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5601
Controlling contamination for determination of ultra-trace levels of priority pollutants chlorophenols in environmental water matrices
Published 2019-12-01“…These pollutants can be a public health problem due to their carcinogenic properties. In this work, ultra-high pressure liquid chromatography (UHPLC) coupled to a photodiode array detector (PDA) was used for the development of an analytical method capable of simultaneous identification and quantification of two chlorophenols namely, 2-chlorophenol and 2,4-dichlorophenol in water samples. …”
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5602
Design and Evaluation of a Competitive Phosphorescent Immunosensor for Aflatoxin M1 Quantification in Milk Samples Using Mn:ZnS Quantum Dots as Antibody Tags
Published 2022-01-01“…Aflatoxin M1 (AFM1) is one of the most widespread aflatoxins that can be present in the milk of lactating mammals. It can cause carcinogenicity, mutagenesis, teratogenesis, genotoxicity and immunosuppression. …”
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5603
Assay of p-Chlorophenol Compliance Monitoring in Textile Wet Processing Industry Effluent Using Fenton Oxidation Process
Published 2023-11-01“…Chlorophenols are mostly present in synthetic dyes which are proven carcinogenic and therefore undesirable. A number of techniques were used to remove p-Chlorophenol up to the ZDHC MRSL limit. …”
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5604
An Integrated Approach for Source Apportionment and Health Risk Assessment of Heavy Metals in Subtropical Agricultural Soils, Eastern China
Published 2021-09-01“…The noncarcinogenic risks (HI) of the 8 HMs to adults and children were within the acceptable range, while the carcinogenic risk (RI) of children has exceeded the safety threshold, which needs to be addressed by relevant departments. …”
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5605
Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer
Published 2023-12-01“…Results showed that CAFs could activate multiple carcinogenic pathways and most of these pathways play an important role in cancer metastasis. …”
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5606
Targeting uridine–cytidine kinase 2 induced cell cycle arrest through dual mechanism and could improve the immune response of hepatocellular carcinoma
Published 2022-11-01“…Uridine–cytidine kinase 2 (UCK2), a key regulator of pyrimidine metabolism, is elevated during hepatocellular carcinoma (HCC) development and exhibits carcinogenic effects. However, the key mechanism of UCK2 promoting HCC and the therapeutic value of UCK2 are still undefined. …”
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5607
Effect of Polycyclic Aromatic Hydrocarbons Extracted from Indoor Air of Coffee Shops on Oral Squamous Carcinoma Cell (KB/C152): An in Vitro Approach
Published 2023-12-01“…Toxic substances, including polycyclic aromatic hydrocarbons (PAHs), recognized as human carcinogens, are present in cooking and tobacco smoke. …”
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5608
Hemolymphoreticular Neoplasias from the Ramazzini Institute Long-term Mice and Rat Studies on Aspartame
Published 2023-06-01“…Background: Haemolymphoreticular neoplasias (HLRNs) from the Ramazzini Institute (RI) carcinogenicity studies on Aspartame (APM) in rats and mice were heterogeneously grouped over the years and different statistical methods were applied. …”
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5609
Volatile and semi-volatile organic compounds in landfill gas: Composition characteristics and health risks
Published 2023-04-01“…Gas emitted from landfills contains a large quantity of volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs), some of which are carcinogenic, teratogenic, and mutagenic, thereby posing a serious threat to the health of landfill workers and nearby residents. …”
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5610
Outcome of the first survey of atrazine in drinking water from Ijebu-North, South-West, Nigeria: Human health risk and neurotoxicological implications
Published 2022-01-01“…Values of atrazine obtained were further used to evaluate the non-carcinogenic risk associated with ingestion and dermal contact in adults and children as well as neurotoxicity assessment. …”
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5611
SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways
Published 2023-08-01“…Mechanistically, SLC39A10 exerted its carcinogenic effects by increasing Zn2+ availability and subsequently enhancing the enzyme activity of CK2 (casein kinase 2). …”
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5612
A QSAR, Pharmacokinetic and Toxicological Study of New Artemisinin Compounds with Anticancer Activity
Published 2014-07-01“…These models were used to predict the anticancer activity of eight new artemisinin compounds (test set) with unknown activity, and for these new compounds were predicted pharmacokinetic properties: human intestinal absorption (HIA), cellular permeability (PCaCO2), cell permeability Maden Darby Canine Kidney (PMDCK), skin permeability (PSkin), plasma protein binding (PPB) and penetration of the blood-brain barrier (CBrain/Blood), and toxicological: mutagenicity and carcinogenicity. The test set showed for two new artemisinin compounds satisfactory results for anticancer activity and pharmacokinetic and toxicological properties. …”
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5613
Cellular photo(geno)toxicity of gefitinib after biotransformation
Published 2023-06-01“…This could ultimately result in mutagenic and carcinogenic effects. These results could aid oncologists when prescribing TKIs to cancer patients and, thus, establish the conditions of use and recommend photoprotection guidelines.…”
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5614
Molecular genetic characteristics of thymic epithelial tumors with distinct histological subtypes
Published 2023-05-01“…Abstract Background Due to the low incidence and histological heterogeneity, the molecular features and underlying carcinogenic mechanisms of thymic epithelial tumors (TETs) are yet to be fully elucidated, especially for different subtypes of TETs. …”
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5615
Assessing drinking water quality and health risks of contaminants in the coastal areas of Cambodia
Published 2023-02-01“….; Men, women and children residing in the coastal areas of Cambodia are exposed to carcinogenic risk of As through drinking water pathways…”
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5616
Water-Pipe Smoking Exposure Deregulates a Set of Genes Associated with Human Head and Neck Cancer Development and Prognosis
Published 2020-09-01“…However, the underlying molecular pathways and/or target genes responsible for the carcinogenic process are still unknown. In this study, human normal oral epithelial (HNOE) cells, NanoString PanCancer Pathways panel of 770 gene transcripts and quantitative real-time polymerase chain reaction (qRT-PCR) analysis were applied to discover differentially expressed genes (DEG) modulated by WPS. …”
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5617
Characterization of circulating miRNAs in the treatment of primary liver tumors
Published 2024-02-01“…Moreover, the difference of miRNA expression in SVR‐HCC and HCV‐HCC can be important information for enclosing cases that are prone to carcinogenesis after being cured with antiviral agents, but also for uncovering the mechanism for some carcinogenic potential remains even after persistent virus infection has disappeared.…”
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5618
Lung cancer risk assessment for workers exposed to polycyclic aromatic hydrocarbons in various industries
Published 2019-03-01“…Background: Millions of workers are exposed to carcinogenic polycyclic aromatic hydrocarbon (PAH) mixtures. …”
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5619
Insights into the Underlying Mechanism of Ochratoxin A Production in <i>Aspergillus niger</i> CBS 513.88 Using Different Carbon Sources
Published 2022-08-01“…<i>Aspergillus niger</i> produces carcinogenic ochratoxin A (OTA), a serious food safety and human health concern. …”
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5620
Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico
Published 2021-03-01“…Thus, targeted MEK inhibition causes qualitative alterations of carcinogenic MAPK signals. Phosphorylation of the MEK1 activation loop at the positions S218 and S222 by RAF kinases triggers the conformational alignment of MEK’s catalytic pocket to enable ATP-binding and substrate phosphorylation. …”
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