Anthropogenic activities impact on water quality, fish community and bacteria presence in disturbed and undisturbed North Selangor Peat Swamp Forest, Malaysia by Aliu, Sule Hussein

“…Statistical analyses employed include ANOVA and Turkey LSD, Kruskal-Wallis and Mann- Whitney tests, Principal Component Analysis (PCA) and Canonical Correspondence Analysis (CCA). In addition, fish community structure was calculated using Shannon- Weaver diversity, Pielou’s evenness and Margalef’s richness indexes. …”
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Effect of logging on timaliidae diversity and abundance in Berkelah Forest Reserve, Pahang, Malaysia by Mohd Fauzi, Nor Azlin

“…Most of the Timaliidae species were strongly associated to trees with dbh of 30 cm–50 cm and above as well as shrubs. Based on the canonical correspondence analysis, General Linear Model Statistic (GLMS) and regression analysis, it was found that there were three (3) parameters that are significantly and strongly associated with the presence of bird species based on their preference namely understorey temperature, soil temperature and humidity. …”
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The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient by Chris Happé, Kondababu Kurakula, Xiao-Qing Sun, Denielli da Silva Goncalves Bos, Nina Rol, Christophe Guignabert, Ly Tu, Ingrid Schalij, Karien C. Wiesmeijer, Olga Tura-Ceide, Anton Vonk Noordegraaf, Frances S. de Man, Harm Jan Bogaard, Marie-José Goumans

“…The activation of the BMP pathway was analyzed by determining the level and localization of phosphorylated Smad1/5/8 (pSmad 1/5/8), a downstream mediator of canonical BMPR2 signaling. <b>Results:</b> While BMPR2 and pSmad 1/5/8 expression levels were unaltered in whole lung lysates/homogenates from patients with hereditary and idiopathic PAH, IF analysis showed that BMPR2 and pSmad 1/5/8 levels were markedly decreased in the pulmonary vessels of both PAH patient groups. …”
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A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses by Kara M. Pryke, Jinu Abraham, Tina M. Sali, Bryan J. Gall, Iris Archer, Andrew Liu, Shelly Bambina, Jason Baird, Michael Gough, Marita Chakhtoura, Elias K. Haddad, Ilsa T. Kirby, Aaron Nilsen, Daniel N. Streblow, Alec J. Hirsch, Jessica L. Smith, Victor R. DeFilippis

“…This showed that the compound requires a TRIF-dependent signaling cascade that culminates in IFN regulatory factor 3 (IRF3)-dependent expression and secretion of type I interferon to elicit antiviral responses. The other canonical IRF3-terminal adaptor proteins STING and IPS-1/MAVS were dispensable for AV-C-induced phenotypes. …”
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Neuroanatomical underpinnings of autism symptomatology in carriers and non-carriers of the 22q11.2 microdeletion by Maria Gudbrandsen, Anke Bletsch, Caroline Mann, Eileen Daly, Clodagh M. Murphy, Vladimira Stoencheva, Charlotte E. Blackmore, Maria Rogdaki, Leila Kushan, Carrie E. Bearden, Declan G. M. Murphy, Michael C. Craig, Christine Ecker

“…We employed a 2-by-2 factorial design to identify neuroanatomical variability associated with the main effects of 22q11.2DS and ASD, as well as their interaction. Further, using canonical correlation analysis (CCA), we compared neuroanatomical variability associated with the complex (i.e., multivariate) clinical phenotype of ASD between 22q11.2 deletion carriers and non-carriers. …”
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Salinity changes the nitrification activity and community composition of comammox Nitrospira in intertidal sediments of Yangtze River estuary by Ran Jiang, Wen-Jing Qin, Ru-Yi Zhang, Kai Zhang, Xing Huang, Yong Li, Chen-Hao Zhou, Ting Zhu, Yan Zhang, Bin Zou, Ming Nie, Sung-Keun Rhee, Zhe-Xue Quan

