Effect of AMH on primordial follicle populations in mouse ovaries and human pre-pubertal ovarian xenografts during doxorubicin treatment by Wei, X, Bjarkadottir, BD, Nadjaja, D, Sheikh, S, Fatum, M, Lane, S, Williams, SA

“…Introduction: Survival rates of the childhood cancer patients are improving, however cancer treatments such as chemotherapy may lead to infertility due to loss of the primordial follicle (PMF) reserve. …”

Quantification of Berberine in Berberis vulgaris L. Root Extract and Its Curative and Prophylactic Role in Cisplatin-Induced In Vivo Toxicity and In Vitro Cytotoxicity by Ahmad, Sarfraz, Hussain, Amina, Hussain, Aroosha, Abdullah, Iskandar, Ali, Muhammad Sajjad, Froeyen, Matheus, Mirza, Muhammad Usman

“…Cisplatin is amongst the most potent chemotherapeutic drugs with applications in more than 50% of cancer treatments, but dose-dependent side effects limit its usefulness. …”

Synthesis of zinc oxide (zno)-titanium dioxide (tio2)-chitosan-farnesol nanocomposites and assessment of their anticancer potential in human leukemic molt-4 cell line by Elderdery, Abozer Y., Alzahrani, Badr, Hamza, Siddiqa M. A., Mostafa-Hedeab, Gomaa, Mok, Pooi Ling, Subbiah, Suresh Kumar

“…Thus, the results showed that the synthesized NCs demonstrated a remarkable anticancer potential against leukemic cells and can be potentially valuable in cancer treatments. The findings from this study conclude that this is a new approach for modifying the physicochemical characteristics of ZnO-TiO2-chitosan-farnesol composites to increase their properties and synergistically exhibit anticancer properties in human leukemic cancer cells.…”

ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair by Yuanyuan Chen, Hui Shen, Tingting Liu, Kun Cao, Zhijie Wan, Zhipeng Du, Hang Wang, Yue Yu, Shengzhe Ma, Edward Lu, Wei Zhang, Jianming Cai, Fu Gao, Yanyong Yang

“…Conclusions ScaRNA2 was identified as the most abundant lncRNA bound to ATR and was demonstrated to bridge DNA end resection to ATR activation; thus, it could be applied as a potent target for combined cancer treatments with chemoradiotherapy.…”
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The m6A regulator KIAA1429 stabilizes RAB27B mRNA and promotes the progression of chronic myeloid leukemia and resistance to targeted therapy by Fangyi Yao, Fangmin Zhong, Junyao Jiang, Ying Cheng, Shuai Xu, Jing Liu, Jin Lin, Jing Zhang, Shuqi Li, Meiyong Li, Yanmei Xu, Bo Huang, Xiaozhong Wang

“…Both the acute phase of the disease and the adverse effects of anti-cancer treatments can lead to a poor prognosis. The N6-methyladenine (m6A) modification plays an important regulatory role in various physiological and pathological processes. …”
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MicroRNA analysis of Natural Killer cell-derived exosomes: the microRNA let-7b-5p is enriched in exosomes and participates in their anti-tumor effects against pancreatic cancer cel... by Anna Laura Di Pace, Andrea Pelosi, Piera Filomena Fiore, Nicola Tumino, Francesca Besi, Linda Quatrini, Silvia Santopolo, Paola Vacca, Lorenzo Moretta

“…Our study provides new information on the molecular mechanisms used by NK exosomes to exert anti-tumor-activity and offers new clues to integrate cancer treatments with NK exosomes.…”
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Concordance of a decision algorithm and multidisciplinary team meetings for patients with liver cancer—a study protocol for a randomized controlled trial by Sharlyn S. T. Ng, Robert Oehring, Nikitha Ramasetti, Roland Roller, Philippe Thomas, Yuxuan Chen, Simon Moosburner, Axel Winter, Max-Magnus Maurer, Timo A. Auer, Can Kamali, Johann Pratschke, Christian Benzing, Felix Krenzien

“…Abstract Introduction Multidisciplinary team meetings (MDMs), also known as tumor conferences, are a cornerstone of cancer treatments. However, barriers such as incomplete patient information or logistical challenges can postpone tumor board decisions and delay patient treatment, potentially affecting clinical outcomes. …”
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Effects of Combinations of Untranslated-Region Sequences on Translation of mRNA by Anna Kirshina, Olga Vasileva, Dmitry Kunyk, Kristina Seregina, Albert Muslimov, Roman Ivanov, Vasiliy Reshetnikov

“…mRNA-based therapeutics have been found to be a promising treatment strategy in immunotherapy, gene therapy, and cancer treatments. Effectiveness of mRNA therapeutics depends on the level and duration of a desired protein’s expression, which is determined by various <i>cis</i>- and <i>trans</i>-regulatory elements of the mRNA. …”
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M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way by Kai Li, Zi-Yang Peng, Shan Gao, Qing-Shi Wang, Rui Wang, Xiang Li, Guo-Dong Xiao, Jing Zhang, Hong Ren, Shou-Ching Tang, Xin Sun

“…Abstract Background The small tyrosine kinase inhibitors (TKIs) subversively altered the lung cancer treatments, but patients will inevitably face the therapy resistance and disease recurrence. …”
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Investigating the effect of Sclareol on IRE-1 and PERK genes the pathway of reticulandaplasmic system stress in gastric cancer cells MKN-45 by Elmira Aboutalebi, Ebrahim Sakhinia, Vand Beilanokhi, Homayoun Dolatkhah

