Machine-Learning Analysis of Serum Proteomics in Neuropathic Pain after Nerve Injury in Breast Cancer Surgery Points at Chemokine Signaling via SIRT2 Regulation by Jörn Lötsch, Laura Mustonen, Hanna Harno, Eija Kalso

“…In particular, sirtuin 2 emerged as a key protein, presenting both before and after breast cancer treatments in the PPSNP compared with the non-PPSNP subgroup. …”
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Novel kinome profiling technology reveals drug treatment is patient and 2D/3D model dependent in glioblastoma by Federica Fabro, Nynke M. Kannegieter, Erik L. de Graaf, Karla Queiroz, Martine L. M. Lamfers, Anna Ressa, Sieger Leenstra

“…Small protein kinase inhibitors are molecules that have become widely studied for cancer treatments, including glioblastoma. However, none of these drugs have demonstrated a therapeutic activity or brought more benefit compared to the current standard procedure in clinical trials. …”
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Geriatric assessment domains to predict overall survival in older cancer patients: An analysis of functional status, comorbidities, and nutritional status as prognostic factors by Toshitaka Morishima, Akira Sato, Kayo Nakata, Isao Miyashiro

“…Abstract Cancer treatments for older patients must account for heterogeneity in health and functional status. …”
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The MANTRA study: a new umbrella concept prospectively applied to assess implantable medical devices for heart valve procedures by Bart Meuris, Serdar Günaydın, Patrizio Lancellotti, Luigi Badano, Gabriel Aldea, Rita Herrenknecht, Elisa Cerutti, Sara Gaggianesi, Silvia Dipinto, Paola Morando, Jörg Kempfert

“…Umbrella studies have been developed to address the need for more efficient and flexible trial structures, predominantly for cancer treatments. The umbrella concept foresees data collection within a unifying trial structure, to which one or more substudies may be added at any time to address product- or therapy-specific questions. …”
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Biomechanical stimulation promotes blood vessel growth despite VEGFR-2 inhibition by Bronte Miller Johnson, Allison McKenzie Johnson, Michael Heim, Molly Buckley, Bryan Mortimer, Joel L. Berry, Mary Kathryn Sewell-Loftin

“…Unfortunately, many of these cancer treatments fail to completely stop angiogenesis in the tumor microenvironment (TME). …”
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Patient Reported Outcomes, Paternity, Relationship, and Fertility in Testicular Cancer Survivors: Results from a Prospective Observational Single Institution Trial by Bimbatti D, Lai E, Pierantoni F, Maruzzo M, Msaki A, De Toni C, Dionese M, Feltrin A, Basso U, Zagonel V

“…We attempted to assess Patient Reported Outcomes (PROMs), long-term sexual disorders, and difficulties in achieving fatherhood in a cohort of TC survivors, as well as their possible correlation with previous cancer treatments.Methods: Different questionnaires, such as the Impact of Cancer (IOC) and the Body Image Scale (BIS), were used to investigate the distinct areas of the PROMs. …”
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The loss of B7-H4 expression in breast cancer cells escaping from T cell cytotoxicity contributes to epithelial-to-mesenchymal transition by Linlin Zhou, Jichun Wu, Mei Ruan, Yonglei Xiao, Hailin Lan, Qiongwen Wu, Chen-Wei Yu, Qiuyu Zhang

“…Conclusions Our study illuminates the novel role of renouncing B7-H4 in breast cancer cells through immune escape, which contributes to EMT processes and provides new insights for breast cancer treatments.…”
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Modeling Physical Forces Experienced by Cancer and Stromal Cells Within Different Organ-Specific Tumor Tissue by Morgan Connaughton, Mahsa Dabagh

“…Furthermore, our in silico model of tumor tissue can yield critical, useful information for guiding ex vivo or in vitro experiments, narrowing down variables to be investigated, understanding what factors could be impacting cancer treatments or even biomarkers to be looking for.…”
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Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antitumoral D... by Loredana Bergandi, Eleonora Mungo, Rosa Morone, Ornella Bosco, Barbara Rolando, Sophie Doublier

“…This scenario could be due, at least in part, to a lower efficacy of the cancer treatments which needs to be better investigated. …”
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Radiotherapy-activated NBTXR3 nanoparticles promote ferroptosis through induction of lysosomal membrane permeabilization by Jordan Da Silva, Célia Bienassis, Peter Schmitt, Céline Berjaud, Mickael Guedj, Sébastien Paris

