CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype by Jingjing Zhao, Yue Li, Yan Tang, Jian-Chuan Xia, Yue Huang, Mian He, Weijing Zhang, Libing Song, Han Li, Fan Luo, Xingyu Jiang, Tong Xiang, Qiuzhong Pan, Liming Cai, Desheng Weng, Yuhu Dai, Fengze Sun, Chaopin Yang, Jieying Yang, Yulong Han, Yanna Zhang

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Circulating immune index predicting the prognosis of patients with hepatocellular carcinoma treated with lenvatinib and immunotherapy by De-Zhen Guo, De-Zhen Guo, Shi-Yu Zhang, Shi-Yu Zhang, San-Yuan Dong, Jia-Yan Yan, Jia-Yan Yan, Yu-Peng Wang, Yu-Peng Wang, Ya Cao, Sheng-Xiang Rao, Jia Fan, Jia Fan, Jia Fan, Xin-Rong Yang, Xin-Rong Yang, Ao Huang, Ao Huang, Jian Zhou, Jian Zhou, Jian Zhou, Jian Zhou

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A hierarchical prognostic model for Co-diabetes pancreatic adenocarcinoma by Zelong Wu, Chunsheng Liu, Zuyi Ma, Zhenchong Li, Shujie Wang, Yubin Chen, Mingqian Han, Shanzhou Huang, Qi Zhou, Chuanzhao Zhang, Baohua Hou

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DNA-methylation and genomic copy number in primary tumors and corresponding lymph node metastases in prostate cancer from patients with low and high Gleason score by Kristian Unger, Julia Hess, Vera Link, Alexander Buchner, Chukwuka Eze, Minglun Li, Christian Stief, Thomas Kirchner, Frederick Klauschen, Horst Zitzelsberger, Maximilian Niyazi, Ute Ganswindt, Nina-Sophie Schmidt-Hegemann, Claus Belka

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S101: GENETIC AND EPIGENETIC FACTORS DRIVING PRIMARY MEDIASTINAL B-CELL LYMPHOMA PATHOGENESIS AND OUTCOME by D. Noerenberg, F. Briest, C. Hennch, K. Yoshida, J. Nimo, R. Hablesreiter, Y. Takeuchi, D. Sasca, H. Ueno, L. Mansouri, Y. Inoue, L. Wiegand, A. M. Staiger, B. Casadei, M. Ziepert, F. Asmar, P. Korkolopoulou, M. Kirchner, P. Mertins, J. Weiner, E. Toth, T. Weber, A. Warth, T. Schneider, R.-M. Amini, W. Klapper, M. Hummel, V. Poeschel, G. Kanellis, A. Rosenwald, G. Held, E. Campo, K. Stamatopoulos, I. Anagnostopoulos, L. Bullinger, N. Goldschmidt, P. L. Zinzani, C. Bödor, R. Rosenquist, T. P. Vassilakopoulos, G. Ott, S. Ogawa, F. Damm

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[18F]-fluoroethyl-L-tyrosine (FET) in glioblastoma (FIG) TROG 18.06 study: protocol for a prospective, multicentre PET/CT trial by Eng-Siew Koh, Mustafa Khasraw, Elizabeth H Barnes, Kyle M Walsh, Mark Rosenthal, Rodney J Hicks, Farshad Foroudi, Hui K Gan, Anna K Nowak, Dale L Bailey, Paul Roach, Arian Lasocki, Robyn Leonard, Roel Verhaak, Andrew M Scott, Alisha Moore, Bradford A Moffat, Clare Senko, Roslyn J Francis, Martin Ebert, Sze Ting Lee, Eddie Lau, Greg Fitt, Robert Coffey, Richard De Abreu Lourenco, Lucas Adda, Paul A Thomas, Michael Back

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The C250T Mutation of <i>TERTp</i> Might Grant a Better Prognosis to Glioblastoma by Exerting Less Biological Effect on Telomeres and Chromosomes Than the C228T Mutation by Teresa Gorria, Carme Crous, Estela Pineda, Ainhoa Hernandez, Marta Domenech, Carolina Sanz, Pedro Jares, Ana María Muñoz-Mármol, Oriol Arpí-Llucía, Bárbara Melendez, Marta Gut, Anna Esteve, Anna Esteve-Codina, Genis Parra, Francesc Alameda, Cristina Carrato, Iban Aldecoa, Mar Mallo, Nuria de la Iglesia, Carmen Balana

