Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies by Arnaud Gilles, Léo Frechin, Kundhavai Natchiar, Giulia Biondani, Ottilie von Loeffelholz, Samuel Holvec, Julie-Lisa Malaval, Jean-Yves Winum, Bruno P. Klaholz, Jean-François Peyron

“…Homoharringtonine (HHT) is the only direct ribosome inhibitor currently used in clinics for cancer treatments, although many classical chemotherapeutic drugs also appear to impact on protein synthesis. …”
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Assessment of Sexual Dysfunction in Cervical Cancer Patients after Different Treatment Modality: A Systematic Review by Francesco Tramacere, Valentina Lancellotta, Calogero Casà, Bruno Fionda, Patrizia Cornacchione, Ciro Mazzarella, Rosa Pasqualina De Vincenzo, Gabriella Macchia, Martina Ferioli, Angeles Rovirosa, Maria Antonietta Gambacorta, Cesare Colosimo, Vincenzo Valentini, Roberto Iezzi, Luca Tagliaferri

“…The purpose of this review is to evaluate the dysfunctions of the sexual sphere in patients with cervical cancer undergoing different cervix cancer treatments. <i>Materials and Methods</i>: We performed a comprehensive literature search using Pub med, Scopus and Cochrane to identify all the full articles evaluating the dysfunctions of the sexual sphere. …”
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Deciphering the Elevated Lipid via CD36 in Mantle Cell Lymphoma with Bortezomib Resistance Using Synchrotron-Based Fourier Transform Infrared Spectroscopy of Single Cells by Sudjit Luanpitpong, Montira Janan, Kanjana Thumanu, Jirarat Poohadsuan, Napachai Rodboon, Phatchanat Klaihmon, Surapol Issaragrisil

“…Despite overall progress in improving cancer treatments, the complete response of mantle cell lymphoma (MCL) is still limited due to the inevitable development of drug resistance. …”
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Moving beyond traditional therapies: the role of nanomedicines in lung cancer by Jingjing Zhang, Jingjing Zhang, Yanzhi Li, Sa Guo, Weifen Zhang, Bing Fang, Shaohui Wang

“…This review posits that the progression towards multimodal combination therapies could potentially establish an efficacious platform for multimodal targeted lung cancer treatments. Current nanomedicines split into active and passive targeting. …”
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Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA by Jujun Zhou, John R. Horton, Dan Yu, Ren Ren, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng

“…Epigenetically targeted therapeutic development, particularly for SAM-dependent methylations of DNA, mRNA and histones has been proceeding rapidly for cancer treatments over the past few years. However, this approach has barely begun to be exploited for developing new antibiotics, despite an overwhelming global need to counter antimicrobial resistance. …”
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Glycoprotein 90K Promotes E-Cadherin Degradation in a Cell Density-Dependent Manner via Dissociation of E-Cadherin–p120-Catenin Complex by So-Yeon Park, Somy Yoon, Eun Gene Sun, Rui Zhou, Jeong A. Bae, Young-Woo Seo, Jung-Il Chae, Man-Jeong Paik, Hyung-Ho Ha, Hangun Kim, Kyung Keun Kim

“…To clarify the role of 90K as an indicator for poor prognosis and metastasis in epithelial cancers, the present study investigated the effect of 90K on an adherens junctional protein, E-cadherin, which is frequently absent or downregulated in human epithelial cancers. Treatment of certain cancer cells with 90K significantly reduced E-cadherin levels in a cell-population-dependent manner, and these cells showed decreases in cell adhesion and increases in invasive cell motility. …”
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Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma by Chang Liu, Hong Liu, Moumita Dasgupta, Lance M. Hellman, Xiaogang Zhang, Kai Qu, Hui Xue, Yun Wang, Fenling Fan, Qi Chang, Duo Yu, Linhu Ge, Yu Zhang, Ziyou Cui, Pengbo Zhang, Bradley Heller, Hongbing Zhang, Bingyin Shi, Brian M. Baker, Cheng Liu

