Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance by Cirino Botta, Cristina Perez, Marta Larrayoz, Noemi Puig, Maria-Teresa Cedena, Rosalinda Termini, Ibai Goicoechea, Sara Rodriguez, Aintzane Zabaleta, Aitziber Lopez, Sarai Sarvide, Laura Blanco, Daniele M. Papetti, Marco S. Nobile, Daniela Besozzi, Massimo Gentile, Pierpaolo Correale, Sergio Siragusa, Albert Oriol, Maria Esther González-Garcia, Anna Sureda, Felipe de Arriba, Rafael Rios Tamayo, Jose-Maria Moraleda, Mercedes Gironella, Miguel T. Hernandez, Joan Bargay, Luis Palomera, Albert Pérez-Montaña, Hartmut Goldschmidt, Hervé Avet-Loiseau, Aldo Roccaro, Alberto Orfao, Joaquin Martinez-Lopez, Laura Rosiñol, Juan-José Lahuerta, Joan Blade, Maria-Victoria Mateos, Jesús F. San-Miguel, Jose-Angel Martinez Climent, Bruno Paiva, the Programa Para el Estudio de la Terapéutica en Hemopatías Malignas/Grupo Español de Mieloma (PETHEMA/GEM) cooperative group, the iMMunocell study group

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Risk Factors, Diagnosis and Management of Chyle Leak Following Esophagectomy for Cancers by Sivesh K. Kamarajah, BMedSci, MBChB, MRCS, Manjunath Siddaiah-Subramanya, MD, Alessandro Parente, MD, Richard P. T. Evans, MRCS, MBChB, Ademola Adeyeye, MD, Alan Ainsworth, MD, Alberto M. L. Takahashi, MD, Alex Charalabopoulos, MD, Andrew Chang, MD, Atila Eroglue, MD, Bas Wijnhoven, MD, Claire Donohoe, MD, Daniela Molena, MD, Eider Talavera-Urquijo, MD, Flavio Roberto Takeda, MD, Gail Darling, MD, German Rosero, MD, Guillaume Piessen, MD, Hans Mahendran, MD, Hsu Po Kuei, MD, Ines Gockel, MD, Ionut Negoi, MD, Jacopo Weindelmayer, MD, Jari Rasanen, MD, Kebebe Bekele, MD, Guowei Kim, MD, Lieven Depypere, MD, Lorenzo Ferri, MD, Magnus Nilsson, MD, Frederik Klevebro, MD, B. Mark Smithers, MD, Mark I. van Berge Henegouwen, MD, Peter Grimminger, MD, Paul M. Schneider, MD, C. S. Pramesh, MD, Raza Sayyed, MD, Richard Babor, MD, Shinji Mine, MD, Simon Law, MD, Suzanne Gisbertz, MD, Tim Bright, MD, Xavier Benoit D’Journo, MD, Donald Low, MD, Pritam Singh, PhD FRCS, Ewen A Griffiths, MD, FRCS, on behalf of the Oesophagogastric Anastomosis Audit collaborative

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Polymorphisms within the <i>TNFSF4</i> and <i>MAPKAPK2</i> Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIO... by Jose Manuel Sánchez-Maldonado, Ana Moñiz-Díez, Rob ter Horst, Daniele Campa, Antonio José Cabrera-Serrano, Manuel Martínez-Bueno, María del Pilar Garrido-Collado, Francisca Hernández-Mohedo, Laura Fernández-Puerta, Miguel Ángel López-Nevot, Cristina Cunha, Pedro Antonio González-Sierra, Jan Springer, Michaela Lackner, Laura Alcazar-Fuoli, Luana Fianchi, José María Aguado, Livio Pagano, Elisa López-Fernández, Esther Clavero, Leonardo Potenza, Mario Luppi, Lucia Moratalla, Carlos Solano, Antonio Sampedro, Manuel Cuenca-Estrella, Cornelia Lass-Flörl, PCRAGA Study Group, Federico Canzian, Juergen Loeffler, Yang Li, Hermann Einsele, Mihai G. Netea, Lourdes Vázquez, Agostinho Carvalho, Manuel Jurado, Juan Sainz

