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13081
Novel Thiazolidine-2,4-dione-trimethoxybenzene-thiazole Hybrids as Human Topoisomerases Inhibitors
Published 2023-06-01“…Despite the encouraging advances made over the years in chemotherapy, the development of new compounds for cancer treatments is an urgent priority. In recent years, the design and chemical synthesis of several innovative hybrid molecules, which bring different pharmacophores on the same scaffold, have attracted the interest of many researchers. …”
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13082
Graphene Oxide-Gold Nanorods Nanocomposite-Porphyrin Conjugate as Promising Tool for Cancer Phototherapy Performance
Published 2021-12-01“…The cancer mortality rate has increased, and conventional cancer treatments are known for having many side effects. …”
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13083
Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth
Published 2017-12-01“…Pharmacological compounds able to inhibit Glutamine metabolism may represent novel drugs for cancer treatments. Interestingly, well acknowledged targets for drugs are the Glutamine transporters of plasma membrane and the key enzyme Glutaminase.…”
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13084
Therapeutic Targeting of Cancer-Associated Fibroblasts in the Non-Small Cell Lung Cancer Tumor Microenvironment
Published 2023-01-01“…Recent research has shown several roles of CAFs in NSCLC tumorigenesis, owing to their heterogeneity, so molecular markers of CAFs should be elucidated to better classify tumor-promoting subtypes and facilitate the establishment of CAF-specific targeted therapies. CAF-targeted cancer treatments may suppress EMT and regulate the niche of cancer stem cells and the immunosuppressive network and thus may prove useful for NSCLC treatment through multiple mechanisms.…”
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13085
MR imaging guided iron-based nanoenzyme for synergistic Ferroptosis−Starvation therapy in triple negative breast cancer
Published 2022-01-01“…Ferroptosis, a newly emerging antitumor strategy through enhancing iron-dependent lipid peroxides level to induce cancer cell death without the mediation of cell receptors, has been proved to be feasible in various cancer treatments. However, the high glutathione (GSH) level in tumor microenvironment limits the anti-tumor efficacy of ferroptosis. …”
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13086
Mistletoe Extracts during the Oncological Perioperative Period: A Systematic Review and Meta-Analysis of Human Randomized Controlled Trials
Published 2023-09-01“…In five RCTs, ME was evaluated as adjunctive care and the control group had no additional intervention, whereas in two RCTs, ME was compared head-to-head against common cancer treatments (i.e., etoposide or bacillus Calmette-Guérin) with the intervention groups not receiving standard care. …”
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13087
Anti-cancer Effects of Methotrexate in Combination With Melissa officinalis on HeLa Cancer Cell Line
Published 2022-10-01“…Objectives: One of the well-accepted beliefs about natural products, considering the advances of recently appearing new edges and features of herbal medicine, is paying more attention to cancer treatments. However, they have not been properly studied with reasonable/reliable clinical trials in human subjects in most cases. …”
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13088
Nutritional Support Indications in Gastroesophageal Cancer Patients: From Perioperative to Palliative Systemic Therapy. A Comprehensive Review of the Last Decade
Published 2021-08-01“…Gastric cancer treatments are rapidly evolving, leading to significant survival benefit. …”
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13089
Topical Drug Delivery of Concentrated Cabazitaxel in an α‐Tocopherol and DMSO Solution
Published 2023-10-01“…Abstract Topical chemotherapy approaches are relevant for certain skin cancer treatments. This study observes that cabazitaxel (CTX), a broad‐spectrum second‐generation taxane cytotoxic agent, can be dissolved in α‐tocopherol at high concentrations exceeding 100 mg mL−1. 2D nuclear magnetic resonance (NMR) analysis and molecular dynamics (MD) are used to study this phenomenon. …”
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13090
Predictive model for BNT162b2 vaccine response in cancer patients based on blood cytokines and growth factors
