Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroima... by Yanyi Xu, Junru Liu, Yonghui Tian, Zuo Wang, Zan Song, Kemin Li, Shengxiang Zhang, Haiyu Zhao

“…In a very recent study, making full use of a zebrafish model in both high-throughput behavioral tracking and live neuroimaging, we explored the potential developmental neurotoxicity of Cd²⁺ at environmentally relevant levels and identified multiple connections between Cd²⁺ exposure and neurodevelopmental disorders as well as microglia-mediated neuroinflammation, whereas the underlying neurotoxic mechanisms remained unclear. The canonical Wnt/β-catenin signaling pathway plays crucial roles in many biological processes including neurodevelopment, cell survival, and cell cycle regulation, as well as microglial activation, thereby potentially presenting one of the key targets of Cd²⁺ neurotoxicity. …”
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Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells by Agata Lampart, Katarzyna Dominika Sluzalska, Aleksandra Czyrek, Aleksandra Szerszen, Jacek Otlewski, Antoni Wiedlocha, Malgorzata Zakrzewska

“…Fibroblast growth factor 1 (FGF1) is considered primarily as a ligand for FGF surface receptors (FGFRs) through which it activates a number of cellular responses. In addition to its canonical mode of action, FGF1 can act intracellularly, before secretion or after internalization and translocation from the cell exterior. …”
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Effect of Remotely Supervised Weight Loss and Exercise Training Versus Lifestyle Counseling on Cardiovascular Risk and Clinical Outcomes in Older Adults With Rheumatoid Arthritis:... by Brian J. Andonian, Leanna M. Ross, Alyssa M. Sudnick, Johanna L. Johnson, Carl F. Pieper, Kelsey B. Belski, Julie D. Counts, Alyssa P. King, Jessica T. Wallis, William C. Bennett, Jillian C. Gillespie, Kaileigh M. Moertl, Dylan Richard, Janet L. Huebner, Margery A. Connelly, Ilene C. Siegler, William E. Kraus, Connie W. Bales, Kathryn N. Porter Starr, Kim M. Huffman

“…Compared with CHAT, SWET significantly improved body weight, fat mass, Disease Activity Score‐28 C‐reactive protein, and patient‐reported physical health, physical function, mental health, and fatigue (P < 0.04 for all between‐group comparisons). Based on canonical correlations for fat mass, cardiorespiratory fitness, and leg strength, component‐specific effects were strongest for (1) weight loss improving MSSc, physical health, and mental health; (2) aerobic training improving physical function and fatigue; and (3) resistance training improving Disease Activity Score‐28 C‐reactive protein. …”
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The inviscid incompressible limit of Kelvin–Helmholtz instability for plasmas by A. Briard, J.-F. Ripoll, J.-F. Ripoll, A. Michael, B.-J. Gréa, G. Peyrichon, M. Cosmides, M. Cosmides, H. El-Rabii, M. Faganello, V. G. Merkin, K. A. Sorathia, A. Y. Ukhorskiy, J. G. Lyon, A. Retino, V. Bouffetier, L. Ceurvorst, H. Sio, O. A. Hurricane, V. A. Smalyuk, A. Casner

“…Magnetized KHI is a canonical case for benchmarking hydrocode simulations with extended MHD options.Methods: An objective is to assess whether or not, and under which conditions, the incompressibility hypothesis allows to describe a dynamic compressible system. …”
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Retained Acetylated Histone Four in Bull Sperm Associated With Fertility by Muhammet Rasit Ugur, Naseer Ahmad Kutchy, Naseer Ahmad Kutchy, Erika Bezerra de Menezes, Asma Ul-Husna, Bethany Peyton Haynes, Alper Uzun, Alper Uzun, Alper Uzun, Abdullah Kaya, Einko Topper, Arlindo Moura, Erdogan Memili

“…The results are significant because it demonstrates the replacement of canonical histone H4 into modified H4 acetylation in sperm and regulate its dynamics which is crucial for bull fertility and reproductive biotechnology. …”
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Identification of drivers of mycobacterial resistance to peptidoglycan synthesis inhibitors by Francisco Olivença, Cláudia Ferreira, Alexandra Nunes, Alexandra Nunes, Cátia Silveiro, Madalena Pimentel, João Paulo Gomes, João Paulo Gomes, Maria João Catalão

