The crystal structure of the Hazara virus nucleocapsid protein av Surtees, R, Ariza, A, Punch, E, Trinh, C, Dowall, S, Hewson, R, Hiscox, J, Barr, J, Edwards, T

“…HAZV N has a similar overall structure to CCHFV N, with their globular domains superposing with an RMSD = 0.70 Å, over 368 alpha carbons that share 59 % sequence identity. Four HAZV N monomers crystallised in the asymmetric unit, and their head-to-tail assembly reveals a potential interaction site between monomers. …”

Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation. av Jones, D, Pugh, C, Wigfield, S, Stevens, M, Harris, A

“…In the MDA-MB-468 breast cancer cell line, the compounds inhibited RNA and protein expression of the HIF-alpha target genes, carbonic anhydrase IX, VEGF, and BNIP3, concordantly with HIF-alpha up-regulation. …”

Synthesis of furanocycloalkanes from furans and non-aromatic precursors av Li, S

“…</p> <p><strong>Chapter 1</strong> details methodology studies on the synthesis of furano[<em>b</em>]cycloalkanones with fully alkylated furfurylic carbons and the carbonyl group conjugated to the furan ring. …”

The behaviour of magnesium and its isotopes during glacial weathering in an ancient shield terrain in West Greenland av Wimpenny, J, Burton, K, James, R, Gannoun, A, Mokadem, F, Gislason, SR

“…Rather, variations in the δ26Mg value of the dissolved load are attributed to incongruent weathering of the solid phase: preferential dissolution of carbonate minerals, which have low δ26Mg (-1.1 to -5.2%), imparts a more negative δ26Mg signal to the glacial river waters. …”

Assessing the healthiness of UK food companies' product portfolios using food sales and nutrient composition data av Bandy, LK, Hollowell, S, Harrington, R, Scarborough, P, Jebb, S, Rayner, M

“…The proportion of total volume sales classified as healthy increased from 44% to 51% (p = 0.07) driven by an increase in the volume sales of bottled water, low/no calorie carbonates and juices, but after removing soft drinks, the proportion of foods classified as healthy decreased from 7% to 6% (p = 33). …”

Mathematical studies of morphology in early life palaeobiology av Hoekzema, R

“…In particular, a hexagonal pattern very similar to the most regular specimens of <em>Paleodictyon</em> could be formed in experiments and preserved on the surface of a calcium carbonate paste. </p>…”

A model study of the end bearing capacity of piles in layered calcareous soils av Evans, K, K. M. Evans

“…The samples consisted of a loose, uncemented calcareous sand consisting predominantly of foraminifera and mollusc micro-organisms (D50 = 0.2 mm, calcium carbonate content 92%). Into this was built a layer of the same material artificially cemented by a gypsum plaster. …”

Palaeoclimate evidence of vulnerable permafrost during times of low sea ice av Vaks, A, Mason, AJ, Breitenbach, SFM, Kononov, AM, Osinzev, AV, Rosensaft, M, Borshevsky, A, Gutareva, OS, Henderson, GM

“…Uranium-lead chronology of carbonate deposits (speleothems) in a Siberian cave located at the southern edge of continuous permafrost reveals periods in which the overlying ground was not permanently frozen. …”

Cycle-induced interfacial degradation and transition metal cross-over in LiNi0.8Mn0.1Co0.1O2-graphite cells av Bjorklund, E, Xu, C, Dose, W, Sole, C, Thakur, P, Lee, T-L, De Volder, M, Grey, C, Weatherup, RS

“…This is accompanied by accelerated&nbsp;transition-metal&nbsp;reduction at the NMC surface, thickening of the cathode electrolyte interphase, decomposition of residual lithium carbonate, and increased&nbsp;cell&nbsp;impedance.&nbsp;Transition-metal&nbsp;dissolution is also detected through increased incorporation into and thickening of the SEI, with Mn found to be initially most prevalent, while the proportion of Ni increases with&nbsp;cycling. …”

Detecting archaeological sites in the eastern Sahara using satellite remote sensing and digital image processing av Corrie, RK

“…ASTER thermal infrared (TIR) is used to detect palaeolake deposits from their surface carbonate signatures. Additionally, topographic lake depressions and palaeoshoreline features are identified from SRTM DEM. …”

