Extracorporeal high intensity focused ultrasound for renal tumours: a 3-year follow-up. by Ritchie, R, Leslie, T, Phillips, R, Wu, F, Illing, R, ter Haar, G, Protheroe, A, Cranston, D

“…PATIENTS AND METHODS: Although surgery currently remains the standard treatment for localized renal cell carcinoma (RCC), the increasing incidence of small renal cancers has led to a shift towards nephron-sparing surgery, with associated morbidity in 20-25% of cases, and minimally invasive ablative therapies present an alternative management. …”

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms. by Sim, E, Lack, N, Wang, C, Long, H, Westwood, I, Fullam, E, Kawamura, A

“…It is expressed in many tissues, particularly in oestrogen receptor positive breast cancers. Human NAT1 has an endogenous role in acetylation of a folate catabolite with in vivo evidence from transgenic mice lacking the equivalent gene. …”

Structural and computational studies of fibroblast growth factor receptor signalling complex formation by Zuniga, S

“…It has been implicated in a wide range of human pathologies such as cancers and skeletal disorders which is the reason for a particular interest over recent years. …”

Associations between food group intakes and circulating insulin-like growth factor-I in the UK Biobank: a cross-sectional analysis by Watling, CZ, Kelly, RK, Tong, TYN, Piernas, C, Watts, EL, Tin Tin, S, Knuppel, A, Schmidt, JA, Travis, RC, Key, TJ, Perez-Cornago, A

“…<p><strong>Purpose:</strong>&nbsp;Circulating insulin-like growth factor-I (IGF-I) concentrations have been positively associated with risk of several common cancers and inversely associated with risk of bone fractures. …”

Structural characterization of the Human Endogenous Retrovirus and SARS-CoV-2 by Krebs, AS

“…HERV-K (HML-2) is the most recently acquired HERV but mutations have rendered it mostly silent except in many cancers, neurological diseases, and during the aging process. …”

The spectrum of health conditions in community-based cross-sectional surveys in Southeast Asia 2010-21: a scoping review by Zhang, M, Kozlowski, H, Chew, R, Htun, NSN, Morris, SK, Akladious, C, Sarker, AR, Lubell, Y, Peto, TJ

“…However, other high-burden conditions (e.g. hearing loss, headache disorder, low back pain, chronic liver and kidney diseases, and cancers) were rarely studied. Conclusion: There were relatively few recent surveys from which to estimate representative prevalences and trends of health conditions beyond those known to be high burden. …”

"Sometimes we can't fix things": a qualitative study of health care professionals' perceptions of end of life care for patients with heart failure by Glogowska, M, Simmonds, R, McLachlan, S, Cramer, H, Sanders, T, Johnson, R, Kadam, U, Lasserson, D, Purdy, S

“…<strong>Background:</strong> Although heart failure has a worse prognosis than some cancers, patients often have restricted access to well-developed end of life (EoL) models of care. …”

Low-intensity daily smoking and cause-specific mortality in Mexico: prospective study of 150 000 adults by Thomson, B, Tapia-Conyer, R, Lacey, B, Lewington, S, Ramirez-Reyes, R, Aguilar-Ramirez, D, Gnatiuc, L, Herrington, WG, Torres, J, Trichia, E, Wade, R, Collins, R, Peto, R, Kuri-Morales, P, Alegre-Díaz, J, Emberson, JR

“…The diseases most strongly associated with daily smoking were respiratory cancers, chronic obstructive pulmonary disease and gastrointestinal and vascular diseases. …”

Proliferating cell nuclear antigen (PCNA) activity in hepatocellular carcinoma, benign peri-neoplastic and normal liver by Mun, K.S., Cheah, P.L., Baharuddin, N.B., Looi, L.M.

“…Hepatocellular carcinoma (HCC) is among the ten most common cancers in Malaysian males. As cellular proliferation is an important feature of malignant transformation, we studied the proliferation pattern of normal and benign perineoplastic liver versus hepatocellular carcinoma in an attempt to further understand the tumour transformation process. 39 HCC (21 with accompanying and 18 without cirrhosis) histologically diagnosed at the Department of Pathology, University of Malaya Medical Centre between January 1992 and December 2003 were immunohistochemically studied using a monoclonal antibody to PCNA (Clone PC10: Dako). 20 livers from cases who had succumbed to traumatic injuries served as normal liver controls (NL). …”

Development and user evaluation of an online caregiver education resource for Malaysian parents of children with leukemia or lymphoma by Tan, Chai-Eng, Admodisastro, Novia, Lau, Sie Chong Doris, Tan, Kit Aun, Teh, Kok Hoi, Lee, Chee Chan, Mohd Sidik, Sherina

“…The resource is anticipated to enhance information accessibility and support for Malaysian parents facing hematological cancers in their children. Trial registration: Clinicaltrials.gov NCT05455268. © 2023 The Author(s)…”
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Real-time germanium-doped optical fibers for clinical computed tomography dosimetry by Sarhan, H.G., Saini, S.M., Bahari, N.M., Bradley, D.A., Zubair, H.T., Basaif, A., Oresegun, A.A., Abdul Rashid, H.A., M. Noor, N.

