Exposure Characteristics of Construction Painters to Organic Solvents by Hyunhee Park, Hae Dong Park, Jae-Kil Jang

“…Conclusion: From this study, we recognized that construction painters are exposed to various solvents, including carcinogens and reproductive toxins, and the levels of TVOC concentration in many of the painting tasks exceeded the exposure limits. …”
Get full text

Optimized methyl donor and reduced precursor degradation pathway for seleno-methylselenocysteine production in Bacillus subtilis by Xian Yin, Meiyi Zhao, Yu Zhou, Hulin Yang, Yonghong Liao, Fenghuan Wang

“…Abstract Background Seleno-methylselenocysteine (SeMCys) is an effective component of selenium supplementation with anti-carcinogenic potential that can ameliorate neuropathology and cognitive deficits. …”
Get full text

Integrative evaluation and experimental validation of the immune-modulating potential of dysregulated extracellular matrix genes in high-grade serous ovarian cancer prognosis by Qihui Wu, Xiaoyun He, Jiaxin Liu, Chunlin Ou, Yimin Li, Xiaodan Fu

“…Moreover, patients with higher ECMscores exhibited more active stromal and carcinogenic activation pathways, including apical surface signaling, Notch signaling, apical junctions, Wnt signaling, epithelial-mesenchymal transition, TGF-beta signaling, and angiogenesis. …”
Get full text

Substantial changes in Gaseous pollutants and health effects during COVID-19 in Delhi, India by Bhupendra Singh, Puneeta Pandey, Saikh Mohammad Wabaidur, Ram Avtar, Pramod Kumar, Shakilur Rahman

“…These gaseous pollutants are linked between the health risk assessment and hazard identification for non-carcinogenic. However, in infants (0–1 yr), Health Quotient (HQ) for daily and annual groups was found to be higher than the rest of the exposed group (toddlers, children, and adults) in all the periods. …”
Get full text

A Comparative Evaluation of the Genotoxic Effects of Mobile Phone Radiation Using Buccal Micronucleus Assay by Hamideh Kadeh, Shirin Saravani, Mahas Moradi, Niloofar Alimanesh

“…There are conflicting reports about the carcinogenic effects of cell phone radiation on the oral mucosa. …”
Get full text

Comparative Evaluation of Serum Malondialdehyde (MDA) Level in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma by Havisha Arya, Sindhu M Ganvir, Deovrat N Begde, Arti Dolas Passi

“…Conclusion: The increased level of MDA reflects the extent of lipid peroxidation and is considered to be mutagenic as well as carcinogenic and can also modulate the expression of genes related to tumour promotion.…”
Get full text

Efficiency of Arsenic and Iron Removal Plants (AIRPs) for Groundwater Treatment in Rural Areas of Southwest Bangladesh by Md. Aminur Rahman, Sazal Kumar, A. S. M. Fazle Bari, Abhishek Sharma, Mohammad Mahmudur Rahman

“…Although As removal efficiency was found to be substantial, a cancer risk assessment indicates that hazard quotient (HQ) and carcinogenic risk (CR) of As in treated water for adults and children are above the threshold limits. …”
Get full text

pH-Dependent Structural Dynamics of Cathepsin D-Family Aspartic Peptidase of <i>Clonorchis sinensis</i> by Jung-Mi Kang, Hương Giang Lê, Byoung-Kuk Na, Won Gi Yoo

“…Previously, we characterized the biochemical features of cathepsin D isozyme 2 (CatD2) in the carcinogenic liver fluke <i>Clonorchis sinensis</i> (CsCatD2). …”
Get full text

Histone 2-Hydroxyisobutyryltransferase Encoded by <i>Afngg1</i> Is Involved in Pathogenicity and Aflatoxin Biosynthesis in <i>Aspergillus flavus</i> by Jing Wang, Liuke Liang, Shan Wei, Shuaibing Zhang, Yuansen Hu, Yangyong Lv

“…Aflatoxin, a carcinogenic secondary metabolite produced by <i>Aspergillus flavus</i>, is a significant threat to human health and agricultural production. …”
Get full text

miRNAs involvement in the etiology and targeted therapy of bladder cancer: Interaction between signaling pathway by Rishav Sharma, Rishabha Malviya

“…Elevated genomics has enabled a more extensive investigation of miRNAs whose expression is considerably different in BC patients compared to healthy volunteers or between BC tumor tissues and peripheral tissues. miRNAs have recently been discovered to be important regulators of BC cell carcinogenicity. Inaccurate diagnoses and prolonged treatment delays are more likely to occur due to the current diagnostic process such as lack of sensitivity and specificity and poor image quality. …”
Get full text

Particulate matter – a cancerous threat to our health? by Adam Jasiura, Wiktoria Lipczyńska, Konrad Warchoł, Mateusz Gorzel, Agata Justyńska, Hanna Krafzik, Przemysław Stępień, Hubert Kasprzak

“… Introduction: Particulate matter (PM) as a part of outdoor air pollutants are classified as human carcinogens. They are formed majorly as a result of combustion process by industry, power plants and engines. …”
Get full text

<i>Bifidobacterium animalis</i> and <i>Laetiporus sulphureus</i> Extract Induce a Strong Increase in GSH Levels in MRC-5 Cells in Response to Oxidative Stress by Dejan Arsenijević, Milena Jovanović, Katarina Pecić, Katarina Mladenović, Dragana Šeklić

“…GSH (glutathione) is crucial for the removal and detoxification of carcinogens in healthy cells, while in cancer cells, GSH is associated with cancer expansion and increased resistance to drugs. …”
Get full text

