Critical Role of the Sulfiredoxin-Peroxiredoxin IV Axis in Urethane-Induced Non-Small Cell Lung Cancer by Yanning Hao, Hong Jiang, Pratik Thapa, Na Ding, Aziza Alshahrani, Junichi Fujii, Michel B. Toledano, Qiou Wei

“…Together with wild-type litter mates, these mice were exposed to carcinogenic urethane and the development of lung tumorigenesis was evaluated. …”
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Pilot Study to Detect Genes Involved in DNA Damage and Cancer in Humans: Potential Biomarkers of Exposure to E-Cigarette Aerosols by Samera H. Hamad, Marielle C. Brinkman, Yi-Hsuan Tsai, Namya Mellouk, Kandice Cross, Ilona Jaspers, Pamela I. Clark, Courtney A. Granville

“…There is a paucity of data on how gene expression enables identification of individuals who are at risk of exposure to carcinogens from e-cigarette (e-cig) vaping; and how human vaping behaviors modify these exposures. …”
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Adaptive immune response in pathogenesis and treatment of head and neck squamous cell carcinoma: the influence of immunosuppression factors and gender by A. I.  Stukan, R.  A. Murashko, N. A. Tsygan, A. Yu. Goryainova, O. N. Nefedov, V. A. Porkhanov

“…The review presents an analysis of the differences in the type and degree of immunosuppression, as well as treatment response in head and neck squamous cell carcinoma patients in accordance with influencing carcinogenic factor, gender, age of the patient and concomitant diseases. …”
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Seasonal Variation in Essential Oil Composition and Antioxidant Capacity of <i>Aniba canelilla</i> (Lauraceae): A Reliable Source of 1-Nitro-2-phenylethane by Ellen de Nazaré S. da Cruz, Luana de Sousa P. Barros, Bruna de A. Guimarães, Rosa Helena V. Mourão, José Guilherme S. Maia, William N. Setzer, Joyce Kelly do R. da Silva, Pablo Luis B. Figueiredo

“…<i>Aniba canelilla</i> (Kunth) Mez essential oil has many biological activities due to its main compound 1-nitro-2-phenylethane (1N2F), followed by methyleugenol, a carcinogenic agent. This study analyzed the influence of seasonality on yields, antioxidant capacity, and 1N2F content of <i>A. canelilla</i> leaf and twig essential oils. …”
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Removal of Polycyclic Aromatic Hydrocarbons (PAHs) from Produced Water by Ferrate (VI) Oxidation by Tahir Haneef, Muhammad Raza Ul Mustafa, Khamaruzaman Wan Yusof, Mohamed Hasnain Isa, Mohammed J.K. Bashir, Mushtaq Ahmad, Muhammad Zafar

“…Polycyclic aromatic hydrocarbons (PAHs) are mutagenic and carcinogenic contaminants made up of fused benzene rings. …”
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Phylogenomic Analysis of Human Papillomavirus Type 31 and Cervical Carcinogenesis: A Study of 2093 Viral Genomes by Maisa Pinheiro, Ariana Harari, Mark Schiffman, Gary M. Clifford, Zigui Chen, Meredith Yeager, Michael Cullen, Joseph F. Boland, Tina Raine-Bennett, Mia Steinberg, Sara Bass, Yanzi Xiao, Vanessa Tenet, Kai Yu, Bin Zhu, Laurie Burdett, Sevilay Turan, Thomas Lorey, Philip E. Castle, Nicolas Wentzensen, Robert D. Burk, Lisa Mirabello

“…Human papillomavirus (HPV) type 31 (HPV31) is closely related to the most carcinogenic type, HPV16, but only accounts for 4% of cervical cancer cases worldwide. …”
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Cytotoxic necrotizing factor 1 hinders colon tumorigenesis induced by colibactin-producing Escherichia coli in ApcMin/+ mice by Héloïse Chat, Guillaume Dalmasso, Catherine Godfraind, Virginie Bonnin, Racha Beyrouthy, Mathilde Bonnet, Nicolas Barnich, Amel Mettouchi, Emmanuel Lemichez, Richard Bonnet, Julien Delmas

