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5501
A novel MB-tagged aptasensor for Aflatoxin B1 detection in food using Fe3O4 nanoparticles substantiated with in silico modelling
Published 2023-12-01“…Aspergillus fungi species found in wheat, maize, rice, and other agricultural products produce the carcinogenic mycotoxin known as Aflatoxin B1 (AFB1), which can cause cancer in animals and humans. …”
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5502
Histopathological evaluation of lesions induced by dimethyl hydrazine in male rats
Published 2022-12-01“…This study evaluated dimethylhydrazines' carcinogenic and toxic effect (DMH) in male rats; 30 albino rats were divided into three groups, randomly ten rates for each one. …”
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5503
Pirfenidone regulates antioxidant response via NRF2 in an experimental model of hepatocellular carcinoma
Published 2022-12-01“…Materials and methods: Eighteen Fischer-344 rats divided into three groups were used: 1) untreated (NT), 2) carcinogenic damage (HCC) generated by weekly administration of diethylnitrosamine (50mg/kg/week;i.p.) and 2-Acetylaminofluorene (25mg/ kg/wk, p.o) and 3) HCC treated with PFD (300 mg/kg, p.o.) …”
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5504
Effect of Rs5746136 genotypes on SOD activity and biomarkers levels in breast cancer patients
Published 2023-01-01“…Oxidative stress factors are among the most common carcinogens, Superoxide dismutase enzyme-2 (SOD2) is an endogenous antioxidant involved in the scavenging of superoxide anions. …”
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5505
Redistribution of the SWI/SNF Complex Dictates Coordinated Transcriptional Control over Epithelial–Mesenchymal Transition of Normal Breast Cells through TGF-β Signaling
Published 2022-08-01“…However, whether modulating ARID1A function in premalignant breast epithelial cells could be exploited to reduce carcinogenic potential remains to be elucidated. In search of chromatin-modulating mechanisms activated by anti-proliferative agents in normal breast epithelial (HME-hTert) cells, we identified a distinct pattern of genome-wide H3K27 histone acetylation marks characteristic for the combined treatment by the cancer preventive rexinoid bexarotene (Bex) and carvedilol (Carv). …”
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5506
Source apportionment and source-specific risk evaluation of potential toxic elements in oasis agricultural soils of Tarim River Basin
Published 2023-02-01“…The PTEs in the Hotan Oasis corresponded to a moderate level of risk to the ecological environment, and the noncarcinogenic risk of soil PTEs in the four oases to local children exceeded the threshold (TH > 1), while the carcinogenic risk to local residents was acceptable (1E−06 < TCR < 1E−04). …”
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5507
Heavy metal concentration from gas flaring sites in Umuebulu Etche l.g.a and Agbada II in ObioAkpor/Ikwere l.g.a, Rivers State, Nigeria
Published 2023-09-01“…Heavy metal contamination is of great concern due to its effect as being carcinogenic in nature. Heavy metal concentration was determined in bitter leaf, plantain leaf, cassava leaf, cassava tuber, pepper leaf, pepper fruit, pawpaw leaf, pawpaw fruit, water leaf around gas flaring sites in Umuebulu Etche LGA and Agbada II in Obio/Akpor LGA Rivers State. …”
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5508
Determination of Aflatoxin B<sub>1</sub> in Grains by Aptamer Affinity Column Enrichment and Purification Coupled with High Performance Liquid Chromatography Detection
Published 2024-02-01“…Aflatoxin B<sub>1</sub> (AFB<sub>1</sub>) is a highly teratogenic and carcinogenic secondary metabolite produced by <i>Aspergillus</i>. …”
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5509
Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery
Published 2023-12-01“…Although viral vectors have shown high transfection efficiency, concerns regarding teratogenicity or carcinogenicity have been raised. Non-viral vehicles, including cationic polymers, liposomes, and inorganic materials possess advantages in terms of safety, ease of preparation, and low cost. …”
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5510
Development of a method to assess the risk of aflatoxin contamination of corn within counties in southern Georgia, USA using remotely sensed data
