A prognostic prediction model for ovarian cancer using a cross-modal view correlation discovery network by Huiqing Wang, Xiao Han, Jianxue Ren, Hao Cheng, Haolin Li, Ying Li, Xue Li

“…Finally, we perform Gene Ontology (GO) term analysis and biological pathway analysis on the genes identified by MDCADON, revealing the underlying mechanisms of ovarian cancer and providing certain support for guiding ovarian cancer treatments.…”
Get full text

scMuffin: an R package to disentangle solid tumor heterogeneity by single-cell gene expression analysis by Valentina Nale, Alice Chiodi, Noemi Di Nanni, Ingrid Cifola, Marco Moscatelli, Cinzia Cocola, Matteo Gnocchi, Eleonora Piscitelli, Ada Sula, Ileana Zucchi, Rolland Reinbold, Luciano Milanesi, Alessandra Mezzelani, Paride Pelucchi, Ettore Mosca

“…Abstract Introduction Single-cell (SC) gene expression analysis is crucial to dissect the complex cellular heterogeneity of solid tumors, which is one of the main obstacles for the development of effective cancer treatments. Such tumors typically contain a mixture of cells with aberrant genomic and transcriptomic profiles affecting specific sub-populations that might have a pivotal role in cancer progression, whose identification eludes bulk RNA-sequencing approaches. …”
Get full text

The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages by Enhong Li, Bingqiang Wen, Dengfeng Gao, Timothy R. Kalin, Guolun Wang, Tanya V. Kalin, Tanya V. Kalin, Vladimir V. Kalinichenko, Vladimir V. Kalinichenko

“…Radiation-induced lung injury (RILI) is a common complication of anti-cancer treatments for thoracic and hematologic malignancies. …”
Get full text

Introduction of an Ultraviolet C-Irradiated 4T1 Murine Breast Cancer Whole-Cell Vaccine Model by Gábor J. Szebeni, Róbert Alföldi, Lajos I. Nagy, Patrícia Neuperger, Nikolett Gémes, József Á. Balog, László Tiszlavicz, László G. Puskás

“…The advent of immunotherapy has revolutionized cancer treatments. However, the application of immune checkpoint inhibitors may entail severe side effects, with the risk of therapeutic resistance. …”
Get full text

The effects of statins in patients with advanced-stage cancers - a systematic review and meta-analysis by Qiang Zhou, Zhihua Jiao, Yuxi Liu, Peter N. Devreotes, Zhenyu Zhang, Zhenyu Zhang

“…Concomitant use of statin drugs as cancer treatments is highly recommended in future clinical trials.…”
Get full text

Identification of Novel Cytotoxic Peptide KENPVLSLVNGMF from Marine Sponge Xestospongia testudinaria, with Characterization of Stability in Human Serum by Quah, Yixian, Mohd Ismail, Nor Ismaliza, Ooi, Jillian Lean Sim, Affendi, Yang Amri, Abd Manan, Fazilah, Wong, Fai Chu, Chai, Tsun Thai

“…Marine sponges hold great promise as a source of potent cytotoxic peptides with future applications in cancer treatments. This study aimed to purify and identify cytotoxic peptides from the protein hydrolysates of the giant barrel sponge Xestospongia testudinaria, guided by a cytotoxicity assay based on the human cervical cancer cell line (HeLa). …”

Ethics of access to newly approved expensive medical treatments: multi-stakeholder dialogues in a publicly funded healthcare system by Charlotte H. C. Bomhof, Jilles Smids, Sybren Sybesma, Maartje Schermer, Eline M. Bunnik

“…Background: Due to rising healthcare expenditures, countries with publicly funded healthcare systems face challenges when providing newly approved expensive anti-cancer treatments to all eligible patients. In the Netherlands in 2015, the so-called Coverage Lock (CL), was introduced to help safeguard the sustainability of the healthcare system. …”
Get full text

Investigation of Intervention Solutions to Enhance Adherence to Oral Anticancer Medicines in Adults: Overview of Reviews by Thu Ha Dang, Abdur Rahim Mohammad Forkan, Nilmini Wickramasinghe, Prem Prakash Jayaraman, Marliese Alexander, Kate Burbury, Penelope Schofield

“… BackgroundAdherence to anticancer medicines is critical for the success of cancer treatments; however, nonadherence remains challenging, and there is limited evidence of interventions to improve adherence to medicines in patients with cancer. …”
Get full text

Neoadjuvant Gold Nanoshell-Based Photothermal Therapy Combined with Liposomal Doxorubicin in a Mouse Model of Colorectal Cancer by Simón M, Jørgensen JT, Norregaard K, Henriksen JR, Clergeaud G, Andresen TL, Hansen AE, Kjaer A

“…Marina Simón,1,* Jesper Tranekjær Jørgensen,1,* Kamilla Norregaard,1 Jonas Rosager Henriksen,2 Gael Clergeaud,2 Thomas L Andresen,2 Anders Elias Hansen,2 Andreas Kjaer1 1Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; 2Department of Health Technology, Section for Biotherapeutic Engineering and Drug Targeting, Technical University of Denmark, Kongens Lyngby, Denmark*These authors contributed equally to this workCorrespondence: Andreas Kjaer, Department of Clinical Physiology and Nuclear Medicine & Cluster for Molecular Imaging, Copenhagen University Hospital – Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, Email akjaer@sund.ku.dkIntroduction: Traditional cancer treatments, such as chemotherapy, are often incapable of achieving complete responses as standalone therapies. …”
Get full text

