High miR-30 Expression Associates with Improved Breast Cancer Patient Survival and Treatment Outcome by Maral Jamshidi, Rainer Fagerholm, Taru A. Muranen, Sippy Kaur, Swapnil Potdar, Sofia Khan, Eliisa Netti, John-Patrick Mpindi, Bhagwan Yadav, Johanna I. Kiiski, Kristiina Aittomäki, Päivi Heikkilä, Jani Saarela, Ralf Bützow, Carl Blomqvist, Heli Nevanlinna

“…We conducted a two-stage drug-screen to investigate the impact of miR-30 family members (miR-30a-30e) on sensitivity to doxorubicin and lapatinib in six breast cancer cell lines HCC1937, HCC1954, MDA-MB-361, MCF7, MDA-MB-436 and CAL-120, using drug sensitivity scores (DSS) to compare the miR-30 family mimics to their specific inhibitors. …”
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circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling by Lin Zheng, Hui Liang, Qiaoling Zhang, Zichu Shen, Yixin Sun, Xuyang Zhao, Jingjing Gong, Zhiyuan Hou, Kewei Jiang, Quan Wang, Yan Jin, Yuxin Yin

“…Low expression of circPTEN1 promotes metastasis in PDX models in vivo and accelerates cancer cell invasion in vitro, whereas overexpression of circPTEN1 reveals opposite roles. …”
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The prognostic value of the systemic immune-inflammation index for patients with bladder cancer after radical cystectomy by Shiyu Zhang, Jiajia Du, Xin Zhong, Ping Tan, Ping Tan, Hang Xu, Jiapeng Zhang, Di Jin, Yifan Li, Weizhen Le, Xingyu Xiong, Tianhai Lin, Qiang Wei

“…Inflammation plays a crucial role in cancer cell initiation, proliferation, and metastasis. …”
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CD24+CD44+CD54+EpCAM+ gastric cancer stem cells predict tumor progression and metastasis: clinical and experimental evidence by Angel A. Gómez-Gallegos, Lizbeth Ramírez-Vidal, Jared Becerril-Rico, Elizabeth Pérez-Islas, Zuly J. Hernandez-Peralta, Mariel E. Toledo-Guzmán, Alejandro García-Carrancá, Elizabeth Langley, Angélica Hernández-Guerrero, Fernando López-Casillas, Roberto Herrera-Goepfert, Luis F. Oñate-Ocaña, Elizabeth Ortiz-Sánchez

“…Specific and thorough identification of cancer cell subsets with higher tumorigenicity and chemoresistance, such as cancer stem cells (CSCs), could lead to the development of new and promising therapeutic targets. …”
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CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas by Jaime M. Pita, Eric Raspé, Katia Coulonval, Myriam Decaussin-Petrucci, Maxime Tarabichi, Geneviève Dom, Frederick Libert, Frederick Libert, Ligia Craciun, Guy Andry, Laurence Wicquart, Emmanuelle Leteurtre, Christophe Trésallet, Christophe Trésallet, Laura A. Marlow, John A. Copland, Cosimo Durante, Carine Maenhaut, Branca M. Cavaco, Jacques E. Dumont, Giuseppe Costante, Pierre P. Roger

“…Treatment of cell lines with CDK4/6i and combination with BRAF/MEK inhibitors (dabrafenib/trametinib) was comprehensively evaluated by western blot, characterization of immunoprecipitated CDK4 and CDK2 complexes and clonogenic assays.ResultsCDK4 phosphorylation was detected in all well-differentiated thyroid carcinomas (n=29), 19/20 PDTC, 16/23 ATC and 18/21 thyroid cancer cell lines, including 11 ATC-derived ones. Tumors and cell lines without phosphorylated CDK4 presented very high p16CDKN2A levels, which were associated with proliferative activity. …”
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miR-302a-5p/367-3p-HMGA2 axis regulates malignant processes during endometrial cancer development by Jian Ma, Da Li, Fan-Fei Kong, Di Yang, Hui Yang, Xiao-Xin Ma

