Optimising radiotherapy of liver tumours: radiobiology of yttrium-90 microsphere treatment by Abbott, EM

“…</p> <p><strong>Materials and Methods:</strong> Clonogenic assays of cancer cell lines were used to assess radiosensitivity from exposure to 90Y SIRT and EBRT (LINAC and 137Cs). …”

Investigating the role of IGF-1R in radio-sensitivity by Ellis, M

“…The insulin-like growth factor (IGF) axis is an important regulator of cancer cell proliferation, growth, invasion, and can also mediate therapy resistance. …”

Phytochemical, antioxidant and cytotoxic activities of white mulberry (morus alba l.) from Kampung Tudan, Ranau, Sabah by Centhyea

“…Samples were analysed for their antioxidant activity, phytochemical components’ values, and cell viability activity against the human breast cancer cell line (MCF-7). As a result, data from fruits demonstrated maturity-dependent increment for antioxidant activities, total phenolic content (TPC), total flavonoids content (TFC), and total anthocyanin content (TAC). …”
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In vitro and in vivo anti-lung cancer properties of leaf ethanolic extract of morinda citrifolia l. by Lim, Swee Ling

“…The MLE inhibited the proliferation and induced apoptosis in A549 cells (IC50 = 23.47 μg/mL), arrested cancer cell cycle at G0/G1 phases and significantly increased caspase-3/-8 without changing caspase-9 levels. …”
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Photoprotective properties, chemical, biological and product formulation studies on Zanthoxylum rhetsa (Roxb.) DC by Santhanam, Rameshkumar

“…Subsequently, the extract and fractions were tested for their cytotoxic effect against human dermal fibroblasts (HDF) and mouse melanoma (B16-F10), representing normal and cancer cell lines, respectively. All the test samples were found to be nontoxic to HDF cells. …”
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Phytochemistry of Calophyllum inophyllum L. and Calophyllum teysmannii Miq. and their biological activities by Lee, Kar Wei

“…Lastly, cytotoxicity screening via MTT assay of ananixanthone (29) and four of its modified derivatives against three cancer cell lines, SNU-1, LS-174T and K562 resulted in ananixanthone (29) showing the greatest activities against SNU-1 and K562 cell lines with the IC50 values of 8.97±0.11 μg/mL and 2.96±0.06 μg/mL respectively. …”
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Phytochemical constituents from Calophyllum buxifolium Vesque and Calophyllum hosei Ridl and their biological activities by Daud, Shaari

“…The crude extracts for both plants gave a weak cytotoxic activity through MTT assay against two human cancer cell lines, HL60 (human promyelocytic leukemia) and MCF7 (human breast adenocarcinoma) cell line. …”
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Toxicology evaluations of Rhaphidophora decursiva (Roxb.) Schott extract in Sprague Dawley by Arsad, Siti Suriani

“…The study aims to evaluate the toxic effects of the methanol extract of R. decursiva after single dose toxicity study (14-day acute toxicity study), repeated 28-day subacute toxicity and 90-day subchronic toxicity study in male Sprague Dawley rats, and also to determine the anti-proliferative activity of R. decursiva extract on colon cancer cell lines (HT-29) and normal cell lines (3T3). …”
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Surface-Modified Zinc Oxide Nanoparticles And Their Bioactivity Towards Hela Cell Lines, Escherichia Coli And Shigella Flexneri by Sirelkhatim, Amna Hassan

“…The main objective of this thesis is to investigate the structural, morphological, optical and physiochemical properties of zinc oxide nanoaprticles (ZnO-NPs) with their correlation on anti-cancer activity towards human cervical cancer cell lines (HeLa). The antibacterial activity of ZnO-NPs towards E.coli and Shigella Flexneri was studied as well to get considerable indication of the bioactivity of ZnO-NPs. …”
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Transcriptional and translational expression of PPARY in the human colorectal cancer dell llne, colo 205 by Yaacob, Nik Soriani

“…In agreement with the potential role of PPARy ligands for the treatment of cancer, our present study was aimed at observing the growth inhibition of the colorectal cancer cell line, COL0205 by the PPARy ligand, ciglitazone. …”
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Antioxidant and antiproliferative activities of six Malaysian medicinal plants and mechanism of action through microrna in thyroid cell lines by Ismail, Aziana

“…Despite various reports on the anti-cancer activities of plant extracts on a variety of cancer cell lines, the cellular targets and the underlying mechanisms remain unclear. …”
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CLEC4s as Potential Therapeutic Targets in Hepatocellular Carcinoma Microenvironment by Yinjiang Zhang, Yinjiang Zhang, Yinjiang Zhang, Hongyun Wei, Hongyun Wei, Lu Fan, Lu Fan, Mingyan Fang, Mingyan Fang, Xu He, Xu He, Binan Lu, Binan Lu, Zongran Pang, Zongran Pang

“…C-type (Ca2+ -dependent) lectin (CLEC) receptors, essential in innate pattern recognition, have potential regulatory effects on immune cell trafficking and modulatory effects on cancer cell activity. However, information on the expression and prognostic value of CLECs in HCC is scanty. …”
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Comparative Analysis of Colon Cancer-Derived Fusobacterium nucleatum Subspecies: Inflammation and Colon Tumorigenesis in Murine Models by Jessica Queen, Jada C. Domingue, James Robert White, Courtney Stevens, Barath Udayasuryan, Tam T. D. Nguyen, Shaoguang Wu, Hua Ding, Hongni Fan, Madison McMann, Alina Corona, Tatianna C. Larman, Scott S. Verbridge, Franck Housseau, Daniel J. Slade, Julia L. Drewes, Cynthia L. Sears

