Protocol for orthotopic single-lung transplantation in mice as a tool for lung metastasis studies by Anastasios D. Giannou, Birte Ohm, Dimitra E. Zazara, Jöran Lücke, Tao Zhang, Morsal Sabihi, Philipp Seeger, Jun Oh, Rainer Grotelüschen, Philipp Busch, Oliver Mann, Thilo Hackert, Jakob R. Izbicki, Yoshito Yamada, Samuel Huber, Wolfgang Jungraithmayr

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KIR- Ligand Interactions in Hypertensive Disorders in Pregnancy by Katarzyna Stefańska, Martyna Tomaszewicz, Joanna Dębska-Zielkowska, Dorota Zamkowska, Karolina Piekarska, Justyna Sakowska, Maciej Studziński, Bogusław Tymoniuk, Przemysław Adamski, Joanna Jassem-Bobowicz, Piotr Wydra, Katarzyna Leszczyńska, Renata Świątkowska-Stodulska, Sebastian Kwiatkowski, Krzysztof Preis, Piotr Trzonkowski, Natalia Marek-Trzonkowska, Natalia Marek-Trzonkowska, Maciej Zieliński

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Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 1st–3rd, 2022—Naples, Italy) by Paolo A. Ascierto, Sanjiv S. Agarwala, Allison Betof Warner, Marc S. Ernstoff, Bernard A. Fox, Thomas F. Gajewski, Jérôme Galon, Claus Garbe, Brian R. Gastman, Jeffrey E. Gershenwald, Pawel Kalinski, Michelle Krogsgaard, Rom S. Leidner, Roger S. Lo, Alexander M. Menzies, Olivier Michielin, Poulikos I. Poulikakos, Jeffrey S. Weber, Corrado Caracò, Iman Osman, Igor Puzanov, Magdalena Thurin

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Clinical characteristics and variant analyses of transient infantile hypertriglyceridemia related to GPD1 gene by Jun Wang, Jun Wang, Xinrong Sun, Lianying Jiao, Zhengtao Xiao, Farooq Riaz, Yufeng Zhang, Pengfei Xu, Ruiqing Liu, Tiantian Tang, Meiqi Liu, Dongmin Li

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Oncogenic PIK3CA recruits myeloid‐derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5‐lipoxygenase‐dependent arac... by Xingchen Li, Guidong Chen, Fanchen Wang, Xiaojing Guo, Rui Zhang, Pengpeng Liu, Li Dong, Wenwen Yu, Huan Wang, Hailong Wang, Jinpu Yu

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First‐in‐human study of JNJ‐67571244, a CD33 × CD3 bispecific antibody, in relapsed/refractory acute myeloid leukemia and myelodysplastic syndrome by Rupa Narayan, Ana Alfonso Piérola, William B. Donnellan, Antonieta Molero Yordi, Maher Abdul‐Hay, Uwe Platzbecker, Marion Subklewe, Tapan Mahendra Kadia, Juan Manuel Alonso‐Domínguez, James McCloskey, Kathryn Bradford, Martin Curtis, Nikki Daskalakis, Christina Guttke, Karim Safer, Brett Hiebert, Joseph Murphy, Xiang Li, Ken Duchin, Daniel Esteban

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Adenosine A2B receptor agonist improves epidermal barrier integrity in a murine model of epidermal hyperplasia by Asunción Marín-Castejón, Miguel Marco-Bonilla, M. Carmen Terencio, Jorge Arasa, M. Carmen Carceller, M. Luisa Ferrandiz, M. Antonia Noguera, Rosa Andrés-Ejarque, M. Carmen Montesinos

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IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities by Xu He, Abdalla Wedn, Jian Wang, Yanlun Gu, Hongjin Liu, Juqi Zhang, Zhiqiang Lin, Renpeng Zhou, Xiaocong Pang, Yimin Cui

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Antagonism of regulatory ISGs enhances the anti-melanoma efficacy of STING agonists by Jessica N. Filderman, Jennifer L. Taylor, Jianmin Wang, Yali Zhang, Prashant Singh, Mark A. Ross, Simon C. Watkins, Ayah Nedal Al Bzour, Lilit Karapetyan, Pawel Kalinski, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus, Walter J. Storkus

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Repurposing the Antibacterial Agents Peptide 19-4LF and Peptide 19-2.5 for Treatment of Cutaneous Leishmaniasis by Rima El-Dirany, Celia Fernández-Rubio, José Peña-Guerrero, Esther Moreno, Esther Larrea, Socorro Espuelas, Fadi Abdel-Sater, Klaus Brandenburg, Guillermo Martínez-de-Tejada, Paul Nguewa

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NeoAdjuvant pembrolizumab and STEreotactic radiotherapy prior to nephrectomy for renal cell carcinoma (NAPSTER): A phase II randomised clinical trial by Muhammad Ali, Simon Wood, David Pryor, Daniel Moon, Mathias Bressel, Arun A. Azad, Catherine Mitchell, Declan Murphy, Homi Zargar, Nick Hardcastle, Jamie Kearsley, Renu Eapen, Lih Ming Wong, Katharine Cuff, Nathan Lawrentschuk, Paul J. Neeson, Shankar Siva

