Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy by Andreia Maia, Mubin Tarannum, Joana R. Lérias, Sara Piccinelli, Luis Miguel Borrego, Markus Maeurer, Rizwan Romee, Mireia Castillo-Martin

“…Natural killer (NK) cells have gained attention as a promising adoptive cell therapy platform for their potential to improve cancer treatments. NK cells offer distinct advantages over T-cells, including major histocompatibility complex class I (MHC-I)-independent tumor recognition and low risk of toxicity, even in an allogeneic setting. …”
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Time-related survival prediction in molecular subtypes of breast cancer using time-to-event deep-learning-based models by Saba Zarean Shahraki, Mehdi Azizmohammad Looha, Pooya Mohammadi kazaj, Mehrad Aria, Atieh Akbari, Hassan Emami, Farkhondeh Asadi, Mohammad Esmaeil Akbari

“…Future clinical trials should further explore the response of different molecular subtypes to treatment in order to optimize the efficacy of breast cancer treatments.…”
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Tumor infiltrating leukocyte density is independent of tumor grade and molecular subtype in aggressive breast cancer of Western Kenya by Rispah T. Sawe, Simeon K. Mining, Ayub V. Ofulla, Kirtika Patel, Bernard Guyah, David Chumba, Jenifer R. Prosperi, Maggie Kerper, Zonggao Shi, Mayra Sandoval-Cooper, Katherine Taylor, Sunil Badve, M. Sharon Stack, Laurie E. Littlepage

“…Future research is required to determine if the aberrant recruitment of TILs to tumors contributes to cancer progression and response to cancer treatments.…”
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Changes in Body Weight, Body Composition, Phase Angle, and Resting Metabolic Rate in Male Patients with Stage IV Non-Small-Cell Lung Cancer Undergoing Therapy by Paraskevi Detopoulou, Theodora Tsiouda, Maria Pilikidou, Foteini Palyvou, Eirini Tsekitsidi, Maria Mantzorou, Persefoni Pezirkianidou, Krystallia Kyrka, Spyridon Methenitis, Gavriela Voulgaridou, Pavlos Zarogoulidis, Rena Oikonomidou, Dimitris Matthaios, Κonstantinos Porpodis, Dimitrios Giannakidis, Sousana K. Papadopoulou

“…<i>Background and Objectives</i>: Cancer treatments can adversely influence body weight status, body composition, phase angle (PhA), and resting metabolic rate (RMR), which could possibly affect disease course. …”
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Improving the diagnosis of cancer in primary care: a feasibility economic analysis of the ThinkCancer! study. by Bethany F Anthony, Stefanie Disbeschl, Nia Goulden, Annie Hendry, Julia Hiscock, Zoe Hoare, Ruth Lewis, Jessica Roberts, Jan Rose, Nefyn H Williams, Dan Walker, Richard Neal, Clare Wilkinson, Rhiannon T Edwards

“…Primary care interventions to expedite the diagnosis of symptomatic cancer have the potential to reduce large costs to the NHS and improve patient and carer outcomes as later stage cancer treatments are often longer, more aggressive to patients, with larger associated healthcare costs compared to earlier stage treatment. …”
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Honeybee Venom Synergistically Enhances the Cytotoxic Effect of CNS Drugs in HT-29 Colon and MCF-7 Breast Cancer Cell Lines by Diana Duarte, Soraia I. Falcão, Iouraouine El Mehdi, Miguel Vilas-Boas, Nuno Vale

“…Overall, the present study corroborates the enormous bioactive potential of honeybee venom for colon and breast cancer treatments, both alone and in combination with chemotherapy or repurposed drugs.…”
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Digital Life Coaching During Stem Cell Transplantation: Development and Usability Study by Rahul Banerjee, Chiung-Yu Huang, Lisa Dunn, Jennifer Knoche, Chloe Ryan, Kelly Brassil, Lindsey Jackson, Dhiren Patel, Mimi Lo, Shagun Arora, Sandy W Wong, Jeffrey Wolf, Thomas Martin III, Anand Dhruva, Nina Shah

“…ConclusionsDLC may be feasible for older patients during intensive hospital-based cancer treatments such as autologous SCT for multiple myeloma. …”
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Oncolytic activity of Newcastle disease virus strain AF2240 in hypoxic cancer cells by Abd Aziz, Noraini

“…Solid tumors have different microenvironment that can influence the capability of cancer treatments. Cancer cells in low oxygen condition or hypoxia, present an obstacle as they are more resistant towards chemotherapy and radiotherapy. …”
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A 16-year bicentric retrospective analysis of ovarian tissue cryopreservation in pediatric units: indications, results, and outcome by Marine Grellet-Grün, Béatrice Delepine, Pauline Le Van Quyen, Gerlinde Avérous, Anne Durlach, Cécile Greze, Laetitia Ladureau-Fritsch, Isabelle Lichtblau, Anne-Sophie Canepa, Antoine Liné, Catherine Paillard, Claire Pluchart, Olivier Pirrello, Catherine Rongieres, Ghassan Harika, François Becmeur, Marius Teletin, Marius Teletin

“…BackgroundCancer treatments of the last decades improve the survival rate of children and adolescents. …”
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Clinical and radiological features associated with EGFR mutation in non-small-cell lung cancer: a study of 149 cases by Abdelaali Yahya Mourabiti, Meryem Sqalli Houssaini, Anass Benfares, Nizar El Bouardi, Moulay Youssef Alaoui Lamrani, Hind El Fatemi, Mounia Serraj, Bouchra Amara, Hassan Qjidaa, Mohammed Smahi, Mustapha Maaroufi, Badereddine Alami

