CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition by Adele M. Musicant, Kshitij Parag-Sharma, Weida Gong, Monideepa Sengupta, Arindam Chatterjee, Erin C. Henry, Yi-Hsuan Tsai, Michele C. Hayward, Siddharth Sheth, Renee Betancourt, Trevor G. Hackman, Ricardo J. Padilla, Joel S. Parker, Jimena Giudice, Colin A. Flaveny, David N. Hayes, Antonio L. Amelio

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Chemotherapeutic Activities of New η⁶-<i>p</i>-Cymene Ruthenium(II) and Osmium(II) Complexes with Chelating SS and Tridentate SNS Ligands by David O. Ywaya, Halliru Ibrahim, Holger B. Friedrich, Muhammad D. Bala, Lynette Soobramoney, Aliscia Daniels, Moganavelli Singh

“…The complexes were investigated for in vitro chemotherapeutic activities against human cervical carcinoma (HeLa) and the non-cancerous cell line (Hek293) using the MTT assay. The compounds <b>3a_ii</b>, <b>5c_iv</b>, <b>5b_i</b>, <b>4a_iii</b>, <b>6c_i</b>, <b>6c_iv</b>, and the reference drug, 5-fluorouracil were found to be selective toward the tumor cells; the compounds <b>3a_i</b>, <b>3a_iii</b>, <b>3b_ii</b>, <b>4b_i</b>, <b>4b_ii</b>, and <b>6b_i</b>, which were found not to be selective between normal and tumor cell lines. …”
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Analysis of the heavy metal contents’ effect on steroidal saponins and the anti-breast cancer activity of Paris polyphylla var. yunnanensis by Hai-Ling Li, Cui-Ping Yan, Cui-Ping Yan, Jun-Sheng Qi, Shuo Zhang, Shuo Zhang, Dong-Qin Guo, Wen-Chao Gu, Ying-Mei Wu, Yu Wu, Yu Wu, Nong Zhou, Nong Zhou

“…TUNEL assay and immunohistochemistry were used for the examination of the effect of P. polyphylla var. yunnanensis from different origins on cancer cell proliferation and apoptosis induction in 4T1 tumor mice.Results: Heavy metal contents were highly correlated with the content of steroidal saponins. …”
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Design, synthesis and anticancer evaluation of polymethoxy aurones as potential cell cycle inhibitors by Zheng Wu, Yaoyao Han, Xiaolan Li, Qiuping Zhang, Renjin Deng, Hong Ren, Wenjing He, Xinduo Wu, Hongwei Guo, Dan Zhu

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Enhanced Malignant Phenotypes of Glioblastoma Cells Surviving NPe6-Mediated Photodynamic Therapy are Regulated via ERK1/2 Activation by Tatsuya Kobayashi, Makoto Miyazaki, Nobuyoshi Sasaki, Shun Yamamuro, Eita Uchida, Daisuke Kawauchi, Masamichi Takahashi, Yohei Otsuka, Kosuke Kumagai, Satoru Takeuchi, Terushige Toyooka, Naoki Otani, Kojiro Wada, Yoshitaka Narita, Hideki Yamaguchi, Yoshihiro Muragaki, Takakazu Kawamata, Kentaro Mori, Koichi Ichimura, Arata Tomiyama

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Retrospective Evaluation of Somatic Alterations in Cell-Free DNA from Blood in Retinoblastoma by David H. Abramson, MD, Diana Mandelker, MD, PhD, Jasmine H. Francis, MD, Ira J. Dunkel, MD, A. Rose Brannon, PhD, Ryma Benayed, PhD, Michael F. Berger, PhD, Maria E. Arcila, MD, Marc Ladanyi, MD, Danielle Novetsky Friedman, MD, Gowtham Jayakumaran, MS, Monica S. Diosdado, MA, Melissa A. Robbins, MPH, Dianna Haggag-Lindgren, BS, Neerav Shukla, MD, Michael Walsh, MD, Prachi Kothari, DO, Dana W.Y. Tsui, PhD