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The Australian Reproductive Genetic Carrier Screening Project (Mackenzie’s Mission): Design and Implementation by Alison D. Archibald, Belinda J. McClaren, Jade Caruana, Erin Tutty, Emily A. King, Jane L. Halliday, Stephanie Best, Anaita Kanga-Parabia, Bruce H. Bennetts, Corrina C. Cliffe, Evanthia O. Madelli, Gladys Ho, Jan Liebelt, Janet C. Long, Jeffrey Braithwaite, Jillian Kennedy, John Massie, Jon D. Emery, Julie McGaughran, Justine E. Marum, Kirsten Boggs, Kristine Barlow-Stewart, Leslie Burnett, Lisa Dive, Lucinda Freeman, Mark R. Davis, Martin J. Downes, Mathew Wallis, Monica M. Ferrie, Nicholas Pachter, Paul A. Scuffham, Rachael Casella, Richard J. N. Allcock, Royston Ong, Samantha Edwards, Sarah Righetti, Sebastian Lunke, Sharon Lewis, Susan P. Walker, Tiffany F. Boughtwood, Tristan Hardy, Ainsley J. Newson, Edwin P. Kirk, Nigel G. Laing, Martin B. Delatycki, The Mackenzie’s Mission Study Team

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Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk by Wilcox, Naomi, Dumont, Martine, González-Neira, Anna, Carvalho, Sara, Beauparlant, Charles Joly, Crotti, Marco, Luccarini, Craig, Soucy, Penny, Dubois, Stéphane, Nuñez-Torres, Rocio, Pita, Guillermo, Gardner, Eugene J., Dennis, Joe, Alonso, M. Rosario, Álvarez, Nuria, Baynes, Caroline, Collin-Deschesnes, Annie Claude, Desjardins, Sylvie, Becher, Heiko, Behrens, Sabine, Bolla, Manjeet K., Castelao, Jose E., Chang-Claude, Jenny, Cornelissen, Sten, Dörk, Thilo, Engel, Christoph, Gago-Dominguez, Manuela, Guénel, Pascal, Hadjisavvas, Andreas, Hahnen, Eric, Hartman, Mikael, Herráez, Belén, Jung, Audrey, Keeman, Renske, Kiechle, Marion, Li, Jingmei, Loizidou, Maria A., Lush, Michael, Michailidou, Kyriaki, Panayiotidis, Mihalis I., Sim, Xueling, Teo, Soo Hwang, Tyrer, Jonathan P., van der Kolk, Lizet E., Wahlström, Cecilia, Wang, Qin, Perry, John R. B., Benitez, Javier, Schmidt, Marjanka K., Schmutzler, Rita K., Pharoah, Paul D. P., Droit, Arnaud, Dunning, Alison M., Kvist, Anders, Devilee, Peter, Easton, Douglas F., Simard, Jacques, Tan, Benita Kiat-Tee, Tan,Veronique Kiak Mien, Tan, Su-Ming, Lim, Geok Hoon, Tan, Ern Yu, Ho, Peh Joo, Khng, Alexis Jiaying

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LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells by Cuozzo, Federica, Viloria, Katrina, Shilleh, Ali H., Nasteska, Daniela, Frazer-Morris, Charlotte, Tong, Jason, Jiao, Zicong, Boufersaoui, Adam, Marzullo, Bryan, Rosoff, Daniel B., Smith, Hannah R., Bonner, Caroline, Kerr-Conte, Julie, Pattou, Francois, Nano, Rita, Piemonti, Lorenzo, Johnson, Paul R. V., Spiers, Rebecca, Roberts, Jennie, Lavery, Gareth G., Clark, Anne, Ceresa, Carlo D. L., Ray, David W., Hodson, Leanne, Davies, Amy P., Rutter, Guy A., Oshima, Masaya, Scharfmann, Raphaël, Merrins, Matthew J., Akerman, Ildem, Tennant, Daniel A., Ludwig, Christian, Hodson, David J.

