Comprehensive Assessment of Biological Substrates of Professional Sick Person Group by Chemometric and Nuclear Physical Methods by Maryna Коzhevnikova, Volodymyr Levenets, Oleksandr Omelnyk, Andriy Shchur

“…Beryllium and its compounds render a general toxic, allergenic and carcinogenic effect on the organism. The high biological activity and toxicity of Be is due to its chemical activity and penetrating ability. …”
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Health Risk Assessment for the Exposure of Workers to BTEX at the Gasoline Stations by Nguyen Thanh Giao, Phan Kim Anh, Huynh Thi Hong Nhien

“…Life time cancer risk for gasoline station workers due to exposure to benzene, ethylbenzene, formaldehyde, and acetaldehyde was calculated in the ranges of 2.13x10-5 - 6.14x10-4 , 4.96x10-7 - 3.79x10-5 , 4.81x10-6 - 2.03x10-4 , and 7.99x10-7 - 1.75x10-5 , respectively. For non-carcinogenic  compounds, the hazard index due to benzene, toluene, m, p-xylene, o-xylene were respectively in the range of 0.13 - 3.81, 7.97x10-4 -  0.04, 0.01 - 0.70 and 0.01 - 0.25. …”
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The role of low density lipoprotein receptor-related protein 11 as a tumor promoter in cervical cancer by Wang Y, Han S, You X, Shi X, Liu L, Sun Y, Ma Y, Qian Q, Liu H, Cui B, Zhang Y

“…Ying Wang,1,2,* Sai Han,1,* Xuewu You,1 Xuejiao Shi,3 Lu Liu,1 Yu Sun,1 Yana Ma,1 Qiuhong Qian,1 Hongli Liu,1 Baoxia Cui,1 Youzhong Zhang11Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People’s Republic of China; 2Department of Obstetrics and Gynecology, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, People’s Republic of China; 3Department of Rheumatism and Immunology, Weihai Municipal Hospital, Weihai, Shandong 264200, People’s Republic of ChinaCorrespondence: Youzhong ZhangDepartment of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong 250012, People’s Republic of ChinaEmail zhangyouzhong@sdu.edu.cn*These authors contributed equally to this workBackground: It is unclear whether low density lipoprotein receptor-related protein 11 (LRP11), a newly found lipoprotein receptor regulatory protein, has the carcinogenic effects in cervical cancer.Methods: Bioinformatics analysis, immunohistochemical (IHC) staining and evaluation, cell proliferation assay, flow cytometry, transwell migration and invasion assays, Western blotting, growth of LRP11-silenced cells in athymic nude mice were performed in this research.Results: We found that LRP11 expression was higher in high-grade squamous intraepithelial lesions (HSIL) and cervical cancer tissue than in normal cervix, and high expression of LRP11 was associated with differentiation degree (P=0.0266), indicating poor prognosis (P=0.0210). …”
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Cauliflower stem-derived biochar for effective adsorption and reduction of hexavalent chromium in synthetic wastewater: A sustainable approach by Rajesh Kumar Chanda, Toslim Jahid, Md. Nahid Hassan, Tamanna Yeasmin, Biplob Kumar Biswas

“…Contamination with hexavalent chromium (Cr(VI)) has drawn immense interest of national and global regulatory authorities due to its toxic and carcinogenic threat. Although various approaches have been applied for Cr(VI) removal from aqueous solution, adsorption has been proven to be the most promising method. …”
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RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats. by B Alex Merrick, Dhiral P Phadke, Scott S Auerbach, Deepak Mav, Suzy M Stiegelmeyer, Ruchir R Shah, Raymond R Tice

“…We hypothesized RNA-Seq would reveal more differentially expressed genes (DEG) than microarray analysis, including low copy and novel transcripts related to AFB1's carcinogenic activity compared to feed controls (CTRL). …”
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Assessment of Air Pollution with Polychlorinated Dibenzodioxins (PCDDs) and Polychlorinated Dibenzofuranes (PCDFs) in Lithuania by Vigilija Klima, Renata Chadyšienė, Rūta Ivanec-Goranina, Dainius Jasaitis, Vaida Vasiliauskienė

