…<p>Childhood Leukaemia accounts for nearly one in three of all childhood cancers, with approximately 400 cases diagnosed in the UK every year. …”