“…Background & Aims:  Despite the decline in the prevalence of gastric cancer in recent years, it remains the fourth leading cause of death from cancer in the world. Common cancer treatments may reduce the size of the tumor, but it is transient and does not have a positive effect on the patient's survival and there is a possibility of recurrence of the disease. …”
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Extraction, Separation and Purification of Bioactive Anticancer Components from <i>Peganum harmala</i> against Six Cancer Cell Lines Using Spectroscopic Techniques by Huma Mehreen Sadaf, Yamin Bibi, Samha Al Ayoubi, Naila Safdar, Ahmad Sher, Darima Habib, Sobia Nisa, Khafsa Malik, Sunjeet Kumar, Waseem Ahmed, Abdul Qayyum

“…Conventional cancer treatments normally involve chemotherapy or a combination of radio- and chemotherapy. …”
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Tumor-targeting hydroxyapatite nanoparticles for remodeling tumor immune microenvironment (TIME) by activating mitoDNA-pyroptosis pathway in cancer by Yuxuan Yang, Jia Yang, Nan Zhu, Haosen Qiu, Wenxiang Feng, Ying Chen, Xinhua Chen, Yuehong Chen, Wenbo Zheng, Min Liang, Tian Lin, Jiang Yu, Zhaoze Guo

“…Transforming non-responsive “cold” tumor types into immuno-responsive “hot” ones is critical to enhance the efficacy of immune-based cancer treatments. Pyroptosis, a programmed cell death mechanism, not only effectively eliminates tumor cells but also triggers a potent inflammatory response to initiate anti-tumor immune activities. …”
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Melatonin as an immunomodulator in CD19-targeting CAR-T cell therapy: managing cytokine release syndrome by Na Zheng, Yihao Long, Zixuan Bai, Jianing Li, Hongyu Wang, Dan-Dan Song, Hong-Lin Liu, Jian-Hong Shi, Shuli Zhao

“…This research contributes to the evolving understanding of how to harness immunomodulatory agents to enhance the clinical application of innovative cancer treatments.…”
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Maximizing ovarian function and fertility following chemotherapy in premenopausal patients: Is there a role for ovarian suppression? by Kelsey A. Roof, Kerri E. Andre, Susan C. Modesitt, D. Austin Schirmer

“…As more premenopausal patients undergo fertility preserving cancer treatments, there is an increased need for fertility counseling and ovarian sparing strategies. …”
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Chlorogenic Acid Attenuates Doxorubicin-Induced Oxidative Stress and Markers of Apoptosis in Cardiomyocytes via Nrf2/HO-1 and Dityrosine Signaling by Betul Cicek, Ahmet Hacimuftuoglu, Yesim Yeni, Betul Danisman, Mustafa Ozkaraca, Behzad Mokhtare, Mecit Kantarci, Marios Spanakis, Dragana Nikitovic, Georgios Lazopoulos, Konstantinos Tsarouhas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi

“…(1) Background: Doxorubicin (DOX) is extensively used for cancer treatments; however, its clinical application is limited because of its cardiotoxic adverse effects. …”
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PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer by Qianzhi Chen, Qingyi Hu, Yan Chen, Na Shen, Ning Zhang, Anshu Li, Lei Li, Junjun Li

“…Abstract Overcoming distant metastasis stands as a paramount challenge in enhancing the outcomes of breast cancer treatments. Thus, delving deeper into comprehending the intricate mechanisms underlying breast cancer metastasis becomes imperative, offering potential avenues for pioneering therapeutic approaches. …”
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Establishment and application of a multiplex genetic mutation-detection method of lung cancer based on MassARRAY platform by Hong-Xia Tian, Xu-Chao Zhang, Zhen Wang, Jian-Guang Chen, Shi-Liang Chen, Wei-Bang Guo, Yi-Long Wu

“…<br><b>Objective: </b>We reviewed the related literature and data on lung cancer treatments. We also identified 99 mutation hot spots in 13 target genes closely related to the pathogenesis, drug resistance, and metastasis of lung cancer. …”
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IL-6/ERK signaling pathway participates in type I IFN-programmed, unconventional M2-like macrophage polarization by Limin Yang, Panpan Guo, Pei Wang, Wei Wang, Jianghuai Liu

“…The present work establishes a role of IL-6/ERK signaling in promoting M2-like macrophage polarization, and suggests this axis as a potential therapeutic target for combination with IFN-I-based cancer treatments.…”
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Overexpression of MTHFD2 represents an inflamed tumor microenvironment and precisely predicts the molecular subtype and immunotherapy response of bladder cancer by Xiaokai Shi, Xiaokai Shi, Xiangrong Peng, Xiangrong Peng, Yin Chen, Yin Chen, Zebin Shi, Zebin Shi, Chuang Yue, Chuang Yue, Li Zuo, Li Zuo, Lifeng Zhang, Lifeng Zhang, Shenglin Gao, Shenglin Gao

“…The predictors of cancer treatments effectiveness, including the expression and mutation of certain genes, molecular subtypes, and several signatures were evaluated as well. …”
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Trends in medical care utilization in patients with cancer: An analysis of real‐world data in a tertiary hospital in Korea, 2014–2019 by Jung‐Hyun Won, Tae Kyu Chung, Joochul Lee, Sangwon Yoon, Yoomin Jeon, Howard Lee

“…Abstract Background Rising costs of cancer treatments challenge even areas with universal health coverage. …”
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