Published 2023-02-01“…Aflatoxins (AFs) are carcinogenic toxins produced by fungi in many staple grain crops. …”
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5511
Polychlorinated biphenyls in residential soils and their health risk and hazard in an industrial city in India
Published 2014-07-01“…Their close proximity may also lead to human exposure through ingestion, inhalation, dermal contact, and may exert neurotoxic, mutagenic and carcinogenic health effects. <br /><em>Design and Methods</em>. …”
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5512
Dipeptidyl peptidase-4 inhibitors and the risk of skin cancer among patients with type 2 diabetes: a UK population-based cohort study
Published 2023-11-01“…Introduction The dipeptidyl peptidase-4 (DPP-4) enzyme significantly influences carcinogenic pathways in the skin. The objective of this study was to determine whether DPP-4 inhibitors are associated with the incidence of melanoma and nonmelanoma skin cancer, compared with sulfonylureas.Research design and methods Using the United Kingdom Clinical Practice Research Datalink, we assembled two new-user active comparator cohorts for each skin cancer outcome from 2007 to 2019. …”
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5513
Anthropogenic hyperactivity for natural resources increases heavy metals concentrations in the environment: Toxicity of healthy food and cancer risks estimated
Published 2023-06-01“…This review highlights high concentration of heavy metals and metalloids in principal food daily intake and nutritionally accepted as healthy products, which were correlated with production sites, plus carcinogenic risks calculated and some metabolic diseases associated with reported cancer risk. …”
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5514
Impact and underlying mechanisms of osteoblast-derived exosomes on biological characteristics of prostate cancer cells
Published 2024-03-01“…Conclusion Osteoblast-derived exosomes are pro-carcinogenic factors in PC, and miR-223 may be a key molecule in exosomes, which plays a oncogenic role by regulating APC in PC cells. …”
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5515
Cell Adhesion Molecules Affected by Ionizing Radiation and Estrogen in an Experimental Breast Cancer Model
Published 2022-10-01“…Cancer develops in a multi-step process where environmental carcinogenic exposure is a primary etiological component, and where cell–cell communication governs the biological activities of tissues. …”
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5516
Scientific opinion on the renewal of the authorisation of Scansmoke SEF7525 (SF‐004) as a smoke flavouring Primary Product
Published 2023-11-01“…Considering that the exposure estimates for styrene and benzofuran are above the threshold of toxicological concern (TTC) value of 0.0025 kg/kg bw per day for DNA‐reactive mutagens and/or carcinogens and since further data are needed to clarify their potential genotoxicity, the Panel concluded that the potential safety concern for genotoxicity of the Primary Product cannot be ruled out.…”
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5517
Update of the risk assessment of mineral oil hydrocarbons in food
Published 2023-09-01“…Genotoxicity and carcinogenicity are associated with MOAH with three or more aromatic rings. …”
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5518
Evaluation of efficiency of copper-nickel ferrite nanoparticles loaded onto multi-walled carbon nanotubes in activation of peroxymonosulfate for degradation of reactive black dye 5...
Published 2022-03-01“…The presence of these solutions due to their toxicity and carcinogenic potential can be a threat to human health. …”
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5519
Inflammatory cytokines and a diverse cervicovaginal microbiota associate with cervical dysplasia in a cohort of Hispanics living in Puerto Rico.
Published 2023-01-01“…We found significant differences in the diversity and composition of the microbiota according to HPV type according to carcinogenic risk, cervical disease, and cytokine abundance. …”
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5520
Comparative Risk Assessment of Three Native <i>Heliotropium</i> Species in Israel
Published 2021-01-01“…Pyrrolizidine alkaloids (PAs) are genotoxic carcinogenic phytotoxins mostly prevalent in the Boraginaceae, Asteraceae and Fabaceae families. …”
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