Enhancing anti-tumor immune responses through combination therapies: epigenetic drugs and immune checkpoint inhibitors by Ying Liang, Lingling Wang, Peijun Ma, Dongen Ju, Minggao Zhao, Yun Shi

“…Moreover, we discuss how to leverage the intricate relationship between cancer epigenetics and cancer immunology to create treatment regimens that integrate epigenetic therapies with immunotherapies.…”
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Untangling Extracellular Proteasome-Osteopontin Circuit Dynamics in Multiple Sclerosis by Chiara Dianzani, Domizia Vecchio, Nausicaa Clemente, Annalisa Chiocchetti, Filippo Martinelli Boneschi, Daniela Galimberti, Umberto Dianzani, Cristoforo Comi, Michele Mishto, Juliane Liepe

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Protocol for generation of 3D bone marrow surrogate microenvironments in a rotary cell culture system by Daniela Belloni, Marina Ferrarini, Elisabetta Ferrero, Virginia Guzzeloni, Federica Barbaglio, Paolo Ghia, Cristina Scielzo

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In ovo model in cancer research and tumor immunology by Lea Miebach, Lea Miebach, Julia Berner, Julia Berner, Julia Berner, Sander Bekeschus, Sander Bekeschus

“…In this view, the present review aims to emphasize and discuss opportunities and limitations of the chicken embryo model for pre-clinical research in cancer and cancer immunology.…”
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Identification of the prognostic value of LACTB2 and its correlation with immune infiltrates in ovarian cancer by integrated bioinformatics analyses by Weiwei Cao, Chao Wang, Yue Zhang, Jiani Yang, Xiaomei Luo, Yaqian Zhao, Meixuan Wu, Shanshan Cheng, Yu Wang

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Diagnostic and prognostic role of long non-coding RNAs (lncRNAs) in metastatic melanoma patients with BRAF gene mutation receiving BRAF and MEK inhibitors by Łukasz Galus, Tomasz Kolenda, Michał Michalak, Jacek Mackiewicz

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Biological Activity of Oleanolic Acid Derivatives HIMOXOL and Br-HIMOLID in Breast Cancer Cells Is Mediated by ER and EGFR by Natalia Lisiak, Patrycja Dzikowska, Urszula Wisniewska, Mariusz Kaczmarek, Barbara Bednarczyk-Cwynar, Lucjusz Zaprutko, Blazej Rubis

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Acidovorax temperans skews neutrophil maturation and polarizes Th17 cells to promote lung adenocarcinoma development by Joshua K. Stone, Natalia von Muhlinen, Chenran Zhang, Ana I. Robles, Amy L. Flis, Eleazar Vega-Valle, Akihiko Miyanaga, Masaru Matsumoto, K. Leigh Greathouse, Tomer Cooks, Giorgio Trinchieri, Curtis C. Harris

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Expression Profile of New Marker Genes Involved in Differentiation of Canine Adipose-Derived Stem Cells into Osteoblasts by Maurycy Jankowski, Mariusz Kaczmarek, Grzegorz Wąsiatycz, Claudia Dompe, Paul Mozdziak, Jędrzej M. Jaśkowski, Hanna Piotrowska-Kempisty, Bartosz Kempisty

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Systemic Treatment-Decision Algorithms in Muscle-Invasive Bladder Cancer: Clinical Complexities and Navigating for Improved Outcomes by Giles M, Crabb SJ

“…Megan Giles,1 Simon J Crabb1,2 1Department of Medical Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, UK; 2School of Cancer Sciences, University of Southampton, Southampton, UKCorrespondence: Simon J Crabb, University of Southampton, Mailpoint 824, Centre for Cancer Immunology, Southampton General Hospital, Southampton, SO16 6YD, UK, Email S.J.Crabb@southampton.ac.ukAbstract: Muscle-invasive bladder cancer has poor prognosis. …”
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Necroptosis-related lncRNAs: Combination of bulk and single-cell sequencing reveals immune landscape alteration and a novel prognosis stratification approach in lung adenocarcinoma by Yizhu Yao, Liudan Gu, Ziyi Zuo, Dandan Wang, Tianlin Zhou, Xiaomei Xu, Lehe Yang, Xiaoying Huang, Liangxing Wang

“…Necroptosis, which is recently recognized as a form of programmed cell death, plays a critical role in cancer biology, including tumorigenesis and cancer immunology. It was recognized not only to defend against tumor progression by suppressing adaptive immune responses but also to promote tumorigenesis and cancer metastasis after recruiting inflammatory responses. …”
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Functional T Cell Reactivity to Melanocyte Antigens Is Lost during the Progression of Malignant Melanoma, but Is Restored by Immunization by Anna Przybyla, Alexander A. Lehmann, Ting Zhang, Jacek Mackiewicz, Łukasz Galus, Greg A. Kirchenbaum, Andrzej Mackiewicz, Paul V. Lehmann