“…Here, we demonstrate the effect of salinity on comammox Nitrospira, canonical ammonia-oxidizing bacteria (AOB), and ammonia-oxidizing archaea (AOA) in the intertidal sediments of the Yangtze River estuary based on microcosm experiments, DNA stable-isotope probing (DNA-SIP), and potential ammonium-oxidation rate (PAR) tests for different groups of ammonia oxidizers with selective inhibitors. …”
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Oral Immunization of Larvae and Juvenile of Lumpfish (<i>Cyclopterus lumpus</i>) against <i>Vibrio anguillarum</i> Does Not Influence Systemic Immunity by My Dang, Trung Cao, Ignacio Vasquez, Ahmed Hossain, Hajarooba Gnanagobal, Surendra Kumar, Jennifer R. Hall, Jennifer Monk, Danny Boyce, Jillian Westcott, Javier Santander

“…Vaccine intake and immune response were evaluated by microscopy and quantitative polymerase chain reaction (qPCR) analysis, respectively. qPCR analyses showed that the oral immunization of lumpfish larvae resulted in a subtle stimulation of canonical immune transcripts such as <i>il8b</i>, <i>il10</i>, <i>igha</i>, <i>ighmc</i>, <i>ighb</i>, <i>ccl19</i>, <i>ccl20</i>, <i>cd8a</i>, <i>cd74</i>, <i>ifng</i>, and <i>lgp2</i>. …”
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Prevalence of Vertebral Fractures and Their Prognostic Significance in the Survival in Patients with Chronic Kidney Disease Stages 3‒5 Not on Dialysis by Cristina Castro-Alonso, Luis D’Marco, Jaume Pomes, Monserrat Del Amo Conill, Ana Isabel García-Diez, Pablo Molina, María Jesús Puchades, José Manuel Valdivielso, Verónica Escudero, Jordi Bover, Juan Navarro-González, Begoña Ribas, Luis Manuel Pallardo, José Luis Gorriz

“…Three radiologists specialized in musculoskeletal radiology performed consensual reading of individual images obtained using a Raim DICOM Viewer and a Canon EOS 350 camera to measure with Java Image software in those who had traditional acetate X-ray. …”
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Dual thick and thin filament linked regulation of stretch- and L-NAME-induced tone in young and senescent murine basilar artery by Lubomir T. Lubomirov, Lubomir T. Lubomirov, Lubomir T. Lubomirov, Mechthild M. Schroeter, Mechthild M. Schroeter, Veronika Hasse, Marina Frohn, Doris Metzler, Maria Bust, Galyna Pryymachuk, Galyna Pryymachuk, Jürgen Hescheler, Olaf Grisk, Olaf Grisk, Joseph M. Chalovich, Neil R. Smyth, Gabriele Pfitzer, Symeon Papadopoulos

“…While in y-and o-BA the canonical pathways, i.e., inhibition of MLCP by ROK and increase in pMLC20, predominate, tone regulation in senescence involves ROK regulated mechanisms, involving non-muscle-myosin and thin filament linked mechanisms involving caldesmon.…”
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Linguistic profile automated characterisation in pluripotential clinical high-risk mental state (CHARMS) conditions: methodology of a multicentre observational study by Andrea Amerio, Lisa Marzano, Andrea Aguglia, Alessandra Costanza, Gianluca Serafini, Mario Amore, Luca Carmisciano, Luca Magnani, Felice dell’Orletta, Ornella Bettinardi, Silvia Chiesa, Massimiliano Imbesi, Giuliano Limonta, Elisa Montagna, Ilaria Turone, Dario Martinasso, Francesca Sibilla, Pietro Calcagno, Sara Patti, Gabriella Molino, Andrea Escelsior, Alice Trabucco, Dominique Brunato, Andrea Amelio Ravelli, Marco Cappucciati, Roberta Fiocchi, Gisella Guerzoni, Davide Maravita, Fabio Macchetti, Elisa Mori, Chiara Anna Paglia, Federica Roscigno, Antonio Saginario