“…Using multiple murine models, in vitro assays with a human colon cancer cell line, and whole-genome sequencing analysis, we investigated the proinflammatory and tumorigenic potential of several F. nucleatum clinical isolates. …”
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Aculeaxanthones A–E, new xanthones from the marine-derived fungus Aspergillus aculeatinus WHUF0198 by Jun Wu, Jun Wu, Hua Shui, Mengke Zhang, Yida Zeng, Mingxin Zheng, Kong-Kai Zhu, Shou-Bao Wang, Hongkai Bi, Kui Hong, You-Sheng Cai, You-Sheng Cai

“…Compounds 1–9 were tested for cytotoxicity against the Bel-7402, A549, and HCT-116 cancer cell lines. Of the dimeric tetrahydroxanthone derivatives, only compound 6 provided cytotoxicity effect against Bel-7402 cell line (IC50, 1.96 µM). …”
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Cell-free DNA next-generation sequencing liquid biopsy as a new revolutionary approach for arteriovenous malformation by Maria Palmieri, MS, Aurora Currò, MD, Andrea Tommasi, MD, Laura Di Sarno, MS, Gabriella Doddato, MS, Margheria Baldassarri, MD, Elisa Frullanti, MS, Ann Rita Giliberti, MS, Chiara Fallerini, MS, Angelo Spinazzola, MD, Anna Maria Pinto, MD, PhD, Alessandra Renieri, MD, PhD, Massimo Vaghi, MD

“…The cfDNA libraries were performed using Oncomine Pan-Cancer Cell-Free Assay. We used Ion Proton for sequencing and Ion Reporter Software for analysis (Life Technologies, Carlsbad, Calif). …”
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RSK3 switches cell fate: from stress-induced senescence to malignant progression by Anda Huna, Jean-Michel Flaman, Catalina Lodillinsky, Kexin Zhu, Gabriela Makulyte, Victoria Pakulska, Yohann Coute, Clémence Ruisseaux, Pierre Saintigny, Hector Hernandez-Vargas, Pierre-Antoine Defossez, Mathieu Boissan, Nadine Martin, David Bernard

“…Results A screen with active kinases in HMECs upon TGFβ treatment identified that the serine threonine kinase RSK3, or RPS6KA2, a kinase mainly known to regulate cancer cell death including in breast cancer, reverted TGFβ-induced senescence. …”
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Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown <i>Physalis co... by Ya-Ming Xu, E. M. Kithsiri Wijeratne, Manping X. Liu, Lijiang Xuan, Wenqiong Wang, A. A. Leslie Gunatilaka

“…Evaluation against a panel of prostate cancer (LNCaP, VCaP, DU-145, and PC-3) and renal carcinoma (ACHN) cell lines, and normal human foreskin fibroblast (WI-38) cells revealed that <b>8, 13</b>, <b>15</b>, and <b>17</b>–<b>19</b> had potent and selective activity for prostate cancer cell lines. Facile conversion of the 5,6-chlorohydrin <b>17</b> to its 5,6-epoxide <b>8</b> in cell culture medium used for the bioassay suggested that the cytotoxic activities observed for <b>17</b>–<b>19</b> may be due to in situ formation of their corresponding 5β,6β-epoxides, <b>8</b>, <b>27</b>, and <b>28</b>.…”
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Low-Dimensional Compounds Containing Bioactive Ligands. Part XIX: Crystal Structures and Biological Properties of Copper Complexes with Halogen and Nitro Derivatives of 8-Hydroxyqu... by Martina Kepeňová, Martin Kello, Romana Smolková, Michal Goga, Richard Frenák, Ľudmila Tkáčiková, Miroslava Litecká, Jan Šubrt, Ivan Potočňák

“…Cytotoxic activity of the complexes and ligands was tested against MCF-7, MDA-MB-231, HCT116, CaCo2, HeLa, A549 and Jurkat cancer cell lines. The selectivity of the complexes was verified on a noncancerous Cos-7 cell line. …”
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Concomitant High Apoptosis Inhibitor of Macrophage (AIM) and Low Prostate-Specific Antigen (PSA) Indicates Activated T Cell-Mediated Anticancer Immunity, Enhance Sensitivity to Pem... by Oluwaseun Adebayo Bamodu, Yuan-Hung Wang, Chi-Tai Yeh, Chen-Hsun Ho, Yi-Te Chiang, Wei-Tang Kao, Chia-Hung Liu, Chia-Chang Wu

“…There are reports that the apoptosis inhibitor of macrophage (AIM), secreted mainly by macrophages and epithelial cells, is upregulated during inflammation and facilitates immune recognition of cancerous cells by blocking human regulator of complement activation. …”
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(Arg)9-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling by An-dong Liu, Hui Xu, Ya-nan Gao, Dan-ni Luo, Zhao-feng Li, Courtney Voss, Shawn S. C. Li, Xuan Cao

“…The remarkable ability of (Arg)9-SH2 superbinder to inhibit cancer cell proliferation and tumor growth might open the door to explore the SH2 superbinder as a therapeutic agent for cancer treatment.…”
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