Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs by Kanbin Wang, Chengwei Zhou, Lijun Li, Chengxin Dai, Zhongxiang Wang, Weijun Zhang, Jianxiang Xu, Yueliang Zhu, Zhijun Pan

“…Conclusions Our study demonstrates the dual effects of AU in not only promoting bone-fracture healing by regulating osteogenesis of hBM-MSCs partly via canonical BMP2/Smads signaling pathway but also suppressing oxidative stress damage partly via Nrf2/HO1 signaling pathway.…”
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New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies by Agata Ciechanowska, Ewelina Rojewska, Anna Piotrowska, Justyna Barut, Katarzyna Pawlik, Katarzyna Ciapała, Grzegorz Kreiner, Joanna Mika

“…Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in nociceptive transmission; however, the participation of its two receptors, canonical chemokine-C-motif receptor 1 (XCR1) and integrin alpha-9 (ITGA9), recently recognized as a second receptor, has not been clarified to date. …”
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La "zona desierta" de lo fantástico argentino: narradoras en la primera mitad del siglo XX by Gabriela Nájera

“…This “wild zone” –which is verified in anthologies and studies of the genre– is striking, as it contradicts what happened in that geographical territory in that period, when Darío, Lugones, Holmberg and Quiroga published works that led to the fantastic short story acquiring the status of canonical literature. While it is true that female authors did not achieve the recognition that the aforementioned writers did, they did venture into fantastic literature, but their works remained, for the most part, on the pages of periodicals. …”
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Work Fluctuations in Ergotropic Heat Engines by Giovanni Chesi, Chiara Macchiavello, Massimiliano Federico Sacchi

“…We study the work fluctuations in ergotropic heat engines, namely two-stroke quantum Otto engines where the work stroke is designed to extract the ergotropy (the maximum amount of work by a cyclic unitary evolution) from a couple of quantum systems at canonical equilibrium at two different temperatures, whereas the heat stroke thermalizes back the systems to their respective reservoirs. …”
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Functional Linear and Nonlinear Brain–Heart Interplay during Emotional Video Elicitation: A Maximum Information Coefficient Study by Vincenzo Catrambone, Alberto Greco, Enzo Pasquale Scilingo, Gaetano Valenza

“…The functional linear and nonlinear couplings are quantified using the maximum information coefficient calculated between time-varying electroencephalography (EEG) power spectra within the canonical bands (<inline-formula> <math display="inline"> <semantics> <mrow> <mi>&#948;</mi> <mo>,</mo> <mi>&#952;</mi> <mo>,</mo> <mi>&#945;</mi> <mo>,</mo> <mi>&#946;</mi> </mrow> </semantics> </math> </inline-formula> and <inline-formula> <math display="inline"> <semantics> <mi>&#947;</mi> </semantics> </math> </inline-formula>), and time-varying low-frequency and high-frequency powers from heartbeat dynamics. …”
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In the Model Host <i>Caenorhabditis elegans</i>, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria by Kiho Lee, Iliana Escobar, Yeeun Jang, Wooseong Kim, Frederick M. Ausubel, Eleftherios Mylonakis

“…Here, we report an evolutionally conserved function for S1P and a non-canonical role for S1P transporters in the <i>C. elegans</i> immune response to bacterial pathogens. …”
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Association of <i>SLC12A1</i> and GLUR4 Ion Transporters with Neoadjuvant Chemoresistance in Luminal Locally Advanced Breast Cancer by Montserrat Justo-Garrido, Alejandro López-Saavedra, Nicolás Alcaraz, Carlo C. Cortés-González, Luis F. Oñate-Ocaña, Claudia Haydee Sarai Caro-Sánchez, Clementina Castro-Hernández, Cristian Arriaga-Canon, José Díaz-Chávez, Luis A. Herrera

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Low-Rank Gradient Descent by Romain Cosson, Ali Jadbabaie, Anuran Makur, Amirhossein Reisizadeh, Devavrat Shah

“…In this article, we leverage such low-rank structure to reduce the high computational cost of canonical gradient-based methods such as gradient descent (<monospace>GD</monospace>). …”
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Phylogenomic, structural, and cell biological analyses reveal that Stenotrophomonas maltophilia replicates in acidified Rab7A-positive vacuoles of Acanthamoeba castellanii by Javier Rivera, Julio C. Valerdi-Negreros, Diana M. Vázquez-Enciso, Fulvia-Stefany Argueta-Zepeda, Pablo Vinuesa

“…Phylogenomic and structural analyses of the 11 Neff Rab7 paralogs found in the RefSeq assembly revealed that eight of them had non-canonical sequences. After correcting the gene annotation for the Rab7A ortholog, we generated a line stably expressing an mEGFP-Rab7A fusion, demonstrating its correct localization to acidified macropinocytic and phagocytic vacuoles using fluorescence microscopy live cell imaging (LCI). …”
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Analysis of Signal Transduction Pathways Downstream M2 Receptor Activation: Effects on Schwann Cell Migration and Morphology by Elisabetta Botticelli, Michael Sebastian Salazar Intriago, Roberta Piovesana, Ada Maria Tata

“…Conclusions: The data obtained demonstrated that M2 receptor activation in addition to the canonical Gi protein-coupled pathway modulates noncanonical pathways involving the mTORC1 complex and other kinases whose activation may contribute to the inhibition of SC proliferation and migration and address SC differentiation.…”
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Tablets as an Option for Telemedicine—Evaluation of Diagnostic Performance and Efficiency in Intracranial Arterial Aneurysm Detection by Elif Can, Pimrapat Gebert, Elisa Birgit Sodemann, Johannes Kolck, Thula Canon Walter-Rittel, Anna Maaßen, Christopher Güttler, Juliane Stöckel, Georg Bohner, Georg Böning

