Encapsulation of Bromelain in Combined Sodium Alginate and Amino Acid Carriers: Experimental Design of Simplex-Centroid Mixtures for Digestibility Evaluation by Philipi Cavalcante Ricardo, Ricardo Lima Serudo, Ştefan Ţălu, Carlos Victor Lamarão, Henrique Duarte da Fonseca Filho, Jaqueline de Araújo Bezerra, Edgar Aparecido Sanches, Pedro Henrique Campelo

“…Bromelain has potential as an analgesic, an anti-inflammatory, and in cancer treatments. Despite its therapeutic effects, this protein undergoes denaturation when administered orally. …”
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Double knockout CRISPR screen for cancer resistance to T cell cytotoxicity by Jonathan J. Park, Adan Codina, Lupeng Ye, Stanley Lam, Jianjian Guo, Paul Clark, Xiaoyu Zhou, Lei Peng, Sidi Chen

“…Abstract Immunotherapy has transformed cancer treatments; however, a large fraction of patients encounter resistance. …”
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Deciphering the Enigmatic Influence: Non-Coding RNAs Orchestrating Wnt/β-Catenin Signaling Pathway in Tumor Progression by Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang

“…Targeting ncRNAs and molecules associated with the Wnt/β-catenin signaling pathway may emerge as a promising and effective therapeutic strategy in future cancer treatments.…”
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Comparison of Different Techniques for the Determination of Platinized Cytostatic Drugs in Urine Samples by Marina Arenas, Julia Martín, Juan Luis Santos, Irene Aparicio, Omar Fernández-Sanfrancisco, Esteban Alonso

“…Platinum-based cytostatic drugs are one of the most widely used cancer treatments. They are excreted via the urinary tract and can reach the environment through wastewater, posing a risk to human health due to their side effects. …”
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A Review of Biomimetic and Biodegradable Magnetic Scaffolds for Bone Tissue Engineering and Oncology by Gheorghe Paltanea, Veronica Manescu (Paltanea), Iulian Antoniac, Aurora Antoniac, Iosif Vasile Nemoianu, Alina Robu, Horatiu Dura

“…These therapies are based on <i>in vitro</i> and <i>in vivo</i> studies and could be included in clinical trials for large bone defect regeneration and cancer treatments in the near future. We highlight the scaffolds’ main attributes and focus on natural and synthetic polymeric biomaterials combined with magnetic nanoparticles and their production methods. …”
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Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury by Rachel A. Schlaak, Anne Frei, Brian L. Fish, Leanne Harmann, Tracy Gasperetti, Jamie L. Pipke, Yunguang Sun, Hallgeir Rui, Michael J. Flister, Benjamin N. Gantner, Carmen Bergom

“…The increasing use of immunotherapies in conjunction with traditional cancer treatments demands better models to study the interactions between immunity and RT for effective therapy. …”
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Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC) by Christoph Schatz, Susanne Sprung, Volker Schartinger, Helena Codina-Martínez, Matt Lechner, Mario Hermsen, Johannes Haybaeck

“…Eukaryotic translation initiation factors have been described as promising targets for novel cancer treatments in many cancers, but hardly anything is known about these factors in ITAC. …”
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Breast reconstruction in young women and their peculiarities by Marcela Caetano Cammarota, Gabriel Campelo dos Santos, José Carlos Daher, Bruno Peixoto Esteves, Leonardo David Pires Barcelos, Daniel Augusto dos Santos Soares, Ismar Ribeiro Junior, Milena Carvalho Almeida Aldino, Fabrício Tavares Mendonça

“…Most were diagnosed with invasive ductal carcinoma. Additional cancer treatments were administered in most cases. All patients underwent a full mastectomy in the breast with cancer, and in 16, there was the option of contralateral risk-reducing mastectomy. …”
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TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy by Eric Deutsch, Michele Mondini, Nicolas Signolle, Pauline Hamon, Marine Gerbé De Thoré, Marion Classe, Winchygn Liu, Olivia Bawa, Lydia Meziani, Céline Clémenson, Fabien Milliat

“…Background Transforming growth factor-beta (TGFβ) can limit the efficacy of cancer treatments, including radiotherapy (RT), by inducing an immunosuppressive tumor environment. …”
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SAA suppresses α-PD-1 induced anti-tumor immunity by driving TH2 polarization in lung adenocarcinoma by Xin Wang, Shaodi Wen, Xiaoyue Du, Yihan Zhang, Xiao Yang, Renrui Zou, Bing Feng, Xiao Fu, Feng Jiang, Guoren Zhou, Zi Liu, Wei Zhu, Rong Ma, Jifeng Feng, Bo Shen

“…CSCs are also known to be more resistant to cancer treatments. However, the interaction between CSCs and the immune microenvironment is complex and not fully understood. …”
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Enantioselective theranostics of brain glioma using chiral quantum structures by Junjie Hao, Die Hu, Peixian Chen, Liu Ma, Miao Xia, Meijuan Chen, Hefeng Xu, Hanmeng Liu, Yiwen Li, Jiaji Cheng, Xue Jin, Pengfei Duan, Xiaoqian Xu

