Immunotherapy in Squamous Cell Cancer of the Esophagus by Peter Thuss-Patience, Alexander Stein

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Generation of B-cell-based cellular vaccine for cancer in murine models by David Hou, Joshua L. Katz, Catalina Lee-Chang

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Ewing’s Sarcoma of Mandible: Practical Approach to a Challenging Case by Mohammad Saeid Ahmadi, Fateme Sheida, Ahmad Ameri, Seyed Alireza Javadinia, Farhad Farahani, Omid Soltaninia, Leila Moaddab Shoar, Abdolazim Sedighi Pashaki, Mohammad Hadi Gharib, Rohollah Abbasi, Zahra Keshtpour Amlashi

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P1306: CLINICAL AND GENOMIC ANALYSIS OF HIGH-GRADE TRANSFORMATION OF MARGINAL ZONE LYMPHOMA by C. Yannakou, D. Villa, C. Gould, Y. Kankanige, J. Lickiss, G. Ryland, S. Lade, G. Slack, W. Limvorapitak, C. Tam, J. Seymour, D. Westerman, P. Blombery

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Emerging Roles of Small Extracellular Vesicles in Gastrointestinal Cancer Research and Therapy by Nora Schneider, Patrick Christian Hermann, Tim Eiseler, Thomas Seufferlein

“…Discovered in the late eighties, sEVs are small extracellular nanovesicles (30–150 nm diameter) that gained increasing attention due to their profound roles in cancer, immunology, and therapeutic approaches. They were initially described as cellular waste bins; however, in recent years, sEVs have become known as important mediators of intercellular communication. …”
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Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer by Courtney T. Stump, Kevin Roehle, Nataly Manjarrez Orduno, Stephanie K. Dougan

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Strategies for Improving the Efficacy of CAR T Cells in Solid Cancers by Jon Amund Kyte

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Characterization of immune populations in the tumor microenvironment of diffuse midline glioma orthotopic mouse models by flow cytometry by Iker Ausejo-Mauleon, Sara Labiano, Marta M. Alonso

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A flow-cytometry-based assay to assess the cytolytic activity against tumor cells by combination of mouse MAIT cells and natural killer cells by Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao

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FOXP3+ regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity by Xinnan Liu, Weiqi Zhang, Yichao Han, Hao Cheng, Qi Liu, Shouyu Ke, Fangming Zhu, Ying Lu, Xin Dai, Chuan Wang, Gonghua Huang, Bing Su, Qiang Zou, Huabing Li, Wenyi Zhao, Lianbo Xiao, Linrong Lu, Xuemei Tong, Fan Pan, Hecheng Li, Bin Li

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Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment by Wenhao Zhou, Shusuke Kawashima, Takamasa Ishino, Katsushige Kawase, Youki Ueda, Kazuo Yamashita, Tomofumi Watanabe, Masahito Kawazu, Hiromichi Dansako, Yutaka Suzuki, Hiroyoshi Nishikawa, Takashi Inozume, Joji Nagasaki, Yosuke Togashi

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Immunophenotyping of Circulating and Intratumoral Myeloid and T Cells in Glioblastoma Patients by Sascha Marx, Fabian Wilken, Lea Miebach, Mikael Ispirjan, Frederik Kinnen, Sebastian Paul, Sandra Bien-Möller, Eric Freund, Jörg Baldauf, Steffen Fleck, Nikolai Siebert, Holger Lode, Andreas Stahl, Bernhard H. Rauch, Stephan Singer, Christoph Ritter, Henry W. S. Schroeder, Sander Bekeschus

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Manufacture of CD22 CAR T cells following positive versus negative selection results in distinct cytokine secretion profiles and γδ T cell output by Hannah W. Song, Mehdi Benzaoui, Alka Dwivedi, Sarah Underwood, Lipei Shao, Sooraj Achar, Vesna Posarac, Victoria A. Remley, Michaela Prochazkova, Yihua Cai, Ping Jin, Robert P. Somerville, David F. Stroncek, Grégoire Altan-Bonnet, Nirali N. Shah, Christopher D. Chien, Naomi Taylor, Steven L. Highfill

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Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response by Timurs Maculins, Erik Verschueren, Trent Hinkle, Meena Choi, Patrick Chang, Cecile Chalouni, Shilpa Rao, Youngsu Kwon, Junghyun Lim, Anand Kumar Katakam, Ryan C Kunz, Brian K Erickson, Ting Huang, Tsung-Heng Tsai, Olga Vitek, Mike Reichelt, Yasin Senbabaoglu, Brent Mckenzie, John R Rohde, Ivan Dikic, Donald S Kirkpatrick, Aditya Murthy

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Phase I/II trial of a peptide-based COVID-19 T-cell activator in patients with B-cell deficiency by Jonas S. Heitmann, Claudia Tandler, Maddalena Marconato, Annika Nelde, Timorshah Habibzada, Susanne M. Rittig, Christian M. Tegeler, Yacine Maringer, Simon U. Jaeger, Monika Denk, Marion Richter, Melek T. Oezbek, Karl-Heinz Wiesmüller, Jens Bauer, Jonas Rieth, Marcel Wacker, Sarah M. Schroeder, Naomi Hoenisch Gravel, Jonas Scheid, Melanie Märklin, Annika Henrich, Boris Klimovich, Kim L. Clar, Martina Lutz, Samuel Holzmayer, Sebastian Hörber, Andreas Peter, Christoph Meisner, Imma Fischer, Markus W. Löffler, Caroline Anna Peuker, Stefan Habringer, Thorsten O. Goetze, Elke Jäger, Hans-Georg Rammensee, Helmut R. Salih, Juliane S. Walz

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Protocol to generate traceable CAR T cells for syngeneic mouse cancer models by Duo Zhang, Elisavet Krimitza, Katherine Han, Ruiying Su, David J. Xu, Jaiden R. Xu, Yanqing Gong, Yi Fan

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Protocol for ex vivo culture of patient-derived tumor fragments by Lisanne M. Roelofsen, Paula Voabil, Marjolein de Bruijn, Petra Herzig, Alfred Zippelius, Ton N. Schumacher, Daniela S. Thommen

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RNA polymerase II transcription attenuation at the yeast DNA repair gene <i>DEF1</i> is biologically significant and dependent on the Hrp1 RNA-recognition motif by Maria E Amodeo, Shane P C Mitchell, Vincent Pavan, Jason N Kuehner

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Multimodal Functionalities of HIV-1 Integrase by Alan N. Engelman, Mamuka Kvaratskhelia

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Update on current and new potential immunotherapies in breast cancer, from bench to bedside by Emmanuelle Alaluf, Emmanuelle Alaluf, Michal Mia Shalamov, Amir Sonnenblick, Amir Sonnenblick

“…However, a significant gap between clinical oncology and basic cancer research impairs the understanding of cancer immunology and immunotherapy, hampering cancer therapy research and development. …”
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