Controlling contamination for determination of ultra-trace levels of priority pollutants chlorophenols in environmental water matrices by Yassine Kadmi, Lidia Favier, Tania Yehya, Isabelle Soutrel, Andrei Ionuţ Simion, Christophe Vial, Dominique Wolbert

“…These pollutants can be a public health problem due to their carcinogenic properties. In this work, ultra-high pressure liquid chromatography (UHPLC) coupled to a photodiode array detector (PDA) was used for the development of an analytical method capable of simultaneous identification and quantification of two chlorophenols namely, 2-chlorophenol and 2,4-dichlorophenol in water samples. …”
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Design and Evaluation of a Competitive Phosphorescent Immunosensor for Aflatoxin M1 Quantification in Milk Samples Using Mn:ZnS Quantum Dots as Antibody Tags by Sergio Forcada, Adrián Sánchez-Visedo, Candela Melendreras, Mario Menéndez-Miranda, José M. Costa-Fernández, Luis J. Royo, Ana Soldado

“…Aflatoxin M1 (AFM1) is one of the most widespread aflatoxins that can be present in the milk of lactating mammals. It can cause carcinogenicity, mutagenesis, teratogenesis, genotoxicity and immunosuppression. …”
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Assay of p-Chlorophenol Compliance Monitoring in Textile Wet Processing Industry Effluent Using Fenton Oxidation Process by Muhammad Owais, Asad A. Zaidi, Abdul Hameed Memon, Ahmad Hussain, Arsalan Ahmed

“…Chlorophenols are mostly present in synthetic dyes which are proven carcinogenic and therefore undesirable. A number of techniques were used to remove p-Chlorophenol up to the ZDHC MRSL limit. …”
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An Integrated Approach for Source Apportionment and Health Risk Assessment of Heavy Metals in Subtropical Agricultural Soils, Eastern China by Ping Li, Tao Wu, Guojun Jiang, Lijie Pu, Yan Li, Jianzhen Zhang, Fei Xu, Xuefeng Xie

“…The noncarcinogenic risks (HI) of the 8 HMs to adults and children were within the acceptable range, while the carcinogenic risk (RI) of children has exceeded the safety threshold, which needs to be addressed by relevant departments. …”
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Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer by Kang Yao, Zhu Xiaojun, Zhao Tingxiao, Liao Shiyao, Ji Lichen, Zhang Wei, Li Yanlei, Tian Jinlong, Ding Xiaoyan, Zhang Jun, Bi Qing, Lv Jun

“…Results showed that CAFs could activate multiple carcinogenic pathways and most of these pathways play an important role in cancer metastasis. …”
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Targeting uridine–cytidine kinase 2 induced cell cycle arrest through dual mechanism and could improve the immune response of hepatocellular carcinoma by Dehai Wu, Congyi Zhang, Guanqun Liao, Kaiming Leng, Bowen Dong, Yang Yu, Huilin Tai, Lining Huang, Feng Luo, Bin Zhang, Tiexiang Zhan, Qiuhui Hu, Sheng Tai

“…Uridine–cytidine kinase 2 (UCK2), a key regulator of pyrimidine metabolism, is elevated during hepatocellular carcinoma (HCC) development and exhibits carcinogenic effects. However, the key mechanism of UCK2 promoting HCC and the therapeutic value of UCK2 are still undefined. …”
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Effect of Polycyclic Aromatic Hydrocarbons Extracted from Indoor Air of Coffee Shops on Oral Squamous Carcinoma Cell (KB/C152): An in Vitro Approach by Shahnaz Sargazi, Ali Asghar Ebrahimi, Seyed Mehdi Tabatabaei, Mohammad Hassan Ehrampoush, Ramin Saravani, Mohammad Javad Zare Sakhvidi, Hossein Fallahzadeh, Sheida Shahraki

“…Toxic substances, including polycyclic aromatic hydrocarbons (PAHs), recognized as human carcinogens, are present in cooking and tobacco smoke. …”
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Hemolymphoreticular Neoplasias from the Ramazzini Institute Long-term Mice and Rat Studies on Aspartame by Federica Gnudi, Simona Panzacchi, Eva Tibaldi, Martina Iuliani, Daria Sgargi, Luciano Bua, Daniele Mandrioli

“…Background: Haemolymphoreticular neoplasias (HLRNs) from the Ramazzini Institute (RI) carcinogenicity studies on Aspartame (APM) in rats and mice were heterogeneously grouped over the years and different statistical methods were applied. …”
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Volatile and semi-volatile organic compounds in landfill gas: Composition characteristics and health risks by Qi Pan, Qing-Yu Liu, Jing Zheng, Yan-Hong Li, Song Xiang, Xiao-Jie Sun, Xiao-Song He

“…Gas emitted from landfills contains a large quantity of volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs), some of which are carcinogenic, teratogenic, and mutagenic, thereby posing a serious threat to the health of landfill workers and nearby residents. …”
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Outcome of the first survey of atrazine in drinking water from Ijebu-North, South-West, Nigeria: Human health risk and neurotoxicological implications by Folarin Owagboriaye, Rasheed Oladunjoye, Sulaimon Aina, Oladunni Adekunle, Titilola Salisu, Adedamola Adenekan, Oyindamola Abesin, Jesulayomi Oguntubo, Oyebamiji Fafioye, Gabriel Dedeke, Olusegun Lawal