“…Overall, this study provides evidence that CNF1 decreases the carcinogenic effects of CoPEC in ApcMin/+ mice by decreasing CoPEC-induced cellular senescence and inflammation.…”
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In Vitro Radiosensitization of T47D and MDA-MB-231 Breast Cancer Cells with the Neoflavonoid Dalbergin by Fereshte Mahdizade Valojerdi, Bahram Goliaei, Nakisa Rezakhani, Alireza Nikoofar, Hoda Keshmiri Neghab, Mohammad Hasan Soheilifar, Bahareh Bigdeli

“…Dalbergin, a natural antioxidant, inhibits carcinogens and tumor progression. In the present study, we investigated the effect of Dalbergin on the response of T47D and MDA-MB-231 breast cancer cell lines to ionizing radiation.Method: In this experimental in vitro study, doubling time of T47D and MDAMB- 231 were obtained from the growth curve. …”
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3DP Printing of Oral Solid Formulations: A Systematic Review by Chiara R. M. Brambilla, Ogochukwu Lilian Okafor-Muo, Hany Hassanin, Amr ElShaer

“…Moreover, each technique has its specific advantages and disadvantages, such as for FDM the biggest challenge is the degradation of the drug, due to high printing temperature process or for SLA is the toxicity of the carcinogenic risk of the photopolymerising material.…”
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HK2 contributes to the proliferation, migration, and invasion of diffuse large B-cell lymphoma cells by enhancing the ERK1/2 signaling pathway by Zhao Hongcan, Xiang Guoqian, Shao Tingjun, Wang Minmin, Dai Weijian

“…Hexokinase 2 (HK2) has been associated with carcinogenic growth in numerous kinds of malignancies as essential regulators during the processing of glucose. …”
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Serum Response Factor-Regulated IDO1/Kyn-Ahr Pathway Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by Mingyan Xu, Feixiang Zhu, Qi Yin, Hao Yin, Shaobin Fang, Gongwei Luo, Jie Huang, Wenxia Huang, Fan Liu, Ming Zhong, Xiaoling Deng

“…Serum response factor (SRF) regulates pro-carcinogenic genes in various cancers, but its role in oral squamous cell carcinoma (OSCC) remains unclear. …”
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REVIEW OF RESEARCH ON THE RELATIONSHIP BETWEEN CIRCADIAN RHYTHMS AND CARCINOGENESIS USING ANIMAL MODELS by G. S. Kireeva, E. A. Gubareva, M. A. Maydin, A. V. Panchenko, M. L. Tyndyk, E. I. Fedoros, S. S. Kruglov, V. K. Osetnik, V. N. Anisimov

“…Purpose of the study: to review in vivo studies on the relationship and role of various molecular genetic components of the circadian rhythm system in the initiation and development of malignant neoplasms. in contrast to clinical and epidemiological studies, animal models, including transgenic animal models, can model various changes and disturbances in the activity of clock genes and track the results of these changes.Material and Methods. the review includes data from studies carried out over the past 10 years in animal models, studying the mechanisms and effects of disturbances in the system of circadian rhythms related to the formation and development of tumors. the data sources for the review were the Medline, embase and scopus databases.Results. analysis of the literature has shown that interference with the work of the «biological clock» by changing the light cycle, disrupting the expression of clock genes and other manipulations is a factor predisposing to the development of tumors. in tumors of various types, the expression of clock genes is often mismatched, and it is unclear at what stage of their formation this occurs. in addition, the development of tumors disrupts the circadian homeostasis of the body. there are three key areas of research aimed at studying the role of circadian rhythms in tumor development: disturbance of circadian rhythms as a carcinogenic factor, disturbances in the clock gene system in a tumor, disturbances in the clock gene system of the whole organism, provoked by tumor development.Conclusion. the results of studies on animal models demonstrate that the relationship between the disturbance of circadian rhythms and the tumor process is complex since the causal relationship has not yet been studied. in this regard, the prospect of targeted pharmacological correction of circadian rhythms in clinical practice in cancer patients does not seem to be the nearest one.…”
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Zinc alleviates cadmium-induced reproductive toxicity via regulating ion homeostasis, metallothionein expression, and inhibiting mitochondria-mediated apoptosis in the freshwater c... by Jing Liu, Ermeng Wang, Ziru Cheng, Yuan Gao, Chienmin Chen, Ru Jia, Zhi Luo, Lan Wang

