The Indigenous Australian Human Papillomavirus (HPV) Cohort Study 2, Continuation for 5 to 10 Years: Protocol for a Longitudinal Study by Joanne Hedges, Sneha Sethi, Gail Garvey, Lisa J Whop, Karen Canfell, Zell Dodd, Priscilla Larkins, Annika Antonsson, Megan A Smith, Murthy Mittinty, Catherine Leane, Nicolas Reid, Eng H Ooi, Xiangqun Ju, Richard Logan, Lisa Jamieson

“…ConclusionsOur findings have potential to change the way in which OPSCC among Australian Indigenous adults is managed, with desired impacts including cost-savings on expensive cancer treatments; improved nutritional, social, and emotional outcomes; and improved quality of life for both Indigenous adults and the Indigenous community more broadly. …”
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Use of computed tomography coronary calcium score for prediction of cardiovascular events in cancer patients: a retrospective cohort analysis by Sinal Patel, Francisco X. Franco, Malcolm McDonald, Carlos Rivera, Bernardo Perez-Villa, Patrick Collier, Rohit Moudgil, Neha Gupta, Diego B. Sadler

“…Cancer patients (C) may have a higher risk for CV disease than non-cancer patients (NC) related not only to cancer treatments but also to shared biological factors and pathways. …”
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Activation of Akt–mTORC1 signalling reverts cancer‐dependent muscle wasting by Alessia Geremia, Roberta Sartori, Martina Baraldo, Leonardo Nogara, Valeria Balmaceda, Georgia Ana Dumitras, Stefano Ciciliot, Marco Scalabrin, Hendrik Nolte, Bert Blaauw

“…While Akt–mTORC1 signalling is important for adult muscle homeostasis, it is also a major target of numerous cancer treatments. Which role Akt–mTORC1 signalling plays during cancer cachexia in muscle is currently not known. …”
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Fertility preservation in pre-pubertal boys with cancer: a three-dimensional (3D) prepubertal testicular organoid culture system for in vitro spermatogonial stem cell (SSCs) propag... by Tang, S

“…However, aggressive cancer treatments, such as chemo- or radiotherapy, can leave young prepubertal boys infertile. …”

Integrating digital pathology with transcriptomic and epigenomic tools for predicting metastatic uterine tumor aggressiveness by Giorgia Sonzini, Sofia Granados-Aparici, Sabina Sanegre, Sabina Sanegre, Angel Diaz-Lagares, Angel Diaz-Lagares, Juan Diaz-Martin, Juan Diaz-Martin, Carlos de Andrea, Carlos de Andrea, Núria Eritja, Núria Eritja, Aida Bao-Caamano, Aida Bao-Caamano, Nicolás Costa-Fraga, Nicolás Costa-Fraga, David García-Ros, Carmen Salguero-Aranda, Carmen Salguero-Aranda, Ben Davidson, Ben Davidson, Rafael López-López, Rafael López-López, Ignacio Melero, Ignacio Melero, Samuel Navarro, Samuel Navarro, Santiago Ramon y Cajal, Santiago Ramon y Cajal, Enrique de Alava, Enrique de Alava, Xavier Matias-Guiu, Xavier Matias-Guiu, Rosa Noguera, Rosa Noguera

“…In this regard, precision oncology and its diagnostic tools are essential for developing personalized cancer treatments. Digital pathology (DP) is a particularly key strategy to study the interactions of tumor cells and the tumor microenvironment (TME), which play a crucial role in tumor initiation, progression and metastasis. …”
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In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeuti... by Fatima Ezzahra Bennani, Khalid Karrouchi, Latifa Doudach, Mario Scrima, Noor Rahman, Luca Rastrelli, Trina Ekawati Tallei, Christopher E. Rudd, My El Abbes Faouzi, M’hammed Ansar

