K-nearest-neighbor algorithm to predict the survival time and classification of various stages of oral cancer: a machine learning approach [version 2; peer review: 2 approved] by Sekar Kanagaraj, Rashmi Siddalingappa

“…Background:For years now, cancer treatments have entailed tried-and-true methods. …”
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Integrative oncology for breast cancer patients: introduction of an expert-based model by Dobos Gustav J, Voiss Petra, Schwidde Ilka, Choi Kyung-Eun, Paul Anna, Kirschbaum Barbara, Saha Felix J, Kuemmel Sherko

“…Herbal medicines and dietary supplements, especially, may interfere with primary cancer treatments or have other detrimental effects. Thus, expertise in this highly specialized field of integrative medicine should be available to patients so that they can be advised about the benefits and negative effects of such preparations and practices.…”
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Immunomodulatory, Antioxidant, Anticancer, and Pharmacokinetic Activity of Ulvan, a Seaweed-Derived Sulfated Polysaccharide: An Updated Comprehensive Review by Biswajita Pradhan, Prajna Paramita Bhuyan, Jang-Seu Ki

“…The inefficiency of conventional cancer treatments as a result of drug resistance, nontargeted delivery, and chemotherapy-related negative side effects has caused bioactive phytochemicals to come into focus. …”
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Xenogeneic cell therapy provides a novel potential therapeutic option for cancers by restoring tissue function, repairing cancer wound and reviving anti-tumor immune responses by Chi-Ping Huang, Chi-Cheng Chen, Chih-Rong Shyr

“…Abstract Conventional cancer treatments such as surgery, radiotherapy, chemotherapy and targeted therapy, not only destruct tumors, but also injure the normal tissues, resulting in limited efficacy. …”
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KLF4 Regulates Metabolic Homeostasis in Response to Stress by Andrew Blum, Kate Mostow, Kailey Jackett, Estelle Kelty, Tenzing Dakpa, Carly Ryan, Engda Hagos

“…Collectively, these results relate KLF4 to non-Warburg metabolic behaviors that support its role as a tumor suppressor and could make KLF4 a target for new cancer treatments.…”
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Combination of ethyl acetate fraction from Calotropis gigantea stem bark and sorafenib induces apoptosis in HepG2 cells. by Pattaraporn Chaisupasakul, Dumrongsak Pekthong, Apirath Wangteeraprasert, Worasak Kaewkong, Julintorn Somran, Naphat Kaewpaeng, Supawadee Parhira, Piyarat Srisawang

“…Our results present valuable knowledge to support the development of anticancer regimens derived from the CGEtOAc with the chemotherapeutic agent sorafenib, both of which were administered at half-IC50, which may minimize the toxic implications of cancer treatments while improving the therapeutic effectiveness toward future medical applications.…”
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Identification of a Gene Signature That Predicts Dependence upon YAP/TAZ-TEAD by Ryan Kanai, Emily Norton, Patrick Stern, Richard O. Hynes, John M. Lamar

“…Targeted therapies are effective cancer treatments when accompanied by accurate diagnostic tests that can help identify patients that will respond to those therapies. …”
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Survival of Lung Cancer Patients by Histopathology in Taiwan from 2010 to 2016: A Nationwide Study by Hsuan-Chih Tsai, Jing-Yang Huang, Ming-Yu Hsieh, Bing-Yen Wang

“…Together with immune therapy, the landscape of lung cancer treatments is changing.…”
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How Do We Taper and Discontinue Opioids in Cancer Patients? Considerations from the Activities of a Palliative Care Team at a University Hospital by Ayumi Kihara, Kazuki Shimada, Satoru Tsuneto

“…Background: The more the cancer treatments progress, the more the needs increase to taper and discontinue opioids in cancer patients. …”
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Metabolic engineering of <it>Agrobacterium </it>sp. strain ATCC 31749 for production of an α-Gal epitope by Chen Rachel R, Ruffing Anne M

“…<p>Abstract</p> <p>Background</p> <p>Oligosaccharides containing a terminal Gal-α1,3-Gal moiety are collectively known as α-Gal epitopes. α-Gal epitopes are integral components of several medical treatments under development, including flu and HIV vaccines as well as cancer treatments. The difficulty associated with synthesizing the α-Gal epitope hinders the development and application of these treatments due to the limited availability and high cost of the α-Gal epitope. …”
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Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells by Joanna Pilch, Patrycja Kowalik, Piotr Bujak, Anna M. Nowicka, Ewa Augustin

