-
13441
The Indigenous Australian Human Papillomavirus (HPV) Cohort Study 2, Continuation for 5 to 10 Years: Protocol for a Longitudinal Study
Published 2023-05-01“…ConclusionsOur findings have potential to change the way in which OPSCC among Australian Indigenous adults is managed, with desired impacts including cost-savings on expensive cancer treatments; improved nutritional, social, and emotional outcomes; and improved quality of life for both Indigenous adults and the Indigenous community more broadly. …”
Get full text
Article -
13442
Use of computed tomography coronary calcium score for prediction of cardiovascular events in cancer patients: a retrospective cohort analysis
Published 2024-01-01“…Cancer patients (C) may have a higher risk for CV disease than non-cancer patients (NC) related not only to cancer treatments but also to shared biological factors and pathways. …”
Get full text
Article -
13443
Activation of Akt–mTORC1 signalling reverts cancer‐dependent muscle wasting
Published 2022-02-01“…While Akt–mTORC1 signalling is important for adult muscle homeostasis, it is also a major target of numerous cancer treatments. Which role Akt–mTORC1 signalling plays during cancer cachexia in muscle is currently not known. …”
Get full text
Article -
13444
Fertility preservation in pre-pubertal boys with cancer: a three-dimensional (3D) prepubertal testicular organoid culture system for in vitro spermatogonial stem cell (SSCs) propag...
Published 2022“…However, aggressive cancer treatments, such as chemo- or radiotherapy, can leave young prepubertal boys infertile. …”
Thesis -
13445
Integrating digital pathology with transcriptomic and epigenomic tools for predicting metastatic uterine tumor aggressiveness
Published 2022-11-01“…In this regard, precision oncology and its diagnostic tools are essential for developing personalized cancer treatments. Digital pathology (DP) is a particularly key strategy to study the interactions of tumor cells and the tumor microenvironment (TME), which play a crucial role in tumor initiation, progression and metastasis. …”
Get full text
Article -
13446
In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeuti...
Published 2022-10-01“…Multiple drug resistance has also emerged in several cancer cell types, leaving them unresponsive to the many cancer treatments. Such a condition always prompts the development of next-generation cancer therapies that have a better chance of inhibiting selective target macromolecules with less toxicity. …”
Get full text
Article -
13447
In silico and in vitro study of bioactive compounds of Nigella sativa for targeting neuropilins in breast cancer
Published 2023-10-01“…These findings highlight the potential health benefits of N. sativa leaves and their possible role in anti-cancer treatments targeting angiogenesis.Conclusion:Nigella sativa leaves have shown significant medical potential due to their bioactive compounds, which exhibit strong properties in supporting organogenic processes related to cancer. …”
Get full text
Article -
13448
Functional Trajectories and Resilience Among Adults With Advanced Lung Cancer
Published 2022-06-01“…Introduction: To evaluate whether and the degree to which patients with advanced NSCLC (aNSCLC) receiving lung cancer treatments will experience functional disability or have resilience and to identify characteristics associated with functional disability. …”
Get full text
Article -
13449
Complex Mitochondrial Dysfunction Induced by TPP<sup>+</sup>-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cel...
Published 2020-02-01“…The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. …”
Get full text
Article -
13450
Measurement of CYP1A2 and CYP3A4 activity by a simplified Geneva cocktail approach in a cohort of free-living individuals: a pilot study
Published 2024-02-01“…Introduction: The cytochrome P450 enzyme subfamilies, including CYP3A4 and CYP1A2, have a major role in metabolism of a range of drugs including several anti-cancer treatments. Many factors including environmental exposures, diet, diseaserelated systemic inflammation and certain genetic polymorphisms can impact the activity level of these enzymes. …”
Get full text
Article -
13451
A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes
Published 2023-06-01“…IMPORTANCE Bacteria resistant to one or several antibiotics are a very large problem, threatening not only treatment of infections but also surgery and cancer treatments. Thus, new types of antibacterial drugs are desperately needed. …”
Get full text
Article -
13452
Identification and Potential Use of Clusters of Patients With Colorectal Cancer and Patients With Prostate Cancer in Clinical Practice: Explorative Mixed Methods Study
Published 2022-12-01“…As a result of primary cancer treatments, patients have numerous additional complaints, increasing the need for cancer aftercare. …”
Get full text
Article -
13453
Random and aligned electrospun PLGA nanofibers embedded in microfluidic chips for cancer cell isolation and integration with air foam technology for cell release
Published 2019-02-01“…Technologies for the isolation and recovery of CTCs can be powerful cancer diagnostic tools for liquid biopsies, allowing the identification of malignancies and guiding cancer treatments for precision medicine. Methods We have used an electrospinning process to prepare poly(lactic-co-glycolic acid) (PLGA) nanofibrous arrays in random or aligned orientations on glass slips. …”
Get full text
Article -
13454
Cytotoxic potential on human breast and lung cancer cells of the biosynthesized gold nanoparticles from the reduction of chloroauric acid by lactic acid isolated from Lactobacillus...
Published 2022-10-01“…Chemotherapy side effects, drug resistance, and tumor metastasis hinder the progress of cancer treatments, which has led to cancer patients having a poor prognosis. …”
Get full text
Article -
13455
Integrated investigation of the clinical implications and targeted landscape for RNA methylation modifications in hepatocellular carcinoma
Published 2023-01-01“…In response to anti-cancer treatments, the RM_Score had a negative correlation (drug sensitive) with drugs that focused on the MAPK/ERK and metabolism signaling, and a positive correlation (drug resistant) with compounds targeting RKT and PI3K/mTOR signaling pathway. …”
Get full text
Article -
13456
Combined Treatment with Ultrasound and Immune Checkpoint Inhibitors for Prostate Cancer
Published 2022-04-01“…Background: Ultrasound (US) is mostly used for diagnostic purpose but could be used for cancer treatments with a US intensity or frequency fitted to such a purpose. …”
Get full text
Article -
13457
Effect of Newcastle Disease Virus AF2240 on Allografted 4T1 Breast Cancer Cells in Balb/c Mice
Published 2010“…In summary, NDV AF2240 alone can inhibit growth of 4T1 cancer cells and, thus, can be used as a potential oncolytic agent for breast cancer treatments. NDV is significantly more effective than tamoxifen and can be a very useful alternative anticancer agent for breast tumours.…”
Get full text
Thesis -
13458
Effectiveness of intensive nutrition intervention on nutritional, side-effects and functional outcomes among head and neck cancer outpatients on radiotheraphy
Published 2020“…Patients who already started on ONS, tube feeding and cancer treatments prior to the study period were excluded. …”
Get full text
Thesis -
13459
Renoprotective effects of Cucumeropsis mannii seed oil on cisplatin-induced nephrotoxicity in Wistar rats
Published 2024-05-01“…These findings have significant implications for developing complementary therapies to mitigate chemotherapy-associated kidney damage, potentially enhancing the safety and efficacy of cisplatin-based cancer treatments. Further investigation is needed to explore the clinical applications of CMSO for cancer patients.…”
Get full text
Article -
13460
Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer: a multicenter randomized...
Published 2023-02-01“…Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments (preoperative chemotherapy or chemoradiation) within three months were randomly assigned to undergo standard pancreatoduodenectomy (SPD) or EPD, with the latter followed by dissection of additional lymph nodes (LNs), nerves and soft tissues 270° on the right side surrounding the superior mesenteric artery and celiac axis. …”
Get full text
Article