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12961
Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges
Published 2023-01-01“…Targeted drug delivery is considered a pivotal contributor to precision medicine for cancer treatments as this method helps deliver medication to patients by systematically increasing the drug concentration on the targeted body parts. …”
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Article -
12962
Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics
Published 2014-02-01“…Both functional single-nucleotide polymorphisms and inhibitory agents of ABCG2/BCRP modulate the in vivo pharmacokinetics and pharmacodynamics of these molecular cancer treatments, so the pharmacogenetics of ABCG2/BCRP is an important consideration in the application of molecular-targeted chemotherapies. …”
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Article -
12963
The Anti-Inflammatory Activity of <i>Viscum album</i>
Published 2023-03-01“…However, since the last century, medical interest in mistletoe has come back in force due to its utilization in clinical cancer treatments, based on its selective action on tumor cells. …”
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Article -
12964
The Network of Non-coding RNAs in Cancer Drug Resistance
Published 2018-08-01“…We finally discussed the higher integration of the drug-ncRNA clusters with the goal of disentangling effectors from downstream effects and further clarify the involvement of ncRNAs in the cellular mechanisms underlying resistance to cancer treatments.…”
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Article -
12965
Performance Comparisons of AlexNet and GoogLeNet in Cell Growth Inhibition IC50 Prediction
Published 2021-07-01“…Drug responsiveness prediction is important in clinical response to specific cancer treatments. Recently, multi-class drug responsiveness models based on deep learning (DL) models using molecular fingerprints and mutation statuses have emerged. …”
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Article -
12966
Modulation of the Magnetic Hyperthermia Response Using Different Superparamagnetic Iron Oxide Nanoparticle Morphologies
Published 2021-03-01“…The use of magnetic nanoparticles in hyperthermia, that is, heating induced by alternating magnetic fields, is gaining interest as a non-invasive, free of side effects technique that can be considered as a co-adjuvant of other cancer treatments. Having sufficient control on the field characteristics, within admissible limits, the focus is presently on the magnetic material. …”
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Article -
12967
Sex-specific outcomes in cancer therapy: the central role of hormones
Published 2024-02-01“…Therapeutically, the utilization of hormone replacement therapy (HRT) during cancer treatments presents both potential risks and benefits. …”
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Article -
12968
IDICAP: A Novel Tool for Integrating Drug Intervention Based on Cancer Panel
Published 2016-10-01“…Tremendous resources have been and continue to be devoted to the development of cancer treatments that target the unique mutation profiles of patients, namely targeted cancer therapy. …”
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Article -
12969
The Mining Of Nigerian Medicinal Plants For Cancer Therapy
Published 2015-06-01“…As a result of the heterogeneity of cancers, treatment strategies should be tailored to be patient and cancer-specific.…”
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Article -
12970
Phyto-therapeutics as anti-cancer agents in breast cancer: Pathway targeting and mechanistic elucidation
Published 2024-03-01“…Therefore, in order to increase the effectiveness of current cancer treatments, new tactics and cutting-edge chemoprevention drugs are required. …”
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Article -
12971
Supplementary protection certificates and their impact on access to medicines in Europe: case studies of sofosbuvir, trastuzumab and imatinib
Published 2020-12-01“…On the basis of an analysis of three medicines for hepatitis C and cancer treatments, the present article critically engages with the policy justifications underlying SPCs. …”
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Article -
12972
Computational Approaches for Cancer-Fighting: From Gene Expression to Functional Foods
Published 2021-08-01“…Nutrigenomics studies are therefore taking place with the aim to test the effects of nutrients at molecular level and contribute to the search for anti-cancer treatments. These efforts are expanding the precious source of information necessary for the selection of natural compounds useful for the design of novel drugs or functional foods. …”
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Article -
12973
In-silico identification of novel inhibitors for human Aurora kinase B form the ZINC database using molecular docking-based virtual screening
Published 2022-12-01“…Conclusion: The findings suggest that the six compounds could be used as a potential agent for cancer treatments. Graphical abstract…”
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Article -
12974
Hyponatraemia and the syndrome of inappropriate antidiuresis (SIAD) in cancer
Published 2023-01-01“…Causes of SIAD include ectopic production of vasopressin (AVP) from an underlying tumour, cancer treatments, nausea and pain. Cortisol deficiency is an important differential in the assessment of hyponatraemia, as it has an identical biochemical pattern to SIAD and is easily treatable. …”
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Article -
12975
Can a Low-Phosphate Diet for Chronic Kidney Disease Treat Cancer? An Interdisciplinary Literature Review
Published 2024-01-01“…An interdisciplinary approach is needed to translate basic, clinical, and remote fields of research knowledge into novel cancer treatments. Recent research has identified high dietary phosphate intake as a risk factor associated with cancer incidence. …”
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Article -
12976
Comprehensive Analysis of KCNJ14 Potassium Channel as a Biomarker for Cancer Progression and Development
Published 2023-01-01“…More recently, potassium (K<sup>+</sup>) channels have been studied as a potential biological target for the creation of cancer treatments. Potassium Inwardly Rectifying Channel Subfamily J Member 14 (KCNJ14) is one of the cancer genome’s least investigated genes. …”
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Article -
12977
Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD
Published 2024“…Targeted therapies are effective cancer treatments when accompanied by accurate diagnostic tests that can help identify patients that will respond to those therapies. …”
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Article -
12978
Comparing the efficiency of Pseudomonas Aeruginosa (PAO1) and Escherichia coli (BL21) to deliver fluorescence in mammalian cancer cells
Published 2016“…Cancer has been a prevalent health problem that continues to be fatal largely due to the late diagnosis of cancer and the lack of monitoring of the progress of cancer treatments on patients. Therefore over the years, researchers have been leveraging on the advantages of nanosensors as they have great potential in overcoming those issues. …”
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Final Year Project (FYP) -
12979
A Peer Review Intervention for Monitoring and Evaluating sites (PRIME) that improved randomized controlled trial conduct and performance
Published 2011“…The intervention was evaluated in the ProtecT trial, a UK randomized controlled trial of localized prostate cancer treatments (ISRCTN20141297). The ProtecT coordinator and senior nurses conducted three monitoring rounds at eight sites (2004-2007). …”
Journal article -
12980
Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
Published 2020“…The processes of PARP activation and the PARP catalytic cycle we describe can explain mechanisms of resistance to PARP inhibitors and will aid the development of better inhibitors as cancer treatments12,13,14,15,16.…”
Journal article