“…Mutations in L,D-transpeptidases and major PBPs, canonical targets, or BlaC were not found. The transcriptional regulator PhoP (Rv0757) emerged as a common denominator for Mtb resistance to both amoxicillin and meropenem, while Rv2864c, a lipoprotein with PBP activity, appears to be specifically involved in decreased susceptibility to the carbapenem. …”
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CITEViz: interactively classify cell populations in CITE-Seq via a flow cytometry-like gating workflow using R-Shiny by Garth L. Kong, Thai T. Nguyen, Wesley K. Rosales, Anjali D. Panikar, John H. W. Cheney, Theresa A. Lusardi, William M. Yashar, Brittany M. Curtiss, Sarah A. Carratt, Theodore P. Braun, Julia E. Maxson

“…Results We applied CITEViz to a peripheral blood mononuclear cell CITE-Seq dataset and gated for several major blood cell populations (CD14 monocytes, CD4 T cells, CD8 T cells, NK cells, B cells, and platelets) using canonical surface protein markers. The visualization features of CITEViz were used to investigate cellular heterogeneity in CD14 and CD16-expressing monocytes and to detect differential numbers of detected antibodies per patient donor. …”
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Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells by Filip Bergqvist, Elena Ossipova, Helena Idborg, Joan Raouf, Antonio Checa, Karin Englund, Petter Englund, Payam Emami Khoonsari, Kim Kultima, Craig E. Wheelock, Karin Larsson, Marina Korotkova, Per-Johan Jakobsson

“…Our proteomics results revealed that CIII downregulated multiple canonical pathways including eIF2, eIF4/P70S6K, and mTOR signaling, compared to NS-398 that activated these pathways. …”
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Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway by Carla Lima, Aline Ingrid Andrade-Barros, Jefferson Thiago Gonçalves Bernardo, Eniko Balogh, Valerie F. Quesniaux, Bernhard Ryffel, Monica Lopes-Ferreira

“…Natterin is a potent pro-inflammatory fish molecule, inducing local and systemic IL-1β/IL-1R1-dependent neutrophilia mediated by non-canonical NLRP6 and NLRC4 inflammasome activation in mice, independent of NLRP3. …”
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Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation by Liying Shan, Xiaoli Yang, Xiaoxia Liao, Zheng Yang, Jie Zhou, Xiaoxia Li, Baoli Wang

“…KDM7A suppresses osteoblast differentiation and bone formation through. upregulating FAP expression and inactivating canonical Wnt signaling, and conversely promotes osteoclast differentiation and bone resorption through upregulating RANKL expression. …”
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Environmental determinants and demographic influences on global urban microbiomes, antimicrobial resistance and pathogenicity by Yang Chen, Xi Fu, Zheyuan Ou, Jiang Li, Simiao Lin, Yaoxuan Wu, Xuwei Wang, Yiqun Deng, Yu Sun

“…The β-diversity of urban microbiome was shaped by seven environmental characteristics, including Köppen climate type, vegetation type, greenness fraction, soil type, PM2.5 concentration, annual average precipitation and temperature (PERMANOVA, p < 0.001, R 2 = 0.01–0.06), cumulatively accounted for 20.3% of the microbial community variance. Canonical correspondence analysis (CCA) identified microbial species most strongly associated with environmental characteristic variation. …”
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Measuring forest health at stand level: A multi-indicator evaluation for use in adaptive management and policy by Shiekh Marifatul Haq, Muhammad Waheed, Aadil Abdullah Khoja, Muhammad Shoaib Amjad, Rainer W. Bussmann, Kishwar Ali, David Aaron Jones

“…The Pearson method and canonical correspondence analysis (CCA) were used to investigate the relationship between tree species and edaphic factors. …”
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Computerised cognitive assessment in patients with traumatic brain injury: an observational study of feasibility and sensitivity relative to established clinical scalesResearch in... by Martina Del Giovane, William R. Trender, Maria Bălăeţ, Emma-Jane Mallas, Amy E. Jolly, Niall J. Bourke, Karl Zimmermann, Neil S.N. Graham, Helen Lai, Ethan J.F. Losty, Garazi Araña Oiarbide, Peter J. Hellyer, Irene Faiman, Sarah J.C. Daniels, Philippa Batey, Matthew Harrison, Valentina Giunchiglia, Magdalena A. Kolanko, Michael C.B. David, Lucia M. Li, Célia Demarchi, Daniel Friedland, David J. Sharp, Adam Hampshire

“…Between September 2019 and February 2020, we evaluated the online battery against standard face-to-face neuropsychological tests at the Imperial College London research centre. Canonical Correlation Analysis (CCA) determined the shared variance between the online battery and standard neuropsychological tests. …”
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MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study by Ah Young Park, Mi-Ryung Han, Bo Kyoung Seo, Hye-Yeon Ju, Gil Soo Son, Hye Yoon Lee, Young Woo Chang, Jungyoon Choi, Kyu Ran Cho, Sung Eun Song, Ok Hee Woo, Hyun Soo Park

