Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges by Kaushik Pratim Das, Chandra J

“…Targeted drug delivery is considered a pivotal contributor to precision medicine for cancer treatments as this method helps deliver medication to patients by systematically increasing the drug concentration on the targeted body parts. …”
Get full text

Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics by Noguchi K, Katayama K, Sugimoto Y

“…Both functional single-nucleotide polymorphisms and inhibitory agents of ABCG2/BCRP modulate the in vivo pharmacokinetics and pharmacodynamics of these molecular cancer treatments, so the pharmacogenetics of ABCG2/BCRP is an important consideration in the application of molecular-targeted chemotherapies. …”
Get full text

The Anti-Inflammatory Activity of <i>Viscum album</i> by Marcello Nicoletti

“…However, since the last century, medical interest in mistletoe has come back in force due to its utilization in clinical cancer treatments, based on its selective action on tumor cells. …”
Get full text

The Network of Non-coding RNAs in Cancer Drug Resistance by Fabio Corrà, Chiara Agnoletto, Linda Minotti, Federica Baldassari, Stefano Volinia

“…We finally discussed the higher integration of the drug-ncRNA clusters with the goal of disentangling effectors from downstream effects and further clarify the involvement of ncRNAs in the cellular mechanisms underlying resistance to cancer treatments.…”
Get full text

Performance Comparisons of AlexNet and GoogLeNet in Cell Growth Inhibition IC50 Prediction by Yeeun Lee, Seungyoon Nam

“…Drug responsiveness prediction is important in clinical response to specific cancer treatments. Recently, multi-class drug responsiveness models based on deep learning (DL) models using molecular fingerprints and mutation statuses have emerged. …”
Get full text

Modulation of the Magnetic Hyperthermia Response Using Different Superparamagnetic Iron Oxide Nanoparticle Morphologies by Felisa Reyes-Ortega, Ángel V. Delgado, Guillermo R. Iglesias

“…The use of magnetic nanoparticles in hyperthermia, that is, heating induced by alternating magnetic fields, is gaining interest as a non-invasive, free of side effects technique that can be considered as a co-adjuvant of other cancer treatments. Having sufficient control on the field characteristics, within admissible limits, the focus is presently on the magnetic material. …”
Get full text

Sex-specific outcomes in cancer therapy: the central role of hormones by Parisa Bakhshi, Jim Q. Ho, Steven Zanganeh

“…Therapeutically, the utilization of hormone replacement therapy (HRT) during cancer treatments presents both potential risks and benefits. …”
Get full text

IDICAP: A Novel Tool for Integrating Drug Intervention Based on Cancer Panel by Noelle Kosarek, Eric S. Ho

“…Tremendous resources have been and continue to be devoted to the development of cancer treatments that target the unique mutation profiles of patients, namely targeted cancer therapy. …”
Get full text

The Mining Of Nigerian Medicinal Plants For Cancer Therapy by Isa Marte Hussaini

“…As a result of the heterogeneity of cancers, treatment strategies should be tailored to be patient and cancer-specific.…”
Get full text

Phyto-therapeutics as anti-cancer agents in breast cancer: Pathway targeting and mechanistic elucidation by Abdullah Almilaibary

“…Therefore, in order to increase the effectiveness of current cancer treatments, new tactics and cutting-edge chemoprevention drugs are required. …”
Get full text

Supplementary protection certificates and their impact on access to medicines in Europe: case studies of sofosbuvir, trastuzumab and imatinib by Yuanqiong Hu, Dimitri Eynikel, Pascale Boulet, Gaelle Krikorian

“…On the basis of an analysis of three medicines for hepatitis C and cancer treatments, the present article critically engages with the policy justifications underlying SPCs. …”
Get full text

Computational Approaches for Cancer-Fighting: From Gene Expression to Functional Foods by Francesco Monticolo, Maria Luisa Chiusano

“…Nutrigenomics studies are therefore taking place with the aim to test the effects of nutrients at molecular level and contribute to the search for anti-cancer treatments. These efforts are expanding the precious source of information necessary for the selection of natural compounds useful for the design of novel drugs or functional foods. …”
Get full text

In-silico identification of novel inhibitors for human Aurora kinase B form the ZINC database using molecular docking-based virtual screening by Ashraf Ahmed Ali Abdusalam

“…Conclusion: The findings suggest that the six compounds could be used as a potential agent for cancer treatments. Graphical abstract…”
Get full text

Hyponatraemia and the syndrome of inappropriate antidiuresis (SIAD) in cancer by D Mc Donald, M Sherlock, C J Thompson

“…Causes of SIAD include ectopic production of vasopressin (AVP) from an underlying tumour, cancer treatments, nausea and pain. Cortisol deficiency is an important differential in the assessment of hyponatraemia, as it has an identical biochemical pattern to SIAD and is easily treatable. …”
Get full text

Can a Low-Phosphate Diet for Chronic Kidney Disease Treat Cancer? An Interdisciplinary Literature Review by Ronald B. Brown, Philip Bigelow

“…An interdisciplinary approach is needed to translate basic, clinical, and remote fields of research knowledge into novel cancer treatments. Recent research has identified high dietary phosphate intake as a risk factor associated with cancer incidence. …”
Get full text

Comprehensive Analysis of KCNJ14 Potassium Channel as a Biomarker for Cancer Progression and Development by Glowi Alasiri

“…More recently, potassium (K⁺) channels have been studied as a potential biological target for the creation of cancer treatments. Potassium Inwardly Rectifying Channel Subfamily J Member 14 (KCNJ14) is one of the cancer genome’s least investigated genes. …”
Get full text

Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD by Kanai, Ryan, Norton, Emily, Stern, Patrick, Hynes, Richard O., Lamar, John M.

“…Targeted therapies are effective cancer treatments when accompanied by accurate diagnostic tests that can help identify patients that will respond to those therapies. …”
Get full text

Comparing the efficiency of Pseudomonas Aeruginosa (PAO1) and Escherichia coli (BL21) to deliver fluorescence in mammalian cancer cells by Nurrashidah Bte Mansoor

“…Cancer has been a prevalent health problem that continues to be fatal largely due to the late diagnosis of cancer and the lack of monitoring of the progress of cancer treatments on patients. Therefore over the years, researchers have been leveraging on the advantages of nanosensors as they have great potential in overcoming those issues. …”
Get full text

A Peer Review Intervention for Monitoring and Evaluating sites (PRIME) that improved randomized controlled trial conduct and performance by Lane, J, Wade, J, Down, L, Bonnington, S, Holding, P, Lennon, T, Jones, A, Salter, C, Neal, D, Hamdy, F, Donovan, J

“…The intervention was evaluated in the ProtecT trial, a UK randomized controlled trial of localized prostate cancer treatments (ISRCTN20141297). The ProtecT coordinator and senior nurses conducted three monitoring rounds at eight sites (2004-2007). …”

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin by Bilokapic, S, Suskiewicz, MJ, Ahel, I, Halic, M

“…The processes of PARP activation and the PARP catalytic cycle we describe can explain mechanisms of resistance to PARP inhibitors and will aid the development of better inhibitors as cancer treatments12,13,14,15,16.…”