“…Multiple drug resistance has also emerged in several cancer cell types, leaving them unresponsive to the many cancer treatments. Such a condition always prompts the development of next-generation cancer therapies that have a better chance of inhibiting selective target macromolecules with less toxicity. …”
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In silico and in vitro study of bioactive compounds of Nigella sativa for targeting neuropilins in breast cancer by Imran Zafar, Arfa Safder, Hassan Imran Afridi, Sania Riaz, Rizwan -ur-Rehman, Ahsanullah Unar, Fakhar Un Nisa, Abdel-Rhman Z. Gaafar, Mohammed Bourhia, Gezahign Fentahun Wondmie, Rohit Sharma, Dileep Kumar, Dileep Kumar, Dileep Kumar

“…These findings highlight the potential health benefits of N. sativa leaves and their possible role in anti-cancer treatments targeting angiogenesis.Conclusion:Nigella sativa leaves have shown significant medical potential due to their bioactive compounds, which exhibit strong properties in supporting organogenic processes related to cancer. …”
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Functional Trajectories and Resilience Among Adults With Advanced Lung Cancer by Carolyn J. Presley, MD, MHS, Nicole A. Arrato, MA, Peter G. Shields, MD, David P. Carbone, MD, PhD, Melisa L. Wong, MD, MAS, Jason Benedict, MS, Sarah A. Reisinger, PhD, MPH, Ling Han, MD, PhD, Thomas M. Gill, MD, Heather Allore, PhD, Barbara L. Andersen, PhD, Sarah Janse, PhD

“…Introduction: To evaluate whether and the degree to which patients with advanced NSCLC (aNSCLC) receiving lung cancer treatments will experience functional disability or have resilience and to identify characteristics associated with functional disability. …”
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Complex Mitochondrial Dysfunction Induced by TPP⁺-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cel... by Sebastián Fuentes-Retamal, Cristian Sandoval-Acuña, Liliana Peredo-Silva, Daniela Guzmán-Rivera, Mario Pavani, Natalia Torrealba, Jaroslav Truksa, Vicente Castro-Castillo, Mabel Catalán, Ulrike Kemmerling, Félix A. Urra, Jorge Ferreira

“…The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. …”
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Measurement of CYP1A2 and CYP3A4 activity by a simplified Geneva cocktail approach in a cohort of free-living individuals: a pilot study by Constance A. Sobsey, Constance A. Sobsey, Noor Mady, Noor Mady, Vincent R. Richard, Andre LeBlanc, Thomas Zakharov, Thomas Zakharov, Christoph H. Borchers, Christoph H. Borchers, R. Thomas Jagoe, R. Thomas Jagoe

“…Introduction: The cytochrome P450 enzyme subfamilies, including CYP3A4 and CYP1A2, have a major role in metabolism of a range of drugs including several anti-cancer treatments. Many factors including environmental exposures, diet, diseaserelated systemic inflammation and certain genetic polymorphisms can impact the activity level of these enzymes. …”
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A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes by Hasan Tükenmez, Pardeep Singh, Souvik Sarkar, Melike Çakır, Ana H. Oliveira, Cecilia Lindgren, Karolis Vaitkevicius, Mari Bonde, A. Elisabeth Sauer-Eriksson, Fredrik Almqvist, Jörgen Johansson

“…IMPORTANCE Bacteria resistant to one or several antibiotics are a very large problem, threatening not only treatment of infections but also surgery and cancer treatments. Thus, new types of antibacterial drugs are desperately needed. …”
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Identification and Potential Use of Clusters of Patients With Colorectal Cancer and Patients With Prostate Cancer in Clinical Practice: Explorative Mixed Methods Study by Maik J M Beuken, Iris M Kanera, Nicole Paulina Maria Ezendam, Susy Braun, Martijn Zoet

“…As a result of primary cancer treatments, patients have numerous additional complaints, increasing the need for cancer aftercare. …”
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Random and aligned electrospun PLGA nanofibers embedded in microfluidic chips for cancer cell isolation and integration with air foam technology for cell release by Chia-Cheng Yu, Yi-Wen Chen, Po-Ying Yeh, Yu-Sheng Hsiao, Wei-Ting Lin, Chiung-Wen Kuo, Di-Yen Chueh, Yun-Wen You, Jing-Jong Shyue, Ying-Chih Chang, Peilin Chen

