Therapeutic Role of Carotenoids in Blood Cancer: Mechanistic Insights and Therapeutic Potential by Yaseen Hussain, Abdullah, Khalaf F. Alsharif, Michael Aschner, Abdulrahman Theyab, Fazlullah Khan, Luciano Saso, Haroon Khan

“…To cope with these challenges, treatment strategies from phyto-medicine scaffolds have been evaluated for blood cancer treatments. Carotenoids represent a versatile class of phytochemical that offer therapeutic efficacy in the treatment of cancer, and specifically blood cancer. …”
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Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity – Exploring the armoury of obscurity by Kanchanlata Singh, Mustansir Bhori, Yasar Arfat Kasu, Ganapathi Bhat, Thankamani Marar

“…Among the conventional cancer treatments, chemotherapy is most frequently carried out to treat malignant cancer rather than localised lesions which is amenable to surgery and radiotherapy. …”
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Integration of Complementary Medicine in Supportive Cancer Care: Survey of Healthcare Providers’ Perspectives by Suha Omran, Ziad Qadri, Ghada Shahrour

“…Implications to Nursing: CTM usage does involve some risks, so HCPs should be trained in why cancer patients choose to integrate CTM with conventional cancer treatments and how they can safely help them do so.…”
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Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity through the Nrf2-Mediated Pathway by Kuen-Jang Tsai, Hsin-Yi Tsai, Chin-Chuan Tsai, Tai-Yu Chen, Tsung-Hua Hsieh, Chun-Lin Chen, Lulekiwe Mbuyisa, Yaw-Bin Huang, Ming-Wei Lin

“…Luteolin constitutes a potential agent for use in cancer stemness-targeted breast cancer treatments.…”
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Case report: Metastatic urothelial cancer with an exceptional response to immunotherapy and comprehensive understanding of the tumor and the tumor microenvironment by Cora N. Sternberg, Nara Shin, Konstantin Chernyshov, Fabio Calabro, Linda Cerbone, Giuseppe Procopio, Natalia Miheecheva, Georgy Sagaradze, Alisa Zaichikova, Naira Samarina, Alexandra Boyko, Jessica H. Brown, Leysan Yunusova, Daniela Guevara, Jyothi Manohar, Michael Sigouros, Majd Al Assaad, Olivier Elemento, Juan Miguel Mosquera

“…The tumor microenvironment (TME) is recognized as a key player in tumor progression and the response to certain anti-cancer treatments. This study aims to investigate the mechanism of response using integrated genomic and transcriptomic profiling of a UC patient who was part of the KEYNOTE-045 trial and showed an exceptional response to pembrolizumab. …”
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A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells by Jana Tomisch, Vincent Busse, Francesca Rosato, Olga N. Makshakova, Pavel Salavei, Anna-Sophia Kittel, Emilie Gillon, Levin Lataster, Anne Imberty, Ana Valeria Meléndez, Winfried Römer

“…The lectibody developed in this study, therefore, highlights the potential that lectibodies and lectins in general have for usage in immunotherapeutic approaches to boost the efficacy of established cancer treatments.…”
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Oxygen Nanocarriers for Improving Cardioplegic Solution Performance: Physico-Chemical Characterization by Maria Tannous, Gjylije Hoti, Francesco Trotta, Roberta Cavalli, Takanobu Higashiyama, Pasquale Pagliaro, Claudia Penna

“…Nanocarriers for oxygen delivery have been the focus of extensive research to ameliorate the therapeutic effects of current anti-cancer treatments and in the organ transplant field. In the latter application, the use of oxygenated cardioplegic solution (CS) during cardiac arrest is certainly beneficial, and fully oxygenated crystalloid solutions may be excellent means of myocardial protection, albeit for a limited time. …”
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Cerebrovascular accident in a child with precursor B-cell acute lymphoblastic leukemia and coronavirus disease 2019: a case report by Hanie Karimi, Roham Sarmadian, Abolfazl Gilani, Poorya salajegheh, Habibe Nejad Biglari, Mahsa Gholizadeh

“…A rare event in this report is stroke following COVID-19 disease in a patient with an immunocompromised background due to leukemia and anti-cancer treatments. Case presentation A 6-year-old iranian girl with precursor B-cell leukemia receiving vincristine therapy presented with fever and absolute neutrophil count < 500. …”
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Near‐infrared‐induced drug release from antibody–drug double conjugates exerts a cytotoxic photo‐bystander effect by Kazuomi Takahashi, Hirotoshi Yasui, Shunichi Taki, Misae Shimizu, Chiaki Koike, Kentaro Taki, Hiroshi Yukawa, Yoshinobu Baba, Hisataka Kobayashi, Kazuhide Sato

“…Abstract Ideal cancer treatments specifically target and eradicate tumor cells without affecting healthy cells. …”
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Role of advanced cardiovascular imaging in chemotherapy-induced cardiotoxicity by Maria Teresa Cannizzaro, Maria Cristina Inserra, Giulia Passaniti, Antonio Celona, Tommaso D'Angelo, Placido Romeo, Antonio Basile