“…In the endometrial cancer cell lines Ishikawa and HEC-1A, the overexpression of miR-302a-5p/367-3p significantly inhibited the expression of HMGA2 mRNA. …”
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Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking by Qingmin He, Qingmin He, Chuan Liu, Xiaohan Wang, Xiaohan Wang, Kang Rong, Kang Rong, Mingyang Zhu, Mingyang Zhu, Liying Duan, Liying Duan, Pengyuan Zheng, Pengyuan Zheng, Pengyuan Zheng, Yang Mi, Yang Mi, Yang Mi

“…Curcumin may interfere with colon cancer cell proliferation and apoptosis by regulating signal transduction pathways such as PI3K-Akt signaling pathway,IL-17 signaling pathway, Cell cycle. …”
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Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting by James H. A. Clubb, James H. A. Clubb, James H. A. Clubb, Tatiana V. Kudling, Tatiana V. Kudling, Mykhailo Girych, Lyna Haybout, Lyna Haybout, Santeri Pakola, Santeri Pakola, Firas Hamdan, Firas Hamdan, Víctor Cervera-Carrascon, Víctor Cervera-Carrascon, Víctor Cervera-Carrascon, Annabrita Hemmes, Susanna Grönberg-Vähä-Koskela, Susanna Grönberg-Vähä-Koskela, Susanna Grönberg-Vähä-Koskela, João Manuel Santos, João Manuel Santos, João Manuel Santos, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Dafne C. A. Quixabeira, Saru Basnet, Saru Basnet, Camilla Heiniö, Camilla Heiniö, Victor Arias, Victor Arias, Elise Jirovec, Elise Jirovec, Shreyas Kaptan, Riikka Havunen, Riikka Havunen, Riikka Havunen, Suvi Sorsa, Suvi Sorsa, Suvi Sorsa, Abdullah Erikat, Joel Schwartz, Marjukka Anttila, Katri Aro, Katri Aro, Tapani Viitala, Ilpo Vattulainen, Vincenzo Cerullo, Vincenzo Cerullo, Anna Kanerva, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki, Akseli Hemminki

“…The oncolytic virus (OV) and ICI combination approach was then evaluated using 11B12-1 and TILT-123 in a Syrian hamster model of pancreatic ductal adenocarcinoma (PDAC).ResultsSupernatants from hybridoma parent subclone 11B12B4 provided the highest positive PD-L1 signal, on Syrian hamster PBMCs and three cancer cell lines (HT100, HapT1 and HCPC1). In vitro co-cultures revealed superior immune modulated profiles of cell line matched HT100 tumour infiltrating lymphocytes when using subclones of 7G2, 11B12 and 12F1. …”
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Knockdown of <i>FLT4</i>, <i>Nup98</i>, and <i>Nup205</i> cellular genes as a suppressor for the viral activity of Influenza A/WSN/33 (H1N1) in A549 cell culture by E. A. Pashkov, E. B. Faizuloev, E. R. Korchevaya, A. A. Rtishchev, B. S. Cherepovich, А. V. Sidorov, A. V. Poddubikov, Е. P. Bystritskaya, Yu. E. Dronina, A. S. Bykov, O. А. Svitich, V. V. Zverev

“…To evaluate the effect of cellular genes FLT4, Nup98, and Nup205 on the reproduction of the influenza A virus in A549 human lung cancer cell line.Methods. The work was carried out using the equipment of the center for collective use of the I.I. …”
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Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment by Alison E. Obr, Sushil Kumar, Yun-Juan Chang, Joseph J. Bulatowicz, Betsy J. Barnes, Raymond B. Birge, Deborah A. Lazzarino, Emily Gallagher, Derek LeRoith, Teresa L. Wood