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Development of anti-cancer and anti-hypertensive nanodelivery systems using magnetite iron oxide-polymeric nanoparticles by Dorniani, Dena

“…According to the World Health Organization and Cancer Research UK, the top two causes of death in the world are due to the hypertension (one of the primary risks factors for cardiovascular diseases) and different known cancers that affect humans. …”
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Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial by Menon Usha, Gentry-Maharaj Aleksandra, Burnell Matthew, Ryan Andy, Kalsi Jatinderpal K, Singh Naveena, Dawnay Anne, Fallowfield Lesley, McGuire Alistair J, Campbell Stuart, Skates Steven J, Parmar Mahesh, Jacobs Ian J

“…Funding Long-term follow-up UKCTOCS (2015–2020) – National Institute for Health and Care Research (NIHR HTA grant 16/46/01), Cancer Research UK, and The Eve Appeal. UKCTOCS (2001–2014) – Medical Research Council (MRC) (G9901012/G0801228), Cancer Research UK (C1479/A2884), and the UK Department of Health, with additional support from The Eve Appeal. …”
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Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases by Alistair T. Pagnamenta, Carme Camps, Edoardo Giacopuzzi, John M. Taylor, Mona Hashim, Eduardo Calpena, Pamela J. Kaisaki, Akiko Hashimoto, Jing Yu, Edward Sanders, Ron Schwessinger, Jim R. Hughes, Gerton Lunter, Helene Dreau, Matteo Ferla, Lukas Lange, Yesim Kesim, Vassilis Ragoussis, Dimitrios V. Vavoulis, Holger Allroggen, Olaf Ansorge, Christian Babbs, Siddharth Banka, Benito Baños-Piñero, David Beeson, Tal Ben-Ami, David L. Bennett, Celeste Bento, Edward Blair, Charlotte Brasch-Andersen, Katherine R. Bull, Holger Cario, Deirdre Cilliers, Valerio Conti, E. Graham Davies, Fatima Dhalla, Beatriz Diez Dacal, Yin Dong, James E. Dunford, Renzo Guerrini, Adrian L. Harris, Jane Hartley, Georg Hollander, Kassim Javaid, Maureen Kane, Deirdre Kelly, Dominic Kelly, Samantha J. L. Knight, Alexandra Y. Kreins, Erika M. Kvikstad, Craig B. Langman, Tracy Lester, Kate E. Lines, Simon R. Lord, Xin Lu, Sahar Mansour, Adnan Manzur, Reza Maroofian, Brian Marsden, Joanne Mason, Simon J. McGowan, Davide Mei, Hana Mlcochova, Yoshiko Murakami, Andrea H. Németh, Steven Okoli, Elizabeth Ormondroyd, Lilian Bomme Ousager, Jacqueline Palace, Smita Y. Patel, Melissa M. Pentony, Chris Pugh, Aboulfazl Rad, Archana Ramesh, Simone G. Riva, Irene Roberts, Noémi Roy, Outi Salminen, Kyleen D. Schilling, Caroline Scott, Arjune Sen, Conrad Smith, Mark Stevenson, Rajesh V. Thakker, Stephen R. F. Twigg, Holm H. Uhlig, Richard van Wijk, Barbara Vona, Steven Wall, Jing Wang, Hugh Watkins, Jaroslav Zak, Anna H. Schuh, Usha Kini, Andrew O. M. Wilkie, Niko Popitsch, Jenny C. Taylor

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Metagenomic Next-Generation Sequencing Versus Traditional Laboratory Methods for the Diagnosis and Treatment of Infection in Liver Transplantation by Jun-Feng Huang, Jun-Feng Huang, Jun-Feng Huang, Qing Miao, Jian-Wen Cheng, Jian-Wen Cheng, Ao Huang, Ao Huang, De-Zhen Guo, De-Zhen Guo, Ting Wang, Liu-Xiao Yang, Du-Ming Zhu, Ya Cao, Xiao-Wu Huang, Xiao-Wu Huang, Jia Fan, Jia Fan, Jia Fan, Jian Zhou, Jian Zhou, Jian Zhou, Xin-Rong Yang, Xin-Rong Yang

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A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors by Maria Eugénia Marques Da Costa, Sakina Zaidi, Jean-Yves Scoazec, Robin Droit, Wan Ching Lim, Antonin Marchais, Jerome Salmon, Sarah Cherkaoui, Raphael J. Morscher, Anouchka Laurent, Sébastien Malinge, Thomas Mercher, Séverine Tabone-Eglinger, Isabelle Goddard, Francoise Pflumio, Julien Calvo, Francoise Redini, Natacha Entz-Werlé, Aroa Soriano, Alberto Villanueva, Stefano Cairo, Pascal Chastagner, Massimo Moro, Cormac Owens, Michela Casanova, Raquel Hladun-Alvaro, Pablo Berlanga, Estelle Daudigeos-Dubus, Philippe Dessen, Laurence Zitvogel, Ludovic Lacroix, Gaelle Pierron, Olivier Delattre, Gudrun Schleiermacher, Didier Surdez, Birgit Geoerger