“…Abstract Monoclonal antibodies are at the vanguard of the most promising cancer treatments. Whereas traditional therapeutic antibodies have been limited to extracellular antigens, T cell receptor mimic (TCRm) antibodies can target intracellular antigens presented by cell surface major histocompatibility complex (MHC) proteins. …”
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Thymoquinone enhances cisplatin-induced neprotoxicity in high dose by Ahmet Dirican, Osman Sahin, Funda Tasli, Erkan Sogut, Yuksel Kucukzeybek, Ahmet Alacacioglu, Mustafa Gunes, Gulcan Saglam, Eyup Coban, Mustafa Oktay Tarhan, Buket Demirci

“…Background: Cisplatin-induced nephrotoxicity is an important problem of the cancer treatments. The major bioactive component of Nigella sativa, thymoquinone (TQ) might limit the nephrotoxic effect of cisplatin in low doses. …”
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Machine Learning of Multi-Modal Tumor Imaging Reveals Trajectories of Response to Precision Treatment by Nesrin Mansouri, Daniel Balvay, Omar Zenteno, Caterina Facchin, Thulaciga Yoganathan, Thomas Viel, Joaquin Lopez Herraiz, Bertrand Tavitian, Mailyn Pérez-Liva

“…The standard assessment of response to cancer treatments is based on gross tumor characteristics, such as tumor size or glycolysis, which provide very indirect information about the effect of precision treatments on the pharmacological targets of tumors. …”
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Real-World Data and Evidence in Lung Cancer: A Review of Recent Developments by Eleni Kokkotou, Maximilian Anagnostakis, Georgios Evangelou, Nikolaos K. Syrigos, Ioannis Gkiozos

“…Real-world data (RWD) studies offer a promising solution to address evidence gaps and provide essential information about the effects of cancer treatments in real-world settings. The distinction between RWD and data derived from randomized clinical trials lies in the method of data collection, as RWD by definition are obtained at the point of care. …”
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Preparation of a 3D printable high-performance GelMA hydrogel loading with magnetic cobalt ferrite nanoparticles by Yiwan Shi, Yiwan Shi, Zhaozhen Wang, Zhaozhen Wang, Xinting Zhou, Chengxiong Lin, Chao Chen, Botao Gao, Weikang Xu, Xiaofei Zheng, Tingting Wu, Huajun Wang, Huajun Wang

“…Magnetic hyperthermia based on magnetic nanoparticles can kill tumor cells by raising the temperature without causing the side effects of conventional cancer treatments. This research aims to design a high-performance magnetic hydrogel composed of gelatin methacrylate and highly magnetic cobalt ferrite (CFO) nanoparticles for osteosarcoma treatment. …”
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Amelioration effects of vitamin e, melatonin, l-carnitine, and atorvastatin, on destructive effects of busulfan in the testes of male rats: a gene expression evaluation by Forutan SALEHINEZHAD, Hamidreza ESHRAGHI, Ali KADIVAR, Sadegh SHIRIAN, Ahmad ASGHARI, Ehsan AALI, Najmeh DAVOODIAN

“…According to toxicity of various types of cancer treatments on different kind of cells with high division activities such as germ cells, antioxidants may protect these cells in testes against the toxic effects of the chemotherapeutic drugs. …”
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Chick Chorioallantoic Membrane (CAM) Assays as a Model of Patient-Derived Xenografts from Circulating Cancer Stem Cells (cCSCs) in Breast Cancer Patients by Monika Pizon, Dorothea Schott, Ulrich Pachmann, Rainer Schobert, Marek Pizon, Marta Wozniak, Rafal Bobinski, Katharina Pachmann

“…Background: cCSCs are a small subset of circulating tumor cells with cancer stem cell features: resistance to cancer treatments and the capacity for generating metastases. …”
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Nanoplatform for the Delivery of Topotecan in the Cancer Milieu: An Appraisal of its Therapeutic Efficacy by Mohammed Kanan Alshammari, Mohammed Khalid Alghazwni, Abrar Saleh Alharbi, Ghayda Ghazi Alqurashi, Mehnaz Kamal, Salman Rahim Alnufaie, Salem Sayer Alshammari, Bandar Ali Alshehri, Rami Hatem Tayeb, Rashad Jameel M. Bougeis, Alaa Adel Aljehani, Nawaf M. Alotaibi, Abida Abida, Mohd. Imran

