PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair by Anna Huguet Ninou, Jemina Lehto, Dimitrios Chioureas, Hannah Stigsdotter, Korbinian Schelzig, Emma Åkerlund, Greta Gudoityte, Ulrika Joneborg, Joseph Carlson, Jos Jonkers, Brinton Seashore-Ludlow, Nina Marie Susanne Gustafsson

“…Collectively, targeting PFKFB3 opens up therapeutic possibilities to improve the efficacy of ICL-inducing cancer treatments.…”
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Empagliflozin treatment of cardiotoxicity: A comprehensive review of clinical, immunobiological, neuroimmune, and therapeutic implications by Zahra Vaziri, Kiarash Saleki, Cena Aram, Parsa Alijanizadeh, Ramtin Pourahmad, Abbas Azadmehr, Naghmeh Ziaei

“…Chemotherapy-induced cardiotoxicity has been associated with various cancer treatments, such as anthracyclines, immune checkpoint inhibitors, and kinase inhibitors. …”
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Role of hypoxia-activated prodrugs in combination with radiation therapy: An in silico approach by Cameron Meaney, Gibin G Powathil, Ala Yaromina, Ludwig J Dubois, Philippe Lambin, Mohammad Kohandel

“…Tumour hypoxia has been associated with increased resistance to various cancer treatments, particularly radiation therapy. Conversely, tumour hypoxia is a validated and ideal target for guided cancer drug delivery. …”
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Upper-Limb Disability and the Severity of Lymphedema Reduce the Quality of Life of Patients with Breast Cancer-Related Lymphedema by Karol Ramirez-Parada, Angela Gonzalez-Santos, Layla Riady-Aleuy, Mauricio P. Pinto, Carolina Ibañez, Tomas Merino, Francisco Acevedo, Benjamin Walbaum, Rodrigo Fernández-Verdejo, Cesar Sanchez

“…BRCL is caused via the blockage or disruption of the lymphatic vessels following cancer treatments, leading to an accumulation of fluid in the affected arm. …”
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Identification of Transferrin Receptor 1 (TfR1) Overexpressed in Lung Cancer Cells, and Internalization of Magnetic Au-CoFe₂O₄ Core-Shell Nanoparticles Functi... by Rocío Villalobos-Manzo, Emmanuel Ríos-Castro, José Manuel Hernández-Hernández, Goldie Oza, Mauricio A. Medina, José Tapia-Ramírez

“…Our results are important in obtaining essential information for monitoring the disease and/or choosing better treatments, and this finding will pave the way for future synthesis of nanoparticles including chemotherapeutic drugs for lung cancer treatments.…”
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PROTACs in the Management of Prostate Cancer by Poornachandra Yedla, Ahmed O. Babalghith, Vindhya Vasini Andra, Riyaz Syed

“…Cancer treatments with targeted therapy have gained immense interest due to their low levels of toxicity and high selectivity. …”
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A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products by Luca Melotti, Andrea Venerando, Giulia Zivelonghi, Anna Carolo, Stefania Marzorati, Giordana Martinelli, Michela Sugni, Lisa Maccatrozzo, Marco Patruno

“…In addition, the PHNQs extract, in combination with Antimycin A, displayed a synergistic pro-apoptotic effect, envisaging its possible employment against chemoresistance in cancer treatments. Overall, this study highlights the validity of a zero-waste approach in the seafood chain to obtain high-value products, which, in turn, may be exploited for different biomedical applications.…”
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Pharmacological correction of pathological changes in the viable offspring of rats, caused by cytostatic impact at the stage of progenesis by T. G. Borovskaya, M. E. Poluektova, А. V. Vychuzhanina, Yu. А. Shchemerovа, V. E. Goldberg

“…The number of reproductive-aged women with cancer, who desire child bearing, has increased with improvements in cancer detection and treatment. Cancer treatments have the potential to cause germline mutations that might increase the risk of cancer in the progeny of cancer patients. the aim of the study was to assess the feasibility of reducing the long-term side effects of Etoposide on the progeny of rats using Glutaxim. material and methods. …”
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Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation by Rodney E. Shackelford, Yan Li, Ghali E. Ghali, Christopher G. Kevil

“…As H₂S and the enzymes that synthesize it are increased in many human malignancies, it is likely that H₂S synthesis inhibition by these therapies is an underappreciated aspect of these cancer treatments. Moreover, both H₂S and DDR protein activities in cancer and cardiovascular diseases are becoming increasingly apparent, implicating a DDR–H₂S signaling axis in these pathophysiologic processes. …”
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Steroidogenesis and androgen/estrogen signaling pathways are altered in in vitro matured testicular tissues of prepubertal mice by Laura Moutard, Caroline Goudin, Catherine Jaeger, Céline Duparc, Estelle Louiset, Tony Pereira, François Fraissinet, Marion Delessard, Justine Saulnier, Aurélie Rives-Feraille, Christelle Delalande, Hervé Lefebvre, Nathalie Rives, Ludovic Dumont, Christine Rondanino

