An Aspect of the History of Medicine in Ancient Korea as Examined through Silla Buddhist Monks’Annotations on the “Chapter on Eliminating Disease” in the Sutra of Golden Light... by Chaekun OH, Jongwook JEON, Dongwon SHIN

“…The medical knowledge of Wonhyo, Gyeongheung, and Seungjang demonstrates that intellectual circles in contemporary Silla were arenas in which not only traditional East Asian medicine as represented by works such as the Inner Canon of the Yellow Emperor (Huangdi Neijing) but also Indian medicine of Buddhism coexisted in almost real time.…”
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DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight by Vicky A. Cameron, Gregory T. Jones, L. John Horwood, Anna P. Pilbrow, Julia Martin, Chris Frampton, Wendy T. Ip, Richard W. Troughton, Charlotte Greer, Jun Yang, Michael J. Epton, Sarah L. Harris, Brian A. Darlow

“…In neonates, methylation at over 16,400 CpG methylation sites differed between VLBW cases and controls and the canonical pathway most enriched for these CpGs was Cardiac Hypertrophy Signaling (p = 3.44E−11). …”
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Nitrogen cycling in the deep sedimentary biosphere: nitrate isotopes in porewaters underlying the oligotrophic North Atlantic by S. D. Wankel, C. Buchwald, W. Ziebis, C. B. Wenk, M. F. Lehmann

“…Results indicate variability of reaction rates across and within the three boreholes that are generally consistent with the differential distribution of dissolved oxygen at this site, though not necessarily with the canonical view of how redox thresholds separate nitrate regeneration from dissimilative consumption spatially. …”
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Forward genetic screen in Caenorhabditis elegans suggests F57A10.2 and acp-4 as suppressors of C9ORF72 related phenotypes by XIN WANG, XIN WANG, Limin Hao, Taixiang Saur, Katelyn JOYAL, Ying Zhao, Desheng Zhai, Jie Li, Mochtar Pribadi, Giovanni Coppola, Bruce M Cohen, Edgar(Ned) A Buttner

“…Eight suppressor genes carrying nonsense canonical splicing site mutations were confirmed, among which a nonsense mutation of F57A10.2 VAMP was found in all three mutant strains, and a nonsense mutation of acp-4 ACP2 was only found in EAB164. …”
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Spore density and root colonization by arbuscular mycorrhizal fungi in preserved or disturbed Araucaria angustifolia (Bert.) O. Ktze. ecosystems Densidade de esporos e colonização... by Milene Moreira, Dilmar Baretta, Siu Mui Tsai, Elke Jurandy Bran Nogueira Cardoso

“…This study aimed at surveying data on the spore density and root colonization (CR) by arbuscular mycorrhizal fungi (AMF) in Araucaria angustifolia forest ecosystems, in order to discriminate natural, implemented, and anthropic action-impacted ecosystems, by means of Canonical Discriminant Analysis (CDA). Three ecosystems representative of the Campos do Jordão (SP, Brazil) region were selected: 1. a native forest (FN); 2. a replanted Araucaria forest (R); and 3. a replanted Araucaria forest, submitted to accidental fire (RF). …”
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The Automated External Defibrillator: Heterogeneity of Legislation, Mapping and Use across Europe. New Insights from the ENSURE Study by Enrico Baldi, Niccolò B. Grieco, Giuseppe Ristagno, Hajriz Alihodžić, Valentine Canon, Alexei Birkun, Ruggero Cresta, Diana Cimpoesu, Carlo Clarens, Julian Ganter, Andrej Markota, Pierre Mols, Olympia Nikolaidou, Martin Quinn, Violetta Raffay, Fernando Rosell Ortiz, Ari Salo, Remy Stieglis, Anneli Strömsöe, Ingvild Tjelmeland, Stefan Trenkler, Jan Wnent, Jan-Thorsten Grasner, Bernd W. Böttiger, Simone Savastano