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Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study by Alfredo Caturano, Raffaele Galiero, Erica Vetrano, Giulia Medicamento, Maria Alfano, Domenico Beccia, Chiara Brin, Sara Colantuoni, Jessica Di Salvo, Raffaella Epifani, Riccardo Nevola, Raffaele Marfella, Celestino Sardu, Carmine Coppola, Ferdinando Scarano, Paolo Maggi, Cecilia Calabrese, Pellegrino De Lucia Sposito, Carolina Rescigno, Costanza Sbreglia, Fiorentino Fraganza, Roberto Parrella, Annamaria Romano, Giosuele Calabria, Benedetto Polverino, Antonio Pagano, Fabio Giuliano Numis, Carolina Bologna, Mariagrazia Nunziata, Vincenzo Esposito, Nicola Coppola, Nicola Maturo, Rodolfo Nasti, Pierpaolo Di Micco, Alessandro Perrella, Luigi Elio Adinolfi, Marina Di Domenico, Marcellino Monda, Vincenzo Russo, Roberto Ruggiero, Giovanni Docimo, Luca Rinaldi, Ferdinando Carlo Sasso

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Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C by Vera Binder, Wantong Li, Muhammad Faisal, Konur Oyman, Donn L. Calkins, Jami Shaffer, Emily M. Teets, Steven Sher, Andrew Magnotte, Alex Belardo, William Deruelle, T. Charles Gregory, Shelley Orwick, Elliott J. Hagedorn, Julie R. Perlin, Serine Avagyan, Asher Lichtig, Francesca Barrett, Michelle Ammerman, Song Yang, Yi Zhou, William E. Carson, Heather R. Shive, James S. Blachly, Rosa Lapalombella, Leonard I. Zon, Bradley W. Blaser

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BRAF-mediated brain tumors in adults and children: A review and the Australian and New Zealand experience by Sarah M. Trinder, Campbell McKay, Phoebe Power, Phoebe Power, Monique Topp, Bosco Chan, Santosh Valvi, Geoffrey McCowage, Geoffrey McCowage, Dinisha Govender, Maria Kirby, David S. Ziegler, David S. Ziegler, David S. Ziegler, Neevika Manoharan, Neevika Manoharan, Tim Hassall, Stewart Kellie, John Heath, Frank Alvaro, Paul Wood, Stephen Laughton, Karen Tsui, Andrew Dodgshun, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat, Raelene Endersby, Raelene Endersby, Stephen J. Luen, Eng-Siew Koh, Eng-Siew Koh, Eng-Siew Koh, Hao-Wen Sim, Hao-Wen Sim, Hao-Wen Sim, Hao-Wen Sim, Benjamin Kong, Benjamin Kong, Nicholas G. Gottardo, Nicholas G. Gottardo, James R. Whittle, Dong-Anh Khuong-Quang, Jordan R. Hansford, Jordan R. Hansford, Jordan R. Hansford

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Characteristics and outcomes of SARS-CoV-2 breakthrough infections among double-vaccinated and triple-vaccinated patients with inflammatory rheumatic diseases by Tobias Alexander, Hendrik Schulze-Koops, Ulf Müller-Ladner, Rebecca Fischer-Betz, Martin Aringer, Rieke Alten, Petra Saar, Tim Schmeiser, Marina Backhaus, Stephanie Finzel, Cornelia Glaser, Hildrun Haibel, Hanns-Martin Lorenz, Gamal Chehab, Christof Specker, Reinhard E Voll, Anja Strangfeld, Norbert Blank, Matthias Braun, Alexander Pfeil, Rebecca Hasseli, Andreas Krause, Anne Constanze Regierer, Peer Aries, Ioana Andreica, Jacqueline Detert, Elvira Decker, Urs Hartmann, Joerg Henes, Kirsten de Groot, JOACHIM GEORGI, Hans Bastian, Christoph Fiehn, Martin Feuchtenberger, Martin Fleck, Christian Blum, Mathias Grunke, Martin Bohl-Bühler, Georg Gauler, Bimba Franziska Hoyer, Guido Hoese, Janine Günther, Matthias Braunisch, Jutta G. Richter, Sabine Reckert, Anett Gräßler, Andreas Kapelle, Silke Osiek, Anna Knothe, Jan Brandt-Jürgens, Anja Maltzahn, Fredrik Albach, Annette Alberding, Susanne Aman, Christopher Amberger, Michaela Amberger, Bianka Andermann, Nils Anders, Jan Andresen, Nikolaos Andriopoulos, Elizabeth Arauj, Uta Arndt, Sarah Avemarg, Christoph Baerwald, Erich Bärlin, Nora Bartholomä, Michael Bäuerle, Jutta Bauhammer, Christine Baumann, Klaus Becker, Heidemarie Becker, Michaela Bellm, Sylvia Berger, Andrea Berghofen, Gerhard Birkner, Daniel Blendea, Hans Bloching, Sebastian Blötz, Stephanie Boeddeker, Susanne Bogner, Lara Bohnen, Ilka Bösenberg, Nicole Böttcher, Diana Braun, Jan Philipp Bremer, Matthias Broll, Andreas Bruckner, Veronika Brumberger, Martin Brzank, Sahra Büllesfeld, Sandra Burger, Michaela Christenn, Anne Claußnitzer, Frank Demtröder, Rainer Dörfler, Elke Drexler, Valeria Dudics, Edmund Edelmann, Roman Eder, Christina Eisterhues, Joachim Michael Engel, Brigitte Erbslöh-Möller, Miriam Feine, Samantha Ferdinan, Claudia Franke, Stefanie Freudenberg, Christian Fräbel, Petra Fuchs, Regina Gaissmaier, Ino Gao, Oliver Gardt, Katrin Geißler, Karolina Gente, Jasmin Gilly, Yannik Gkanatsas, Agnes Gniezinski- Schwister, Rahel Gold, Norman Görl, Ralf Görlitz, Karl-Heinz Göttl, Beate Göttle, Ricardo Grieshaber Bouyer, Gisela Grothues, Florian Günther, Mirjam Haag, Linda Haas, Anna Haas-Wöhrle, Denitsa Hadjiski, Till Hallmann-Böhm, Peter Härle, Charlotte Hasenkamp, Maura-Maria Hauf, Matthias Hauser

