The developmental and evolutionary roles of isoforms of regulator of G protein signalling 3 in neuronal differentiation by Fleenor, S

“…The negative regulatory role which all isoforms play in different cell-biological contexts is intriguing in light of the fact that they all share a C-terminal RGS domain, which canonically negatively regulates G protein signalling. …”

Molecular and cellular analysis of the membrane binding C2 domain of Notch ligands in health and disease by Meng, Y

“…In particular, the N-terminal C2 domain, with distinct lipid-binding and Notch-binding faces, present in all canonical mammalian Notch ligands, has been suggested to modulate activation through its membrane-binding capacity.…”

Snapshots of Early Modern English responses to French poets by Auger, P

“…</p><p>TCP texts allow us to supplement the findings of earlier research on English responses to canonical French poets like Joachim Du Bellay and Pierre de Ronsard. …”

Molecular mechanisms of recombination hotspots in humans by Noor, N

“…</p> <p>We first explored the relationship between PRDM9 binding and DNA sequence, to directly confirm whether PRDM9 binds to the 13-bp hotspot motif using in-vitro gel-shift assays, and found that it does bind sequence specifically to the canonical 13-mer motif. PRDM9 is able to bind the motif in a highly selective manner, with certain single base pair changes abolishing binding. …”

Assessment and translation of novel biomarkers for diagnosis of maturity onset diabetes of the young due to HNF1A variants by Juszczak, A

“…Furthermore, the combination of functional assessment and clinical phenotype can guide management in those without canonical monogenic phenotypes found to have variant <em>HNF1A</em> alleles.…”

Next generation sequencing to identify new genetic causes of familial craniosynostosis by Hashimoto, A

“…</p> <p>In a second large family with syndromic metopic synostosis, a nonsynonymous variant in <em>HIST1H2AD</em>, encoding one of the canonical histone H2A components of the nucleosome, was identified. …”

Hepcidin regulation in Malaria by Spottiswoode, N

“…Chapter 2 presents data from a mouse model of malaria infection which indicate that hepcidin upregulation in malaria infection is associated with increased activity of the sons of mothers against decapentaplegic (Smad) signaling pathway. Although the canonical Smad pathway activators, bone morphogenetic proteins (Bmp) are not increased at the message level following infection, activin B, which has been recently shown to increase hepcidin through the Smad signaling pathway in conditions of inflammation and infection, is upregulated in the livers of malaria-infected mice. …”

Fish biodiversity and assemblages along the altitudinal gradients of tropical mountainous forest streams by Soo, Chen Lin, Lee Nyanti, Nur Ezaimah Idris, Ling, Teck Yee, Sim, Siong Fong, Jongkar Grinang, Tonny Ganyai, Lee, Karen Suan Ping

“…This phenomenon is apparent when the Canonical Correspondence Analysis (CCA) revealed that the frst axis (CCA1) explained 42.5% of the variation and has positive loading on dissolved oxygen (DO) and negative loading on water conductivity; whereas CCA2 explained 37.5% of the variation and positively loaded on elevation, water pH, and DO. …”
Get full text
Get full text

Diversity and spatial pattern of ground-dwelling ants in different habitat types, Kalabakan, Sabah by Muhammad Afif Zakaria

“…Species richness was significantly higher in OG (121) than in LF (105) and OP (70) (ANOVA, df=2, F=89.869, p<0.001). Canonical Correspondence Analysis (CCA) showed that air temperature, canopy cover, abundance of low vegetation, abundance of liana, soil pH, forest quality and litter depth influenced the ants’ assemblage. …”
Get full text
Get full text

Practice of code of ethics and accuracy in reporting by print media criminal court reporters by Musalayah, Mageswari

“…For journalists in Malaysia, they have their own Canons of Journalism (COJ) since 1989 (Shivadas & Krishnamoorthy, 2004) but there is no watchdog to oversee that such code of conduct of news media is strictly adhered to by the journalists (Kamarul Ariffin, 1996). …”
Get full text

Morphometrics of selected forest babbler species and genetic variations of Black-capped Babbler [Pellorneum capistratum, (Temminck, 1823)] in Peninsular Malaysia by Abdl Jalil, Norehan

“…However, the DFA was not conducted for the Black-capped Babbler due to small sample size for females. Based on canonical function plots for Short-tailed and Chestnut-winged Babblers, there is no difference in morphometric measurements for all individuals at four sampling sites. …”
Get full text

Catch composition, diversity and temporal changes in trawl net fishery in inshore waters of Bintulu Coast, Sarawak, Malaysia by Kumar, Uttam

“…No significant temporal difference was found on chlorophyll a and water nutrients. Canonical Correspondence Analysis (CCA) indicated that dissolved oxygen, total suspended solid (TSS), rainfall and salinity were the most important ecological factors affecting fish assemblage structure. …”
Get full text

C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma by Nabizadeh, Jamileh A., Manthey, Helga D., Panagides, Nadya, Steyn, Frederik J., Lee, John D., Li, Xaria X., M. Akhir, Fazrena N., Chen, Weiyu, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M., Rolfe, Barbara E.