“…The development of cardiotoxicity induced by cancer treatments has emerged as a significant clinical problem, both in the short run, as it may influence drug administration in chemotherapeutic protocols, and in the long run, because it may determine adverse cardiovascular outcomes in survivors of various malignant diseases. …”
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Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2<i>H</i>)-one Derivatives by Zuleima Blanco, Esteban Fernandez-Moreira, Michael R. Mijares, Carmen Celis, Gricelis Martínez, Juan B. De Sanctis, Soňa Gurská, Petr Džubák, Marián Hajdůch, Ali Mijoba, Yael García, Xenón Serrano, Nahum Herrera, Jhonny Correa-Abril, Yonathan Parra, Jorge Ángel, Hegira Ramírez, Jaime E. Charris

“…Based on the structural analysis, these chalcones represent new compounds potentially useful for <i>Leishmania</i>, <i>Trypanosoma</i> <i>cruzi</i>, and some cancer treatments.…”
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The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage by Rodrigo Crespo Mosca, Sofia Nascimento Santos, Gesse Eduardo Calvo Nogueira, Daisa Lima Pereira, Francielli Campos Costa, Jonathas Xavier Pereira, Carlos Alberto Zeituni, Praveen Ravindra Arany

“…The results from this study support future mechanistic lab studies and controlled human clinical studies to utilize this innovative therapy in managing side effects from radiation cancer treatments.…”
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Symptom Management and Quality of Life of Breast Cancer Patients Using Acupuncture-Related Therapies and Herbal Medicine: A Scoping Review by Gajin Han, Ye-Seul Lee, Hee Jae Jang, Song-Yi Kim, Yoon Jae Lee, In-Hyuk Ha

“…The side effects associated with breast cancer treatments often reduce the patients’ quality of life. …”
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A comprehensive review of the anticancer effects of decursin by Yueming Chu, Yueming Chu, Qiang Yuan, Qiang Yuan, Hangyu Jiang, Hangyu Jiang, Liang Wu, Yutao Xie, Yutao Xie, Xiaofen Zhang, Lin Li, Lin Li

“…With the increasing resistance to current anticancer drugs, efforts have been made to develop effective cancer treatments. Currently, natural products are considered promising cancer therapeutic agents due to their potent anticancer activity and low intrinsic toxicity. …”
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A Miniaturized Platform for Multiplexed Drug Response Imaging in Live Tumors by Sharath Bhagavatula, Devon Thompson, Sebastian W. Ahn, Kunj Upadhyaya, Alex Lammers, Kyle Deans, Christine Dominas, Benjamin Ferland, Veronica Valvo, Guigen Liu, Oliver Jonas

“…By observing the activity of anti-cancer agents directly in tumors, there is potential to greatly expand our understanding of drug response and develop more personalized cancer treatments. Implantable microdevices (IMD) have been recently developed to deliver microdoses of chemotherapeutic agents locally into confined regions of live tumors; the tissue can be subsequently removed and analyzed to evaluate drug response. …”
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Rapamycin Plus Doxycycline Combination Affects Growth Arrest and Selective Autophagy-Dependent Cell Death in Breast Cancer Cells by Titanilla Dankó, Gábor Petővári, Dániel Sztankovics, Dorottya Moldvai, Regina Raffay, Péter Lőrincz, Tamás Visnovitz, Viktória Zsiros, Gábor Barna, Ágnes Márk, Ildikó Krencz, Anna Sebestyén

“…Based on these results, we suggest considering inducing metabolic stress and targeting mTOR hyperactivity and mitochondrial functions in combined anti-cancer treatments.…”
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Suicide rates among patients with first and second primary cancer by Yanting Jiang, Yiqi Wang, Xiaofei Cheng, Ziyang Zhou, Jili Wang, Haogang Yu, Guorong Yao, Zhongjie Lu, Xin Chen, Senxiang Yan, Feng Zhao

“…Abstract Aims With advancements in cancer treatments, the survival rates of patients with their first primary cancer (FPC) have increased, resulting in a rise in the number of patients with second primary cancer (SPC). …”
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KPNB1 Inhibitor Importazole Reduces Ionizing Radiation-Increased Cell Surface PD-L1 Expression by Modulating Expression and Nuclear Import of IRF1 by Hironori Yoshino, Yoshiaki Sato, Manabu Nakano

“…Recent reports indicate that anti-cancer treatments, such as radiation therapy, increase PD-L1 expression on the surface of tumor cells. …”
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Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers by Kousalya Lavudi, Kousalya Lavudi, Kousalya Lavudi, Shreya Madhav Nuguri, Zianne Olverson, Anantha Krishna Dhanabalan, Srinivas Patnaik, Rekha Rani Kokkanti

“…In addition to the genomic effects of ATRA, we also highlighted the role of ATRA in non-canonical mechanisms as an immune checkpoint inhibitor, thus targeting the immune oncological perspective of cancer treatments in the current era. The role of ATRA in activating independent mechanisms is also explained in this review. …”
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The Potential of DHA as Cancer Therapy Strategies: A Narrative Review of In Vitro Cytotoxicity Trials by Jaqueline de Freitas Rodrigues, Hellen Kempfer Philippsen, Maria Fani Dolabela, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka

“…Docosahexaenoic acid (DHA), also known as omega-3 (<i>n</i>-3) polyunsaturated fatty acid (PUFA), is a natural compound that has demonstrated pharmacological activity against several malignant neoplasms. Available cancer treatments cause side effects, affect healthy cells, reduce the quality of life of patients and may cause resistance to antineoplastics. …”
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