“…Values of atrazine obtained were further used to evaluate the non-carcinogenic risk associated with ingestion and dermal contact in adults and children as well as neurotoxicity assessment. …”
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SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways by Xiaojuan Ren, Chao Feng, Yubo Wang, Pu Chen, Simeng Wang, Jianling Wang, Hongxin Cao, Yujun Li, Meiju Ji, Peng Hou

“…Mechanistically, SLC39A10 exerted its carcinogenic effects by increasing Zn2+ availability and subsequently enhancing the enzyme activity of CK2 (casein kinase 2). …”
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A QSAR, Pharmacokinetic and Toxicological Study of New Artemisinin Compounds with Anticancer Activity by Josinete B. Vieira, Francinaldo S. Braga, Cleison C. Lobato, César F. Santos, Josivan S. Costa, José Adolfo H. M. Bittencourt, Davi S. B. Brasil, Jocivânia O. Silva, Lorane I. S. Hage-Melim, Williams Jorge C. Macêdo, José Carlos T. Carvalho, Cleydson Breno R. Santos

“…These models were used to predict the anticancer activity of eight new artemisinin compounds (test set) with unknown activity, and for these new compounds were predicted pharmacokinetic properties: human intestinal absorption (HIA), cellular permeability (PCaCO2), cell permeability Maden Darby Canine Kidney (PMDCK), skin permeability (PSkin), plasma protein binding (PPB) and penetration of the blood-brain barrier (CBrain/Blood), and toxicological: mutagenicity and carcinogenicity. The test set showed for two new artemisinin compounds satisfactory results for anticancer activity and pharmacokinetic and toxicological properties. …”
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Cellular photo(geno)toxicity of gefitinib after biotransformation by Meryem El Ouardi, Meryem El Ouardi, Lorena Tamarit, Lorena Tamarit, Ignacio Vayá, Ignacio Vayá, Miguel A. Miranda, Miguel A. Miranda, Inmaculada Andreu, Inmaculada Andreu

“…This could ultimately result in mutagenic and carcinogenic effects. These results could aid oncologists when prescribing TKIs to cancer patients and, thus, establish the conditions of use and recommend photoprotection guidelines.…”
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Molecular genetic characteristics of thymic epithelial tumors with distinct histological subtypes by Jun Yang, Biao Zhang, Wenyan Guan, Zhiwen Fan, Xiaohong Pu, Linyue Zhao, Wen Jiang, Weijing Cai, Xueping Quan, Shuying Miao, Ling Nie, Lu He

“…Abstract Background Due to the low incidence and histological heterogeneity, the molecular features and underlying carcinogenic mechanisms of thymic epithelial tumors (TETs) are yet to be fully elucidated, especially for different subtypes of TETs. …”
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Assessing drinking water quality and health risks of contaminants in the coastal areas of Cambodia by Vibol Sao, Chan Oeurn Chey, Tharith Sriv, Noreaksatya The, Samnang Phin, Sophanith Hoeng, Kongkea Phan

“….; Men, women and children residing in the coastal areas of Cambodia are exposed to carcinogenic risk of As through drinking water pathways…”
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Water-Pipe Smoking Exposure Deregulates a Set of Genes Associated with Human Head and Neck Cancer Development and Prognosis by Vanessa M. López-Ozuna, Ishita Gupta, Ryan Liu Chen Kiow, Emad Matanes, Hadeel Kheraldine, Amber Yasmeen, Ashraf Khalil, Semir Vranic, Ala-Eddin Al Moustafa, Halema F Al Farsi

“…However, the underlying molecular pathways and/or target genes responsible for the carcinogenic process are still unknown. In this study, human normal oral epithelial (HNOE) cells, NanoString PanCancer Pathways panel of 770 gene transcripts and quantitative real-time polymerase chain reaction (qRT-PCR) analysis were applied to discover differentially expressed genes (DEG) modulated by WPS. …”
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Characterization of circulating miRNAs in the treatment of primary liver tumors by Tomohiro Umezu, Shogo Tanaka, Shoji Kubo, Masaru Enomoto, Akihiro Tamori, Takahiro Ochiya, Y.‐H. Taguchi, Masahiko Kuroda, Yoshiki Murakami

“…Moreover, the difference of miRNA expression in SVR‐HCC and HCV‐HCC can be important information for enclosing cases that are prone to carcinogenesis after being cured with antiviral agents, but also for uncovering the mechanism for some carcinogenic potential remains even after persistent virus infection has disappeared.…”
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Lung cancer risk assessment for workers exposed to polycyclic aromatic hydrocarbons in various industries by Pascal Petit, Anne Maître, Renaud Persoons, Dominique J. Bicout

“…Background: Millions of workers are exposed to carcinogenic polycyclic aromatic hydrocarbon (PAH) mixtures. …”
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Insights into the Underlying Mechanism of Ochratoxin A Production in <i>Aspergillus niger</i> CBS 513.88 Using Different Carbon Sources by Shan Wei, Chaojiang Hu, Ping Nie, Huanchen Zhai, Shuaibing Zhang, Na Li, Yangyong Lv, Yuansen Hu

“…<i>Aspergillus niger</i> produces carcinogenic ochratoxin A (OTA), a serious food safety and human health concern. …”
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Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico by Jakob Fleischmann, Andreas Feichtner, Louis DeFalco, Valentina Kugler, Selina Schwaighofer, Roland G Huber, Eduard Stefan

“…Thus, targeted MEK inhibition causes qualitative alterations of carcinogenic MAPK signals. Phosphorylation of the MEK1 activation loop at the positions S218 and S222 by RAF kinases triggers the conformational alignment of MEK’s catalytic pocket to enable ATP-binding and substrate phosphorylation. …”
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