Discrimination of maize inbreds for kernel quality traits and fatty acid composition by a multivariate technique=Análise de linhagens de milho quanto às características de qualidad... by Fatih Kahrıman, Cem Ömer Egesel, Muhammet Kemal Gül

“…A new statistical approach, Canonical Discriminant Analysis with Hypothesis-Error plot technique was utilized to evaluate the data. …”
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A Mesorhizobium japonicum quorum sensing circuit that involves three linked genes and an unusual acyl-homoserine lactone signal by Zehui Suo, Dale A. Cummings, Aaron W. Puri, Amy L. Schaefer, E. Peter Greenberg

“…Indeed, we report that an additional gene is required for synthesis of the unique signal, and we propose that this is a three-component QS circuit as opposed to the canonical two-component AHL QS circuits. The signaling system is exquisitely selective. …”
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ACUTE MYELOID LEUKEMIA IN COMPLETE RESPONSE FOR 2 YEARS WITH AZACYTIDINE ASSOCIATED WITH HIGH-DOSE VITAMINS by VM Sthel, VLP Figueiredo

“…Vitamin B1 - cofactor in the pyruvate dehydrogenase enzyme complex, as thiamine triphosphate, which prevents the transformation of pyruvate into lactate and favors respiration through the Krebs cycle, cofactor in the metabolism of alpha-ketoglutarate, and decreases the formation of 2-hydroxyglutarate (DNA methylation), activation of the immune system, and increased neoplastic cell death via P53 (non-canonical pathway, PUMA and NOXA). Vitamin C - cofactor in the Krebs cycle reaction involving the TET2 and IDH2 genes, promoting DNA demethylation, immunomodulatory effects activating antiretroviral reactions, and increased VDR expression in primitive hematopoietic cells. …”
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Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein by Alice J. Stelfox, Kasopefoluwa Y. Oguntuyo, Ilona Rissanen, Karl Harlos, Robert Rambo, Benhur Lee, Thomas A. Bowden

“…Crystallographic analysis of the C-terminal head region of the dimeric MosV and NarV RBPs demonstrates that while these glycoproteins retain the canonical six-bladed β-propeller fold found in other paramyxoviral RBPs, they lack the structural motifs associated with established paramyxovirus host-cell receptor entry pathways. …”
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Genomes from Uncultivated Pelagiphages Reveal Multiple Phylogenetic Clades Exhibiting Extensive Auxiliary Metabolic Genes and Cross-Family Multigene Transfers by Fabian Wittmers, David M. Needham, Elisabeth Hehenberger, Stephen J. Giovannoni, Alexandra Z. Worden

“…Together, these functions have important implications for phage evolution and for how Pelagiphage infection influences host biology in manners extending beyond canonical viral lysis and mortality.…”
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Francesco Borosini – tenorista a impresário by Claudia Michels

“…V roce 1747 pobýval Borosini podruhé v Londýně, kde vystupuje jako vydavatel díla One Hundred Cantici in Italian after the manner of English Canons and Catches. Po návratu do Vídně se stal poradcem barona Loprestiho (impresária vídeňského dvorního divadla a jakožto následovníka Sellierova také Divadla u Korutanské brány) a v roce 1749 sepsal paměti s názvem Memoria del Sigr. …”
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RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing by Marta Mellini, Morgana Letizia, Lorenzo Caruso, Alessandra Guiducci, Carlo Meneghini, Stephan Heeb, Paul Williams, Miguel Cámara, Paolo Visca, Francesco Imperi, Livia Leoni, Giordano Rampioni

“…ABSTRACTIn its canonical interpretation, quorum sensing (QS) allows single cells in a bacterial population to synchronize gene expression and hence perform specific tasks collectively once the quorum cell density is reached. …”
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Powstanie i rozwój Kościoła nowacjańskiego by Krzysztof Sordyl

“…Eppure non vi è modo di stabilire, anche approssimativamente, il numero di singole comunità. L’ottavo canone del concilio di Nicea presumeva che in alcuni posti la chiesa di Novaziano avesse attratto la totalità della popolazione cristiana. …”
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Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated‐Beta‐Catenin Signaling in Murine Liver and Human Liver Cancer Cells by Nirmala Mavila, Yuanyuan Tang, Joshua Berlind, Komal Ramani, Jiaohong Wang, José M. Mato, Shelly C. Lu

“…Conclusion: PHB1 acts as a negative regulator of WNT signaling, and its down‐regulation causes the induction of multiple WNT ligands and downstream activation of canonical WNT‐beta‐catenin signaling in murine liver and human HCC cells, in part through E2F1.…”
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Virtual Screening of Protein Data Bank via Docking Simulation Identified the Role of Integrins in Growth Factor Signaling, the Allosteric Activation of Integrins, and P-Selectin as... by Yoshikazu Takada, Masaaki Fujita, Yoko K. Takada

“…It has been well-established that platelet integrin αIIbβ3 is activated by signals from the inside of platelets induced by platelet agonists (inside-out signaling). In addition to the canonical inside-out signaling, we showed that αIIbβ3 can be allosterically activated by inflammatory cytokines/chemokines that are stored in platelet granules (e.g., CCL5, CXCL12) in the absence of inside-out signaling (e.g., soluble integrins in cell-free conditions). …”
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Unchanged nitrate and nitrite isotope fractionation during heterotrophic and Fe(II)-mixotrophic denitrification suggest a non-enzymatic link between denitrification and Fe(II) oxid... by Anna-Neva Visser, Scott D. Wankel, Claudia Frey, Andreas Kappler, Andreas Kappler, Moritz F. Lehmann

