Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters. by Di Pietro, A, Conseil, G, Pérez-Victoria, J, Dayan, G, Baubichon-Cortay, H, Trompier, D, Steinfels, E, Jault, J, De Wet, H, Maitrejean, M, Comte, G, Boumendjel, A, Mariotte, A, Dumontet, C, McIntosh, D, Goffeau, A, Castanys, S, Gamarro, F, Barron, D

“…Cancer cell resistance to chemotherapy is often mediated by overexpression of P-glycoprotein, a plasma membrane ABC (ATP-binding cassette) transporter which extrudes cytotoxic drugs at the expense of ATP hydrolysis. …”

Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC) by Auzair, L.M., Vincent-Chong, V.K., Ghani, W.M.N.W.A., Kallarakkal, T.G., Ramanathan, A., Lee, C.E., Rahman, Z.A.A., Ismail, S.M., Abraham, M.T., Zain, R.B.

“…Caveolin-1 (Cav-1) and Actin-Related Protein 2/3 Complex, Subunit 1B (ARPC1B) have been implicated in various human cancers, yet its role in tumorigenesis remains controversial. …”

Quantification of Circulating Epstein-Barr Virus Latent Membrane Protein 1 Gene and Analysis Of 30-Bp Deletion and Xhoi-Loss Variants in Nasopharyngeal Carcinoma by See, Hui Shien

“…In Malaysia, NPC has become the second most frequent cancers among males and fifth most frequent cancers in females. …”
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Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade by Weinberg, Robert A. (Robert Allan), 1942-

“…Immunotherapy using checkpoint-blocking antibodies against PD-1 has produced impressive results in a wide range of cancers. However, the response remains heterogeneous among patients. …”
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A random forest based computational model for predicting novel lncRNA-disease associations by Yao, Dengju, Zhan, Xiaojuan, Zhan, Xiaorong, Kwoh, Chee Keong, Li, Peng, Wang, Jinke

“…Moreover, case studies on three cancers demonstrate that 43 of the 45 lncRNAs predicted by the RFLDA are validated by experimental data, and the other two predicted lncRNAs are supported by other LDA prediction models. …”
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Obesity and associated health related factors among university staff in Serdang, Malaysia by Gyanchand Rampal, Lekhraj Rampal, Saeedi, Pouya, Bezenjani, Somayeh Aminzadeh, Md Said, Salmiah, Othman, Norlijah

“…Obesity is a well-established risk factor for coronary heart disease, ischemic stroke, type 2 diabetes, cancers of the breast, colon, prostate and other organs. …”
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Diagnostic and therapeutic devices and applications of endoscopic optical coherence tomography by Ahsen, Osman Oguz

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OptMAVEn-2.0: De novo Design of Variable Antibody Regions Against Targeted Antigen Epitopes by Chowdhury, Ratul, Maranas, Costas D., Allan, Matthew Frederick

“…Monoclonal antibodies are becoming increasingly important therapeutic agents for the treatment of cancers, infectious diseases, and autoimmune disorders. …”
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Design, development, and testing of a stochastically modulated Raman spectrometer by Zervas, Michael Jay.

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Leading the field: Fortune favors the bold in Thurstonian choice models by Evans, Steven N., Rivest, Ronald L, Stark, Philip B.

“…Schools with the highest average student performance are often the smallest schools; localities with the highest rates of some cancers are frequently small; and the effects observed in clinical trials are likely to be largest for the smallest numbers of subjects. …”
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Transcriptional role of cyclin D1 in development revealed by a “genetic-proteomic” screen by Bienvenu, Frederic, Jirawatnotai, Siwanon, Elias, Joshua E., Meyer, Clifford A., Mizeracka, Karolina, Marson, Alexander, Frampton, Garrett M., Cole, Megan F., Odom, Duncan, Odajima, Junko, Geng, Yan, Zagozdzon, Agnieszka, Jecrois, Marie, Young, Richard A., Liu, X. Shirley, Cepko, Constance L., Gygi, Steven P., Sicinski, Piotr

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Evolution's footsteps : reconstructing in vitro and in vivo evolutionary trajectories via massively parallel sequencing and profiling by Funt, Jason Michael