“…Gene networks, enriched functions, and canonical pathways were analyzed using Ingenuity Pathway Analysis. …”
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Ultrastructural analysis of zinc oxide nanospheres enhances anti-tumor efficacy against Hepatoma by Amr Hassan, Fawziah A. Al-Salmi, Tamer M. M. Abuamara, Emadeldin R. Matar, Mohamed E. Amer, Ebrahim M. M. Fayed, Mohamed G. A. Hablas, Tahseen S. Mohammed, Haytham E. Ali, Fayez M. Abd EL-fattah, Wagih M. Abd Elhay, Mohammad A. Zoair, Aly F. Mohamed, Eman M. Sharaf, Eldessoky S. Dessoky, Fahad Alharthi, Hussam Awwadh E. Althagafi, Ahmed I. Abd El Maksoud

“…Interestingly, the appearance of canonical ultrastructure features of apoptotic morphology of Huh7, Furthermore, many vacuoles existed in the cytoplasm, the majority of which were lipid droplets, which were like foamy cells. …”
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A Novel Glutathione <i>S</i>-Transferase Gtt2 Class (VpGSTT2) Is Found in the Genome of the AHPND/EMS <i>Vibrio parahaemolyticus</i> Shrimp Pathogen by Ignacio Valenzuela-Chavira, David O. Corona-Martinez, Karina D. Garcia-Orozco, Melissa Beltran-Torres, Filiberto Sanchez-Lopez, Aldo A. Arvizu-Flores, Rocio Sugich-Miranda, Alonso A. Lopez-Zavala, Ramon E. Robles-Zepeda, Maria A. Islas-Osuna, Adrian Ochoa-Leyva, Michael D. Toney, Hugo Serrano-Posada, Rogerio R. Sotelo-Mundo

“…The crystal structure showed a canonical two-domain structure comprising a glutathione binding G-domain and a hydrophobic ligand H domain. …”
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A novel gluconeogenic route enables efficient use of erythritol in zoonotic Brucella by Leticia Lázaro-Antón, Maria Veiga-da-Cunha, Aitor Elizalde-Bielsa, Nathalie Chevalier, Raquel Conde-Álvarez, Maite Iriarte, Jean Jacques Letesson, Ignacio Moriyón, Emile Van Schaftingen, Amaia Zúñiga-Ripa

“…While Brucella sugar and erythritol catabolic pathways are known, growth on 3–4 carbon substrates persists in Fbp- and GlpX-deleted mutants, the canonical gluconeogenic fructose 1,6-bisphosphate (F1,6bP) bisphosphatases. …”
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The <i>CDH1</i> c.1901C>T Variant: A Founder Variant in the Portuguese Population with Severe Impact in mRNA Splicing by Rita Barbosa-Matos, Rafaela Leal Silva, Luzia Garrido, Ana Cerqueira Aguiar, José Garcia-Pelaez, Ana André, Susana Seixas, Sónia Passos Sousa, Luísa Ferro, Lúcia Vilarinho, Irene Gullo, Vitor Devezas, Renata Oliveira, Susana Fernandes, Susy Cabral Costa, André Magalhães, Manuela Baptista, Fátima Carneiro, Hugo Pinheiro, Sérgio Castedo, Carla Oliveira

“…We validated the cryptic splice site within <i>CDH1</i>-exon 12, which was preferred over the canonical one in 100% of sequenced clones. Cryptic splicing induced an out-of-frame 37bp deletion in exon 12, premature truncation (<i>p.Ala634ProfsTer7</i>), and consequently RNA mediated decay. …”
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Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression by Xu-Qiao Chen, Carlos A. Barrero, Rodrigo Vasquez-Del Carpio, E. Premkumar Reddy, Chiara Fecchio, Salim Merali, Alessia Deglincerti, Cheng Fang, Jack Rogers, Maria L. Maccecchini

“…Conversely, Posiphen did not bind the IRP1/IRE complex of mRNAs with canonical IREs, and the translation of these mRNAs was not affected by Posiphen. …”
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Structural-functional connectivity bandwidth of the human brain by Nicholas Parsons, Julien Ugon, Kerri Morgan, Sergiy Shelyag, Alex Hocking, Su Yuan Chan, Govinda Poudel, Juan F. Domìnguez D, Karen Caeyenberghs

“…We then mapped paths with the highest SC-FC Bandwidth across 7 canonical resting-state networks. Findings: We found that most pairs of FC nodes were connected by SC paths of length two and three (SC paths of length >5 were virtually non-existent). …”
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