biological evaluation of medical devices - Part 3 : tests for genotoxicity, carcinogenicity and reproductive toxicity (ISO 10993-3:2003, IDT) by Department of Standards Malaysia

Evaluation of Occupational Exposure Risk for Employees Working in Dynamic Olfactometry: Focus On Non-Carcinogenic Effects Correlated with Exposure to Landfill Emissions by Elisa Polvara, Baharak Essna ashari, Laura Capelli, Selena Sironi

“…This work aims to evaluate the non-carcinogenic health effects related to landfill odor emissions, therefore focusing on workers involved in dynamic olfactometry. …”
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The Cell Transformation Assay: A Historical Assessment of Current Knowledge of Applications in an Integrated Approach to Testing and Assessment for Non-Genotoxic Carcinogens by Annamaria Colacci, Raffaella Corvi, Kyomi Ohmori, Martin Paparella, Stefania Serra, Iris Da Rocha Carrico, Paule Vasseur, Miriam Naomi Jacobs

“…The complementary key biomarkers with respect to the precursor key events and respective CTAs are mapped, providing a structured mechanistic approach to represent the complexity of the (non-genotoxic) carcinogenesis process, and specifically their capacity to identify non-genotoxic carcinogenic chemicals in a human relevant IATA.…”
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Synergistic Effects of Curcumin and Nano-Curcumin against Toxicity, Carcinogenicity, and Oxidative Stress Induced by Tartrazine at Normal and Cancer Cell Levels by Gaber E. El-Desoky, Saikh M. Wabaidur, Mohamed A. Habila, Zeid A. AlOthman

“…CUR-NPs also overcome the side effect of using TZ as a yellow color and food preservative additive, due to its reduced toxicity, oxidative stress, and carcinogenicity. In agreement with our previous findings, CUR and CUR-NPs were able to protect against cellular oxidative stress by stimulating endogenous antioxidant defense enzymes, including superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), and glutathione-S-transferase (GST). …”
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Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent by Borhane Annabi, Simon Lord-Dufour, Amélie Vézina, Richard Béliveau

“…Decreased resveratrol inhibitory potential of carcinogen-induced IκB phosphorylation in siSirt1-transfected HBMEC was however observed. …”
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A method for assessing carcinogenic risk of air fine particle-associated polycyclic aromatic hydrocarbons by considering bioaccessibility in lung fluids by Xinlei Liu, Yuejiao Wang, Zelin Shen, Xuan Wu, Yu Shi, Fang Wang

“…This study was conducted to evaluate the inhalation carcinogenic risk of PAHs in biochar fine particles using total concentration-based assessment approach and bioaccessibility-based assessment approach. …”
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Correlation of Occupational Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons (cPAHs) and Blood Levels of p53 and p21 Proteins by Saleh A. K. Saleh, Heba M. Adly, Imad A. Aljahdali, Abdullah A. Khafagy

Subjects: “…carcinogenic polycyclic aromatic hydrocarbons (cPAHs)…”
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Carcinogenic and Genotoxicity of some PAHs in commonly consumed smoked fish (<i>Parachanna obscura</i> and <i>Ethmalosa fimbriata) </i> by N.O. Erhunmwunse, S.A. Ekaye

“…Risk assessment conducted using benzo(a)pyrene carcinogenic and mutagenic toxicity equivalent factor (TEQ & MEQ) showed slight to high risk (7.44 x10-5 -1.95 x10-3 ) and exceeded the USEPA guideline (1.0 x 10-5 ) for potential Cancer. …”
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Characterization, ratio analysis, and carcinogenic risk assessment of polycyclic aromatic hydrocarbon compounds bounded PM10 in a southwest of Iran by Marzye Enshaey Nezhad, Gholamreza Goudarzi, Ali Akbar Babaei, Mohammad Javad Mohammadi

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Efficient removal of carcinogenic Rosaniline Hydrochloride (Fuchsine) dye with Mg doped FeTiO nanocomposites: Experimental and statistical evaluation by Salman Latif, Fahad Abdulaziz, Amir Al-Ahmed

