Raman microspectroscopy reveals unsaturation heterogeneity at the lipid droplet level and validates an in vitro model of bone marrow adipocyte subtypes by Josefine Tratwal, Guillaume Falgayrac, Alexandrine During, Nicolas Bertheaume, Charles Bataclan, Daniel N. Tavakol, Vasco Campos, Ludovic Duponchel, George Q. Daley, Guillaume Penel, Christophe Chauveau, Olaia Naveiras, Olaia Naveiras, Olaia Naveiras

“…We observed similar canonical adipogenesis transcriptional signatures for spontaneously-differentiated (sOP9) and induced (iOP9) cultures, while fatty acid composition and desaturase expression of Scd1 and Fads2 differed at the population level. …”
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A Novel Vaccine Strategy Employing Serologically Different Chimpanzee Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection by Felicity Hartnell, Anthony Brown, Stefania Capone, Jakub Kopycinski, Carly Bliss, Shokouh Makvandi-Nejad, Leo Swadling, Emma Ghaffari, Paola Cicconi, Mariarosaria Del Sorbo, Roberta Sbrocchi, Ilaria Esposito, Ventzislav Vassilev, Paula Marriott, Clair M. Gardiner, Ciaran Bannan, Colm Bergin, Matthias Hoffmann, Bethany Turner, Alfredo Nicosia, Alfredo Nicosia, Alfredo Nicosia, Antonella Folgori, Tomáš Hanke, Tomáš Hanke, Eleanor Barnes, Eleanor Barnes, Lucy Dorrell, Lucy Dorrell

“…Intracellular cytokine analysis indicated that the responding populations comprised polyfunctional CD4+ and CD8+ T cells. Canonical pathway analysis showed that in the single and combined vaccination groups, pathways associated with antiviral and innate immune responses were enriched for upregulated interferon-stimulated genes 24 h after priming and boosting vaccinations.Conclusions: Serologically distinct adenoviral vectors encoding HCV and HIV-1 immunogens can be safely co-administered without reducing the immunogenicity of either vaccine. …”
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A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis by Mona Bensalah, Laura Muraine, Alexis Boulinguiez, Lorenzo Giordani, Victorine Albert, Victor Ythier, Jamila Dhiab, Alison Oliver, Valentine Hanique, Teresa Gidaro, Sophie Perié, Jean Lacau St‐Guily, Aurélien Corneau, Gillian Butler‐Browne, Anne Bigot, Vincent Mouly, Elisa Negroni, Capucine Trollet

“…This effect is likely linked to the increased activation of the canonical TGFβ‐SMAD pathway in FAPs from fibrotic muscles evidenced by pSMAD3 immunostaining (P < 0.05). …”
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Differentiation of hypervirulent and classical Klebsiella pneumoniae with acquired drug resistance by Thomas A. Russo, Cassandra L. Alvarado, Connor J. Davies, Zachary J. Drayer, Ulrike Carlino-MacDonald, Alan Hutson, Ting L. Luo, Melissa J. Martin, Brendan W. Corey, Kara A. Moser, J. Kamile Rasheed, Alison L. Halpin, Patrick T. McGann, Francois Lebreton

“…Biomarker number, siderophore production, mucoviscosity, virulence plasmid’s Mash/Jaccard distances to the canonical pLVPK, and Kleborate virulence score were measured and evaluated to accurately differentiate these pathotypes. …”
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N-terminal region is responsible for mHv1 channel activity in MDSCs by Antonio Peña-Pichicoi, Antonio Peña-Pichicoi, Miguel Fernández, Miguel Fernández, Nieves Navarro-Quezada, Nieves Navarro-Quezada, Juan J. Alvear-Arias, Juan J. Alvear-Arias, Christian A. Carrillo, Christian A. Carrillo, Emerson M. Carmona, Jose Garate, Jose Garate, Angelica M. Lopez-Rodriguez, Alan Neely, Alan Neely, Erick O. Hernández-Ochoa, Carlos González, Carlos González, Carlos González

“…Specifically, the longest isoform, mHv1.2, displays a right-shifted conductance–voltage (GV) curve and slower opening kinetics, compared to the mid-length isoform, mHv1.3, and the shortest canonical isoform, mHv1.1. While mHv1.3 exhibits a V0.5 similar to that of mHv1.1, mHv1.3 demonstrates significantly slower activation kinetics than mHv1.1. …”
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New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex by E. Crampon, E. Covernton, M. C. Vaney, M. Dellarole, S. Sommer, A. Sharma, A. Haouz, P. England, J. Lepault, S. Duquerroy, F. A. Rey, G. Barba-Spaeth