“…Nanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. …”
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Exploring animal models in oral cancer research and clinical intervention: A critical review by Danial Khayatan, Ahmed Hussain, Hamid Tebyaniyan

“…To induce cancer in rodents, xenografts are often used, but companion animals with spontaneous tumours are underutilized for rapid advancement in human and veterinary cancer treatments. Like humans with cancer, companion animals exhibit biological behaviour, treatment responses, and cytotoxic agent responses similar to humans. …”
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Epigenomic perturbation of novel EGFR enhancers reduces the proliferative and invasive capacity of glioblastoma and increases sensitivity to temozolomide by Craig A. Vincent, Itzel Nissen, Soran Dakhel, Andreas Hörnblad, Silvia Remeseiro

“…This study demonstrates how CRISPR/Cas9-based perturbation of enhancers can be used to modulate the expression of key cancer genes, which can help improve the effectiveness of existing cancer treatments and potentially the prognosis of difficult-to-treat cancers such as glioblastoma.…”
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COVID-19 Vaccination in Cancer Patients: A Review Article by Rana Mekkawi BSc (Pharm), PharmD, Bassant A. Elkattan BSc (Pharm), Alaaeldin Shablak MD, MSc, MRCP, Mohammad Bakr MB BCh, MSc, MD, Mohamed A. Yassin MBBS, MSc, Nabil E. Omar BSc (Pharm), PharmD, BCOP, PhD(c)

“…Generally, the vaccine should be given before starting the chemotherapy if possible or in between chemotherapy cycles and away from nadir phase. For other cancer treatments, it is recommended to give the vaccine when there is evidence of blood count recovery. …”
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A Promotive Process of Resource Gain Against Harsh and Inconsistent Discipline in Mothers Coping With Breast Cancer: A Serial Mediation Model by Osnat Zamir, Gabriella Bentley, Yaliu He

“…A sample of 100 Israeli mothers receiving breast cancer treatments was recruited through social media. The participants completed online self-report questionnaires. …”
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Cancer Detection Using a New Hybrid Method Based on Pattern Recognition in MicroRNAs Combining Particle Swarm Optimization Algorithm and Artificial Neural Network by Sepideh Molaei, Stefano Cirillo, Giandomenico Solimando

“…This method can serve as a supplementary tool for cancer diagnosis and potentially aid in developing personalized cancer treatments.…”
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Preparation and Characterization of Gold Nanorods Coated with Gellan Gum and Lipoic Acid by Paola Varvarà, Luigi Tranchina, Gennara Cavallaro, Mariano Licciardi

“…Gold nanorods (AuNRs) can combine therapeutic hyperthermia with diagnostic features, representing a smart choice to address personalized cancer treatments. In this regard, a crucial quest is the selection of the right biocompatible coating agent able to stabilize them in the physiological environment, further endowing the possibility to load bioactive molecules and/or targeting moieties. …”
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Premature ovarian insufficiency in female adolescent and young adult survivors of non-gynecological cancers: a population-based cohort study by Sydney B. Flatt, Amanda Baillargeon, Chad McClintock, Jessica Pudwell, Maria P. Velez

“…Previous research has shown that there is a higher risk of premature ovarian insufficiency in adolescent and young adult cancer survivors, due to the toxicity of cancer treatments on reproductive organs. Prior research was limited in its applicability by having small sample sizes, only including childhood cancer, excluding young adults, and studying fewer types of cancer. …”
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Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity by Rachel A. Schlaak, Gopika SenthilKumar, Marjan Boerma, Carmen Bergom

“…An understanding of the biological pathways and mechanisms involved in normal tissue toxicity from RT will improve future cancer treatments by reducing the risk of long-term side effects. …”
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Sodium-glucose cotransporter 2 (SGLT2) inhibitor initiation and hepatocellular carcinoma prognosis. by Michael Hendryx, Yi Dong, Jonas M Ndeke, Juhua Luo

“…Further, we found that SGLT2 inhibitor initiation was associated with a lower risk mortality risk ranging from 14% to 60% regardless of patient demographic variables, tumor characteristics, and cancer treatments.<h4>Conclusion</h4>Our large SEER-Medicare linked data study indicates that SGLT2 inhibitor initiation was associated with improved overall survival of HCC patients with pre-existing type 2 diabetes compared with no SGLT2 inhibitor use. …”
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