Synthesis of Zinc Oxide (ZnO)-Titanium Dioxide (TiO2)-Chitosan-Farnesol Nanocomposites and Assessment of Their Anticancer Potential in Human Leukemic MOLT-4 Cell Line by Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A. Hamza, Gomaa Mostafa-Hedeab, Pooi Ling Mok, Suresh Kumar Subbiah

“…Thus, the results showed that the synthesized NCs demonstrated a remarkable anticancer potential against leukemic cells and can be potentially valuable in cancer treatments. The findings from this study conclude that this is a new approach for modifying the physicochemical characteristics of ZnO-TiO2-chitosan-farnesol composites to increase their properties and synergistically exhibit anticancer properties in human leukemic cancer cells.…”
Get full text

An In-Vivo Study of Sonodynamic Therapy with Encapsulated Hematoporphyrin by Shukufeh Souri, Majid Jadidi, Hadi Hasanzadeh, Tahereh Khani, Vahid Semnani

“… Purpose: According to the side effects of invasive cancer treatments, Sonodynamic Therapy (SDT) as a noninvasive method for breast adenocarcinoma was considered. …”
Get full text

Chemotherapy Induced Neutropenia, Febrile-Neutropenia and Determinants Among Solid Cancer Patients Attending Oncology Unit of a Tertiary Care Teaching Hospital in Ethiopia by Dessalegn M, Fantahun M, Yesufe AA, Hussein M, Tsegaye A

“…Adriamycin + cyclophosphamide and Adriamycin + cyclophosphamide + paclitaxel were the most commonly used anti-cancer treatments in this study. None of the tested factors were associated with chemo-induced neutropenia.Conclusion: More than two thirds of the patients had chemotherapy associated neutropenia while half of the patients had febrile neutropenia; close monitoring of such patients is warranted.Keywords: solid tumors, cancer, chemotherapy, neutropenia, febrile neutropenia…”
Get full text

Effectiveness of cognitive-based interventions for improving body image of patients having breast cancer: A systematic review and meta-analysis by Wenqian Zhao, Yuen Yu Chong, Wai Tong Chien

“…Objective: Breast cancer patients often suffer from body image disturbance due to impairment of their body/appearance resulting from surgeries, other cancer treatments, and/or their complications. Cognitive-based interventions (CBIs) have recently been adopted for patients having breast cancer but their effects on improving body image are uncertain. …”
Get full text

Aqueous Extract of Leaves and Flowers of Acmella caulirhiza Reduces the Proliferation of Cancer Cells by Underexpressing Some Genes and Activating Caspase-3 by Huiny Miriane Tienoue Fotso, Mary-Ann Mbong Angie, Françoise Raïssa Ntentie, Inelle Makamwe, Ferdinand Lanvin Edoun Ebouel, Emmerencia Kenjing Ndansack, Enyong Julius Oben

“…The increasing prevalence of cancers and the multiple side effects of cancer treatments have led researchers to constantly search for plants containing bioactive compounds with cell death properties. …”
Get full text

Protocol for a systematic review of self-management interventions for older adults living with cancer by Kristen R. Haase, Martine Puts, Schroder Sattar, Mikaela Gray, Cindy Kenis, Valentina Donison, Steven Hall, Bianca McLean, Aria Wills, Doris Howell

“…Abstract Background Cancer predominates in adults over age 65. Cancer treatments are known to create physical and psychosocial challenges, which may be amplified for older adults with cancer. …”
Get full text

The Role of Resilience in the Relationship between Sociodemographic, Clinical Characteristics, and Social Support among Breast Cancer Patients in Serbia by Sanja D Tomić, Goran Malenković, Armin Šljivo, Ermina Mujičić, Slobodan Tomić

“…The management of breast cancer treatments within the limitations of family, social, and professional life is emotionally burdening and negatively affects physical, psychological, and social well-being, reducing the overall quality of life of patients and their families. …”
Get full text

Natural Gallic Acid and Methyl Gallate Induces Apoptosis in Hela Cells through Regulation of Intrinsic and Extrinsic Protein Expression by Hasmah Abdullah, Ilyana Ismail, Rapeah Suppian, Nor Munirah Zakaria

“…As previously reported, natural products can induce apoptosis in in vitro cancer treatments. However, the underlying mechanisms of cancer cell death are poorly understood. …”
Get full text

Polyploid giant cancer cells, cytokines and cytomegalovirus in breast cancer progression by Sandy Haidar Ahmad, Ranim El Baba, Georges Herbein

“…Conclusions The analysis of cytokine profiles in PGCCs present mostly in basal-like breast cancer biopsies and derived from CTH cells chronically infected with the high-risk HCMV strains might have the potential to provide novel therapies such as cytokine-based immunotherapy which is a promising field in cancer treatments.…”
Get full text

Influence of Comorbidity Burden, Socioeconomic Status, and Race and Ethnicity on Survival Disparities in Patients With Cancer by Robert M. Cooper, Chun Chao, Amrita Mukherjee, Zimin Zhuang, Reina Haque

“…After adjusting for age, sex, race/ethnicity, cancer stage, smoking status, insurance payor, medical center, year of cancer diagnosis, and cancer treatments, we observed a trend demonstrating higher mortality risk by decreasing socioeconomic status (SES) (P-trend<.05). …”
Get full text

Scoping Review of International Experience of a Dedicated Fund to Support Patient Access to Cancer Drugs: Policy Implications for Thailand by Parnnaphat Luksameesate, Osot Nerapusee, Chanthawat Patikorn, Puree Anantachoti

“…Health insurers need to balance providing cancer treatments with overall system preparedness.…”
Get full text