Published 2022-12-01“…Importantly, this unique signature of vaccine response was present at different studied timepoints both before and after vaccination and was not majorly affected by different anti-cancer treatments.ConclusionWe propose a blood-based signature of cytokines and growth factors that can be employed in identifying cancer patients at persistent high risk of COVID-19 despite vaccination with BNT162b2. …”
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13091
Combination Chemotherapy with Cisplatin and Chloroquine: Effect of Encapsulation in Micelles Formed by Self-Assembling Hybrid Dendritic–Linear–Dendritic Block Copolymers
Published 2021-05-01“…Cisplatin (CDDP) is the standard component for many cancer treatments, yet its principal dose-limiting side effect is nephrotoxicity. …”
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13092
Analysis of the Reversible Impact of the Chemodrug Busulfan on Mouse Testes
Published 2021-09-01“…It is well known that cancer treatments are associated with reversible or irreversible fertility disorders. …”
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13093
Targeting potential receptor molecules in non-small cell lung cancer (NSCLC) using in silico approaches
Published 2023-02-01“…Chemotherapy, radiation therapy, and other conventional cancer treatments have a low success rate. Thus, creating new medications is essential to halt the spread of lung cancer.Methods: In this study bioactive nature of lochnericine against Non-Small Cell Lung Cancer (NSCLC) was analyzed using various computational approaches such as quantum chemical calculations, molecular docking, and molecular dynamic simulation. …”
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13094
In silico and in vitro studies on the anti-cancer activity of artemetin, vitexicarpin and penduletin compounds from Vitex negundo
Published 2022-09-01“…In addition, those compounds increased the level of reactive oxygen species production, induced cell death occurred via apoptosis, demonstrated by Annexin V-staining cells, contributed significantly to DNA damage, and led to the activation of caspase3/caspase8 pathways.Additionally, molecular docking was also conducted to rationalize the cancer cells inhibitory and to evaluate the ability of the FLV1, FLV2, and FLV3 compounds to be developed as good drug candidates for cancers treatment.…”
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13095
A Systematic Review on the Potential Acceleration of Neurocognitive Aging in Older Cancer Survivors
Published 2023-02-01“…Individual risk factors included cancer subtypes (e.g., brain cancer, hormone-related cancers), treatment (e.g., anti-hormonal therapy, chemotherapy, cranial radiation), genetic predisposition (e.g., APOE, COMT, BDNF), age, comorbidities (e.g., frailty, cognitive reserve), and psychological (e.g., depression, (post-traumatic) distress, sleep, fatigue) and social factors (e.g., loneliness, limited caregiver support, low SES). …”
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13096
Aptamer Therapeutics in Cancer: Current and Future
Published 2018-03-01“…This review discusses the advantages and challenges of aptamers and introduces therapeutic aptamers under investigation and in clinical trials for cancer treatments.…”
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13097
Endothelial <i>Nogo-B</i> Suppresses Cancer Cell Proliferation via a Paracrine TGF-β/Smad Signaling
Published 2022-09-01“…These findings not only broaden our understanding of the crosstalk between cancer cells and endothelial cells but also provide a novel prognostic biomarker and a therapeutic target for cancer treatments.…”
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13098
Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and apoptosis in rats
Published 2023-07-01“…Objective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical use. …”
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13099
THE INTEGRATIVE APPROACH TO THE PSYCHO- PHYSICAL REHABILITATION ISSUES OF BREAST CANCER SURVIVORS
Published 2024-01-01“…During and beyond cancer treatments, patients tend to reduce their physical activity levels, gain weight and may complain about chronic pain, lymphedema, fatigue, cognitive problems, depression and anxiety, reduced social contacts and difficulties in resuming daily activities. …”
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13100
Towards Unravelling the Role of ERα-Targeting miRNAs in the Exosome-Mediated Transferring of the Hormone Resistance
Published 2021-11-01“…Hormone therapy is one of the most effective breast cancer treatments, however, its application is limited by the progression of hormonal resistance, both primary or acquired. …”
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