Novel Thiazolidine-2,4-dione-trimethoxybenzene-thiazole Hybrids as Human Topoisomerases Inhibitors by Maria Stefania Sinicropi, Jessica Ceramella, Patrice Vanelle, Domenico Iacopetta, Camillo Rosano, Omar Khoumeri, Shawkat Abdelmohsen, Wafaa Abdelhady, Hussein El-Kashef

“…Despite the encouraging advances made over the years in chemotherapy, the development of new compounds for cancer treatments is an urgent priority. In recent years, the design and chemical synthesis of several innovative hybrid molecules, which bring different pharmacophores on the same scaffold, have attracted the interest of many researchers. …”
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Graphene Oxide-Gold Nanorods Nanocomposite-Porphyrin Conjugate as Promising Tool for Cancer Phototherapy Performance by Thabang Calvin Lebepe, Sundararajan Parani, Vuyelwa Ncapayi, Rodney Maluleke, Grace It Mwad Mbaz, Olufunto Tolulope Fanoro, Jose Rajendran Varghese, Atsuki Komiya, Tetsuya Kodama, Oluwatobi Samuel Oluwafemi

“…The cancer mortality rate has increased, and conventional cancer treatments are known for having many side effects. …”
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Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth by Mariafrancesca Scalise, Lorena Pochini, Michele Galluccio, Lara Console, Cesare Indiveri, Cesare Indiveri

“…Pharmacological compounds able to inhibit Glutamine metabolism may represent novel drugs for cancer treatments. Interestingly, well acknowledged targets for drugs are the Glutamine transporters of plasma membrane and the key enzyme Glutaminase.…”
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Therapeutic Targeting of Cancer-Associated Fibroblasts in the Non-Small Cell Lung Cancer Tumor Microenvironment by Yasushi Shintani, Toru Kimura, Soichiro Funaki, Naoko Ose, Takashi Kanou, Eriko Fukui

“…Recent research has shown several roles of CAFs in NSCLC tumorigenesis, owing to their heterogeneity, so molecular markers of CAFs should be elucidated to better classify tumor-promoting subtypes and facilitate the establishment of CAF-specific targeted therapies. CAF-targeted cancer treatments may suppress EMT and regulate the niche of cancer stem cells and the immunosuppressive network and thus may prove useful for NSCLC treatment through multiple mechanisms.…”
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MR imaging guided iron-based nanoenzyme for synergistic Ferroptosis−Starvation therapy in triple negative breast cancer by Duo Wang, Weimin Fang, Cuiqing Huang, Zerong Chen, Tianqi Nie, Jinghao Wang, Liangping Luo, Zeyu Xiao

“…Ferroptosis, a newly emerging antitumor strategy through enhancing iron-dependent lipid peroxides level to induce cancer cell death without the mediation of cell receptors, has been proved to be feasible in various cancer treatments. However, the high glutathione (GSH) level in tumor microenvironment limits the anti-tumor efficacy of ferroptosis. …”
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Mistletoe Extracts during the Oncological Perioperative Period: A Systematic Review and Meta-Analysis of Human Randomized Controlled Trials by Elise Cogo, Mohamed Elsayed, Sukriti Bhardwaj, Kieran Cooley, Christilynn Aycho, Vivian Liang, Peter Papadogianis, Athanasios Psihogios, Dugald Seely

“…In five RCTs, ME was evaluated as adjunctive care and the control group had no additional intervention, whereas in two RCTs, ME was compared head-to-head against common cancer treatments (i.e., etoposide or bacillus Calmette-Guérin) with the intervention groups not receiving standard care. …”
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Anti-cancer Effects of Methotrexate in Combination With Melissa officinalis on HeLa Cancer Cell Line by Parviz Faraji, Mostafa Araj-Khodaei, Amir Jafari, Maryam Ghaffari, Reza Mohammadinasab, Sanaz Hamedeyazdan, Miguel de la Guardia, Jafar Ezzati Nazhad Dolatabadi