High precision Faraday collector MC-ICPMS thorium isotope ratio determination av Potter, E, Stirling, C, Andersen, M, Halliday, A

“…Uranium-series dating of carbonate materials requires precise determination of the spike sample thorium isotope ratio, 230Th/229Th. …”

Basin analysis of the Katangan Basin of Zambia: subsidence mechanisms, dynamic stratigraphy, and mineral systems av Purkiss, M

“…The overlying Upper Roan Group shows a sharp transition to carbonate-dominated facies and evaporite successions deposited in an epicontinental sea with extensive paralic zones as the basin transitioned from fault-controlled to predominantly thermally controlled subsidence.…”

Recent advances in osteoclast biology and pathological bone resorption. av Blair, H, Athanasou, N

“…Humans who are deficient in carbonic anhydrase II or who have defects in phagocytosis also have variable defects in bone remodelling. …”

Uranium-series dating of corals in situ using laser-ablation MC-ICPMS av Potter, E, Stirling, C, Wiechert, U, Halliday, A, Spotl, C

“…Approximately 70 μg of carbonate is consumed during each analysis, containing approximately 0.2 ng of 238U, ∼10 pg of 234U and less than 3 fg of 230Th. …”

Prevalence of high screen time and associated factors among students: a cross-sectional study in Zhejiang, China av Wang, H, Zhong, J, Hu, R, Bragg, F, Yu, M, Du, H

“…Multivariable logistic analysis showed that older age, attendance at vocational high school, non-intact family, poor academic performance, bad self-reported health status, loneliness and drinking carbonated beverages ≥3 times every day were positively associated with high ST. …”

Sphaerosiderites as sensitive recorders of non-marine depositional and diagenetic history: insights from the Lower Cretaceous Wealden Supergroup av Sengupta, R, Robinson, SA, Tosca, N

“…Waterlogged, reducing soils in modern and ancient wetlands feature distinctive syndepositional to early diagenetic spherical iron carbonate concretions, known as sphaerosiderites. Sphaerosiderites are thought to record pore water elemental chemistry and local palaeoenvironmental conditions, and are widely used in palaeohydrological reconstructions throughout the Phanerozoic. …”

The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression av Stengel, C, Newman, S, Leese, M, Thomas, M, Potter, B, Reed, M, Purohit, A, Foster, P

“…The level of mRNA expression of vascular endothelial growth factor (VEGF), glucose transporter 1 (GLUTI), phosphoglycerate kinase (PGK), ATP-binding cassette sub-family B member 1 (ABCB1) and carbonic anhydrase IX (CAIX) was quantified by Real-time Polymerase Chain Reaction (RT-PCR). …”

Regulation of hepatocyte growth factor activator inhibitor 2 by hypoxia in breast cancer. av Generali, D, Fox, S, Berruti, A, Moore, J, Brizzi, M, Patel, N, Allevi, G, Bonardi, S, Aguggini, S, Bersiga, A, Campo, L, Dogliotti, L, Bottini, A, Harris, A

“…HAI-2 also correlated with hypoxia markers such as carbonic anhydrase IX expression (P = 0.01) and HIF-1alpha. …”

Ra-226 and Ba concentrations in the Ross Sea measured with multicollector ICP mass spectrometry av Foster, D, Staubwasser, M, Henderson, G

“…This result makes the dating of carbonates from the area using 226Ra/Ba possible. The lack of surface depletion in either Ba or 226Ra differs from the pattern observed in the open Southern Ocean where concentrations increase with depth, suggesting that either the calcite-dominated productivity in the Ross Sea area does not remove 226Ra and Ba as effectively as opal-dominated productivity in the Southern Ocean, or that water column mixing in the Ross Sea is effective at the time scale of removal. © 2004 Elsevier B.V. …”

Insights into surface chemistry down to nanoscale: an accessible colour hyperspectral imaging approach for scanning electron microscopy av Nohl, JF, Farr, NTH, Sun, Y, Hughes, GM, Stehling, N, Zhang, J, Longman, F, Ives, G, Pokorná, Z, Mika, F, Kumar, V, Mihaylova, L, Holland, C, Cussen, SA, Rodenburg, C

“…Based on the evaluation, CSEHI is well placed to differentiate/track several lithium compounds formed through a solution reaction mechanism on a LMA surface (eg. lithium carbonate, lithium hydroxide and lithium nitride). …”