“…The canonical complement component 5a (C5a) receptor (C5aR) 1 has well-described roles in tumorigenesis but the contribution of the second receptor, C5aR2, is unclear. …”

Progress in Constraining Nuclear Symmetry Energy Using Neutron Star Observables Since GW170817 by Bao-An Li, Bao-Jun Cai, Wen-Jie Xie, Nai-Bo Zhang

“…Based on various model analyses of these new data by many people in the nuclear astrophysics community, while our brief review might be incomplete and biased unintentionally, we learned in particular the following: (1) The slope parameter <i>L</i> of nuclear symmetry energy at saturation density <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>ρ</mi><mn>0</mn></msub></semantics></math></inline-formula> of nuclear matter from 24 new analyses of neutron star observables was about <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>L</mi><mo>≈</mo><mn>57.7</mn><mo>±</mo><mn>19</mn></mrow></semantics></math></inline-formula> MeV at a 68% confidence level, consistent with its fiducial value from surveys of over 50 earlier analyses of both terrestrial and astrophysical data within error bars. (2) The curvature <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>K</mi><mi>sym</mi></msub></semantics></math></inline-formula> of nuclear symmetry energy at <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>ρ</mi><mn>0</mn></msub></semantics></math></inline-formula> from 16 new analyses of neutron star observables was about <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>K</mi><mi>sym</mi></msub><mo>≈</mo><mo>−</mo><mn>107</mn><mo>±</mo><mn>88</mn></mrow></semantics></math></inline-formula> MeV at a 68% confidence level, in very good agreement with the systematics of earlier analyses. (3) The magnitude of nuclear symmetry energy at <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>2</mn><msub><mi>ρ</mi><mn>0</mn></msub></mrow></semantics></math></inline-formula>, i.e., <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>E</mi><mi>sym</mi></msub><mrow><mo>(</mo><mn>2</mn><msub><mi>ρ</mi><mn>0</mn></msub><mo>)</mo></mrow><mo>≈</mo><mn>51</mn><mo>±</mo><mn>13</mn></mrow></semantics></math></inline-formula> MeV at a 68% confidence level, was extracted from nine new analyses of neutron star observables, consistent with the results from earlier analyses of heavy-ion reactions and the latest predictions of the state-of-the-art nuclear many-body theories. (4) While the available data from canonical neutron stars did not provide tight constraints on nuclear symmetry energy at densities above about <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>2</mn><msub><mi>ρ</mi><mn>0</mn></msub></mrow></semantics></math></inline-formula>, the lower radius boundary <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>R</mi><mrow><mn>2.01</mn></mrow></msub><mo>=</mo><mn>12.2</mn></mrow></semantics></math></inline-formula> km from NICER’s very recent observation of PSR J0740+6620 of mass <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>2.08</mn><mo>±</mo><mn>0.07</mn></mrow></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>M</mi><mo>⊙</mo></msub></semantics></math></inline-formula> and radius <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>R</mi><mo>=</mo><mn>12.2</mn><mo>–</mo><mn>16.3</mn></mrow></semantics></math></inline-formula> km at a 68% confidence level set a tight lower limit for nuclear symmetry energy at densities above <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>2</mn><msub><mi>ρ</mi><mn>0</mn></msub></mrow></semantics></math></inline-formula>. (5) Bayesian inferences of nuclear symmetry energy using models encapsulating a first-order hadron–quark phase transition from observables of canonical neutron stars indicated that the phase transition shifted appreciably both <i>L</i> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>K</mi><mi>sym</mi></msub></semantics></math></inline-formula> to higher values, but with larger uncertainties compared to analyses assuming no such phase transition. (6) The high-density behavior of nuclear symmetry energy significantly affected the minimum frequency necessary to rotationally support GW190814’s secondary component of mass (2.50–2.67) <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>M</mi><mo>⊙</mo></msub></semantics></math></inline-formula> as the fastest and most massive pulsar discovered so far. …”
Get full text

Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity by Yi Wang, David Carbone, Zihai Li, Margaret Gatti-Mays, Yiping Yang, Kai He, Anqi Li, Qin Ma, Yuzhou Chang, No-Joon Song, Xingjun Wu, Dongjun Chung, Brian P Riesenberg, Maria Velegraki, Giuseppe D Giuliani, Komal Das, Tamio Okimoto, Hyunwoo Kwon, Karthik B Chakravarthy, Chelsea Bolyard, Jayajit Das, Daniel T Gewirth

“…Mechanistically, PIIO-1 treatment reduces canonical TGFβ signaling in tumor-infiltrating immune cells, prevents T cell exhaustion, and enhances CD8+ T cell migration into the TME in a C-X-C motif chemokine receptor 3 (CXCR3)-dependent manner.Conclusion GARP contributes to multiple aspects of immune resistance in cancer. …”
Get full text

Sustained release of a highly specific GSK3β inhibitor SB216763 in the PCL scaffold creates an osteogenic niche for osteogenesis, anti-adipogenesis, and potential angiogenesis by Weimin Gong, Molin Li, Lizhou Zhao, Pengtao Wang, Xiaofang Wang, Bo Wang, Xing Liu, Xiaolin Tu

“…Here, we show that S33 initiates canonical Wnt signaling by inhibiting GSK3β activity in the bone marrow stromal cell line ST2 and increases osteoblast marker alkaline phosphatase activity, osteoblast marker gene expression including Alpl, Col1α1, and Runx2, promoting osteogenic differentiation and mineralization of ST2 cells. …”
Get full text

A Generic Pixel Pitch Calibration Method for Fundus Camera via Automated ROI Extraction by Tengfei Long, Yi Xu, Haidong Zou, Lina Lu, Tianyi Yuan, Zhou Dong, Jiqun Dong, Xin Ke, Saiguang Ling, Yingyan Ma

“…In consequence, the pixel pitch of a fundus image of 45° FOV can be directly estimated according to the automatically measured diameter of ROI in the pixel, and results show the pixel pitches of Canon CR2, Topcon NW400, Zeiss Visucam 200, and Newvision RetiCam 3100 cameras are 6.825 ± 0.666 μm, 6.625 ± 0.647 μm, 5.793 ± 0.565 μm, and 5.884 ± 0.574 μm, respectively. …”
Get full text

N-acylethanolamide metabolizing enzymes are upregulated in human neural progenitor-derived neurons exposed to sub-lethal oxidative stress by R. Scott Duncan, Sean M. Riordan, Conner W. Hall, Andrew J. Payne, Kent D. Chapman, Peter Koulen, Peter Koulen, Peter Koulen

“…In this study, we determined whether ReN cells, a superior cell model system for studying neurodevelopment, differentiation, and neuroprotection, express proteins involved in canonical eCB NAE signaling and whether oxidative stress can induce their expression. …”
Get full text

Tryptophan metabolism and gut flora profile in different soybean protein induced enteritis of pearl gentian groupers by Wei Zhang, Wei Zhang, Wei Zhang, Aobo Pang, Aobo Pang, Aobo Pang, Beiping Tan, Beiping Tan, Beiping Tan, Yu Xin, Yu Xin, Yu Xin, Yu Liu, Yu Liu, Yu Liu, Ruitao Xie, Haitao Zhang, Qihui Yang, Qihui Yang, Qihui Yang, Junming Deng, Junming Deng, Junming Deng, Shuyan Chi, Shuyan Chi, Shuyan Chi

“…According to the “3 + 2” full-length transcriptome sequencing, soy meals at the three experimental levels inhibited the key gene expressions of tryptophan metabolic pathway in fish gut, however, there are some differences in the types of key genes that are inhibited. The canonical correlation analysis showed that the changes in key gene expressions in tryptophan metabolic pathway had a positive correlation with the expressions of pro-inflammatory genes (P &lt; 0.05) and negatively correlated with the expression of anti-inflammatory genes (P &lt; 0.05). …”
Get full text

Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure by Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee

“…The complement system, a key effector of the innate immune system, produces the C5–cleaved activation product C5a upon activation, initiating inflammatory responses through the canonical C5a receptor 1 (C5aR1). While C5aR1 is expressed in stress-responsive brain regions, its role in stress responsiveness remains unknown. …”
Get full text