“…The X-ray structure of the YFV pr/sE complex shows essentially the same pattern of interactions reported for dengue virus, while the X-ray structure of YFV sE at neutral pH shows the same canonical head-to-tail sE dimer. pr binding to the sE dimer is precluded by the E “150-loop,” indicating it must adopt a different conformation in the E dimers on virions at acidic pH for pr binding. …”
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Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single-cell RNA sequencing by Phillip Cohen, Emma J. DeGrace, Oded Danziger, Roosheel S. Patel, Erika A. Barrall, Tesia Bobrowski, Thomas Kehrer, Anastija Cupic, Lisa Miorin, Adolfo García-Sastre, Brad R. Rosenberg

“…After establishing a workflow that maximizes the detection of SARS-CoV-2 subgenomic mRNAs, we explore patterns of SARS-CoV-2 gene expression across cells with variable levels of total viral RNA, assess host gene expression differences between infected and bystander cells, and identify non-canonical and lowly abundant SARS-CoV-2 RNAs. The sequencing and data processing strategies developed here can enhance studies of coronavirus RNA biology at single-cell resolution and thereby contribute to our understanding of viral pathogenesis.…”
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„To nie była Ameryka”. Z Michaelem Charlesem Steinlaufem rozmawia Elżbieta Janicka (Warszawa – Nowy Jork – Warszawa, 2014–2015) by Elżbieta Janicka

“…The fate of the brothers was introduced into the canon of Polish culture by Hanna Krall’s short story Dybuk (1995, English edition 2005 as The Dybbuk) and its eponymous stage adaptation by Krzysztof Warlikowski (2003). …”
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The impact of utilizing oyster shell soil conditioner on the growth of tomato plants and the composition of inter-root soil bacterial communities in an acidic soil environment by Yi Zheng, Yi Zheng, Chaofan Yu, Yujun Xiao, Tinge Ye, Songgang Wang

“…The correlation analysis yielded conclusive evidence indicating that, which involved the use of CCA (Canonical Correlation Analysis) graphs and Spearman correlation coefficients, pH exhibited a positive correlation (p &lt; 0.05) with Shewanella and a negative correlation (p &lt; 0.05) with Bradyrhizobium. …”
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Alienación territorial a través del patrimonio mundial: análisis de la Lista del Patrimonio Mundial de América Latina y el Caribe desde la perspectiva de la geopolítica crítica... by Rocío Arroyo Belmonte

“…Se concluye que en el patrimonio mundial que se ubica en la región latinoamericana, pese a un proceso tardío de adhesión por desconfianza inicial a la convención de 1972, prevalece una subrepresentación frente a otras regiones del mundo, permean deficiencias estructurales entre países que impiden participar igualitariamente en los órganos decisorios y se presenta una forzada adopción de categorías patrimoniales que propicia una reproducción acrítica de narrativas históricas bajo cánones valorativos europeos. El resultado final es que muchos de estos territorios sufren un proceso de alienación donde se separa en forma artificial la relación entre ser humano y naturaleza, se menosprecia a las culturas originarias y se sobrevalora el legado del pasado colonial europeo, así como del cristianismo católico, lo cual repite una tradición extractivista y periférica de la región, absorbiendo o negando otras relaciones territoriales del pasado y presente.…”
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دور التصور في الربط بين التمثيل الذهني والتمثيل اللغوي في مواضيع ساكنة: دراسة تجريبية by جلال راعي, أحمد شمّو

“…LRI in Kurdish includes canonical copular clauses (CCCs), existential sentence + present perfect (Pre Per), and periphrastic factitive constructions but LRI in Arabic includes nominal sentences only. …”
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The Necessity of Ugliness Theory in Literary Texts: a case study of one poem in Hafiz’ Divine by javad Sattari, Hassan Heidari, Mohsen Zolfghary, Mehrdad Akbari gandomani

“…Rosankranz, like Walter Benjamin, emphasized the ugly nature of aesthetic canons and their active role in the metropolis. His collection of caricatures and popular prints is extensive. …”
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Tectonic of the offshore Manzanillo and Tecpan basins, Mexican Pacific, from heat flow, bathymetric and seismic data by M. D. Khutorskoyt, L. A. Delgado-Argotez, R. Fernández, V. I. Kononovt, B. G. Polyakt

“…En la región limitada por cañones submarinos de la Cuenca de Manzanillo, el perfilado sísmico y la batimetría indican levantamiento reciente asociado con Callamiento de desplazamiento lateral. …”
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Ictiofauna de sistemas cárstico-palustres con impacto antrópico: los petenes de Campeche, México by Ivette Liliana Torres-Castro, María Eugenia Vega-Cendejas, Juan Jacobo Schmitter-Soto, Gerardo Palacio-Aponte, Rocío Rodiles-Hernández