“…Technologies for the isolation and recovery of CTCs can be powerful cancer diagnostic tools for liquid biopsies, allowing the identification of malignancies and guiding cancer treatments for precision medicine. Methods We have used an electrospinning process to prepare poly(lactic-co-glycolic acid) (PLGA) nanofibrous arrays in random or aligned orientations on glass slips. …”
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Cytotoxic potential on human breast and lung cancer cells of the biosynthesized gold nanoparticles from the reduction of chloroauric acid by lactic acid isolated from Lactobacillus... by Elmer Casley Repotente, Angelo Jose Carreon, Mark Kevin Devanadera, Mark Kevin Devanadera, Mark Kevin Devanadera, Maria Salvacion Esmalla, Myla Santiago-Bautista, Myla Santiago-Bautista

“…Chemotherapy side effects, drug resistance, and tumor metastasis hinder the progress of cancer treatments, which has led to cancer patients having a poor prognosis. …”
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Integrated investigation of the clinical implications and targeted landscape for RNA methylation modifications in hepatocellular carcinoma by Jianping Zhang, Jie Gao, Mingchao Hu, Shiyu Xu, Chun Cheng, Wenjie Zheng, Jie Zhang

“…In response to anti-cancer treatments, the RM_Score had a negative correlation (drug sensitive) with drugs that focused on the MAPK/ERK and metabolism signaling, and a positive correlation (drug resistant) with compounds targeting RKT and PI3K/mTOR signaling pathway. …”
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Combined Treatment with Ultrasound and Immune Checkpoint Inhibitors for Prostate Cancer by Fuuka Hayashi, Katsumi Shigemura, Koki Maeda, Aya Hiraoka, Noriaki Maeshige, Tooru Ooya, Shian-Ying Sung, Yong-Ming Yang, Masato Fujisawa

“…Background: Ultrasound (US) is mostly used for diagnostic purpose but could be used for cancer treatments with a US intensity or frequency fitted to such a purpose. …”
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Effect of Newcastle Disease Virus AF2240 on Allografted 4T1 Breast Cancer Cells in Balb/c Mice by Swaminathan, Setareh

“…In summary, NDV AF2240 alone can inhibit growth of 4T1 cancer cells and, thus, can be used as a potential oncolytic agent for breast cancer treatments. NDV is significantly more effective than tamoxifen and can be a very useful alternative anticancer agent for breast tumours.…”
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Effectiveness of intensive nutrition intervention on nutritional, side-effects and functional outcomes among head and neck cancer outpatients on radiotheraphy by Jamhuri, Norshariza

“…Patients who already started on ONS, tube feeding and cancer treatments prior to the study period were excluded. …”
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Renoprotective effects of Cucumeropsis mannii seed oil on cisplatin-induced nephrotoxicity in Wistar rats by Boniface Anthony Ale, Patrick Maduabuchi Aja, Ikechukwu Jacob Okoro, Felix Emmanuel Nwite, Peter Chinedu Agu, Ejike Daniel Eze, Vitus Ikenna Nnamani, Victor Nwadiogbu Ogugua

“…These findings have significant implications for developing complementary therapies to mitigate chemotherapy-associated kidney damage, potentially enhancing the safety and efficacy of cisplatin-based cancer treatments. Further investigation is needed to explore the clinical applications of CMSO for cancer patients.…”
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Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer: a multicenter randomized... by Qing Lin, Shangyou Zheng, Xianjun Yu, Meifu Chen, Yu Zhou, Quanbo Zhou, Chonghui Hu, Jing Gu, Zhongdong Xu, Lin Wang, Yimin Liu, Qingyu Liu, Min Wang, Guolin Li, He Cheng, Dongkai Zhou, Guodong Liu, Zhiqiang Fu, Yu Long, Yixiong Li, Weilin Wang, Renyi Qin, Zhihua Li, Rufu Chen

“…Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments (preoperative chemotherapy or chemoradiation) within three months were randomly assigned to undergo standard pancreatoduodenectomy (SPD) or EPD, with the latter followed by dissection of additional lymph nodes (LNs), nerves and soft tissues 270° on the right side surrounding the superior mesenteric artery and celiac axis. …”
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