“…Objectives: One of the well-accepted beliefs about natural products, considering the advances of recently appearing new edges and features of herbal medicine, is paying more attention to cancer treatments. However, they have not been properly studied with reasonable/reliable clinical trials in human subjects in most cases. …”
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Nutritional Support Indications in Gastroesophageal Cancer Patients: From Perioperative to Palliative Systemic Therapy. A Comprehensive Review of the Last Decade by Giulia E.G. Mulazzani, Francesca Corti, Serena Della Valle, Maria Di Bartolomeo

“…Gastric cancer treatments are rapidly evolving, leading to significant survival benefit. …”
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Topical Drug Delivery of Concentrated Cabazitaxel in an α‐Tocopherol and DMSO Solution by Boyang Sun, Georgios Paraskevopoulos, Jiwei Min, Robert Rossdeutcher, Sanjana Ghosh, Breandan Quinn, Meng‐Hsuan Lin, Debanjan Sarkar, Dinesh Sukumaran, Yuefei Wang, Kateřina Vávrová, Jonathan F. Lovell, Yumiao Zhang

“…Abstract Topical chemotherapy approaches are relevant for certain skin cancer treatments. This study observes that cabazitaxel (CTX), a broad‐spectrum second‐generation taxane cytotoxic agent, can be dissolved in α‐tocopherol at high concentrations exceeding 100 mg mL−1. 2D nuclear magnetic resonance (NMR) analysis and molecular dynamics (MD) are used to study this phenomenon. …”
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Predictive model for BNT162b2 vaccine response in cancer patients based on blood cytokines and growth factors by Angelina Konnova, Angelina Konnova, Fien H. R. De Winter, Akshita Gupta, Akshita Gupta, Lise Verbruggen, An Hotterbeekx, Matilda Berkell, Matilda Berkell, Laure-Anne Teuwen, Greetje Vanhoutte, Greetje Vanhoutte, Bart Peeters, Silke Raats, Isolde Van der Massen, Sven De Keersmaecker, Yana Debie, Yana Debie, Manon Huizing, Pieter Pannus, Kristof Y. Neven, Kristof Y. Neven, Kristof Y. Neven, Kevin K. Ariën, Kevin K. Ariën, Geert A. Martens, Marc Van Den Bulcke, Ella Roelant, Ella Roelant, Isabelle Desombere, Sébastien Anguille, Zwi Berneman, Zwi Berneman, Maria E. Goossens, Herman Goossens, Surbhi Malhotra-Kumar, Evelina Tacconelli, Timon Vandamme, Timon Vandamme, Marc Peeters, Marc Peeters, Peter van Dam, Peter van Dam, Samir Kumar-Singh, Samir Kumar-Singh

“…Importantly, this unique signature of vaccine response was present at different studied timepoints both before and after vaccination and was not majorly affected by different anti-cancer treatments.ConclusionWe propose a blood-based signature of cytokines and growth factors that can be employed in identifying cancer patients at persistent high risk of COVID-19 despite vaccination with BNT162b2. …”
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Combination Chemotherapy with Cisplatin and Chloroquine: Effect of Encapsulation in Micelles Formed by Self-Assembling Hybrid Dendritic–Linear–Dendritic Block Copolymers by Rebeca González-Pastor, Alexandre Lancelot, Violeta Morcuende-Ventura, María San Anselmo, Teresa Sierra, José L. Serrano, Pilar Martin-Duque

“…Cisplatin (CDDP) is the standard component for many cancer treatments, yet its principal dose-limiting side effect is nephrotoxicity. …”
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Analysis of the Reversible Impact of the Chemodrug Busulfan on Mouse Testes by Laura Thirouard, Hélène Holota, Mélusine Monrose, Manon Garcia, Angélique De Haze, Jean-Paul Saru, Françoise Caira, Claude Beaudoin, David H. Volle

“…It is well known that cancer treatments are associated with reversible or irreversible fertility disorders. …”
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Targeting potential receptor molecules in non-small cell lung cancer (NSCLC) using in silico approaches by C. Kirubhanand, J. Merciline Leonora, S. Anitha, R. Sangeetha, K. T. Nachammai, K. Langeswaran, S. Gowtham Kumar