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RNA-Seq reveals infection-induced gene expression changes in the snail intermediate host of the carcinogenic liver fluke, Opisthorchis viverrini. by Sattrachai Prasopdee, Javier Sotillo, Smarn Tesana, Thewarach Laha, Jutharat Kulsantiwong, Matthew J Nolan, Alex Loukas, Cinzia Cantacessi

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Integrating single-cell RNA sequencing and prognostic model revealed the carcinogenicity and clinical significance of FAM83D in ovarian cancer by Jie Li, Zhefeng Li, Yan Gao, Hongyu Zhao, Jiahao Guo, Zhibin Liu, Chenghong Yin, Xiaoting Zhao, Wentao Yue

“…MiR-138-5p was identified to regulate FAM83D’s carcinogenic effect in OC cells.ConclusionsOur findings highlight the importance of miR-138 -5p/FAM83D/EMT signaling and may provide new insights into therapeutic strategies for OC.…”
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Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model by Yuko Goto, Arata Saito, Kenji Takanobu, Hideki Senoh, Misae Saito, Yumi Umeda, Shotaro Yamano

“…Abstract 2-Bromopropane (2-BP) is a colorless liquid at room temperature and is used in closed systems in factories, mainly as an intermediate for medicines, pesticides, and other chemicals. However, the carcinogenicity of 2-BP is still unknown. The CByB6F1-Tg(HRAS)2Jic (rasH2) transgenic mouse model has been established as an alternative to long-term studies (1.5 years—lifetime) to detect carcinogenicity in as short a time as six months. …”
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miRNA-214-3p stimulates carcinogen-induced mammary epithelial cell apoptosis in mammary cancer-resistant species by Rebecca M. Harman, Sanjna P. Das, Matt Kanke, Praveen Sethupathy, Gerlinde R. Van de Walle

“…Better understanding of the mechanisms regulating cellular responses to carcinogens improves our overall understanding of mammary cancer resistance mechanisms.…”
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Omega-Class Glutathione Transferases of Carcinogenic Liver Fluke, <i>Clonorchis sinensis</i>, Modulate Apoptosis and Differentiation of Host Cholangiocytes by Chun-Seob Ahn, Jeong-Geun Kim, Insug Kang, Yoon Kong

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Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study by Fedeles, Bogdan I., Essigmann, John M.

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Comparative carcinogenicity for mouse-skin of smoke condensates prepared from cigarettes made from the same tobacco cured by two processes. by Roe, F, Clack, J, Bishop, D, Peto, R

Committee on Carcinogenicity of Chemicals in Food, Consumer Products and theEnvironment.... by Blain, P

The tobacco carcinogen NNK drives accumulation of DNMT1 at the GR promoter thereby reducing GR expression in untransformed lung fibroblasts by Taylor, K, Wheeler, R, Singh, N, Vosloo, D, Ray, D, Sommer, P

“…DNMT1 expression is further increased by exposure to the tobacco carcinogen NNK. In the untransformed human lung fibroblast cell line, MRC-5, short term NNK treatment decreases GRα mRNA and protein expression due to accumulation of DNMT1 at the GR promoter. …”

3-Chloropropane-1,2-diol (3-MCPD) in soy sauce: A review on the formation, reduction, and detection of this potential carcinogen by Bai, Q.L., Khor, S.M.

“…There are 3 types of soy sauce: fermented, acid-hydrolyzed vegetable protein (acid- HVP), and mixtures of these. 3-Chloropropane-1,2-diol (3-MCPD) is a heat- produced contaminants formed during the preparation of soy sauce and was found to be a by-product of acid-HVPproduced soy sauce in 1978. 3-MCPD has been reported to be carcinogenic, nephrotoxic, and reproductively toxic in laboratory animal testing and has been registered as a chemosterilant for rodent control. 3-MCPD is classified as a possible carcinogenic compound, and the maximum tolerated limit in food has been established at both national and international levels. …”
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