“…Tumor cells with EGFR mutations are very sensitive to cancer treatments called "Targeted Therapies." The search for EGFR mutations requires lung biopsies. …”
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Coping After Breast Cancer: Protocol for a Randomized Controlled Trial of Stress Management eHealth Interventions by Karianne Svendsen, Lise Solberg Nes, Anders Meland, Ine Marie Larsson, Ylva M Gjelsvik, Elin Børøsund, Christine M Rygg, Tor Åge Myklebust, Kristin V Reinertsen, Cecilie E Kiserud, Helle Skjerven, Michael H Antoni, Trudie Chalder, Ingvil Mjaaland, Linda E Carlson, Hege R Eriksen, Giske Ursin

“…If 1 or both interventions prove to be effective in reducing stress and improving psychosocial and physical complains, the StressProffen eHealth interventions could be beneficial, inexpensive, and easily implementable tools for breast cancer survivors when coping with late effects after cancer and cancer treatments. Trial RegistrationClinicaltrials.gov NCT04480203; https://clinicaltrials.gov/ct2/show/NCT04480203 International Registered Report Identifier (IRRID)DERR1-10.2196/47195…”
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Comprehensive Transcriptome Analysis Reveals the Distinct Gene Expression Patterns of Tumor Microenvironment in HPV-Associated and HPV-Non Associated Tonsillar Squamous Cell Carcin... by Reham M. Alahmadi, Najat Marraiki, Mohammed Alswayyed, Hatim A. Khoja, Abdullah E. Al-Anazi, Rawan M. Alahmadi, Meshael M. Alkusayer, Bandar Alosaimi, Maaweya Awadalla

“…Understanding the interaction between cancer inflammation, immunity, oncogenes, and tumor suppressor genes is essential for developing effective cancer treatments. This study aimed to gain a comprehensive understanding of the transcriptomes of the TME in TSCC, both associated with human papillomavirus (HPV) and not associated with HPV. …”
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Early reduction in cardiorespiratory fitness and diastolic reserve following radiation therapy for lung cancer by Georgia Thomas, Elisabeth Weiss, Marco Giuseppe Del Buono, Francesco Moroni, Josh West, Rachel Myers, Emily Kontos, Michele Golino, Antonio Abbate, Justin M. Canada

“…Cardiorespiratory fitness (CRF) is an independent predictor of cardiovascular, cancer-related, and overall mortality and may serve as a sensitive measure of subclinical cardiac toxicity following anti-cancer treatments. Prior work has demonstrated a significant relationship between reduced CRF and impaired left-ventricular (LV) diastolic reserve in cancer survivors following thoracic radiotherapy. …”
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Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells by Mohamed S. Nafie, Mohamed S. Nafie, Abdullah Mohammed Al-Majid, M. Ali, Abdulmajeed Abdullah Alayyaf, Matti Haukka, Sajda Ashraf, Zaheer Ul-Haq, Ayman El-Faham, Assem Barakat

“…Cancer represents a global challenge, and the pursuit of developing new cancer treatments that are potent, safe, less prone to drug resistance, and associated with fewer side effects poses a significant challenge in cancer research and drug discovery. …”
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Antioxidant activities, polyphenolic profile and chemopreventive properties of Cyphomandra betacea L. ethanolic extract on human breast and liver adenocarcinoma cells by Abdul Mutalib, Maisarah

“…The synergistic combination of tamarillo with commercial chemotherapy drug opens a new possible approach in the cancer treatments that are more effective and less toxic effect.…”
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Energy Metabolism, Metabolite, and Inflammatory Profiles in Human Ex Vivo Adipose Tissue Are Influenced by Obesity Status, Metabolic Dysfunction, and Treatment Regimes in Patients... by Fiona O’Connell, Eimear Mylod, Noel E. Donlon, Aisling B. Heeran, Christine Butler, Anshul Bhardwaj, Sinead Ramjit, Michael Durand, Gerard Lambe, Paul Tansey, Ivan Welartne, Kevin P. Sheahan, Xiaofei Yin, Claire L. Donohoe, Narayanasamy Ravi, Margaret R. Dunne, Lorraine Brennan, John V. Reynolds, Helen M. Roche, Jacintha O’Sullivan

“…This study demonstrates that the adipose secretome in OAC patients is enriched with mediators that could prime the tumour microenvironment to aid tumour progression and attenuate responses to conventional cancer treatments, an effect which appears to be augmented by obesity and metabolic dysfunction and exposure to different treatment regimes.…”
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Histological and safety evaluation of cockle shell-derived CaCO₃ nanoparticle loaded with doxorubicin in dogs by Abubakar, Danmaigoro

“…Detrimental tissue effects are associated with chemotherapeutics, despite research progress in cancer treatments. Difficulties are still encountered with tumour targeting due to cancer structural complexity. …”
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Autologous Tumor-Infiltrating Lymphocyte Mono-Therapy Can Rapidly Shrank Tumor in Asian Patient with Stage III/IV Cervical Cancer: Two Cases Report by Li F, Wang Y, Yan J, Wu H, Du X, Feng W, Zhang X, Xue Y, Wang H, Liu W

“…Trial registration number: NCT05366478.Keywords: tumor-infiltrating lymphocytes, clinical response, immune response, metastatic cervical cancer, treatment…”
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