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12881
PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair
Published 2021-07-01“…Collectively, targeting PFKFB3 opens up therapeutic possibilities to improve the efficacy of ICL-inducing cancer treatments.…”
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12882
Empagliflozin treatment of cardiotoxicity: A comprehensive review of clinical, immunobiological, neuroimmune, and therapeutic implications
Published 2023-12-01“…Chemotherapy-induced cardiotoxicity has been associated with various cancer treatments, such as anthracyclines, immune checkpoint inhibitors, and kinase inhibitors. …”
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12883
Role of hypoxia-activated prodrugs in combination with radiation therapy: An in silico approach
Published 2019-07-01“…Tumour hypoxia has been associated with increased resistance to various cancer treatments, particularly radiation therapy. Conversely, tumour hypoxia is a validated and ideal target for guided cancer drug delivery. …”
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12884
Upper-Limb Disability and the Severity of Lymphedema Reduce the Quality of Life of Patients with Breast Cancer-Related Lymphedema
Published 2023-08-01“…BRCL is caused via the blockage or disruption of the lymphatic vessels following cancer treatments, leading to an accumulation of fluid in the affected arm. …”
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12885
Identification of Transferrin Receptor 1 (TfR1) Overexpressed in Lung Cancer Cells, and Internalization of Magnetic Au-CoFe<sub>2</sub>O<sub>4</sub> Core-Shell Nanoparticles Functi...
Published 2022-08-01“…Our results are important in obtaining essential information for monitoring the disease and/or choosing better treatments, and this finding will pave the way for future synthesis of nanoparticles including chemotherapeutic drugs for lung cancer treatments.…”
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12886
PROTACs in the Management of Prostate Cancer
Published 2023-04-01“…Cancer treatments with targeted therapy have gained immense interest due to their low levels of toxicity and high selectivity. …”
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12887
A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products
Published 2023-09-01“…In addition, the PHNQs extract, in combination with Antimycin A, displayed a synergistic pro-apoptotic effect, envisaging its possible employment against chemoresistance in cancer treatments. Overall, this study highlights the validity of a zero-waste approach in the seafood chain to obtain high-value products, which, in turn, may be exploited for different biomedical applications.…”
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12888
Pharmacological correction of pathological changes in the viable offspring of rats, caused by cytostatic impact at the stage of progenesis
Published 2019-02-01“…The number of reproductive-aged women with cancer, who desire child bearing, has increased with improvements in cancer detection and treatment. Cancer treatments have the potential to cause germline mutations that might increase the risk of cancer in the progeny of cancer patients. the aim of the study was to assess the feasibility of reducing the long-term side effects of Etoposide on the progeny of rats using Glutaxim. material and methods. …”
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12889
Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation
Published 2021-11-01“…As H<sub>2</sub>S and the enzymes that synthesize it are increased in many human malignancies, it is likely that H<sub>2</sub>S synthesis inhibition by these therapies is an underappreciated aspect of these cancer treatments. Moreover, both H<sub>2</sub>S and DDR protein activities in cancer and cardiovascular diseases are becoming increasingly apparent, implicating a DDR–H<sub>2</sub>S signaling axis in these pathophysiologic processes. …”
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12890
Steroidogenesis and androgen/estrogen signaling pathways are altered in in vitro matured testicular tissues of prepubertal mice
Published 2023-12-01“…Children undergoing cancer treatments are at risk for impaired fertility. Cryopreserved prepubertal testicular biopsies could theoretically be later matured in vitro to produce spermatozoa for assisted reproductive technology. …”
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12891
Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era
Published 2022-12-01“…By summarizing recent state-of-the-art studies and clinical data on bacteriophage treatment, we introduced (i) the pharmacological mechanisms and advantages of antibacterial bacteriophages, (ii) bacteriophage preparations with clinical potential and bacteriophage-derived anti-bacterial treatment strategies, and (iii) bacteriophage therapeutics aimed at multiple infection types and infection-induced cancer treatments. Finally, we highlighted the challenges and critical perspectives of bacteriophage therapy for future clinical development.…”
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12892
Quality-of-Life Assessment after Head and Neck Oncological Surgery for Advanced-Stage Tumours
Published 2022-08-01“…The unique details of head and neck cancer treatments outline the importance of considering the characteristics of the patient population in quality-of-life research and also identify how quality-of-life data can contribute to the care provided by the multi-disciplinary team involved in a patient’s follow-up.…”
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12893
Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia
Published 2020-09-01“…Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. …”
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12894
Favorable cervical cancer mortality-to-incidence ratios of countries with good human development index rankings and high health expenditures
Published 2023-05-01“…The mortality-to-incidence ratio (MIR) is a marker that reflects the available screening interventions and clinical outcomes of cancer treatments. The association between the MIR for cervical cancer and cancer screening disparities among countries is an interesting issue but rarely investigated. …”
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12895
Vaccine Therapy in Non-Small Cell Lung Cancer
Published 2022-05-01“…The high level of success of several recent vaccines against SARS-CoV-2 has highlighted the evolving advances in science and technology in the vaccines field, raising hope that this strategy can be successfully applied to cancer treatments. In this review, we describe the biology behind the cancer vaccines, and discuss current evidence for the different types of therapeutic cancer vaccines in NSCLC, including their mechanisms of action, current clinical development, and future strategies.…”
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12896
Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
Published 2023-07-01“…Abstract Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. …”
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12897
A Survey of Naturally Occurring Molecules as New Endoplasmic Reticulum Stress Activators with Selective Anticancer Activity
Published 2022-12-01“…Nonetheless, the road toward desirable success rates of cancer treatments is still long and paved with uncertainty. …”
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12898
Delivery of Various Cargos into Cancer Cells and Tissues via Cell-Penetrating Peptides: A Review of the Last Decade
Published 2021-09-01“…Besides their remarkable efficacy owing to fast and efficient delivery, a crucial benefit of CPP-based cancer treatments is delivering anticancer agents selectively, rather than mediating toxicities toward normal tissues. …”
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12899
The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
Published 2023-12-01“…Despite advancements in cancer treatments such as surgery, radiotherapy, chemotherapy, and immunotherapy, the persistent hallmark of cancer enables malignant cells to elude cell death and develop resistance to therapy. …”
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12900
The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis
Published 2020-07-01“…Prostate cancer (PCa), though easily curable during primary stages, represents a clinical challenge in advanced stages because of the acquisition of resistance to anti-cancer treatments, especially androgen-deprivation therapies (ADT), which possibly lead to uncurable metastases such as those affecting the bone. …”
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