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Efficacy and safety of immunochemotherapy, immunotherapy, chemotherapy, and targeted therapy as first-line treatment for advanced and metastatic esophageal cancer: a systematic rev... by Zhen Gao, Shujie Huang, Sichao Wang, Dezhao Tang, Wei Xu, Ruijie Zeng, Guibin Qiao

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Studies on ribosomal oxygenases by Sekirnik, R

“…It was demonstrated that rpL27a hydroxylation is widespread and found in all mouse organs analysed, as well as in cancer cell lines and in clinical cancer tissues. A partial or complete reduction of rpL27a hydroxylation was observed in a number of clinically identified <em>MINA53</em> mutations from the COSMIC database of cancer mutations. …”

Chemical and biological profiling of weeds and medicinal plants targeting protein kinase and phosphatases in signal transduction in cancer by Azlinah Matawali

“…However, cytotoxicity test was only conducted at CE partitions level were found to exhibits cytotoxic activities against HeLa cervix adenocarcinoma (IC50 value 39.00±1.00μg/ml) cancer cell lines. Meanwhile, antibacterial test carried out for UMS71.CE.F2 showed week inhibitory activities on S. pneumonia (11.67±2.08mm), S. aureus (10.33±0.58mm), P. aeruginosa (10.67±0.58mm), E. coli (8.00±0.00mm) and S. typhii (8.00±0.00mm) when compared to ampicillin as control positive.…”
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Phytochemical Analyses and Biological Activities of Different Parts of Three Varieties of Labisia Pumila Benth by Karimi, Ehsan

“…In vitro anticancer activities of extracts against two human cancer cell lines (MCF-7; MDA-MB-231) and Chang cell as a normal human hepatocyte could be categorized as moderate to weak by leaf and root methanolic extracts. …”
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Phytochemical, cytotoxic and acetylcholinesterase inhibition in Kacip Fatimah (Labisia pumila (blume) fern.-vill.) penarahan (Horsfieldia superba (HK. F. & TH.) warb) and paku laya... by Naji Al-Mekhlafi, Nabil Ali

“…Compounds, including 1-acetoxy-4-hydroxy-2-methoxy-6-(pentadec-10Z-enyl)benzene (33) and 1-acetoxy-4-hydroxy-2-methoxy-6-pentadecylbenzene (36) showed strong activity against three cancer cell lines: MCF-7 (breast), HCT-116 (colon) and PC-3 (prostate) with IC50 values 0.5-0.7 μM, whereas compounds (-)-5,6-dihydro-6-undecyl-2H-pyran-2-one (52) and (-)-5,6-dihydro-6-tridecyl-2H-pyran-2-one (53) showed moderate growth inhibition potency against the tested cell lines. …”
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Collection, morphological characterization, bioactivity evaluation and micropropagation of selected Tacca Species (Dioscoreaceae) by Misrol, Mohd Zulhilmi

“…Various plant parts of selected Tacca species [Tacca integrifolia (TI), Tacca chantrieri (TC) and Tacca nivea (TN)] were extracted and tested for their in vitro cytotoxicty in cancer cell lines using MTT assay. Results obtained showed that the rhizome extracts were the most potent among the various parts of the plants. …”
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Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation by Shuai Lu, Xibo Sun, Xibo Sun, Zhongbao Zhou, Huazhen Tang, Ruixue Xiao, Qingchen Lv, Bing Wang, Jinxiu Qu, Jinxuan Yu, Fang Sun, Zhuoya Deng, Yuying Tian, Cong Li, Zhenpeng Yang, Penghui Yang, Benqiang Rao