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Urgency Of The Application Of Sharia Guarantee In Islamic Banking In Indonesia by Syaugi Seff, Muhammad Syarif Hidayatullah

“…Based on the above problems, this study proposes to look at the application of guarantee law in Islamic banking and legal issues that arise related to the implementation of collateral in Islamic banking related to the Western canon, and the offer of the need for sharia security that is based on Islamic law. …”
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A quorum-sensing regulatory cascade for siderophore-mediated iron homeostasis in Chromobacterium violaceum by Bianca B. Batista, Vinicius M. de Lima, Beatriz A. Picinato, Tie Koide, José F. da Silva Neto

“…However, genes related to iron homeostasis and many other processes were regulated by CviR but not CviI, suggesting that CviR acts without its canonical CviI autoinducer. Our data revealed a complex regulatory cascade involving QS that controls siderophore-mediated iron homeostasis in C. violaceum.IMPORTANCEThe iron-chelating compounds siderophores play a major role in bacterial iron acquisition. …”
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Age-Related Risk Factors and Complications of Patients With COVID-19: A Population-Based Retrospective Study by Han Zhang, Yingying Wu, Yuqing He, Xingyuan Liu, Mingqian Liu, Yuhong Tang, Xiaohua Li, Guang Yang, Gang Liang, Shabei Xu, Minghuan Wang, Wei Wang

“…Multivariate logistic regression analyses were used to explore the risk factors for death from COVID-19. Canonical correlation analysis (CCA) was performed to study the associations between comorbidities and complications.Results: There are 36,358 patients in the final cohort, of whom 2,492 (6.85%) died. …”
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Composição da comunidade fitoplanctônica no estuário do rio Apodi-Mossoró, Semiárido brasileiro by Jônnata Fernandes de Oliveira, Rogério Taygra Vasconcelos Fernandes, José Luís Costa Novaes, Rodrigo Fernandes, Rodrigo Silva da Costa

“…For the identification of the main factors responsible for the data variance, the Principal Component Analysis was performed and the variations in the phytoplankton abundance were evaluated using the Correspondence Analysis and Canonical-Correlation Analysis. The Apodi-Mossoró River estuary is a thermally stable tropical ecosystem, influenced by the seasonality of drought and rainy periods. …”
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Development and validation of machine learning models for predicting prognosis and guiding individualized postoperative chemotherapy: A real-world study of distal cholangiocarcinom... by Di Wang, Bing Pan, Jin-Can Huang, Qing Chen, Song-Ping Cui, Ren Lang, Shao-Cheng Lyu

“…Variables identified as independently associated with the primary outcome by least absolute shrinkage and selection operator (LASSO) regression, the random survival forest (RSF) algorithm, and univariate and multivariate Cox regression analyses were introduced to establish the following different machine learning models and canonical regression model: support vector machine (SVM), SurvivalTree, Coxboost, RSF, DeepSurv, and Cox proportional hazards (CoxPH). …”
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Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression by Peifeng Ruan, Jamie L Todd, Hongyu Zhao, Yi Liu, Richard Vinisko, Julia F. Soellner, Ramona Schmid, Robert J. Kaner, Tracy R. Luckhardt, Megan L. Neely, Imre Noth, Mary Porteous, Rishi Raj, Zeenat Safdar, Mary E Strek, Christian Hesslinger, Scott M. Palmer, Thomas B. Leonard, Margaret L. Salisbury

“…Biological characteristics of the molecular subtypes were evaluated via linear regression differential expression and canonical pathways (Ingenuity Pathway Analysis [IPA]) over-representation analyses. …”
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Lrg1 Regulates β (1,3)-Glucan Masking in <named-content content-type="genus-species">Candida albicans</named-content> through the Cek1 MAP Kinase Pathway by Tian Chen, Andrew S. Wagner, Robert N. Tams, James E. Eyer, Sarah J. Kauffman, Eric R. Gann, Elias J. Fernandez, Todd B. Reynolds