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Understanding and manipulating alkaloid biosynthesis by Glenn, Weslee S. (Weslee Sinclair)

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Global analysis of alternative splicing in human cells of myeloid origin by Lorenzini Paolo Alberto

“…The characterization of alternative splicing events in myeloid cells will provide a basis to study perturbations that occur in various human disorders such as allergies, autoimmune diseases and cancers. Thus, we performed two transcriptome studies by RNA-sequencing in the aforementioned cells. …”
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HLA variants have different preferences to present proteins with specific molecular functions which are complemented in frequent haplotypes by Karnaukhov, V, Paes, W, Woodhouse, IB, Partridge, T, Nicastri, A, Brackenridge, S, Ternette, N, Koohy, H, Borrow, P

“…Our observations can be extrapolated to explain the protective effect of certain HLA alleles in infectious diseases, and we hypothesize that they can also explain susceptibility to certain autoimmune diseases and cancers. We demonstrate that these differences lead to differential presentation of HIV, influenza virus, SARS-CoV-1 and SARS-CoV-2 proteins by various HLA alleles. …”

ReN VM spheroids in matrix: A neural progenitor three-dimensional in vitro model reveals DYRK1A inhibitors as potential regulators of radio-sensitivity by Wan, X, Wu, X, Hill, MA, Ebner, DV

“…In contrast, well developed and applied three dimensional (3D) in vitro models could be employed to bridge the gap between 2D in vitro primary screening and expensive in vivo rodent models by incorporating key features of the tissue microenvironment to explore differentiation, cortical development, cancers and various neuronal dysfunctions. These features include an extracellular matrix, co-culture, tension and perfusion and could replace several hundred rodents in the drug screening validation cascade.…”

Health impacts of takeaway management zones around schools in six different local authorities across England: a public health modelling study using PRIMEtime by Rogers, NT, Amies-Cull, B, Adams, J, Chang, M, Cummins, S, Derbyshire, D, Hassan, S, Keeble, M, Liu, B, Medina-Lara, A, Savory, B, Rahilly, J, Smith, R, Thompson, C, White, M, Mytton, O, Burgoine, T

“…Model estimates showed reductions in incidence of disease, including type II diabetes (e.g. 964 (95% UI: 1565, 870) fewer cases/100,000 population for males in Manchester)), cardiovascular diseases, asthma, certain cancers, and low back pain. Savings in healthcare costs (millions) ranged from £1.65 (95% UI: £1.17, £2.25)/100,000 population in North Somerset to £2.02 (95% UI: £1.39, £2.83)/100,000 population in Wandsworth. …”

Impact of heart failure and left ventricular systolic dysfunction on quality of life: a cross-sectional study comparing common chronic cardiac and medical disorders and a represent... by Hobbs, F, Kenkre, J, Roalfe, A, Davis, R, Hare, R, Davies, M

“…BACKGROUND: Heart failure and left ventricular systolic dysfunction (LVSD) are increasingly common disorders, with outcomes worse than many cancers. Evidence-based therapies, such as ACE inhibitors and beta-blockers, improve prognosis and symptoms, and reduce healthcare expenditure. …”

NanoSIMS analysis of arsenic uptake and detoxification mechanisms in angiosperms by Taylor, H

“…<p>Rice irrigated with arsenic (As) contaminated groundwater can contain concentrations of As in the grain high enough to contribute significantly to dietary intake, leading to increased rates of adverse health effects including cancers of the liver, bladder and kidney.</p> <p>The exact mechanisms by which As is transported from growth medium to grain are not fully understood. …”

Mortality in vegetarians and non-vegetarians: a collaborative analysis of 8300 deaths among 76,000 men and women in five prospective studies. by Key, T, Fraser, G, Thorogood, M, Appleby, P, Beral, V, Reeves, G, Burr, M, Chang-Claude, J, Frentzel-Beyme, R, Kuzma, J, Mann, J, McPherson, K

“…Death rate ratios for vegetarians compared to non-vegetarians were calculated for ischaemic heart disease, cerebrovascular disease, cancers of the stomach, large bowel, lung, breast and prostate, and for all causes of death. …”