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Antigen presenting cells in cancer immunity and mediation of immune checkpoint blockade by Wang, Cassia, Chen, Lee, Fu, Doris, Liu, Wendi, Puri, Anusha, Kellis, Manolis, Yang, Jiekun

“…Their role has increasingly been spotlighted in the realm of cancer immunology, particularly as our understanding of immunotherapy continues to evolve and improve. …”
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Prevalence and clinical characteristics of non-malignant CT detected incidental findings in the SUMMIT lung cancer screening cohort by Anthony Edey, Neal Navani, Andrew W Creamer, Kitty Chan, Graham Robinson, Janine Zylstra, Paul Robinson, Laura Green, Anand Devaraj, Jane Rowlands, Allan Hackshaw, Carolyn Horst, Arjun Nair, Sam M Janes, Kate Davies, Jeannie Eng, Mamta Ruparel, Samantha L Quaife, Jennifer L Dickson, Magali Taylor, Angshu Bhowmik, Karen Sennett, Samantha Quaife, Samuel Janes, Hasti Robbie, Joseph Jacob, Laura Farrelly, Sophie Tisi, Andrew Creamer, Helen Hall, Samanjit Hare, Jon Teague, Thea Buchan, Stephen Ellis, Thomas Callender, Rachael Sarpong, John McCabe, Zaheer Mangera, Ethaar El-Emir, Terry O'Shaughnessy, Nick Screaton, Priyam Verghese, William M Ricketts, Anne-Marie Mullin, Vicky Bowyer, Kylie Gyertson, Fanta Bojang, Claire Levermore, Ruth Prendecki, Amyn Bhamani, Malavika Suresh, Judy Airebamen, Alice Cotton, Kaylene Phua, Elodie Murali, Simranjit Mehta, Karen Parry-Billings, Columbus Ife, April Neville, Zahra Hanif, Helen Kiconco, Ricardo McEwen, Dominique Arancon, Nicholas Beech, Derya Ovayolu, Christine Hosein, Sylvia Patricia Enes, Qin April Neville, Aashna Samson, Urja Patel, Fahmida Hoque, Hina Pervez, Sofia Nnorom, Moksud Miah, Julian McKee, Mark Clark, Anant Patel, Sara Lock, Rajesh Banka, Ugo Ekeowa, Charlotte Cash, Tunku Aziz, Alberto Villanueva, Elena Stefan, Charlie Sayer, Navinah Nundlall, Lyndsey Gallagher, Andrew Crossingham, Tanita Limani, Kate Gowers, James Rusius, Jennifer Dickson, Anne-Marie Hacker, Jonathon Teague, Andrew Perugia TaniaAnastasiadis

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Addition of camrelizumab to docetaxel, cisplatin, and radiation therapy in patients with locally advanced esophageal squamous cell carcinoma: a phase 1b study by Wencheng Zhang, Cihui Yan, Tian Zhang, Xi Chen, Jie Dong, Jingjing Zhao, Dong Han, Jun Wang, Gang Zhao, Fuliang Cao, Dejun Zhou, Hongjing Jiang, Peng Tang, Lujun Zhao, Zhiyong Yuan, Quanren Wang, Ping Wang, Qingsong Pang

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Role of the Circadian Clock “Death-Loop” in the DNA Damage Response Underpinning Cancer Treatment Resistance by Ninel Miriam Vainshelbaum, Kristine Salmina, Bogdan I. Gerashchenko, Marija Lazovska, Pawel Zayakin, Mark Steven Cragg, Dace Pjanova, Jekaterina Erenpreisa

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Interventional Treatment Strategies in Intrahepatic Cholangiocarcinoma and Perspectives for Combined Hepatocellular-Cholangiocarcinoma by Timo Alexander Auer, Federico Collettini, Laura Segger, Uwe Pelzer, Raphael Mohr, Felix Krenzien, Bernhard Gebauer, Dominik Geisel, Clarissa Hosse, Wenzel Schöning, Uli Fehrenbach

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Improved characterization and translation of NK cells for canine immunotherapy by Aryana M. Razmara, Alicia A. Gingrich, Christine M. Toedebusch, Robert B. Rebhun, William J. Murphy, Michael S. Kent, Robert J. Canter

“…The field of cancer immunology has seen a meteoric rise in interest and application due to the discovery of immunotherapies that target immune cells, often leading to dramatic anti-tumor effects. …”
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Circulating Melanoma Cell Numbers Correlate with TIGIT-Positive Cytotoxic T Cell Counts in Advanced-Stage Melanoma Patients by Paula Kamińska, Karolina Buszka, Łukasz Galus, Maurycy Jankowski, Michał Nowicki, Jacek Mackiewicz, Mariusz Kaczmarek, Joanna Budna-Tukan

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Dendritic cell vaccination in combination with erlotinib in a patient with inoperable lung adenocarcinoma: a case report by Takuya Kosumi, Masanori Kobayashi, Shigetaka Shimodaira, Haruo Sugiyama, Shigeo Koido

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