“…In vitro, studies have shown that BZD dose-dependently inhibits colon cancer cell growth and invasion and promotes apoptosis. …”
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NK-SPECIFIC CAR DESIGN IMPROVES NK CYTOTOXICITY AGAINST TUMOR CELLS by JTC Azevedo, RN Silvestre, DT Covas, V Picanço-Castro

“…Lastly, we evaluated in vitro potential of CAR-NK92 cells to kill Raji CD19+ cancer cell lines stained with PKH67 cell linker at E:T ratio of 10:1 after 5 hours co-cultivation. …”
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Multigene Panel Germline Testing of 1333 Czech Patients with Ovarian Cancer by Klara Lhotova, Lenka Stolarova, Petra Zemankova, Michal Vocka, Marketa Janatova, Marianna Borecka, Marta Cerna, Sandra Jelinkova, Jan Kral, Zuzana Volkova, Marketa Urbanova, Petra Kleiblova, Eva Machackova, Lenka Foretova, Jana Hazova, Petra Vasickova, Filip Lhota, Monika Koudova, Leona Cerna, Spiros Tavandzis, Jana Indrakova, Lucie Hruskova, Marcela Kosarova, Radek Vrtel, Viktor Stranecky, Stanislav Kmoch, Michal Zikan, Libor Macurek, Zdenek Kleibl, Jana Soukupova

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Excellent effects and possible mechanisms of action of a new antibody–drug conjugate against EGFR-positive triple-negative breast cancer by Dan-Dan Zhou, Wei-Qi Bai, Xiao-Tian Zhai, Li-Ping Sun, Yong-Su Zhen, Zhuo-Rong Li, Qing-Fang Miao

“…The gene expression of EGFR in a series of breast cancer cell lines was assessed using a publicly available microarray dataset (GSE41313) and Western blotting. …”
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PVT1 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer via Regulating miR-148/RAB34 Signal Axis [Retraction] by Xi Y, Shen W, Jin C, Wang L, Yu B

“…Involvement of a novel circularRNA, hsa&#x005F;circ&#x005F;0000520, attenuates tumorigenesis of cervical cancer cell through competitively binding with miR-146b-3p. …”
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Analysis of Chemopredictive Assay for Targeting Cancer Stem Cells in Glioblastoma Patients by Candace M. Howard, Jagan Valluri, Anthony Alberico, Terrence Julien, Rida Mazagri, Robert Marsh, Hoyt Alastair, Antonio Cortese, Michael Griswold, Wanmei Wang, Krista Denning, Linda Brown, Pier Paolo Claudio

“…Administration of ineffective anticancer therapy is not only costly but more importantly burdens the patient with unnecessary toxicity and selects for the development of resistant cancer cell clones. We have developed a drug response assay (ChemoID) that identifies the most effective chemotherapy against CSCs and bulk of tumor cells from of a panel of potential treatments, offering great promise for individualized cancer management. …”
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The role of apatinib combined with paclitaxel (aluminum binding type) in platinum-resistant ovarian cancer by Hong Zhao, Rong Li, Xiaoyan Wang, Xin Lu, Min Hu, Jinbin Zhang, Xia Zhao, Xiaoqin Song, Yangyang Liu

“…Abstract Objective To assess the anti-tumor activity and side effects of different dosages of paclitaxel (albumin binding type) (hereinafter referred to as nab-P) combined with Apatinib (hereinafter referred to as AP) in platinum-resistant ovarian cancer cell line and xenograft models. Methods SKOV-3/DDP cell line was selected as the research object in cytology experiment. …”
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R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells by Shannon M. Weber, Nicole M. Brossier, Amanda Prechtl, Stephen Barnes, Landon S. Wilson, Stephanie N. Brosius, Jody Fromm Longo, Steven L. Carroll

“…We have previously shown that three related Ras proteins (the classic Ras proteins) are highly activated in malignant peripheral nerve sheath tumor (MPNST) cells with neurofibromin loss and that they drive cancer cell proliferation and survival by activating multiple cellular signaling pathways. …”
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