“…Dioxin isomers are highly toxic and may have carcinogenic and mutagenic effects in humans. PCDD/F is detected in air, water, sediment, plants and animals. …”
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The effect of synergistic phytoremediation and bacterial isolates on removal of polycyclic aromatic hydrocarbons (PAHs) from contaminated soil by Mehdi Khazaei, Alireza Etminan, Soolmaz Dashti, Seyed Ahmad Hosseini

“…Having carcinogenic and toxic effects, aromatic hydrocarbons cause serious damage to the environment and living organisms. …”
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Biochar from Rice Husk as Efficient Biosorbent for Procion Red Removal from Aqueous Systems by Neza R. Palapa, Tarmizi Taher, Novie Juleanti, Normah Normah, Aldes Lesbani

“…However, its applicability for adsorbing Procion Red, which causes carcinogenic and mutagenic effects on aquatic life, has not been studied. …”
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The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy by Markus Schosserer, Markus Schosserer, Johannes Grillari, Johannes Grillari, Johannes Grillari, Johannes Grillari, Michael Breitenbach

“…These factors shape their surroundings toward a pro-carcinogenic microenvironment, which fuels the development of aging-associated cancers together with the accumulation of mutations over time. …”
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Role of metformin in prevention and prognosis of breast cancer by Minahil Binte Saleem, Sarah Fatima, Zoha Ali Khan

“…The number of CD8+ tumour-infiltrating lymphocytes (TILS) has been increased with the use of metformin engendering anti-carcinogenic effects.4 In the last 15 years, we have seen a drastic change in the demographics of BC, with an estimated increase of 70.7 to 130.6% in 2020 and 2025 relative to 2015 in the 30-34 age group in Pakistan.5 There has been a significant increase in T2DM along with increased use of metformin for its treatment which thus raises a question about the efficacy of the drug in a neoadjuvant setting for BC on Pakistani society. …”
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Prevalence, knowledge, and concerns regarding the use of heated tobacco products and electronic cigarettes among young Japanese physicians by Yuichiro Otsuka, Yoshitaka Kaneita, Osamu Itani, Suguru Nakajima

“…Despite uncertainties regarding the health effects of HTPs and ECs, concerns regarding nicotine and carcinogens persist. Although physicians play a vital role in smoking cessation, they lack awareness and concerns regarding HTPs. …”
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Photodegradation of Polycyclic Aromatic Hydrocarbons from Coal Tar into Mine Wastewaters and Sewage Wastewater on a Flat-Bed Photoreactor by Jean Bedel Batchamen Mougnol, Frans Waanders, Elvis Fosso-Kankeu, Ali R. Al Alili

“…These activities tend to release organic pollutants, however polycyclic aromatic hydrocarbons (PAHs) happen to be highlighted as the most carcinogenic pollutant that easily comes into contact with the environment and humans. …”
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Exposure to asbestos in patients with malignant mesothelioma in Iran by Gholamreza Pouryaghoub, Ramin Mehrdad, Soussan Salehpour, Mehran Shahryari

“…Approximately 5-10% of all human cancers are thought to be caused by occupational exposure to carcinogens. Dif-fuse mesotheliomas of the peritoneum and pleura are considered "signal tumors," or pa-thognomonic of exposure to asbestos. …”
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Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques by Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma, Kei-ichi Sugiyama

“…Rats are considered suitable models as they share a similar metabolic pathway with humans for processing toxic chemical and exhibit higher responsiveness to chemical carcinogens than mice. To assess mutagenicity in rats, transgenic rodents (TGRs) are widely used for in vivo gene mutation assays. …”
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Determination of Heavy Metals and Health Risk Assessment in Tap Water from Wuhan, China, a City with Multiple Drinking Water Sources by Zufan Liu, Shiyong Tao, Zuyou Sun, Yilin Chen, Jing Xu