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Optimizing margin status for improving prognosis in patients with oral cavity squamous cell carcinoma: A retrospective study from the two highest-volume Taiwanese hospitals by Chun-Ta Liao, Li-Yu Lee, Shu-Ru Lee, Shu-Hang Ng, Tsang-Wu Liu, Chih-Yen Chien, Jin-Ching Lin, Cheng Ping Wang, Shyuang-Der Terng, Chun-Hung Hua, Tsung-Ming Chen, Wen-Cheng Chen, Yao-Te Tsai, Chung-Jan Kang, Chi-Ying Tsai, Ying-Hsia Chu, Chien-Yu Lin, Kang-Hsing Fan, Hung-Ming Wang, Chia-Hsun Hsieh, Chih-Hua Yeh, Chih-Hung Lin, Chung-Kan Tsao, Tzu-Chen Yen, Nai-Ming Cheng, Tuan-Jen Fang, Shiang-Fu Huang, Li-Ang Lee, Ku-Hao Fang, Yu-Chien Wang, Wan-Ni Lin, Li-Jen Hsin, Yu-Wen Wen, Yu-Wen Wen

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SDC: An integrated database for sex differences in cancer by Long-Fei Zhao, Jin-Ge Zhang, Feng-Yu Qi, Wei-Yan Hou, Yin-Rui Li, Dan-Dan Shen, Li-Juan Zhao, Lin Qi, Hong-Min Liu, Yi-Chao Zheng

“…With the development of personalized approaches in cancer treatment, the impact of sex differences has not been systematically incorporated into preclinical and clinical cancer research. The molecular mechanisms underlying sex differences in cancer have not been elucidated. …”
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Infants and Newborns with Atypical Teratoid Rhabdoid Tumors (ATRT) and Extracranial Malignant Rhabdoid Tumors (eMRT) in the EU-RHAB Registry: A Unique and Challenging Population by Karolina Nemes, Pascal D. Johann, Mona Steinbügl, Miriam Gruhle, Susanne Bens, Denis Kachanov, Margarita Teleshova, Peter Hauser, Thorsten Simon, Stephan Tippelt, Wolfgang Eberl, Martin Chada, Vicente Santa-Maria Lopez, Lorenz Grigull, Pablo Hernáiz-Driever, Matthias Eyrich, Jane Pears, Till Milde, Harald Reinhard, Alfred Leipold, Marianne van de Wetering, Maria João Gil-da-Costa, Georg Ebetsberger-Dachs, Kornelius Kerl, Andreas Lemmer, Heidrun Boztug, Rhoikos Furtwängler, Uwe Kordes, Christian Vokuhl, Martin Hasselblatt, Brigitte Bison, Thomas Kröncke, Patrick Melchior, Beate Timmermann, Joachim Gerss, Reiner Siebert, Michael C. Frühwald