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Simultaneous integrated dose reduction intensity-modulated radiotherapy effectively reduces cardiac toxicity in limited-stage small cell lung cancer by Jing Luo, Jiawei Song, Li Xiao, Jiajia Zhang, Yipeng Cao, Jun Wang, Ping Wang, Lujun Zhao, Ningbo Liu

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Blocking LAIR1 signaling in immune cells inhibits tumor development by Jingjing Xie, Xun Gui, Mi Deng, Heyu Chen, Yuanzhi Chen, Xiaoye Liu, Zhiqiang Ku, Lingxiao Tan, Ryan Huang, Yubo He, Bruce Zhang, Cheryl Lewis, Kenian Chen, Kenian Chen, Lin Xu, Lin Xu, Jian Xu, Tao Huang, X. Charlene Liao, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

“…New molecular targets and therapeutic approaches of cancer immunology need to be identified. Leukocyte associated immunoglobulin like receptor 1 (LAIR1) is an immune inhibitory receptor expressing on most immune cell types. …”
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The Role of Immunosuppression for Recurrent Cholangiocellular Carcinoma after Liver Transplantation by Safak Gül-Klein, Paulina Schmitz, Wenzel Schöning, Robert Öllinger, Georg Lurje, Sven Jonas, Deniz Uluk, Uwe Pelzer, Frank Tacke, Moritz Schmelzle, Johann Pratschke, Ramin Raul Ossami Saidy, Dennis Eurich

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Efficacy and safety of neoadjuvant nab‐paclitaxel plus gemcitabine therapy in patients with borderline resectable pancreatic cancer: A multicenter single‐arm phase II study (NAC‐GA... by Ken‐ichi Okada, Kenjiro Kimura, Yo‐Ichi Yamashita, Kazuto Shibuya, Ippei Matsumoto, Sohei Satoi, Kazuhiro Yoshida, Yasuhiro Kodera, Takahiro Akahori, Seiko Hirono, Hidetoshi Eguchi, Mitsuhiro Asakuma, Masaji Tani, Etsuro Hatano, Hisashi Ikoma, Go Ohira, Hiromitsu Hayashi, Ke Wan, Toshio Shimokawa, Manabu Kawai, Hiroki Yamaue, The NAC‐GA investigators

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Pembrolizumab and trastuzumab in combination with FLOT in the perioperative treatment of HER2-positive, localized esophagogastric adenocarcinoma—a phase II trial of the AIO study g... by Joseph Tintelnot, Alexander Stein, Salah-Eddin Al-Batran, Thomas Ettrich, Thorsten Götze, Barbara Grün, Georg Martin Haag, Vera Heuer, Ralf-Dieter Hofheinz, Nils Homann, Tobias Sebastian Bröring, Mariana Santos Cruz, Annika Kurreck, Sylvie Lorenzen, Nicolas Moosmann, Christian Müller, Markus Schuler, Gabriele Siegler, Mascha Binder, Eray Gökkurt

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CD24-Fc suppression of immune related adverse events in a therapeutic cancer vaccine model of murine neuroblastoma by Xiaofang Wu, Priya Srinivasan, Mousumi Basu, Talia Zimmerman, Samuel Li, Yin Wang, Pan Zheng, Yang Liu, Anthony David Sandler

“…The CD24-Siglec 10/G interaction is an innate checkpoint that abrogates inflammatory responses to molecules released by damaged cells, but its role in cancer immunology is not well defined. We investigate irAEs of an effective whole cell neuroblastoma vaccine and subsequently the effect of CD24-Fc, a CD24 and Fc fusion protein, on both the vaccine efficacy and induced irAEs in a mouse neuroblastoma model.MethodsTo test whether the whole tumor cell vaccination leads to autoimmune responses in other organ systems we harvested lung, heart, kidney and colon from naïve mice (n=3), unvaccinated tumor only mice (n=3), and vaccinated mice with CD24 Fc (n=12) or human IgG-Fc control (n=12) after tumor inoculation and vaccination therapy at day 30. …”
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The Detection of Immunity against WT1 and SMAD4^P130L of EpCAM⁺ Cancer Cells in Malignant Pleural Effusion by Terutsugu Koya, Yo Niida, Misa Togi, Kenichi Yoshida, Takuya Sakamoto, Hiroki Ura, Sumihito Togi, Tomohisa Kato, Sohsuke Yamada, Haruo Sugiyama, Shigeo Koido, Shigetaka Shimodaira

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Network Proximity-based computational pipeline identifies drug candidates for different pathological stages of Alzheimer's disease by Qihui Wu, Shijie Su, Chuipu Cai, Lina Xu, Xiude Fan, Hanzhong Ke, Zhao Dai, Shuhuan Fang, Yue Zhuo, Qi Wang, Huafeng Pan, Yong Gu, Jiansong Fang

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A multiphase contrast-enhanced CT radiomics model for prediction of human epidermal growth factor receptor 2 status in advanced gastric cancer by Tingting Ma, Tingting Ma, Tingting Ma, Tingting Ma, Jingli Cui, Jingli Cui, Jingli Cui, Jingli Cui, Lingwei Wang, Lingwei Wang, Lingwei Wang, Lingwei Wang, Hui Li, Hui Li, Hui Li, Zhaoxiang Ye, Zhaoxiang Ye, Zhaoxiang Ye, Zhaoxiang Ye, Xujie Gao, Xujie Gao, Xujie Gao, Xujie Gao

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