Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell–Effector Responses by Devlin, Christine A., Birnbaum, Michael E.

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Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation by Milling, Lauren E, Garafola, Daniel, Agarwal, Yash, Wu, Shengwei, Thomas, Ayush, Donahue, Nathan, Adams, Josetta, Thai, Nikki, Suh, Heikyung, Irvine, Darrell J

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Liquid Biopsy in Colorectal Cancer: Quo Vadis? Implementation of Liquid Biopsies in Routine Clinical Patient Care in Two German Comprehensive Cancer Centers by Laura E. Fischer, Laura E. Fischer, Sebastian Stintzing, Sebastian Stintzing, Volker Heinemann, Volker Heinemann, Volker Heinemann, Ulrich Keilholz, Ulrich Keilholz, Dietmar Keune, Claudia Vollbrecht, Thomas Burmeister, Thomas Burmeister, Andreas Kind, Lena Weiss, David Horst, David Horst, Thomas Kirchner, Thomas Kirchner, Thomas Kirchner, Frederick Klauschen, Frederick Klauschen, Frederick Klauschen, Frederick Klauschen, Andreas Jung, Andreas Jung, Andreas Jung, Christoph Benedikt Westphalen, Christoph Benedikt Westphalen, Christoph Benedikt Westphalen, Ivan Jelas, Ivan Jelas

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Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung can... by François Ghiringhelli, Frederic Bibeau, Laurent Greillier, Jean-David Fumet, Alis Ilie, Florence Monville, Caroline Laugé, Aurélie Catteau, Isabelle Boquet, Amine Majdi, Erwan Morgand, Youssef Oulkhouir, Nicolas Brandone, Julien Adam, Thomas Sbarrato, Alboukadel Kassambara, Jacques Fieschi, Stéphane Garcia, Anne Laure Lepage, Pascale Tomasini, Jérôme Galon

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Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment by Garrett M. Dancik, Lokman Varisli, Lokman Varisli, Ioannis F. Voutsas, Spiros Vlahopoulos

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Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancer by Naoya Sakamoto, Saori Mishima, Akihito Kawazoe, Yasutoshi Kuboki, Hideaki Bando, Takashi Kojima, Takayuki Yoshino, Takeshi Kuwata, Kohei Shitara, Yoshiaki Nakamura, Daisuke Kotani, Masashi Wakabayashi, Shohei Koyama, Hiroyoshi Nishikawa, Yosuke Tanaka, Shogo Takei, Itaru Endo, Motohiro Kojima, Toshihide Ueno, Hiroyuki Mano, Shota Fukuoka, Yi-Tzu Lin, Hiroki Hara, Shinya Kojima

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Impact of PD-L1 Scores and Changes on Clinical Outcome in Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiotherapy by Florian Huemer, Eckhard Klieser, Daniel Neureiter, Verena Schlintl, Gabriel Rinnerthaler, Franck Pagès, Amos Kirilovsky, Carine El Sissy, Wolfgang Iglseder, Franz Singhartinger, Tarkan Jäger, Adam Dinnewitzer, Nadja Zaborsky, Markus Steiner, Richard Greil, Lukas Weiss

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Editorial: Challenges of COVID-19 in dermatology patients on immunosuppression: Risk, outcome, vaccination, and beyond by Hamidreza Mahmoudi, Aikaterini Patsatsi, Dedee F. Murrell, Soheil Tavakolpour, Maryam Daneshpazhooh

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Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer by Emmons, Tiffany R, Giridharan, Thejaswini, Singel, Kelly L, Khan, ANM Nazmul H, Ricciuti, Jason, Howard, Kaitlyn, Silva-Del Toro, Stephanie L, Debreceni, Ivy L, Aarts, Cathelijn EM, Brouwer, Mieke C, Suzuki, Sora, Kuijpers, Taco W, Jongerius, Ilse, Allen, Lee-Ann H, Ferreira, Viviana P, Schubart, Anna, Sellner, Holger, Eder, Jörg, Holland, Steven M, Ram, Sanjay, Lederer, James A, Eng, Kevin H, Moysich, Kirsten B, Odunsi, Kunle, Yaffe, Michael B, Zsiros, Emese, Segal, Brahm H