Next-generation sequencing shows the genomic features of ovarian clear cell cancer and compares the genetic architectures of high-grade serous ovarian cancer and clear cell carcino... by Meifu Gan, Zaixian Tai, Yijian Yu, Chao Zhang, Juan Xu

“…Shared mutational signatures between OCCC and ECCC tissues with commonly observed a C>T change indicated a common carcinogens-exposed between these two carcinomas, but HGSOC and ECCC have common and distinct mutational signatures across cohorts respectively. …”
Get full text

Mineralogy and geochemical characterization of geophagic clays consumed in parts of southern Nigeria by Olusegun Gbenga Olisa, Jerry Olugbenga Olajide-Kayode, Blessing Oluwaseunfunmi Adebayo, Oluwapamilerin Atinuke Ajayi, Kingsley Odukoya, Anuoluwa Ayoyimika Olalemi, Tamara Doubra-Mary Uyakunmor

“…In conclusion, children that consume clay from the markets are more exposed to non-carcinogenic risks than adults. It is therefore advisable that the clays should not be consumed for a long period of time to avoid health problems.…”
Get full text

Monitoring of Aflatoxin M1 in Various Origins Greek Milk Samples Using Liquid Chromatography Tandem Mass Spectrometry by Anthi Panara, Maria Katsa, Marios Kostakis, Erasmia Bizani, Nikolaos S. Thomaidis

“…Because of its possible carcinogenicity, the legislation limits as set by Commission Regulation (EC) No. 1881/2006 are very strict, namely 0.050 μg kg⁻¹ in milk and 0.025 μg kg⁻¹ in infant formulas. …”
Get full text

Re‐evaluation of polydextrose (E 1200) as a food additive by EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Karl‐Heinz Engel, Paul Fowler, Peter Fürst, Rainer Gürtler, Ursula Gundert‐Remy, Trine Husøy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Dina Hendrika Waalkens‐Berendsen, Detlef Wölfle, Matthew Wright, Polly Boon, Riccardo Crebelli, Alessandro Di Domenico, Metka Filipič, Alicja Mortensen, Ruud Woutersen, Henk Van Loveren, Alessandra Giarola, Federica Lodi, Ana Maria Rincon, Alexandra Tard, Maria Jose Frutos Fernandez

“…The Panel followed the conceptual framework for the risk assessment of certain additives and considered that: adequate exposure estimates were available; the margin of safety (MOS)/margin of exposure (MOE) for arsenic was between 0.5‐14 and 8.5 for lead; the exhaustions of the tolerable weekly intake (TWI) for cadmium would be 165%, 10% for mercury, whereas the exhaustion of the tolerable daily intake (TDI) for nickel would be 9%; the absorption is limited and part of polydextrose is fermented in the large intestine into short‐chain fatty acids (SCFA); adequate toxicity data were available; there is no concern with respect to genotoxicity; no adverse effects were reported in subchronic studies in rats, dogs or monkeys nor in chronic or carcinogenicity studies in mice and rats at the highest doses tested of up 12,500 mg/kg body weight (bw) per day and 15,000 mg/kg bw per day, respectively; the nephrocalcinosis in dogs given high doses of polydextrose was considered to be a treatment‐related but a secondary effect related to diarrhoea, and hence not relevant for the risk assessment; no adverse effects were reported in reproductive or developmental toxicity studies in rats administered up to 10,000 mg polydextrose/kg bw per day, or in a developmental toxicity study in rabbits up to 1,818 mg/kg bw per day (the highest dose tested). …”
Get full text

Risk of Mortality from Respiratory Malignant and Non-Malignant Diseases among Talc Miners and Millers: A Systematic Review and Meta-Analysis by Catalina Ciocan, Alessandro Godono, Sandro Stefanin, Paolo Boffetta, Enrico Pira, Marco Clari

“…The small excess in lung cancer mortality may be, in part, explained by the high prevalence of the smokers in some of the analyzed cohorts or by the exposure to other carcinogens like radon decay products and diesel engine exhaust.…”
Get full text

Effective Solid Phase Extraction of Toxic Pyrrolizidine Alkaloids from Honey with Reusable Organosilyl-Sulfonated Halloysite Nanotubes by Tobias Schlappack, Nina Weidacher, Christian W. Huck, Günther K. Bonn, Matthias Rainer

“…However, even low concentrations show toxic behavior in the form of chronic liver diseases and possible carcinogenicity. Since sample preparation for this compound group is in need of more green and sustainable alternatives, modified halloysite nanotubes present an interesting approach. …”
Get full text

Hexavalent chromium promotes differential binding of CTCF to its cognate sites in Euchromatin by Andrew VonHandorf, Hesbon A. Zablon, Jacek Biesiada, Xiang Zhang, Mario Medvedovic, Alvaro Puga

“…Hexavalent chromium compounds are well-established respiratory carcinogens to which humans are commonly exposed in industrial and occupational settings. …”
Get full text

A drug design strategy based on molecular docking and molecular dynamics simulations applied to development of inhibitor against triple-negative breast cancer by Scutellarein deriv... by Shopnil Akash, Farjana Islam Aovi, Md A K Azad, Ajoy Kumer, Unesco Chakma, Md Rezaul Islam, Nobendu Mukerjee, Md Mominur Rahman, Imren Bayıl, Summya Rashid, Rohit Sharma

“…Furthermore, these molecules met the pharmacokinetics requirements for potential therapeutic candidates, displaying non-carcinogenicity, minimal aquatic and non-aquatic toxicity, and greater aqueous solubility. …”
Get full text