“…Further analysis of the METABRIC dataset revealed an increase in IL-6, CCL2, and MMP-9 expression in patients with low IGF-1R, consistent with our mouse tumor model and data in human breast cancer cell lines. Conclusions Our data support the hypothesis that reduction of IGF-1R function increases cellular stress and cytokine production to promote an aggressive tumor microenvironment through infiltration of immune cells and matrix remodeling.…”
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Computational Investigation of 1, 3, 4 Oxadiazole Derivatives as Lead Inhibitors of VEGFR 2 in Comparison with EGFR: Density Functional Theory, Molecular Docking and Molecular Dyna... by Muhammad Sajjad Bilal, Syeda Abida Ejaz, Seema Zargar, Naveed Akhtar, Tanveer A. Wani, Naheed Riaz, Adullahi Tunde Aborode, Farhan Siddique, Nojood Altwaijry, Hamad M. Alkahtani, Haruna Isiyaku Umar

“…Furthermore, the anticancer potential of the derivatives was confirmed by cell viability (MTT) assay using breast cancer and cervical cancer cell lines. At the end, the results of ADMET studies confirmed these derivatives as drug like candidates. …”
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Prognostic and predictive value of androgen receptor expression in postmenopausal women with estrogen receptor-positive breast cancer: results from the Breast International Group T... by Kevin H. Kensler, Meredith M. Regan, Yujing J. Heng, Gabrielle M. Baker, Michael E. Pyle, Stuart J. Schnitt, Aditi Hazra, Roswitha Kammler, Beat Thürlimann, Marco Colleoni, Giuseppe Viale, Myles Brown, Rulla M. Tamimi

“…Androgen treatment inhibits ER signaling in ER+/AR+ breast cancer cell lines, and AR expression is associated with improved survival for this subtype in epidemiologic studies. …”
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Transmembrane Protein 170B is a Prognostic Biomarker and Associated With Immune Infiltrates in Pancreatic Adenocarcinoma by Zilong Zhang, Zilong Zhang, Zilong Zhang, Jin Shang, Jin Shang, Jin Shang, Zonglin Dai, Zonglin Dai, Zonglin Dai, Yutong Yao, Yutong Yao, Yutong Yao, Ying Shi, Deyuan Zhong, Deyuan Zhong, Deyuan Zhong, Yuxin Liang, Yuxin Liang, Yuxin Liang, Chunyou Lai, Chunyou Lai, Qinyan Yang, Qinyan Yang, Tianhang Feng, Tianhang Feng, Tianhang Feng, Xiaolun Huang, Xiaolun Huang, Xiaolun Huang

“…Immunostaining and real-time polymerase chain reaction (RT-PCR) were done to determine TMEM170B expression in human pancreatic cancer cell lines and tissue specimens. Furthermore, the correlation of TMEM170B with clinicopathological features and PAAD prognosis was investigated, and the mechanisms were explored through enrichment analysis and immune cell infiltration analysis.Results: TCGA and GEO dataset analysis revealed that TMEM170B expression in PAAD tissue samples was significantly lower than that in non-tumorous tissues, which was further confirmed by immunohistochemistry and RT-PCR. …”
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Synthesis, Anticancer, Antimicrobial and Antioxidant Potential of Novel 4-(Substituted phenyl-1,3,4-oxadiazol/thiadiazol-2-yl)-4-(4-substituted phenyl) Azetidin-2-One Derivatives by Davinder Kumar, Navidha Aggarwal, Virender Kumar, Harsh Kumar, Aakash Deep, Shabana Bibi, Hitesh Chopra, Rakesh Kumar Marwaha, Abdulrahman Alshammari, Metab Alharbi, Abdul Hayee

