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5241
Association between colorectal cancer and expression levels of miR-21, miR-17-5P, miR-155 genes and the presence of Fusobacterium nucleatum in biopsy samples obtained from Iranian...
Published 2023-03-01“…Abstract Background Colorectal cancer (CRC) is considered the second-deadliest and third-most common malignancy worldwide. Studying the carcinogenic mechanism of bacteria or their role in aggravating cancer can be precious. …”
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5242
Understanding and harnessing triple-negative breast cancer-related microbiota in oncology
Published 2022-11-01“…It may suppress or promote carcinogenesis through the release of carcinogenic metabolites, sustenance of proinflammatory environments and/or the promotion of epigenetic changes in our genome. …”
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5243
Enhanced biodegradation of phenanthrene and anthracene using a microalgal-bacterial consortium
Published 2023-09-01“…The bioaccumulation, carcinogenic and mutagenic potential of PAHs necessitates the bioremediation of these contaminants. …”
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5244
Fatty acid metabolism-related genes as a novel module biomarker for kidney renal clear cell carcinoma: Bioinformatics modeling with experimental verification
Published 2023-12-01“…Conclusions: In this study, a novel risk score model and a module biomarker based on FAM-related genes were screened for KIRC prognosis. More clinical carcinogenic validations will be performed for future translational applications of the findings.…”
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5245
Low Doses of PFOA Promote Prostate and Breast Cancer Cells Growth through Different Pathways
Published 2022-07-01“…Thus, our study demonstrates that even at picomolar (10<sup>−12</sup> M) concentrations PFOA and PCB153 increase the proliferation of prostate and breast cancer cell lines and can be considered possible carcinogens.…”
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5246
p53-dependent HIF-1α /autophagy mediated glycolysis to support Cr(VI)-induced cell growth and cell migration
Published 2024-03-01“…Cr(VI) is known to be seriously toxic and carcinogenic. Hypoxia-inducible factor-1α (HIF-1α) is a crucial regulator to promote tumor development. …”
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5247
N-Glycomic Profiling of Microsatellite Unstable Colorectal Cancer
Published 2023-07-01“…Our results show that molecular subgroups of CRC exhibit characteristic glycan profiles that may explain certain carcinogenic properties of MSI tumors.…”
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5248
Insoluble chitosan complex as a potential adsorbent for aflatoxin B1 in poultry feed
Published 2022-12-01“…As a class of secondary metabolites or toxins produced by fungi, aflatoxins can poison humans and animals; among them, aflatoxin B1 (AFB1) is the most dangerous one owing to its carcinogenic and mutagenic properties that increase risks for hepatocellular carcinoma in humans; hence, adsorbents such as smectites are commonly included in poultry feed to mitigate their effects. …”
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5249
A Review of Titanium Dioxide (TiO<sub>2</sub>)-Based Photocatalyst for Oilfield-Produced Water Treatment
Published 2022-03-01“…Oilfield produced water (OPW) has become a primary environmental concern due to the high concentration of dissolved organic pollutants that lead to bioaccumulation with high toxicity, resistance to biodegradation, carcinogenicity, and the inhibition of reproduction, endocrine, and non-endocrine systems in aquatic biota. …”
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5250
Current Developments of Analytical Methodologies for Aflatoxins’ Determination in Food during the Last Decade (2013–2022), with a Particular Focus on Nuts and Nut Products
Published 2023-01-01“…Indeed, AFs are considered carcinogenic to humans, group 1, by the International Agency for Research on Cancer (IARC). …”
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5251
Identification regulatory noncoding RNAs of human papilloma virus type 16 <i>(Papillomaviridae: Alphapapillomavirus: Human papillomavirus)</i> in cervical tumors
Published 2022-09-01“…Introduction. High carcinogenic-risk human papillomaviruses (hrHPVs) are recognized as etiological agents of cervical cancer. …”
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5252
De Novo Carcinoma after Solid Organ Transplantation to Give Insight into Carcinogenesis in General—A Systematic Review and Meta-Analysis
Published 2021-03-01“…Analysis of the occurrence of different types of de novo carcinomas in relation to specific immunosuppressive drugs may give insight into their carcinogenic process and carcinogenesis in general. Therefore, a systematic search was performed in Embase and PubMed. …”
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5253
Translating the Manufacture of Immunotherapeutic PLGA Nanoparticles from Lab to Industrial Scale: Process Transfer and In Vitro Testing
Published 2022-08-01“…The investigated formulations contain three distinct synthetic peptides derived from the carcinogenic antigen New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1) together with an invariant natural killer T-cell (iNKT) activator, threitolceramide-6 (IMM60). …”
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5254
Exploring the Mechanism of Hepatotoxicity Induced by <i>Dictamnus dasycarpus</i> Based on Network Pharmacology, Molecular Docking and Experimental Pharmacology
Published 2023-06-01“…Our results showed that the targets of DC included CYP1A2 and GSR, participating in heterologous steroid metabolism, REDOX metabolism, drug metabolism, heterocyclic metabolic processes, the synthesis of steroid hormone, cytochrome P450 metabolism, chemical carcinogens and bile secretion pathways. In vitro and in vivo experiments displayed that DC could result in a decrease in GSH-Px and oxidative stress, simultaneously inhibiting the expression of CYP1A2 and inducing hepatotoxicity. …”
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5255
<i>Ascophyllum nodosum</i> (Linnaeus) Le Jolis from Arctic: Its Biochemical Composition, Antiradical Potential, and Human Health Risk
Published 2024-01-01“…According to the calculated target hazard quotient (THQ) and hazard index (HI) values, Arctic <i>A. nodosum</i> samples pose no carcinogenic risk to adult and child health and are safe for regular consumption. …”
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5256
Characteristics and Health Risk Assessment of PM<sub>2.5</sub>-Bound PAHs during Heavy Air Pollution Episodes in Winter in Urban Area of Beijing, China
Published 2021-03-01“…PAHs posed obvious carcinogenic risks to the exposed populations, and the risk was higher during heavy pollution episodes than the average value of the whole monitoring period. …”
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5257
Characterization and Kinetic Studies of Poly(vinylidene fluoride-co-hexafluoropropylene) Polymer Inclusion Membrane for the Malachite Green Extraction
Published 2021-08-01“…Textile industry effluent contains a high amount of toxic colorants. These dyes are carcinogenic and threats to the environment and living beings. …”
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5258
Scientific opinion on the renewal of the authorisation of SmokEz C‐10 (SF‐005) as a smoke flavouring Primary Product
Published 2023-11-01“…Considering that the exposure estimates for these two components are above the threshold of toxicological concern (TTC) of 0.0025 μg/kg bw per day for DNA‐reactive mutagens and/or carcinogens, the Panel concluded that the Primary Product raises concern with respect to genotoxicity.…”
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5259
Corn Flour Intake, Aflatoxin B<sub>1</sub> Exposure, and Risk of Esophageal Precancerous Lesions in a High-Risk Area of Huai’an, China: A Case-Control Study
Published 2020-05-01“…Aflatoxin B<sub>1</sub> (AFB<sub>1</sub>), which has potent toxicity and carcinogenicity, is a common contaminant of important agricultural commodities. …”
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5260
Role of the WNT/β-catenin/ZKSCAN3 Pathway in Regulating Chromosomal Instability in Colon Cancer Cell lines and Tissues
Published 2022-08-01“…However, most of the ZKSCAN3-induced carcinogenic mechanisms remain unknown. In this study, we identified ZKSCAN3 as a downstream effector of the oncogenic Wnt/β-catenin signaling pathway, using RNA sequencing and ChIP analyses. …”
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