“…Cadmium (Cd) is a carcinogenic environmental pollutant that harms male reproductive systems by lowering sperm quality, impairing spermatogenesis, and causing apoptosis. …”
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Role of miRNAs in Sigmoid Colon Cancer: A Search for Potential Biomarkers by Diego Marques, Layse Raynara Ferreira-Costa, Lorenna Larissa Ferreira-Costa, Ana Beatriz Bezerra-Oliveira, Romualdo da Silva Correa, Carlos Cesar de Oliveira Ramos, Tatiana Vinasco-Sandoval, Katia de Paiva Lopes, Ricardo Assunção Vialle, Amanda Ferreira Vidal, Vivian Nogueira Silbiger, Ândrea Ribeiro-dos-Santos

“…Additionally, we found enriched pathways related to the carcinogenic process in which miRNA could be involved, indicating that adjacent-to-tumor tissues may be already altered and cannot be considered as healthy tissues. …”
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<i>K-</i>Mer Analyses Reveal Different Evolutionary Histories of Alpha, Beta, and Gamma Papillomaviruses by Zigui Chen, Filippo Utro, Daniel Platt, Rob DeSalle, Laxmi Parida, Paul K. S. Chan, Robert D. Burk

“…PVs infecting humans (HPVs) phylogenetically cluster into five genera (Alpha-, Beta-, Gamma-, Mu- and Nu-PV), with differences in tissue tropism and carcinogenicity. The evolutionary features associated with the divergence of <i>Papillomaviridae</i> are not well understood. …”
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Chromium Toxicity in Plants: Signaling, Mitigation, and Future Perspectives by Sajad Ali, Rakeeb A. Mir, Anshika Tyagi, Nazia Manzar, Abhijeet Shankar Kashyap, Muntazir Mushtaq, Aamir Raina, Suvin Park, Sandhya Sharma, Zahoor A. Mir, Showkat A. Lone, Ajaz A. Bhat, Uqab Baba, Henda Mahmoudi, Hanhong Bae

“…It has a huge detrimental impact on the physiological, biochemical, and molecular traits of crops, in addition to being carcinogenic to humans. In soil, Cr exists in different forms, including Cr (III) “trivalent” and Cr (VI) “hexavalent”, but the most pervasive and severely hazardous form to the biota is Cr (VI). …”
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Transcriptome Sequencing Revealed an Inhibitory Mechanism of <i>Aspergillus flavus</i> Asexual Development and Aflatoxin Metabolism by Soy-Fermenting Non-Aflatoxigenic <i>Aspergill... by Kunlong Yang, Qingru Geng, Fengqin Song, Xiaona He, Tianran Hu, Shihua Wang, Jun Tian

“…Aflatoxins (AFs) have always been regarded as the most effective carcinogens, posing a great threat to agriculture, food safety, and human health. …”
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Modeling and optimization of independent factors influencing lead(II) biosorption from aqueous systems: A statistical approach by Jonas Bayuo, Mwemezi Rwiza, Moses Abdullai Abukari, Kenneth Bayetimani Pelig-Ba, Kelvin Mtei

“…Lead, [Pb(II)] is a major hazardous contaminant that exists in the soil, surface, and groundwater as a result of human activities. It is carcinogenic in nature and causes damage to the liver, kidney, and bones as well as the digestive, respiratory, and immune systems. …”
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Compliance between Food and Feed Safety: Eight-Year Survey (2013–2021) of Aflatoxin M1 in Raw Milk and Aflatoxin B1 in Feed in Northern Italy by Luca Ferrari, Nicoletta Rizzi, Elisa Grandi, Eleonora Clerici, Erica Tirloni, Simone Stella, Cristian Edoardo Maria Bernardi, Luciano Pinotti

“…Aflatoxins can result in hepatotoxic, carcinogenic, and immunosuppressive effects. The European Union thus set a low threshold limit (50 ng/L) for presence of AFM1 in milk. …”
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Nicotine, Humectants, and Tobacco-Specific Nitrosamines (TSNAs) in IQOS Heated Tobacco Products (HTPs): A Cross-Country Study by Noel J. Leigh, Michelle K. Page, Denisha L. Robinson, Scott D. Heldwein, Richard J. O’Connor, Maciej L. Goniewicz

“…As NNN and NNK are known human carcinogens, and as humectants like PG and VG can degrade into toxic carbonyl compounds upon heating, monitoring the concentration of these chemicals in HTPs is important for protecting users’ health and ensuring compliance with regulations.…”
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