“…Structure-activity relationship (SAR) studies of synthesized novel derivatives revealed that para-substituted halogen and nitro derivatives have remarkable potential against MCF-7 cancer cell lines and different microbial strains. Current evidence indicates that the synthesized derivatives may be promising candidates for use in the prevention and treatment of these infections. …”
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Enhancing antibacterial efficacy and accelerating infectious wound healing in rats using biogenic metal nanoparticles from marine Bacillus subtilis by Raghuveer Varma Pemmadi, Nabil Abdulhafiz Alhakamy, Nabil Abdulhafiz Alhakamy, Hani Z. Asfour, Hani Z. Asfour, Sabna Kotta, Sabna Kotta, Mohamed A. Alfaleh, Mohamed A. Alfaleh, Prasad Sunnapu, Ilyas Uk, Lalitha Pottail, Akhila Chithambharan, Dhanapal Yogananthan, Samuel Thavamani B, Shilpa Valiyaparambil, Sirajudheen Mukriyan Kallungal, Muddukrishnaiah Kotakonda

“…FE-SEM and HR-TEM observations confirmed that NPs caused bacterial cell leakage, damage, and shrinkage. Cancer cell viability was reduced upon treatment with increasing concentrations of CBPPR1Au and AgNPs, and apoptosis was increased in cells treated with CBPPR1Au and AgNPs relative to untreated cells (p &lt; 0.001). …”
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CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis by Yuping Du, Xin Liu, Song Zhang, Shuo Chen, Xue Guan, Qianhui Li, Xi Chen, Yang Zhao

“…MTT viability assay, apoptosis assay, wound healing assay and invasion assay were used to investigate the function of circCRIM1 and CRIM1 in ovarian cancer cell lines OVCAR3 and CAOV3. Mice xenografts experiment was performed. …”
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Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer by Tushar Tomar, Nicolette G. Alkema, Leroy Schreuder, Gert Jan Meersma, Tim de Meyer, Wim van Criekinge, Harry G. Klip, Heidi Fiegl, Els van Nieuwenhuysen, Ignace Vergote, Martin Widschwendter, Ed Schuuring, Ate G. J. van der Zee, Steven de Jong, G. Bea A. Wisman

“…Functional validation of FZD10 on chemosensitivity was carried out in ovarian cancer cell lines using siRNA-mediated silencing. Results Integrated genome-wide methylome and expression analysis identified 45 significantly differentially methylated and expressed genes between two chemoresponse groups. …”
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Phytochemical Profile and Biological Activities of the Extracts from Two <i>Oenanthe</i> Species (<i>O. aquatica</i> and <i>O. silaifolia</i>) by Łukasz Świątek, Elwira Sieniawska, Mohamad Fawzi Mahomoodally, Nabeelah Bibi Sadeer, Krzysztof Kamil Wojtanowski, Barbara Rajtar, Małgorzata Polz-Dacewicz, Mehmet Yavuz Paksoy, Gokhan Zengin

“…All tested extracts exerted selective toxicity towards cancer cell lines, and the highest anticancer potential was found for <i>O. aquatica</i> aqueous extract on FaDu and HeLa cells with CC₅₀ of 57.36 and 47.16 µg/mL, respectively. …”
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The TLR3/IRF1/Type III IFN Axis Facilitates Antiviral Responses against Enterovirus Infections in the Intestine by Rui Su, Muhammad Adnan Shereen, Xiaofeng Zeng, Yicong Liang, Wen Li, Zhihui Ruan, Yongkui Li, Weiyong Liu, Yingle Liu, Kailang Wu, Zhen Luo, Jianguo Wu

“…We reported the epithelial immune response in cultured human normal and cancerous cells (IECs), mouse tissues, and human clinical intestine specimens following infection with enterovirus 71. …”
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Poly(L-histidine)-tagged 5-aminolevulinic acid prodrugs: new photosensitizing precursors of protoporphyrin IX for photodynamic colon cancer therapy by Johnson RP, Chung CW, Jeong YI, Kang DH, Suh H, Kim I

“…In particular, high phototoxicity was observed when the cells were treated with ALA-p(L-His)15, compared with treatment using ALA alone.Conclusion: The newly synthesized ALA-p(L-His)n derivatives are an effective alternative to ALA for enhancing protoporphyrin IX production and the selectivity of the phototoxic effect in tumor cells.Keywords: 5-aminolevulinic acid, photodynamic therapy, poly(L-histidine), bioconjugate, cancer cells…”
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