“…Environmental parameters (except salinity) presented significant differences by site and season; a canonical correspondence analysis indicated that the distribution of fish assemblages was influenced by the environmental parameters in both seasons. …”
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Diagonals of Rational Functions: From Differential Algebra to Effective Algebraic Geometry by Youssef Abdelaziz, Salah Boukraa, Christoph Koutschan, Jean-Marie Maillard

“…We show that the results we had previously obtained on diagonals of 9- and 10-parameter families of rational functions in three variables <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mspace width="0.166667em"></mspace><mi>x</mi></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mspace width="0.166667em"></mspace><mi>y</mi></mrow></semantics></math></inline-formula>, and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mspace width="0.166667em"></mspace><mi>z</mi></mrow></semantics></math></inline-formula>, using creative telescoping, yielding modular forms expressed as pullbacked <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mspace width="0.166667em"></mspace><mn>2</mn></msub><msub><mi>F</mi><mn>1</mn></msub></mrow></semantics></math></inline-formula> hypergeometric functions, can be obtained much more efficiently by calculating the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mspace width="0.166667em"></mspace><mi>j</mi></mrow></semantics></math></inline-formula>-invariant of an elliptic curve canonically associated with the denominator of the rational functions. …”
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Age estimation from mandibles in Malay: A 2D geometric morphometric analysis by Nur Ariessa Farhana Zulkifli, BDS, Nur Aliya Syuhada Mohd Saaid, BDS, Aspalilah Alias, PhD, Nurjehan Mohamed Ibrahim, DClindent, Choy Ker Woon, PhD, Arofi Kurniawan, PhD, Beshlina Fitri Widayanti Roosyanto Prakoeswa, PhD

“…The MorphoJ program was used to perform generalized Procrustes analysis (GPA), Procrustes ANOVA, principal component analysis (PCA), discriminant function analysis (DFA), and canonical variate analysis (CVA). In the tpsDig2 program, the 27 landmarks were applied to the DPT radiographs. …”
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Релациите меѓу Високата Порта и Охридската архиепископија во 18 век (причини за приближување и одделување)... by Валентина [Valentina] Миронска-Христовска [Mironska-Hristovska]

“…Relations between the Sublime Porte and the Archbishopric of Ohrid in the 18th century (reasons for rapprochement and estrangement) Non-canonical abolition of the Ohrid Archbishopric on May 17, 1767 is an act that made deep impact in Macedonian history. …”
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Obesity Is Associated with an Impaired Baseline Repertoire of Anti-Influenza Virus Antibodies by Marwa Abd Alhadi, Lilach M. Friedman, Erik A. Karlsson, Liel Cohen-Lavi, Anat Burkovitz, Stacey Schultz-Cherry, Terry L. Noah, Samuel S. Weir, Lester M. Shulman, Melinda A. Beck, Tomer Hertz

“…While vaccination is the most effective strategy for preventing influenza virus infection, our previous studies showed that influenza vaccines fail to provide optimal protection in obese individuals despite reaching canonical correlates of protection. Here, we show that obesity may impair immune history in humans and cannot be overcome by seasonal vaccination, especially in younger individuals with decreased lifetime exposure to infections and seasonal vaccines. …”
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Sevoflurane inhibits the differentiation and development of neural progenitor cells into neurons in the prefrontal cortex of newborn mice by LIU Siyu, ZHANG Lei

“…The down-regulated genes in PFC neurons after multiple sevoflurane anesthesia were enriched in the negative regulation of cell population proliferation, positive regulation of cell differentiation, forebrain neuron differentiation, positive regulation of canonical Wnt signaling pathway, and cell differentiation.Conclusion·Both single and multiple sevoflurane anesthesia promote PFC neuron proliferation and migration, and multiple sevoflurane anesthesia inhibits the differentiation of neural progenitor cell into neuron in PFC. …”
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Kunst, keskkond ja keskkonnaliikumine Eestis 1960.–1980. aastatel / Art, Environment, and Environmentalism in Estonia in the 1960s–1980s by Linda Kaljundi

“…While the emergence of environmental topics in art is often linked to avant-garde practices such as land art or performance, this article mainly focuses on more traditional forms of art such as painting and graphic print, on the grounds that this enables to discuss a wider body of works and include artists beyond the modernist canon. As the analysis of Late Soviet Estonian art from ecocritical perspectives is only beginning, the present study does not aim at making any definite or extensive claims, but rather offers some preliminary thoughts on how to map the diverse approaches to the changing environment that are becoming increasingly more noticeable in the art of the period. …”
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