“…Such adjuvant approaches would be a viable alternative to cancer treatments with a high possibility of recurrence and poor prognosis.…”
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Apoptotic and Cell Cycle Effects of Triterpenes Isolated from <i>Phoradendron wattii</i> on Leukemia Cell Lines by Lía S. Valencia-Chan, Dafné Moreno-Lorenzana, Jimmy Josué Ceballos-Cruz, Sergio R. Peraza-Sánchez, Antonieta Chávez-González, Rosa E. Moo-Puc

“…This compound [3α,23-dihydroxy-30-oxo-lup-20(29)-en-28-oic acid] s a promising candidate for incorporation into cancer treatments and deserves further study.…”
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Activation of autophagy by in situ Zn2+ chelation reaction for enhanced tumor chemoimmunotherapy by Yang Yang, Yefei Zhu, Kairuo Wang, Yunqiu Miao, Yuanyuan Zhang, Jie Gao, Huanlong Qin, Yang Zhang

“…Herein, we report an autophagy amplification strategy using an ion-chelation reaction to augment chemoimmunotherapy in cancer treatments based on zinc ion (Zn2+)-doped, disulfiram (DSF)-loaded mesoporous silica nanoparticles (DSF@Zn-DMSNs). …”
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Protective effect of early low-dose hydrocortisone on ventilator-associated pneumonia in the cancer patients: a propensity score analysis by David Lagier, Laura Platon, Jérome Lambert, Laurent Chow-Chine, Antoine Sannini, Magali Bisbal, Jean-Paul Brun, Karim Asehnoune, Marc Leone, Marion Faucher, Djamel Mokart

“…Abstract Background Ventilator-associated pneumonia (VAP) is a care-related event that could be promoted by immune suppression caused by critical diseases, malignancies and cancer treatments. Low dose of hydrocortisone was proposed for modulation of immune response in the critically ill population. …”
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Potentiation of combined p19Arf and interferon-beta cancer gene therapy through its association with doxorubicin chemotherapy by Ruan F. V. Medrano, Thiago A. Salles, Rafael Dariolli, Fernanda Antunes, Valker A. Feitosa, Aline Hunger, João P. P. Catani, Samir A. Mendonça, Rodrigo E. Tamura, Marlous G. Lana, Elaine G. Rodrigues, Bryan E. Strauss

“…Abstract Balancing safety and efficacy is a major consideration for cancer treatments, especially when combining cancer immunotherapy with other treatment modalities such as chemotherapy. …”
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Changes of Immune Cell Fractions in Patients Treated with Immune Checkpoint Inhibitors by Hye Ryeon Kim, Jung Hun Kang, Sung Hyun Kim, Seung Tae Kim, Ilhwan Kim, Young Joo Min, Seong Hoon Shin, Sung Yong Oh, Gyeong-Won Lee, Ji Hyun Lee, Jun Ho Ji, Seok Jae Huh, Suee Lee

“…Background: With the development of immunology, immune checkpoint inhibitors (ICIs) have been widely used in various cancer treatments. Although some patients can benefit from ICIs, other patients have no response to ICIs or suffer from hyperprogression. …”
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Understanding and Attitudes toward Cancer Clinical Trials among Patients with a Cancer Diagnosis: National Study through Cancer Trials Ireland by Cathriona Kearns, Ronan Feighery, John Mc Caffrey, Michaela Higgins, Martina Smith, Verena Murphy, Seamus O’Reilly, Anne M. Horgan, Janice Walshe, Ray McDermott, Patrick G. Morris, Maccon Keane, Michael Martin, Conleth Murphy, Karen Duffy, Alina Mihai, John Armstrong, Dearbhaile M. O’Donnell, William M. Gallagher, Ciara M. Kelly, Catherine M. Kelly

“…Several known barriers impede participation and knowing how subpopulations differ in understanding of CCTs can foster targeted approaches to aid accrual and advance cancer treatments. We conducted the first nationwide survey of 1089 patients attending 14 Irish cancer centres, assessing understanding of fundamental concepts in CCT methodology and factors that influence participation, to help tailor patient support for accrual to CCTs. …”
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Hypoxia Selectively Increases a SMAD3 Signaling Axis to Promote Cancer Cell Invasion by Karine Brochu-Gaudreau, Martine Charbonneau, Kelly Harper, Claire M. Dubois

“…Overall, these results suggest that fine-tuning of the pro-invasive HDAC6-SARA-SMAD3 axis could be a better strategy towards effective cancer treatments.…”
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Indocyanine-Green-Loaded Liposomes for Photodynamic and Photothermal Therapies: Inducing Apoptosis and Ferroptosis in Cancer Cells with Implications beyond Oral Cancer by Wei-Ting Liao, Dao-Ming Chang, Meng-Xian Lin, Jeng-Woei Lee, Yi-Chung Tung, Jong-Kai Hsiao

“…This study develops ICG-loaded liposomes (Lipo-ICGs) to further explore their potential in oral cancer treatments. We synthesized and characterized the Lipo-ICGs, conducted in vitro cell culture experiments to assess cellular uptake and photodynamic/photothermal effects, and performed in vivo animal studies to evaluate their therapeutic efficacy. …”
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A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells by Frank Liang, Lisa M. Nilsson, Fabian Byvald, Azar Rezapour, Helena Taflin, Jonas A. Nilsson, Ulf Yrlid

“…As functional activities of autologous TILs are central to the implementation of personalized cancer treatments, we applied a patient-derived xenograft (PDX) model to monitor TILs’ capacity to control CRLM-derived tumors in vivo. …”
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