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The Role of the EZH2 and H3K27me3 Expression as a Predictor of Clinical Outcomes in Salivary Duct Carcinoma Patients: A Large-Series Study With Emphasis on the Relevance to the Com... by Natsuki Saigusa, Hideaki Hirai, Yuichiro Tada, Daisuke Kawakita, Masato Nakaguro, Kiyoaki Tsukahara, Satoshi Kano, Hiroyuki Ozawa, Takahito Kondo, Kenji Okami, Takafumi Togashi, Yukiko Sato, Makoto Urano, Manami Kajiwara, Tomotaka Shimura, Chihiro Fushimi, Akira Shimizu, Isaku Okamoto, Takuro Okada, Takayoshi Suzuki, Yorihisa Imanishi, Yoshihiro Watanabe, Akihiro Sakai, Koji Ebisumoto, Yuichiro Sato, Yoshitaka Honma, Keisuke Yamazaki, Yushi Ueki, Toyoyuki Hanazawa, Yuki Saito, Hideaki Takahashi, Mizuo Ando, Shinji Kohsaka, Takashi Matsuki, Toshitaka Nagao

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The Open-Access European Prevention of Alzheimer’s Dementia (EPAD) MRI dataset and processing workflow by Luigi Lorenzini, Silvia Ingala, Alle Meije Wink, Joost P.A. Kuijer, Viktor Wottschel, Mathijs Dijsselhof, Carole H. Sudre, Sven Haller, José Luis Molinuevo, Juan Domingo Gispert, David M. Cash, David L. Thomas, Sjoerd B. Vos, Ferran Prados, Jan Petr, Robin Wolz, Alessandro Palombit, Adam J. Schwarz, Gaël Chételat, Pierre Payoux, Carol Di Perri, Joanna M. Wardlaw, Giovanni B. Frisoni, Christopher Foley, Nick C. Fox, Craig Ritchie, Cyril Pernet, Adam Waldman, Frederik Barkhof, Henk J.M.M. Mutsaerts

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In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer by Loretta M S Lau, Chelsea Mayoh, Jinhan Xie, Paulette Barahona, Karen L MacKenzie, Marie Wong, Alvin Kamili, Maria Tsoli, Tim W Failes, Amit Kumar, Emily V A Mould, Andrew Gifford, Shu‐Oi Chow, Mark Pinese, Jamie I Fletcher, Greg M Arndt, Dong‐Anh Khuong‐Quang, Carol Wadham, Daniel Batey, Georgina Eden, Peter Trebilcock, Swapna Joshi, Stephanie Alfred, Anjana Gopalakrishnan, Aaminah Khan, Dylan Grebert Wade, Patrick A Strong, Elodie Manouvrier, Lisa T Morgan, Miriam Span, Jin Yi Lim, Roxanne Cadiz, Caitlin Ung, David M Thomas, Katherine M Tucker, Meera Warby, Geoffrey B McCowage, Luciano Dalla‐Pozza, Jennifer A Byrne, Federica Saletta, Andrew Fellowes, Stephen B Fox, Murray D Norris, Vanessa Tyrrell, Toby N Trahair, Richard B Lock, Mark J Cowley, Paul G Ekert, Michelle Haber, David S Ziegler, Glenn M Marshall

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Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation by Fan Zhao, Xiaoli Ma, Wuxia Qiu, Pai Wang, Ru Zhang, Zhihao Chen, Peihong Su, Yan Zhang, Dijie Li, Jianhua Ma, Chaofei Yang, Lei Chen, Chong Yin, Ye Tian, Lifang Hu, Yu Li, Ge Zhang, Xiaoyang Wu, Airong Qian

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Flower lose, a cell fitness marker, predicts COVID‐19 prognosis by Michail Yekelchyk, Esha Madan, Jochen Wilhelm, Kirsty R Short, António M Palma, Linbu Liao, Denise Camacho, Everlyne Nkadori, Michael T Winters, Emily S Rice, Inês Rolim, Raquel Cruz‐Duarte, Christopher J Pelham, Masaki Nagane, Kartik Gupta, Sahil Chaudhary, Thomas Braun, Raghavendra Pillappa, Mark S Parker, Thomas Menter, Matthias Matter, Jasmin Dionne Haslbauer, Markus Tolnay, Kornelia D Galior, Kristina A Matkwoskyj, Stephanie M McGregor, Laura K Muller, Emad A Rakha, Antonio Lopez‐Beltran, Ronny Drapkin, Maximilian Ackermann, Paul B Fisher, Steven R Grossman, Andrew K Godwin, Arutha Kulasinghe, Ivan Martinez, Clay B Marsh, Benjamin Tang, Max S Wicha, Kyoung Jae Won, Alexandar Tzankov, Eduardo Moreno, Rajan Gogna