“…The risk of heavy metals in tap water to human health was evaluated, and the results showed that the total carcinogenic risk (TCR) was in the range of 10⁻⁶ and 10⁻⁴ and the hazard index (HI) was much lower than one in both summer and winter. …”
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Prevalence of viral DNA in high-grade serous epithelial ovarian cancer and correlation with clinical outcomes. by Sharon E Robertson, Maya Yasukawa, Douglas C Marchion, Yin Xiong, Syeda Mahrukh Hussnain Naqvi, Tarik Gheit, Massimo Tommasino, Robert M Wenham, Anna R Giuliano, Johnathan M Lancaster, Mian M K Shahzad

“…<h4>Introduction</h4>Currently 11 infectious agents are classified as carcinogenic but the role of infectious agents on outcomes of epithelial ovarian cancer is largely unknown.…”
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Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions by Md. Ataur Rahman, Kazi Rejvee Ahmed, Farzana Haque, Moon Nyeo Park, Bonglee Kim

“…In cancer cells, oncogenic mutations, carcinogens, and metabolic reprogramming cause increased ROS generation and oxidative stress. …”
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Perioperative treatment with tranexamic acid in melanoma (PRIME): protocol for a Danish multicentre randomised controlled trial investigating the prognostic and treatment-related i... by Henrik Schmidt, Lisbet Rosenkrantz Hölmich, Karoline Assifuah Kristjansen, Andreas Engel Krag, Marie Louise Bønnelykke-Behrndtz

“…Interestingly, the known and thoroughly tested antifibrinolytic drug tranexamic acid reduces the risk of bleeding, but it is also suggested to play important roles in anti-inflammatory pathways, improving wound healing and affecting anti-carcinogenic mechanisms.As a novel approach, we will conduct a randomised controlled trial using perioperative treatment with tranexamic acid, aiming to prevent early relapses by &gt;10% for patients with melanoma.Methods and analysis Design: investigator-initiated parallel, two-arm, randomised, blinded, Danish multicentre superiority trial.Patients: ≥T2 b melanoma and eligible for sentinel lymph node biopsy (n=1204).Project drug: tranexamic acid or placebo.Treatment: before surgery (intravenous 15 mg/kg) and daily (peroral 1000 mg x 3) through postoperative day 4.Primary outcome: relapse within 2 years after surgery.Primary analysis: risk difference between the treatment arms (χ2 test).Secondary outcomes: postoperative complications, adverse events and survival.Inclusion period: summer 2023 to summer 2026.Ethics and dissemination The trial will be initiated during the summer of 2023 and is approved by the National Committee on Health Research Ethics, the Danish Medicine Agency, and registered under the Data Protection Act. …”
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Spatial Distribution Characteristics and Risk Assessment of Nutrient Elements and Heavy Metals in the Ganjiang River Basin by Xiaodong Chu, Daishe Wu, Hao Wang, Fangwen Zheng, Cheng Huang, Liang Hu

“…The comprehensive risks of noncarcinogens (H^c) and comprehensive risks of carcinogens (R^c) for adults and children due to drinking water indicated that the risk from drinking water for the children in the basin was greater than that for adults, and that the H^c for adults and children was acceptable. …”
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Hydroxyanthracene derivates citotoxicity: A differential evaluation between single molecule and whole plant extract by Laura Tinti, Vittoria Cicaloni, Paola Nezi, Giovanni Isoldi, Paolo Etiope, Barbara Barlozzini, Rita Pecorari, Laura Salvini

“…Nevertheless, during the past years, a safety usage of HAD products has been under consideration because some studies reported that HADs are not lacking toxicity (i.e., genotoxic and carcinogenic activity). Thus, the first objective of this study is to shed light on the large variability in composition of botanical food supplements containing HAD by a systematic analysis of the qualitative and quantitative composition of a cohort of extracts and raw materials of plants with high levels of anthraquinones commercially available (Cassia angustifolia, Rhamnus purshiana, Rhamnus frangula, Rheum palmatum, and Rheum raponticum). …”
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