“…In studies focusing on the practice of clinical computed tomography (CT) a particular concern has been that of delivering unnecessary dose to patients and with it the added risk for radiation-induced cancers. For a CT system, present work has investigated the dosimetric characteristics of a Ge-doped optical fiber real-time dosimetry system (model LS-2000, Lumisyns), measuring beam quality, exposure linearity and exposure duration accuracy. …”
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Xanthorrhizol inhibits cell proliferation, cellular cholesterol uptake in HT29 colon cells and adipogenesis in 3T3-L1 adipocytes by Oon, Seok Fang, Nallappan, Meenakshii, Kassim, Nur Kartinee, Shohaimi, Shamarina, Sa'ariwijaya, Mohd Shazrul Fazry, Tee, Thiam Tsui, Cheah, Yew Hoong

“…Hyperlipidemia is defined as the presence of either hypertriglyceridemia or hypercholesterolemia, which could cause atherosclerosis, cardiovascular diseases and certain cancers. Although hyperlipidemia can be treated by hypolipidemic drugs, they are limited due to lack of effectiveness and safety. …”
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Loss of interleukin17RA expression is associated with tumour progression in colorectal carcinoma by Chai, Boon Yean, Yip, Wai Kien, Dusa, Noraini, Mohtaruddin, Norhafizah, Seow, Heng Fong

“…Interleukin-17 (IL-17) is a pro-inflammatory cytokine found in various cancers. Current evidence indicates that IL-17 plays a vital role in tumour initiation and progression in colorectal carcinoma (CRC) via binding with its receptor, IL-17RA. …”
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Elucidation of mRNA targets of miR-145-5p in diabetic kidney disease using bioinformatics analysis by Zahari Sham, Siti Yazmin, Azwar, Shamin, Wai, Kien Yip, Abdullah, Maha, Thevandran, Kalaiselvam, Osman, Malina, Heng, Fong Seow

“…In addition, miR-145 has been implicated as a tumour suppressor in various cancers. Methods: In this study, bioinformatics tools were utilized to predict the mRNA targets of miR- 145-5p. …”
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Sonographic review of thyroid lesion based on ATA and ACR-tirads classification by Nagalindam, Deivind Kumar

“…Background: Thyroid malignancy is one of the commonest cancers among adults with prevalence rate of 3-7%. …”
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Legal protection of air pollution in Iraq by Ashour, Ameel Jabbar, Abdul Wahab, Harlida

“…The estimated leak from the shipping stations and sinking ships was about 8.4 million barrels.It is worth noting that the environment was not just affected by one kind of pollutant, but also involved radio logical, chemical and other electromagnetic pollutants.This accident negatively affected the lives of people, especially those residing in the affected area.Furthermore, the United States' occupation to Iraq in 2003 had a crucial role in increasing the problem of environmental air pollution; they used internationally prohibited weapons, e.g., radioactive uranium and chemical weapons.The use of such weapons led to fatal health problems for the Iraqi people, evidenced mainly by the occurrence of cancerous diseases, distorted new born babies and infertility.Hence, this paper proposes the adoption of the Iraqi criminal law represented by the Iraqi Punishments Law No. 111 of 1969, is a law governing all crimes without exception, whether they are environmental or ordinary crimes. …”
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Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington’s disease mice by Kedaigle, Amanda J, Reidling, Jack C, Lim, Ryan G, Adam, Miriam, Wu, Jie, Wassie, Brook T., Stocksdale, Jennifer T, Casale, Malcolm S, Fraenkel, Ernest, Thompson, Leslie M

“…The drug JQ1, which inhibits histone acetyl-lysine reader bromodomains, has shown promise for multiple cancers and neurodegenerative disease. We tested whether JQ1 could improve behavioral phenotypes in the R6/2 mouse model of HD and modulate HD-associated changes in transcription and epigenomics. …”
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Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation by Cheng, Hong Sheng, Marvalim, Charlie, Zhu, Pengcheng, Law, Daniel Cheng Lui, Low, Jeremy Zhi Yan, Chong, Yuk Kien, Ang, Beng Ti, Tang, Carol, Tan, Nguan Soon

“…Conclusions: Thus, our "bench to bedside (the use of patient-derived GPCs and xenografts for basic research) and back (validation with independent glioblastoma transcriptome databases)" analysis unravels the novel therapeutic indications of c-MET and PI3K/Akt inhibitors for the treatment of glioblastoma, and potentially other cancers, in the hypoxic tumor microenvironment.…”
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N-WASP attenuates cell proliferation and migration through ERK2-dependent enhanced expression of TXNIP by Chung, Yat Joong, Salvi, Amrita, Kalailingam, Pazhanichamy, Alnawaz, Myra, Tan, Suat Hoon, Pan, Jiun Yit, Tan, Nguan Soon, Thanabalu, Thirumaran

“…It has been known that reduced N-WASP expression in breast and colorectal cancers is associated with poor prognosis. Here, we found reduced N-WASP expression in squamous cell carcinoma (SCC) patient samples. …”
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Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters. by Di Pietro, A, Conseil, G, Pérez-Victoria, J, Dayan, G, Baubichon-Cortay, H, Trompier, D, Steinfels, E, Jault, J, De Wet, H, Maitrejean, M, Comte, G, Boumendjel, A, Mariotte, A, Dumontet, C, McIntosh, D, Goffeau, A, Castanys, S, Gamarro, F, Barron, D

“…Cancer cell resistance to chemotherapy is often mediated by overexpression of P-glycoprotein, a plasma membrane ABC (ATP-binding cassette) transporter which extrudes cytotoxic drugs at the expense of ATP hydrolysis. …”