“…However, the relationship between language and high-order cognition seems to evade this canonical and unidirectional description (ie, the notion of language as a simple means of thought communication). …”
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HypoxamiRs Profiling Identify miR-765 as a Regulator of the Early Stages of Vasculogenic Mimicry in SKOV3 Ovarian Cancer Cells by Yarely M. Salinas-Vera, Dolores Gallardo-Rincón, Raúl García-Vázquez, Olga N. Hernández-de la Cruz, Laurence A. Marchat, Juan Antonio González-Barrios, Erika Ruíz-García, Carlos Vázquez-Calzada, Estefanía Contreras-Sanzón, Martha Resendiz-Hernández, Horacio Astudillo-de la Vega, José L. Cruz-Colin, Alma D. Campos-Parra, César López-Camarillo

“…Data showed that after 48 h hypoxia and 12 h incubation on matrigel SKOV3 ovarian cancer cells undergo the formation of matrix-associated intercellular connections referred hereafter as 3D channels-like structures, which arose previous to the apparition of canonical tubular structures representative of VM. …”
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Raman microspectroscopy reveals unsaturation heterogeneity at the lipid droplet level and validates an in vitro model of bone marrow adipocyte subtypes by Josefine Tratwal, Guillaume Falgayrac, Alexandrine During, Nicolas Bertheaume, Charles Bataclan, Daniel N. Tavakol, Vasco Campos, Ludovic Duponchel, George Q. Daley, Guillaume Penel, Christophe Chauveau, Olaia Naveiras, Olaia Naveiras, Olaia Naveiras

“…We observed similar canonical adipogenesis transcriptional signatures for spontaneously-differentiated (sOP9) and induced (iOP9) cultures, while fatty acid composition and desaturase expression of Scd1 and Fads2 differed at the population level. …”
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circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling by Lin Zheng, Hui Liang, Qiaoling Zhang, Zichu Shen, Yixin Sun, Xuyang Zhao, Jingjing Gong, Zhiyuan Hou, Kewei Jiang, Quan Wang, Yan Jin, Yuxin Yin

“…Although the roles of canonical PTEN protein and PTEN isoforms have been extensively explored, the current understanding of PTEN family members cannot fully illustrate the diversity of their roles in biological processes and tumor development. …”
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A Novel Vaccine Strategy Employing Serologically Different Chimpanzee Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection by Felicity Hartnell, Anthony Brown, Stefania Capone, Jakub Kopycinski, Carly Bliss, Shokouh Makvandi-Nejad, Leo Swadling, Emma Ghaffari, Paola Cicconi, Mariarosaria Del Sorbo, Roberta Sbrocchi, Ilaria Esposito, Ventzislav Vassilev, Paula Marriott, Clair M. Gardiner, Ciaran Bannan, Colm Bergin, Matthias Hoffmann, Bethany Turner, Alfredo Nicosia, Alfredo Nicosia, Alfredo Nicosia, Antonella Folgori, Tomáš Hanke, Tomáš Hanke, Eleanor Barnes, Eleanor Barnes, Lucy Dorrell, Lucy Dorrell

“…Intracellular cytokine analysis indicated that the responding populations comprised polyfunctional CD4+ and CD8+ T cells. Canonical pathway analysis showed that in the single and combined vaccination groups, pathways associated with antiviral and innate immune responses were enriched for upregulated interferon-stimulated genes 24 h after priming and boosting vaccinations.Conclusions: Serologically distinct adenoviral vectors encoding HCV and HIV-1 immunogens can be safely co-administered without reducing the immunogenicity of either vaccine. …”
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A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis by Mona Bensalah, Laura Muraine, Alexis Boulinguiez, Lorenzo Giordani, Victorine Albert, Victor Ythier, Jamila Dhiab, Alison Oliver, Valentine Hanique, Teresa Gidaro, Sophie Perié, Jean Lacau St‐Guily, Aurélien Corneau, Gillian Butler‐Browne, Anne Bigot, Vincent Mouly, Elisa Negroni, Capucine Trollet