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Differentially expressed microRNAs in peripheral blood cell are associated with downregulated expression of IgE in nonallergic childhood asthma by Jyh-Hong Lee, Li-Chieh Wang, Yu-Tsan Lin, Yao-Hsu Yang, Hsin-Hui Yu, Ya-Chiao Hu, Bor-Luen Chiang

“…Differentially expressed miRNA signatures associate with downregulation of total IgE expression and predicted target mRNA genes related molecular networks contribute to canonical pathways of nonallergic childhood asthma. …”
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Book Reviews by Anja Klein, Bo Krister Ljungberg, Carl Johan Berglund, Cecilia Wassén, Cian Power, Jan Retsö, Joel Kuhlin, Josef Forsling, LarsOlov Eriksson, Magnus Halle, Martin Wessbrandt, Mikael Larsson, Mikael Tellbe, Paul Linjamaa, Stefan Green, Stig Norin, Tobias Ålöw, Torsten Löfstedt

“…Engle (red.), Remarriage After Divorce in Today’s Church (Bo Krister Ljungberg)  Willgren, David, The Formation of the ‘Book’ of Psalms: Reconsidering the Transmission and Canonization of Psalmody in Light of Material Culture and the Poetics of Anthologies (Anja Klein) Wright, Tom, The Day the Revolution Began: Rethinking the Meaning of Jesus’ Crucifixion (Mikael Tellbe) …”
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An Index for Graphs and Graph Groupoids by Ilwoo Cho, Palle Jorgensen

“…If a graph groupoid <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="double-struck">G</mi></semantics></math></inline-formula><i>G</i> contains at least one loop-reduced finite path, then the order of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="double-struck">G</mi></semantics></math></inline-formula> is infinity; hence, the canonical groupoid index <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mfenced separators="" open="[" close="]"><mi mathvariant="double-struck">G</mi><mo>:</mo><mi mathvariant="double-struck">K</mi></mfenced></semantics></math></inline-formula> of the inclusion <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="double-struck">K</mi><mo>⊆</mo><mi mathvariant="double-struck">G</mi></mrow></semantics></math></inline-formula> is either <i>∞</i> or 1 (under the definition and a natural axiomatization) for the graph groupoids <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="double-struck">K</mi></semantics></math></inline-formula> of all “parts” <i>K</i> of <i>G</i>. …”
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Fotografía, voluntad e incertidumbre by José Cuevas Martín

“…La esencia del pueblo alemán, retratada por medio de atletas apolíneos, de voces altivas y decorados grandilocuentes de mármol y granito, como rememoración de aquel arte clásico grecolatino, regido por cánones geométricos, y aquí entendido de cartón piedra, tiende la mano al principio de indeterminación, verdadera espada de Damocles suspendida sobre la cabeza de la física moderna, e interpretado por el físico alemán como un baluarte de las relaciones formales, puras y geométricas, que definen la esencia del mundo y de las cosas. …”
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Eficiência bionutricional de animais da raça Nelore, F1s Valdostana-Nelore e de mestiços de raças européias adaptadas Bio-nutritional efficiency of Nellore, Valdostana-Nellore F1's... by K. Euclides Filho, G.R. Figueiredo, V.P.B. Euclides, E.C. Vaz, J.B. Trovo, A.G. Razook, L.A. Figueiredo, L.O.C. Silva, V. Rocco

“…<br>Five genetic groups were evaluated by bio-nutritional efficiency (index obtained from the first canonical function in a bivariate analysis encompassing weight gain and dry matter intake): six Nellore (N), five 1/2Romosinuano-1/2Caracu (RSC), four 1/2Senepol-1/2Caracu (SEC), four 1/2Belmont Red-1/2 Caracu (BRC) and seven 1/2Valdostana-1/2Nellore (VAN). …”
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Grapevine Rootstocks Differently Affect Physiological and Molecular Responses of the Scion under Water Deficit Condition by Bhakti Prinsi, Fabio Simeoni, Massimo Galbiati, Franco Meggio, Chiara Tonelli, Attilio Scienza, Luca Espen

“…The present work evaluated the performance of the 101.14 and M4 rootstocks in graft combination with the cultivar Cabernet Sauvignon (Cab) by assessing some of the canonical molecular, biochemical and physiological responses induced by WD. …”
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Ciencia innatural Ciencia innatural by Medawar Peter

“…Thus, in the philosophy of great conservatism there is a canonical belief that the cradle of aman -his genetic constitution- determines absolutely his faculties, his destiny, and whatever happens to him in life; and no less characteristic of Marxism is the idea that, as men are born equal, aman is what his environment and education make bim . …”
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Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling. [version 1; peer review: 2 approved] by Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota

“…We have previously reported that PAWS1 associates with the Ser/Thr protein kinase CK1α through the DUF1669 domain to mediate canonical Wnt signalling. Methods: Co-immunoprecipitation was used to investigate possible changes to PAWS1 interactors caused by the mutations. …”
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A novel brain-controlled prosthetic hand method integrating AR-SSVEP augmentation, asynchronous control, and machine vision assistance by Xiaodong Zhang, Teng Zhang, Yongyu Jiang, Weiming Zhang, Zhufeng Lu, Yu Wang, Qing Tao

“…According to the attentional orienting characteristics of the paradigm, a novel asynchronous pattern recognition algorithm that combines center extended canonical correlation analysis and support vector machine (Center-ECCA-SVM) was proposed. …”
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