“…Recent advances in tumor biology understanding and the emergence of novel targeted drug delivery tools leveraging various nanosystems offer hope for developing effective cancer treatments. Topotecan is a topoisomerase I inhibitor that stabilizes the transient TOPO I-DNA cleavable complex, leading to single-stranded breaks in DNA. …”
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Magnetically active pNIPAM nanosystems as temperature-sensitive biocompatible structures for controlled drug delivery by Beatriz Garcia-Pinel, Alicia Ortega-Rodríguez, Cristina Porras-Alcalá, Laura Cabeza, Rafael Contreras-Cáceres, Raul Ortiz, Amelia Díaz, Ana Moscoso, Francisco Sarabia, José Prados, Juan M. López-Romero, Consolación Melguizo

“…Therefore, the obtained hybrid nanoparticles can be applied as a promising biocompatible nanoplatform for the delivery of 5FU and OXA in the improvement of colon cancer treatments.…”
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Juvenile exposure to doxorubicin alters the cardiovascular response to adult-onset psychosocial stress in mice by Marianne K. O. Grant, Maria Razzoli, Ibrahim Y. Abdelgawad, Rachel Mansk, Davis Seelig, Alessandro Bartolomucci, Beshay N. Zordoky

“…Childhood cancer survivors have a high risk for premature cardiovascular diseases, mainly due to cardiotoxic cancer treatments such as doxorubicin (DOX). Psychosocial stress is a significant cardiovascular risk factor and an enormous burden in childhood cancer survivors. …”
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Pentadecanoic Acid, an Odd-Chain Fatty Acid, Suppresses the Stemness of MCF-7/SC Human Breast Cancer Stem-Like Cells through JAK2/STAT3 Signaling by Ngoc Bao To, Yen Thi-Kim Nguyen, Jeong Yong Moon, Meran Keshawa Ediriweera, Somi Kim Cho

“…These findings indicate that pentadecanoic acid can serve as a novel JAK2/STAT3 signaling inhibitor in breast cancer cells and suggest the beneficial effects of pentadecanoic acid-rich food intake during breast cancer treatments.…”
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Quantification of PD-1/PD-L1 Interaction between Membranes from PBMCs and Melanoma Samples Using Cell Membrane Microarray and Time-Resolved Förster Resonance Energy Transfer by Lissete Sánchez-Magraner, Miguel de la Fuente, Charles Evans, James Miles, Ane Elexpe, Maddalen Rodriguez-Astigarraga, Egoitz Astigarraga, Gabriel Barreda-Gómez

“…The approved therapeutic monoclonal antibodies, such as pembrolizumab, target the PD-1/PD-L1 interaction and are revolutionizing cancer treatments. We developed an assay that provides a quantitative readout of PD-1/PD-L1 interactive states between cell membranes of human immune cells (peripheral blood mononuclear cells, PBMCs) and PD-L1-expressing samples. …”
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Characterization of tRNA-Derived Fragments in Lung Squamous Cell Carcinoma with Respect to Tobacco Smoke by Shruti Magesh, Pranava Gande, Rishabh Yalamarty, Daniel John, Jaideep Chakladar, Wei Tse Li, Weg M. Ongkeko

“…Accordingly, transfer RNA-derived fragments (tRFs) are implicated in both cancer onset and development and demonstrate the potential to act as targets for cancer treatments and therapies. Therefore, we aimed to characterize tRF expression with respect to LUSC pathogenesis and clinical outcomes. …”
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Reducing the Cost of Proton Radiation Therapy: The Feasibility of a Streamlined Treatment Technique for Prostate Cancer by Wayne D. Newhauser, Rui Zhang, Timothy G. Jones, Annelise Giebeler, Phillip J. Taddei, Robert D. Stewart, Andrew Lee, Oleg Vassiliev

“…Proton radiation therapy is an effective modality for cancer treatments, but the cost of proton therapy is much higher compared to conventional radiotherapy and this presents a formidable barrier to most clinical practices that wish to offer proton therapy. …”
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