“…This study improves our understanding of the cellular mechanisms underlying NBTXR3 + RT and highlights its potential as an agnostic therapeutic strategy for solid cancers treatment. Graphical Abstract…”
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Integrating Quality of Life in the Care Pathway of Cancer Patients Undergoing Immunotherapy Treatment: Descriptive, Cross-sectional Survey of an Online Patient Community's Experien... by Ophélie Wilczynski, Anthony Boisbouvier, Lise Radoszycki, François-Emery Cotté, Anne-Françoise Gaudin, Hervé Lemasson

“… BackgroundNew cancer treatments, such as immune checkpoint inhibitors (ICIs), can improve survival and health-related quality of life (HRQoL) in patients with cancer. …”
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Epigenetic Silencing of LMX1A Contributes to Cancer Progression in Lung Cancer Cells by Ti-Hui Wu, Shan-Yueh Chang, Yu-Lueng Shih, Chih-Feng Chian, Hung Chang, Ya-Wen Lin

“…In this study, we used public databases, methylation-specific PCR (MSP), reverse transcription PCR (RT-PCR), and bisulfite genomic sequencing to show that <i>LMX1A</i> was downregulated or silenced due to promoter hypermethylation in lung cancers. Treatment of lung cancer cells with the demethylating agent 5-aza-2’-deoxycytidine restored <i>LMX1A</i> expression. …”
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Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids by Lu, Zeyu, Paolella, Brenton R., Truex, Nicholas L., Loftis, Alexander R., Liao, Xiaoli, Rabideau, Amy E., Brown, Meredith S., Busanovich, John, Beroukhim, Rameen, Pentelute, Bradley L.

“…Antisense oligonucleotide therapies are important cancer treatments, which can suppress genes in cancer cells that are critical for cell survival. …”
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Comparison of wild-type and hotspot mutant p53 interactomes: The hunt for mutant-specific binding partners & Investigation and characterization of natural killer cell responses... by Kohn, Ryan

“…Part 2: While there has long been speculation that the immune system can recognize and kill tumor cells, recent developments in immunotherapy have truly transformed cancer treatments. Although some patients who receive immunotherapy have durable responses, and even cures, a significant subset of patients do not respond, illustrating the need for improved immunotherapies and a better understanding of what drives the differences seen in patients. …”
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Supporting finding and re-finding through personalization by Teevan, Jaime B. (Jaime Brooks), 1976-

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Antitumor and antioxidant effects of Clinacanthus nutans Lindau in 4T1 tumor-bearing mice by Nik Abd Rahman, Nik Mohd Afizan, M.Y., Nurliyana, Mohamed Noor Fuad, Natasha Nur Afiqah, Osman, Mohd Azuraidi, Hamid, Muhajir, Mohd Lila, Mohd Azmi

“…C. nutans is well known as Sabah snake grass in Malaysia, and its leaves have diverse medicinal potential in conventional applications, including cancer treatments. On the basis of literature search, there is less conclusive evidence of the involvement of phytochemical constituents in breast cancer, in particular, animal tumor models. …”
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Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines by Shun, Ying Quah, Charng, Choon Wong, Hui, Chyn Wong, Ho, Kok Lian, Abdul Manan, Nizar, Deb, Pran Kishore, Sagineedu, Sreenivasa Rao, Stanslas, Johnson

“…Chemoresistance poses a major hurdle to cancer treatments. Andrographolide-derived SRJ09 and SRJ23 were reported to exhibit potent, selective inhibitory activities against colon and prostate cancer cells, respectively. …”

Shielding of virus-like nanoparticles of hepatitis B core antigen by poly(2-oxazoline) for reduced antigenicity by Fam, See Yee

“…However, HBcAg VLNPs are highly antigenic and immunogenic, compromising their drug delivery efficacy for cancer treatments. The aim of this study was to reduce the antigenicity of HBcAg VLNPs by shielding them with a hydrophilic polymer, poly(2-ethyl-2-oxazoline) (PEtOx). …”
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Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study by Mónica Bolufer, Clara García-Carro, Miquel Blasco, Luis F. Quintana, Amir Shabaka, Cristina Rabasco, Juliana Draibe, Ana Merino, María Rosa Melero, Fabiola Alonso, Anna Buxeda, Paula Batalha, Maria Teresa Visús, Maria José Soler

“…Background: Currently, following the new advances in cancer treatments and the increasing prevalence of kidney disease in the population, more kidney biopsies are being performed. …”
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Prognostic score and sex-specific nomograms to predict survival in resectable lung cancer: A French nationwide study from the Epithor cohort databaseResearch in context by Marco Alifano, Elisa Daffré, Laurent Brouchet, Pierre Emmanuel Falcoz, Françoise Le Pimpec Barthes, Pierre Benoit Pages, Pascal Alexandre Thomas, Marcel Dahan, Raphael Porcher

“…Summary: Background: Prognostic assessment in patients undergoing cancer treatments is of paramount importance to plan subsequent management. …”
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