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Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments by Marie Nguyen, Adele De Ninno, Arianna Mencattini, Fanny Mermet-Meillon, Giulia Fornabaio, Sophia S. Evans, Mélissande Cossutta, Yasmine Khira, Weijing Han, Philémon Sirven, Floriane Pelon, Davide Di Giuseppe, Francesca Romana Bertani, Annamaria Gerardino, Ayako Yamada, Stéphanie Descroix, Vassili Soumelis, Fatima Mechta-Grigoriou, Gérard Zalcman, Jacques Camonis, Eugenio Martinelli, Luca Businaro, Maria Carla Parrini

“…Summary: A major challenge in cancer research is the complexity of the tumor microenvironment, which includes the host immunological setting. …”
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Digital interventions to moderate alcohol consumption in young people: a Cancer Prevention Europe overview of systematic reviews by Kevin T. McDermott, Caro Noake, Robert Wolff, Carolina Espina, Jérôme Foucaud, Jérôme Foucaud, Karen Steindorf, Joachim Schüz, Mangesh A. Thorat, Mangesh A. Thorat, Mangesh A. Thorat, Matty Weijenberg, Linda Bauld, Jos Kleijnen

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Mortality of early treatment for radiation-induced brain necrosis in head and neck cancer survivors: A multicentre, retrospective, registry-based cohort study by Dong Pan, Xiaoming Rong, Dongping Chen, Jingru Jiang, Wai Tong Ng, Haiqiang Mai, Yi Li, Honghong Li, Jinhua Cai, Jinping Cheng, Yongteng Xu, Melvin Lee Kiang Chua, Charles B. Simone, II, Simona Lattanzi, Yamei Tang

“…Funding: National Natural Science Foundation of China (81925031, 81820108026, 81872549, 81801229, 82003389), the Science and Technology Program of Guangzhou (202007030001), Young Teacher Training Program of Sun Yat-sen University (20ykpy106), Key-Area Research and Development Program of Guangdong Province (2018B030340001), the National Medical Research Council Singapore Clinician Scientist Award (NMRC/CSA-INV/0027/2018, CSAINV20nov-0021), the Duke-NUS Oncology Academic Program Goh Foundation Proton Research Programme, NCCS Cancer Fund, the Kua Hong Pak Head and Neck Cancer Research Programme, and the National Research Foundation Clinical Research Programme Grant (NRF-CRP17-2017-05).…”
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HPV-related anal cancer is associated with changes in the anorectal microbiome during cancer development by Jacob H. Elnaggar, Jacob H. Elnaggar, Victoria O. Huynh, Daniel Lin, R. Tyler Hillman, R. Tyler Hillman, R. Tyler Hillman, Chike O. Abana, Molly B. El Alam, Katarina C. Tomasic, Tatiana V. Karpinets, Ramez Kouzy, Jae L. Phan, Jennifer Wargo, Emma B. Holliday, Prajnan Das, Melissa P. Mezzari, Nadim J. Ajami, Erica J. Lynn, Bruce D. Minsky, Van K. Morris, Andrea Milbourne, Craig A. Messick, Ann H. Klopp, P. Andrew Futreal, Cullen M. Taniguchi, Kathleen M. Schmeler, Lauren E. Colbert

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Effect of Radiotherapy Dose on Outcome in Nonmetastatic Ewing Sarcoma by Josephine Kersting, Andreas Ranft, PhD, Vivek Bhadri, MD, PhD, Bénédicte Brichard, MD, Stéphane Collaud, MD, Sona Cyprová, MD, Hans Eich, MD, Torben Ek, MD, PhD, Hans Gelderblom, MD, PhD, Jendrik Hardes, MD, Lianne Haveman, MD, Wolfgang Hartmann, MD, Peter Hauser, MD, PhD, Philip Heesen, Heribert Jürgens, MD, Jukka Kanerva, MD, Thomas Kühne, MD, Anna Raciborska, MD, Jelena Rascon, MD, PhD, Victor Rechl, Arne Streitbürger, MD, Beate Timmermann, MD, Yasmine Uhlenbruch, MD, Uta Dirksen, MD

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