“…Children undergoing cancer treatments are at risk for impaired fertility. Cryopreserved prepubertal testicular biopsies could theoretically be later matured in vitro to produce spermatozoa for assisted reproductive technology. …”
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Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era by Hao Ling, Xinyu Lou, Qiuhua Luo, Zhonggui He, Mengchi Sun, Jin Sun

“…By summarizing recent state-of-the-art studies and clinical data on bacteriophage treatment, we introduced (i) the pharmacological mechanisms and advantages of antibacterial bacteriophages, (ii) bacteriophage preparations with clinical potential and bacteriophage-derived anti-bacterial treatment strategies, and (iii) bacteriophage therapeutics aimed at multiple infection types and infection-induced cancer treatments. Finally, we highlighted the challenges and critical perspectives of bacteriophage therapy for future clinical development.…”
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Quality-of-Life Assessment after Head and Neck Oncological Surgery for Advanced-Stage Tumours by Paula Luiza Bejenaru, Bogdan Popescu, Alina Lavinia Antoaneta Oancea, Catrinel Beatrice Simion-Antonie, Gloria Simona Berteșteanu, Mihnea Condeescu-Cojocarița, Anca Ionela Cîrstea, Irina Doinița Oașă, Teodora Elena Schipor-Diaconu, Dan Popescu, Raluca Grigore

“…The unique details of head and neck cancer treatments outline the importance of considering the characteristics of the patient population in quality-of-life research and also identify how quality-of-life data can contribute to the care provided by the multi-disciplinary team involved in a patient’s follow-up.…”
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Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia by Jinjoo Lee, Myung In Jeong, Hyo-Rim Kim, Hyejin Park, Won-Kyoung Moon, Bonglee Kim

“…Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. …”
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Favorable cervical cancer mortality-to-incidence ratios of countries with good human development index rankings and high health expenditures by Tzu-Tsen Shen, Cheng-Yu Long, Ming-Ping Wu

“…The mortality-to-incidence ratio (MIR) is a marker that reflects the available screening interventions and clinical outcomes of cancer treatments. The association between the MIR for cervical cancer and cancer screening disparities among countries is an interesting issue but rarely investigated. …”
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Vaccine Therapy in Non-Small Cell Lung Cancer by Miguel García-Pardo, Teresa Gorria, Ines Malenica, Stéphanie Corgnac, Cristina Teixidó, Laura Mezquita

“…The high level of success of several recent vaccines against SARS-CoV-2 has highlighted the evolving advances in science and technology in the vaccines field, raising hope that this strategy can be successfully applied to cancer treatments. In this review, we describe the biology behind the cancer vaccines, and discuss current evidence for the different types of therapeutic cancer vaccines in NSCLC, including their mechanisms of action, current clinical development, and future strategies.…”
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Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments by Gunjan Dagar, Ashna Gupta, Tariq Masoodi, Sabah Nisar, Maysaloun Merhi, Sheema Hashem, Ravi Chauhan, Manisha Dagar, Sameer Mirza, Puneet Bagga, Rakesh Kumar, Ammira S. Al-Shabeeb Akil, Muzafar A. Macha, Mohammad Haris, Shahab Uddin, Mayank Singh, Ajaz A. Bhat

“…Abstract Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. …”
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A Survey of Naturally Occurring Molecules as New Endoplasmic Reticulum Stress Activators with Selective Anticancer Activity by Daniela Correia da Silva, Patrícia Valentão, David M. Pereira

“…Nonetheless, the road toward desirable success rates of cancer treatments is still long and paved with uncertainty. …”
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Delivery of Various Cargos into Cancer Cells and Tissues via Cell-Penetrating Peptides: A Review of the Last Decade by Alireza Shoari, Raheleh Tooyserkani, Mehdi Tahmasebi, Dennis W. P. M. Löwik

“…Besides their remarkable efficacy owing to fast and efficient delivery, a crucial benefit of CPP-based cancer treatments is delivering anticancer agents selectively, rather than mediating toxicities toward normal tissues. …”
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The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment by Mengyuan Li, Ping Jiang, Yuhan Yang, Liting Xiong, Shuhua Wei, Junjie Wang, Chunxiao Li

“…Despite advancements in cancer treatments such as surgery, radiotherapy, chemotherapy, and immunotherapy, the persistent hallmark of cancer enables malignant cells to elude cell death and develop resistance to therapy. …”
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The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis by Francesco Bonollo, George N. Thalmann, Marianna Kruithof-de Julio, Sofia Karkampouna

“…Prostate cancer (PCa), though easily curable during primary stages, represents a clinical challenge in advanced stages because of the acquisition of resistance to anti-cancer treatments, especially androgen-deprivation therapies (ADT), which possibly lead to uncurable metastases such as those affecting the bone. …”
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