“…Here we investigated whether the type of organic substrate, i.e., short-chained organic acids, and the presence/absence of Fe(II) (mixotrophic vs. heterotrophic growth conditions) affect N and O isotope fractionation dynamics during nitrate (NO3–) and nitrite (NO2–) reduction in laboratory experiments with three strains of putative nitrate-dependent Fe(II)-oxidizing bacteria and one canonical denitrifier. Our results revealed that 15ε and 18ε values obtained for heterotrophic (15ε-NO3–: 17.6 ± 2.8‰, 18ε-NO3–:18.1 ± 2.5‰; 15ε-NO2–: 14.4 ± 3.2‰) vs. mixotrophic (15ε-NO3–: 20.2 ± 1.4‰, 18ε-NO3–: 19.5 ± 1.5‰; 15ε-NO2–: 16.1 ± 1.4‰) growth conditions are very similar and fall within the range previously reported for classical heterotrophic denitrification. …”
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Dysregulation of metabolic‐associated pathways in muscle of breast cancer patients: preclinical evaluation of interleukin‐15 targeting fatigue by Joseph Bohlen, Sarah L. McLaughlin, Hannah Hazard‐Jenkins, Aniello M. Infante, Cortney Montgomery, Mary Davis, Emidio E. Pistilli

“…Results RNA‐sequencing and subsequent bioinformatics analyses revealed a dysregulation of canonical pathways involved in oxidative phosphorylation, mitochondrial dysfunction, peroxisome proliferator‐activated receptor signalling and activation, and IL‐15 signalling and production. …”
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AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors by Michele C. Larsen, Catherine M. Rondelli, Ahmed Almeldin, Yong-Seok Song, Alhaji N’Jai, David L. Alexander, E. Camilla Forsberg, Nader Sheibani, Colin R. Jefcoate

“…PAH and allelic selectivity support a non-canonical AhR participation, possibly through RelA. …”
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Spike-Independent Infection of Human Coronavirus 229E in Bat Cells by Marcus G. Mah, Martin Linster, Dolyce H. W. Low, Yan Zhuang, Jayanthi Jayakumar, Firdaus Samsudin, Foong Ying Wong, Peter J. Bond, Ian H. Mendenhall, Yvonne C. F. Su, Gavin J. D. Smith

“…Maintenance of 229E viruses in bat cells appears to be independent of a canonical spike receptor match, which in turn might facilitate cross-species transmission in bats.…”
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Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model by Yitian Lu, Jintao Zhang, Fanning Zeng, Peng Wang, Xiangna Guo, Haitao Wang, Zaisheng Qin, Tao Tao

“…In addition, we showed that the miR-26a-5p in the sEVs regulated Wnt5a/Ryk/CaMKII/NFAT partly take part in the analgesia through anti-neuroinflammation, which suggests an alleviating pain effect through non-canonical Wnt signaling pathway in neuropathic pain model in vivo.…”
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A bacterial sensor taxonomy across earth ecosystems for machine learning applications by Helen Park, Marcin P. Joachimiak, Sean P. Jungbluth, Ziming Yang, William J. Riehl, R. Shane Canon, Adam P. Arkin, Paramvir S. Dehal

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Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability by Ruey-Wen Lin, Guang-Wu Chen, Hsiang-Hsuan Sung, Ren-Jye Lin, Li-Chen Yen, Yu-Ling Tseng, Yung-Kun Chang, Shu-Pei Lien, Shin-Ru Shih, Ching-Len Liao

“…Conclusions Our results thus suggest that the increased adaptability and epidemiological fitness of naturally arising human PB1–216G viruses, which have a canonical low-fidelity replicase, were the biological mechanisms underlying the replacement of PB1–216S viruses with a high-fidelity replicase following the emergence of pdmH1N1. …”
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Rainforest conversion to rubber and oil palm reduces abundance, biomass and diversity of canopy spiders by Daniel Ramos, Tamara R. Hartke, Damayanti Buchori, Nadine Dupérré, Purnama Hidayat, Mayanda Lia, Danilo Harms, Stefan Scheu, Jochen Drescher

“…Community composition of spiders was similar in rainforest and jungle rubber, but differed from rubber and oil palm, which also differed from each other. Canonical Correspondence Analysis showed that canopy openness, aboveground tree biomass and tree density together explained 18.2% of the variation in spider communities at family level. …”
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The PTSNtr-KdpDE-KdpFABC Pathway Contributes to Low Potassium Stress Adaptation and Competitive Nodulation of Sinorhizobium fredii by Xue-Ying Feng, Yu Tian, Wen-Jing Cui, Yue-Zhen Li, Dan Wang, Yanbo Liu, Jian Jiao, Wen-Xin Chen, Chang-Fu Tian

“…The unphosphorylated PtsN1 binds the sensory kinase KdpD through a non-canonical interaction with the GAF domain of KdpD, while the region covering HisKA-HATPase domains mediates the interaction of KdpD with the response regulator KdpE. …”
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“Scent blood, fangs drop”: 'Undead Memory' na trilogia 'Darkness Before Dawn' de J. A. London by Tânia Cerqueira

“…Through the analysis of this immortal being, which links the past to the present, it will also be explored as its presence in the dystopian society of Darkness Before Dawn forces the presence of the past, thus breaking with the destruction of memory, a common theme in canonical dystopias, like 'Swastika Night' by Katharine Burdekin (1937), 'Nineteen Eighty-Four' by George Orwell (1949) and 'Fahrenheit 451' by Ray Bradbury (1953).   …”
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