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CD8[superscript +] T-cell Responses Rapidly Select for Antigen-Negative Tumor Cells in the Prostate by Bak, S. Peter G., Barnkob, Mike Stein, Wittrup, Karl Dane, Chen, Jianzhu

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IX Forum on Translational Immunology and Cancer Immuno-therapy (FIT Cancer 9)

“…FITCancer, which is the largest meeting uniquely focused on cancer immunotherapy, brings together clinicians and researchers, experts in the field of cancer immunology and immunotherapy. Here, we present abstracts submitted by GÉTICA’s members to the IX Forum on Translational Immunology and Cancer Immunotherapy.…”
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Advancing cancer immunotherapy: from innovative preclinical models to clinical insights by Andrew W. Craig, Hermann B. Frieboes, Paula A. Videira

“…Abstract The rapid expansion of cancer immunology and immunotherapy builds upon the success of early immune checkpoint inhibitors (ICI) and chimeric antigen receptor T cells for some cancer types. …”
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Editorial: Strategies to overcome tumor evasion and resistance to immunotherapies by targeting immune suppressor cells by Yu Saida, Satoshi Watanabe, Shohei Koyama, Yosuke Togashi, Toshiaki Kikuchi

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Editorial: Combining chemo/radio therapy and immunotherapy for cancers—perfect mix of old and new by Clare Y. Slaney, Clare Y. Slaney, Peng Luo, Feng-Ming Kong, Feng-Ming Kong, Linlang Guo, Jian Zhang

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Changes in the treatment landscape for metastatic urothelial cancer: current therapy and future directions by Sang Hoon Yeon, Hyo Jin Lee

“…A better understanding of molecular pathobiology of UC and advances in cancer immunology have led to a sharp increase in clinical trials for metastatic UC with the rapidly changing systemic treatment for this disease. …”
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Next-Generation Sequencing Analysis of Mutations in Circulating Tumor DNA from the Plasma of Patients with Head–Neck Cancer Undergoing Chemo-Radiotherapy Using a Pan-Cancer Cell-Fr... by Michael I. Koukourakis, Erasmia Xanthopoulou, Ioannis M. Koukourakis, Sotirios P. Fortis, Nikolaos Kesesidis, Christos Kakouratos, Ioannis Karakasiliotis, Constantin N. Baxevanis

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Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness by Farzaneh Darbeheshti, Sepideh Kadkhoda, Mahsa Keshavarz-Fathi, Sepideh Razi, Afshin Bahramy, Yaser Mansoori, Nima Rezaei

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Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing by Wai Tuck Soh, Hanna P. Roetschke, John A. Cormican, Bei Fang Teo, Nyet Cheng Chiam, Monika Raabe, Ralf Pflanz, Fabian Henneberg, Stefan Becker, Ashwin Chari, Haiyan Liu, Henning Urlaub, Juliane Liepe, Michele Mishto

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Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability by Karver, Mark R., Dinter, Jens, Gall, Sylvie Le, Moynihan, Kelly Dare, Holden, Rebecca Lynn, Mehta, Naveen, Wang, Chensu, Liang, Simon, Abraham, Wuhbet, Melo, Mariane Bandeira, Zhang, Angela Q., Li, Na, Pentelute, Bradley L., Irvine, Darrell J

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Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer by Emmons, Tiffany R., Giridharan, Thejaswini, Singel, Kelly L., Khan, ANM Nazmul H., Ricciuti, Jason, Howard, Kaitlyn, Silva-Del Toro, Stephanie L., Debreceni, Ivy L., Aarts, Cathelijn E.M., Brouwer, Mieke C., Suzuki, Sora, Kuijpers, Taco W., Jongerius, Ilse, Allen, Lee-Ann H., Ferreira, Viviana P., Schubart, Anna, Sellner, Holger, Eder, Jörg, Holland, Steven M., Ram, Sanjay, Lederer, James A., Eng, Kevin H., Moysich, Kirsten B., Odunsi, Kunle, Yaffe, Michael B., Zsiros, Emese, Segal, Brahm H.

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