“…Unmasking and Cek1 activation in the lrg1ΔΔ mutant can be blocked by inhibition of the Ste11 MAP kinase kinase kinase (MAPKKK), indicating that the lrg1ΔΔ mutant acts through the canonical Cek1 MAP kinase cascade. In order to determine how Cek1 hyperactivation specifically impacts virulence, a doxycycline-repressible hyperactive STE11ΔN467 allele was expressed in C. albicans. …”
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Utilización de información molecular en programas de mejoramiento animal by Javier Cañón

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CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality by Carlo Sorrentino, Luigi D’Antonio, Stefania Livia Ciummo, Cristiano Fieni, Lorena Landuzzi, Francesca Ruzzi, Simone Vespa, Paola Lanuti, Lavinia Vittoria Lotti, Pier Luigi Lollini, Emma Di Carlo

“…Here, we shed light on the relationship between IL30 and canonical PC driver genes and explored the anti-tumor potential of CRISPR/Cas9-mediated deletion of IL30. …”
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El método científico en las ciencias de la salud by Wilson Cañón-Montañez

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Importance of water quality on plant abundance and diversity in high-alpine meadows of the Yerba Loca Natural Sanctuary at the Andes of north-central Chile Importancia de la calida... by ROSANNA GINOCCHIO, JOSEFINA HEPP, ELENA BUSTAMANT, YASNA SILVA, LUZ MARÍA DE LA FUENTE, JEAN FRANCOIS CÁSALE, JEAN PAUL DE LA HARPE, PAOLA URRESTARAZU, VINKA ANIC, GLORIA MONTENEGRO

“…Direct gradient analysis was performed through canonical correspondence analysis (CCA) to look for relationships among water chemistry and plant factors. …”
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Early mechanisms of neutrophil activation and transmigration in acute lung injury by L. A. Cagle, A. L. Linderholm, A. L. Linderholm, A. L. Linderholm, L. M. Franzi, J. A. Last, S. I. Simon, N. J. Kenyon, N. J. Kenyon, N. J. Kenyon, R. W. Harper, R. W. Harper, R. W. Harper

“…LPS-induced lung injury resulted in upregulation of CD11b+ neutrophils and shedding of CD62L and CD162 regardless of DUOX expression, whereas VILI resulted in upregulation of CD49+ neutrophils in the Duoxa+/+ (WT) mice but not the Duoxa−/− (KO) mice.Conclusion:Our data suggest DUOX is required for CD18-independent mechanisms of neutrophil recruitment in the lung induced by acute lung injury, but not for canonical CD18depedent mechanisms after LPS exposure.…”
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Spectral Signatures of Hydrogen Thioperoxide (HOSH) and Hydrogen Persulfide (HSSH): Possible Molecular Sulfur Sinks in the Dense ISM by Charles Z. Palmer, Ryan C. Fortenberry, Joseph S. Francisco

“…The present theoretical study couples the accuracy in the anharmonic fundamental vibrational frequencies from the explicitly correlated coupled cluster theory with the accurate rotational constants provided by canonical high-level coupled cluster theory to produce rovibrational spectra for use in the potential observation of HOSH and HSSH. …”
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Novel targeting of PEGylated liposomes for codelivery of TGF-&beta;1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quanti... by Niu NK, Yin JJ, Yang YX, Wang ZL, Zhou ZW, He ZX, Chen XW, Zhang XJ, Duan W, Yang TX, Zhou SF

“…The Ingenuity Pathway Analysis data showed that there were over 40 signaling pathways involved in the proteomic responses to NP-siRNA liposome exposure in human macrophages, with 160 proteins mapped. The top five canonical signaling pathways were eukaryotic initiation factor 2 signaling, actin cytoskeleton signaling, remodeling of epithelial adherens junctions, epithelial adherens junction signaling, and Rho GDP-dissociation inhibitor signaling pathways. …”
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