“…This effect is likely linked to the increased activation of the canonical TGFβ‐SMAD pathway in FAPs from fibrotic muscles evidenced by pSMAD3 immunostaining (P < 0.05). …”
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Differentiation of hypervirulent and classical Klebsiella pneumoniae with acquired drug resistance by Thomas A. Russo, Cassandra L. Alvarado, Connor J. Davies, Zachary J. Drayer, Ulrike Carlino-MacDonald, Alan Hutson, Ting L. Luo, Melissa J. Martin, Brendan W. Corey, Kara A. Moser, J. Kamile Rasheed, Alison L. Halpin, Patrick T. McGann, Francois Lebreton

“…Biomarker number, siderophore production, mucoviscosity, virulence plasmid’s Mash/Jaccard distances to the canonical pLVPK, and Kleborate virulence score were measured and evaluated to accurately differentiate these pathotypes. …”
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In vitro Evaluation of the Anti-inflammatory Effects of Thymoquinone in Osteoarthritis and in silico Analysis of Inter-Related Pathways in Age-Related Degenerative Diseases by Gauthaman Kalamegam, Gauthaman Kalamegam, Gauthaman Kalamegam, Gauthaman Kalamegam, Saadiah M. Alfakeeh, Afnan Omar Bahmaid, Etimad A. AlHuwait, Mamdouh A. Gari, Mamdouh A. Gari, Mamdouh A. Gari, Mohammed M. Abbas, Mohammed M. Abbas, Farid Ahmed, Farid Ahmed, Muhammed Abu-Elmagd, Muhammed Abu-Elmagd, Peter Natesan Pushparaj, Peter Natesan Pushparaj

“…IPA of the molecular interaction of TQ in inflammation and age-related degenerative diseases identified canonical pathways directly related to synaptogenesis, neuroinflammation, TGF-β, and interleukin signaling. …”
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N-terminal region is responsible for mHv1 channel activity in MDSCs by Antonio Peña-Pichicoi, Antonio Peña-Pichicoi, Miguel Fernández, Miguel Fernández, Nieves Navarro-Quezada, Nieves Navarro-Quezada, Juan J. Alvear-Arias, Juan J. Alvear-Arias, Christian A. Carrillo, Christian A. Carrillo, Emerson M. Carmona, Jose Garate, Jose Garate, Angelica M. Lopez-Rodriguez, Alan Neely, Alan Neely, Erick O. Hernández-Ochoa, Carlos González, Carlos González, Carlos González

“…Specifically, the longest isoform, mHv1.2, displays a right-shifted conductance–voltage (GV) curve and slower opening kinetics, compared to the mid-length isoform, mHv1.3, and the shortest canonical isoform, mHv1.1. While mHv1.3 exhibits a V0.5 similar to that of mHv1.1, mHv1.3 demonstrates significantly slower activation kinetics than mHv1.1. …”
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New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex by E. Crampon, E. Covernton, M. C. Vaney, M. Dellarole, S. Sommer, A. Sharma, A. Haouz, P. England, J. Lepault, S. Duquerroy, F. A. Rey, G. Barba-Spaeth

“…The X-ray structure of the YFV pr/sE complex shows essentially the same pattern of interactions reported for dengue virus, while the X-ray structure of YFV sE at neutral pH shows the same canonical head-to-tail sE dimer. pr binding to the sE dimer is precluded by the E “150-loop,” indicating it must adopt a different conformation in the E dimers on virions at acidic pH for pr binding. …”
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Native CGRP Neuropeptide and Its Stable Analogue SAX, But Not CGRP Peptide Fragments, Inhibit Mucosal HIV-1 Transmission by Jammy Mariotton, Anette Sams, Emmanuel Cohen, Alexis Sennepin, Gabriel Siracusano, Francesca Sanvito, Lars Edvinsson, Nicolas Barry Delongchamps, Marc Zerbib, Lucia Lopalco, Morgane Bomsel, Yonatan Ganor

“…This inhibition is mediated via activation of the CGRP receptor non-canonical NFκB/STAT4 signaling pathway that induces a variety of cooperative mechanisms. …”
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