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Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts by Hillary, Robert F., Ng, Hong Kiat, McCartney, Daniel L., Elliott, Hannah R., Walker, Rosie M., Campbell, Archie, Huang, Felicia, Direk, Kenan, Welsh, Paul, Sattar, Naveed, Corley, Janie, Hayward, Caroline, McIntosh, Andrew M., Sudlow, Cathie, Evans, Kathryn L., Cox, Simon R., Chambers, John Campbell, Loh, Marie, Relton, Caroline L., Marioni, Riccardo E., Yousefi, Paul D., Suderman, Matthew

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Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study by Gloria Pérez-Gimeno, Gloria Pérez-Gimeno, Miguel Seral-Cortes, Miguel Seral-Cortes, Sergio Sabroso-Lasa, Luis Mariano Esteban, Empar Lurbe, Empar Lurbe, Laurent Béghin, Frederic Gottrand, Aline Meirhaeghe, Manon Muntaner, Anthony Kafatos, Dénes Molnár, Catherine Leclercq, Kurt Widhalm, Mathilde Kersting, Esther Nova, Diego F. Salazar-Tortosa, Diego F. Salazar-Tortosa, Marcela Gonzalez-Gross, Marcela Gonzalez-Gross, Christina Breidenassel, Christina Breidenassel, Kathrin Sinningen, Thaïs De Ruyter, Idoia Labayen, Azahara I. Rupérez, Gloria Bueno-Lozano, Gloria Bueno-Lozano, Luis A. Moreno, Luis A. Moreno

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Trends in Net Survival from Vulvar Squamous Cell Carcinoma in Italy (1990–2015) by Silvia Mancini, Lauro Bucchi, Federica Zamagni, Flavia Baldacchini, Emanuele Crocetti, Orietta Giuliani, Alessandra Ravaioli, Rosa Vattiato, Mario Preti, Rosario Tumino, Stefano Ferretti, Annibale Biggeri, Paola Ballotari, Lorenza Boschetti, Angelita Brustolin, Adele Caldarella, Rossella Cavallo, Claudia Cirilli, Annarita Citarella, Maria L. Contrino, Luigino Dal Maso, Rosa A. Filiberti, Mario Fusco, Rocco Galasso, Fernanda L. Lotti, Michele Magoni, Lucia Mangone, Giuseppe Masanotti, Guido Mazzoleni, Walter Mazzucco, Anna Melcarne, Maria Michiara, Paola Pesce, Angela Pinto, Daniela Piras, Roberto V. Rizzello, Magda Rognoni, Stefano Rosso, Massimo Rugge, Giuseppe Sampietro, Santo Scalzi, Tiziana Scuderi, Giovanna Tagliabue, Federica Toffolutti, Susanna Vitarelli, Fabio Falcini

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IN MEMORIAM ACADEMICIAN GHEORGHE ȚÎBÎRNĂ

“…În 1992 a fost ales membru al Societăţii „The Europian Society of Cancer Research” şi membru al Comite-tului Asociaţiei medicale din Republica Moldova; în anul 1995 – membru al Societăţii „The European Society of Cancer”, membru al „L’Union Médicale Balkanique”, membru al „American Head and Neck Society”. …”
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Multicenter Real-World Data of Subsequent Chemotherapy after Progression to PARP Inhibitors in a Maintenance Relapse Setting by Margarita Romeo, Marta Gil-Martín, Lydia Gaba, Iris Teruel, Álvaro Taus, Claudia Fina, Maria Masvidal, Paola Murata, Julen Fernández-Plana, Alejandro Martínez, Cristina Pérez, Yolanda García, Valerie Rodriguez, Sara Cros, Marta Parera, Montserrat Zanui, Silvia Catot, Beatriz Pardo, Andrea Plaja, Anna Esteve, Maria Pilar Barretina-Ginesta

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