“…Chemotherapy, radiation therapy, and other conventional cancer treatments have a low success rate. Thus, creating new medications is essential to halt the spread of lung cancer.Methods: In this study bioactive nature of lochnericine against Non-Small Cell Lung Cancer (NSCLC) was analyzed using various computational approaches such as quantum chemical calculations, molecular docking, and molecular dynamic simulation. …”
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In silico and in vitro studies on the anti-cancer activity of artemetin, vitexicarpin and penduletin compounds from Vitex negundo by Giau Van Vo, Thi-Hoai-Thu Nguyen, Thi-Phuong Nguyen, Thi-Hong-Tuoi Do, Nguyen-Minh-An Tran, Huy Truong Nguyen, Thuy Trang Nguyen

“…In addition, those compounds increased the level of reactive oxygen species production, induced cell death occurred via apoptosis, demonstrated by Annexin V-staining cells, contributed significantly to DNA damage, and led to the activation of caspase3/caspase8 pathways.Additionally, molecular docking was also conducted to rationalize the cancer cells inhibitory and to evaluate the ability of the FLV1, FLV2, and FLV3 compounds to be developed as good drug candidates for cancers treatment.…”
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A Systematic Review on the Potential Acceleration of Neurocognitive Aging in Older Cancer Survivors by Charlotte Kerstens, Hans P. M. W. Wildiers, Gwen Schroyen, Mercedes Almela, Ruth E. Mark, Maarten Lambrecht, Sabine Deprez, Charlotte Sleurs

“…Individual risk factors included cancer subtypes (e.g., brain cancer, hormone-related cancers), treatment (e.g., anti-hormonal therapy, chemotherapy, cranial radiation), genetic predisposition (e.g., APOE, COMT, BDNF), age, comorbidities (e.g., frailty, cognitive reserve), and psychological (e.g., depression, (post-traumatic) distress, sleep, fatigue) and social factors (e.g., loneliness, limited caregiver support, low SES). …”
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Aptamer Therapeutics in Cancer: Current and Future by Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, David E. Volk, Takemi Tanaka

“…This review discusses the advantages and challenges of aptamers and introduces therapeutic aptamers under investigation and in clinical trials for cancer treatments.…”
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Endothelial <i>Nogo-B</i> Suppresses Cancer Cell Proliferation via a Paracrine TGF-β/Smad Signaling by Hengyu Li, Zhuo Cheng, Pinghua Yang, Wei Huang, Xizhou Li, Daimin Xiang, Xiaojun Wu

“…These findings not only broaden our understanding of the crosstalk between cancer cells and endothelial cells but also provide a novel prognostic biomarker and a therapeutic target for cancer treatments.…”
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Nephroprotective effects of Datura stramonium leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and apoptosis in rats by Esther Alum, Ademola Famurewa, Obasi Orji, Patrick M Aja, Felix Nwite, Simon Ohuche, Stanley Ukasoanya, Lucy Nnaji, Deborah Joshua, Kingsley Igwe, Stephen Chima

“…Objective: Methotrexate (MTX) is a frontline antimetabolite anticancer drug which is used in different cancer treatments but its nephrotoxicity is a notable drawback that limits its clinical use. …”
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THE INTEGRATIVE APPROACH TO THE PSYCHO- PHYSICAL REHABILITATION ISSUES OF BREAST CANCER SURVIVORS by Cristina Accetta, Daniela Belella, Annalisa Di Micco, Alessio Filippone, Cristina Rossi, Maria Maddalena Rossi, Claudia Maggiore, Luana Forcina, Maria Natale, Francesca Veccia, Daniela Pia Rosaria Chieffo, Riccardo Masetti, Stefano Magno

“…During and beyond cancer treatments, patients tend to reduce their physical activity levels, gain weight and may complain about chronic pain, lymphedema, fatigue, cognitive problems, depression and anxiety, reduced social contacts and difficulties in resuming daily activities. …”
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Towards Unravelling the Role of ERα-Targeting miRNAs in the Exosome-Mediated Transferring of the Hormone Resistance by Olga E. Andreeva, Danila V. Sorokin, Ekaterina I. Mikhaevich, Irina V. Bure, Yuri Y. Shchegolev, Marina V. Nemtsova, Margarita V. Gudkova, Alexander M. Scherbakov, Mikhail A. Krasil’nikov

“…Hormone therapy is one of the most effective breast cancer treatments, however, its application is limited by the progression of hormonal resistance, both primary or acquired. …”
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