4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development by Satya Ranjan Sahu, Satya Ranjan Sahu, Shweta Thakur, Doureradjou Peroumal, Bhabasha Gyanadeep Utkalaja, Bhabasha Gyanadeep Utkalaja, Abinash Dutta, Premlata Kumari, Premlata Kumari, Ipsita Subhadarsini, Ipsita Subhadarsini, Narottam Acharya

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Uncoding the interdependency of tumor microenvironment and macrophage polarization: insights from a continuous network approach by Ugo Avila-Ponce de León, Ugo Avila-Ponce de León, Aarón Vázquez-Jiménez, Pablo Padilla-Longoria, Osbaldo Resendis-Antonio, Osbaldo Resendis-Antonio, Osbaldo Resendis-Antonio

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Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells by Ann-Kathrin Herzfeldt, Marta Puig Gamez, Eva Martin, Lukasz Miloslaw Boryn, Praveen Baskaran, Heinrich J Huber, Michael Schuler, John E Park, Lee Kim Swee

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A peptide puzzle by Jian Guan, Nilabh Shastri

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Single-Cell RNA Sequencing Reveals Immuno-Oncology Characteristics of Tumor-Infiltrating T Lymphocytes in Photodynamic Therapy-Treated Colorectal Cancer Mouse Model by Eun-Ji Lee, Jang-Gi Choi, Jung Ho Han, Yong-Wan Kim, Junmo Lim, Hwan-Suck Chung

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MiR-200c reprograms fibroblasts to recapitulate the phenotype of CAFs in breast cancer progression by Zhao Lin, Megan E. Roche, Víctor Díaz-Barros, Marina Domingo-Vidal, Diana Whitaker-Menezes, Madalina Tuluc, Guldeep Uppal, Jaime Caro, Joseph M. Curry, Ubaldo Martinez-Outschoorn

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Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer by Dennis Wang, Nhu-An Pham, Timothy M. Freeman, Vibha Raghavan, Roya Navab, Jonathan Chang, Chang-Qi Zhu, Dalam Ly, Jiefei Tong, Bradly G. Wouters, Melania Pintilie, Michael F. Moran, Geoffrey Liu, Frances A. Shepherd, Ming-Sound Tsao

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Effects of RANKL-targeted therapy in immunity and cancer by Michael L Cheng, Lawrence eFong

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Antitumor Effect of Korean Red Ginseng through Blockade of PD-1/PD-L1 Interaction in a Humanized PD-L1 Knock-In MC38 Cancer Mouse Model by Eun-Ji Lee, Ju-Hye Yang, Hye Jin Yang, Chong-Kwan Cho, Jang-Gi Choi, Hwan-Suck Chung

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The interconnected roles of TRIM21/Ro52 in systemic lupus erythematosus, primary Sjögren’s syndrome, cancers, and cancer metabolism by Chueh-Hsuan Hsu, Yung-Luen Yu

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Identification of immunoglobulin V(D)J recombinations in solid tumor specimen exome files: Evidence for high level B-cell infiltrates in breast cancer by Wei Lue Tong, Yaping N. Tu, Mohammad D. Samy, Wade J. Sexton, George Blanck

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1032 Early remodelling of CD4 T cell differentiation in lung squamous carcinogenesis by Vítor Teixeira, Kate Davies, Peter Campbell, Bart Vanhaesebroeck, Sam Janes, Kate Gowers, Amalie Kai Bentzen, Teerapon Sahwangarrom, Claudia Peinador Marin, Sam Gamble, Zoe Whiteman, Seng Ung, Lukas Kalinke, Ahmed Alhendi, Adam Pennycuick, Sandra Gomez Lopez, Andrei Enica, Amber Rogers, Kane Foster, Moritz Przybilla, James L Reading

A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses by Kirsten L. Todd, Junyun Lai, Kevin Sek, Yu-Kuan Huang, Dane M. Newman, Emily B. Derrick, Hui-Fern Koay, Dat Nguyen, Thang X. Hoang, Emma V. Petley, Cheok Weng Chan, Isabelle Munoz, Imran G. House, Joel N. Lee, Joelle S. Kim, Jasmine Li, Junming Tong, Maria N. de Menezes, Christina M. Scheffler, Kah Min Yap, Amanda X. Y. Chen, Phoebe A. Dunbar, Brandon Haugen, Ian A. Parish, Ricky W. Johnstone, Phillip K. Darcy, Paul A. Beavis

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Multi-Institutional Evaluation of Pathologists’ Assessment Compared to Immunoscore by Joseph Willis, Robert A. Anders, Toshihiko Torigoe, Yoshihiko Hirohashi, Carlo Bifulco, Inti Zlobec, Bernhard Mlecnik, Sandra Demaria, Won-Tak Choi, Pavel Dundr, Fabiana Tatangelo, Annabella Di Mauro, Pamela Baldin, Gabriela Bindea, Florence Marliot, Nacilla Haicheur, Tessa Fredriksen, Amos Kirilovsky, Bénédicte Buttard, Angela Vasaturo, Lucie Lafontaine, Pauline Maby, Carine El Sissy, Assia Hijazi, Amine Majdi, Christine Lagorce, Anne Berger, Marc Van den Eynde, Franck Pagès, Alessandro Lugli, Jérôme Galon

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Breast cancer associated CD169+ macrophages possess broad immunosuppressive functions but enhance antibody secretion by activated B cells by Frida Björk Gunnarsdottir, Oscar Briem, Aida Yifter Lindgren, Eva Källberg, Cajsa Andersen, Robert Grenthe, Cassandra Rosenqvist, Camilla Rydberg Millrud, Mika Wallgren, Hannah Viklund, Daniel Bexell, Martin E. Johansson, Ingrid Hedenfalk, Catharina Hagerling, Catharina Hagerling, Karin Leandersson

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Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy by Marcel P. Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C. Stinchcombe, Michal A. Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T. Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S. Thommen, Gillian M. Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius

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Cyclophosphamide depletes tumor infiltrating T regulatory cells and combined with anti-PD-1 therapy improves survival in murine neuroblastoma by Emily R. Webb, Julia Moreno-Vincente, Alistair Easton, Silvia Lanati, Martin Taylor, Sonya James, Emily L. Williams, Vikki English, Chris Penfold, Stephen A. Beers, Juliet C. Gray

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P855: SYNERGISTIC EFFICACY OF COMBINED SUMOYLATION AND PROTEASOME INHIBITION IN MULTIPLE MYELOMA by U. Keller, G. Heynen, F. Baumgartner, M. Heider, U. Patra, J. Braune, P. Mertins, S. Müller, F. Bassermann, J. Krönke, M. Wirth

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Long‐term observation of the frequency of secondary colorectal cancer and other malignancies in tyrosine kinase inhibitor treated chronic myeloid leukemia patients and controls by Nina Winkelmann, Michaela Schwarz, Bert Hildebrandt, Oliver Henke, Lars Bullinger, Il‐Kang Na, Sebastian Stintzing, Philipp le Coutre

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A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma by Chao Zhang, Hongru Shen, Tielong Yang, Ting Li, Xinyue Liu, Jin Wang, Zhichao Liao, Junqiang Wei, Jia Lu, Haotian Liu, Lijie Xiang, Yichen Yang, Meng Yang, Duan Wang, Yang Li, Ruwei Xing, Sheng Teng, Jun Zhao, Yun Yang, Gang Zhao, Kexin Chen, Xiangchun Li, Jilong Yang

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