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5621
Acute perchloroethylene intoxication in an elderly woman: a case report
Published 2022-10-01“…Liver and kidney toxicities and carcinogenicity are well-known occupational hazards caused by chronic perchloroethylene exposure. …”
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5622
In vivo mutagenicity assessment of orally treated tert-butyl hydroperoxide in the liver and glandular stomach of MutaMouse
Published 2023-11-01“…In contrast, there is little information about in vivo mutagenicity and no information about carcinogenicity by oral exposure. Results We conducted in vivo gene mutation assay using MutaMice according to the OECD Guidelines for the Testing of Chemicals No. 488 to investigate in vivo mutagenicity of TBHP through oral exposure. …”
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5623
Preliminary Assessment of Occurrence, Potential Origin, and Human Health Risk of Volatile Organic Compounds in Uncontrolled Springs, North Morocco
Published 2022-12-01“…A heatmap clustered the provinces based on their degree of pollution, while a dendrogram was used to classify the studied springs into six main groups. Regarding carcinogenic risk, all the samples were safe for consumption as well as for dermal contact, except for S17, S18, and S8, and S19, which might present a severe threat to inhabitants due to their contents of, respectively, naphthalene (2.1 × 10<sup>−3</sup>), chloroform (2.5 × 10<sup>−4</sup>), and cis and trans-dichlropropene (1.61 × 10<sup>−4</sup> and 1.11 × 10<sup>−4</sup>). …”
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5624
Pollution Characteristics and Health Risk Assessment of VOCs in Jinghong
Published 2022-04-01“…However, the value of the benzene cancer risk to the human body was higher than the safety threshold of 1 × 10<sup>−6</sup>, showing that benzene has carcinogenic risk. This study provides effective support for local governments formulating air pollution control policies.…”
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5625
The Curcumin Analogue, EF-24, Triggers p38 MAPK-Mediated Apoptotic Cell Death via Inducing PP2A-Modulated ERK Deactivation in Human Acute Myeloid Leukemia Cells
Published 2020-08-01“…Demethoxycurcumin (DMC) and diphenyl difluoroketone (EF-24) are natural and synthetic curcumin analogues, respectively, with better solubilities and higher anti-carcinogenic activities in various solid tumors than CUR. …”
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5626
Glyphosate and AMPA in Human Urine of HBM4EU Aligned Studies: Part A Children
Published 2022-08-01“…However, the absence of a group ADI for Gly+AMPA and ongoing discussions on e.g., endocrine disrupting effects cast some uncertainty in relation to the current single substance ADI for Gly. The carcinogenic effects of Gly are still debated in the scientific community. …”
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5627
Ecological and health risks from heavy metal sources surrounding an abandoned mercury mine in the island paradise of Palawan, Philippines
Published 2023-05-01“…Hazard index (HI) exceeded 1 for both adults and children in all the sampling locations, implying non-carcinogenic adverse effects. The total cancer risk over a lifetime (LCR) also exceeded the threshold limit of 10−4 for both adults and children, contributed mainly by Cr (91.8%) and As (8.1%). …”
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5628
GPR39-mediated ERK1/2 signaling reduces permethrin-induced proliferation of estrogen receptor α-negative cells
Published 2024-05-01“…However, it is unclear if estrogen receptor-dependent pathways are the only way in which these compounds induce carcinogenic effects. The objective of this study was to determine the impact of the pyrethroid insecticide permethrin on the growth of estrogen receptor negative breast cancer cells MDA-MB-231. …”
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5629
The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk?
Published 2022-09-01“…The most accepted mechanism proposed for explaining the correlation between meat intake and BC involves the generation of carcinogens, such as heterocyclic amines and polycyclic aromatic hydrocarbons by high-temperature cooking. …”
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5630
Geographical distribution of radon and associated health risks in drinking water samples collected from the Mulazai area of Peshawar, Pakistan
Published 2024-03-01“…There is a formidable threat to human well-being posed by the naturally occurring carcinogenic radon (222Rn) gas due to high solubility in water. …”
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5631
NF‐κB1 promotes miR‐27a‐5p upregulation in acrylamide‐induced toxicity in rats
Published 2024-03-01“…Abstract Acrylamide (AA) is a neurotoxic and potentially carcinogenic contaminant, usually generated during food processing. …”
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5632
Comparative genomic analysis of esophageal squamous cell carcinoma among different geographic regions
Published 2023-01-01“…These differences may be related to differences in environmental carcinogens, incidence, and survival.…”
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5633
Risk Assessment and Evaluation of Analytical Method of Polycyclic Aromatic Hydrocarbons (PAHs) for Deep-Fat Fried Pork Products in Korea
Published 2022-05-01“…Many of them are likely to be carcinogenic and cause mutations. In this study, the PAH4 (benzo[a]pyrene (BaP), benz[a]anthracene (BaA), chrysene (CHR), benzo[b]fluoranthene (BbF)) content in deep-fat fried pork was evaluated according to temperature and time, and a risk assessment was conducted. …”
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5634
TRPS1 regulates the opposite effect of progesterone via RANKL in endometrial carcinoma and breast carcinoma
Published 2023-06-01“…Therefore, TRPS1, the coregulator recruited by PR played a critical role in the selective mechanism of progesterone in EC and BC and could become a potential candidate for targeted therapy to improve the anticancer effect of MPA on EC and avoid its carcinogenic effect on BC.…”
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5635
The correlation between Trichomonas vaginalis infection and reproductive system cancer: a systematic review and meta-analysis
Published 2023-03-01“…Conclusions Our study confirmed that there was a correlation between the infection of T. vaginalis and reproductive system cancer, and provided some possible research directions for clarifying the carcinogenic mechanisms caused by T. vaginalis infection.…”
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5636
Response of Foraminifera to Anthropogenic Nicotine Pollution of Cigarette Butts: An Experimental Approach
Published 2023-10-01“…Toxicants such as nicotine, dangerous metals, total particulate matter, and recognized carcinogens can be introduced and transported via CBs into aquatic ecosystems. …”
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5637
Small RNA-Seq Transcriptome Profiling of Mesothelial and Mesothelioma Cell Lines Revealed microRNA Dysregulation after Exposure to Asbestos-like Fibers
Published 2023-02-01“…Experimental evidence has revealed that a variety of fibers, including fluoro-edenite, can develop chronic respiratory diseases and elicit carcinogenic effects in humans. Fluoro-edenite (FE) is a silicate mineral first found in Biancavilla (Sicily, Italy) in 1997. …”
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5638
Apoptosis and DNA damage mediated by ROS involved in male reproductive toxicity in mice induced by Nickel
Published 2023-12-01“…Ni has been confirmed to have multi-organ toxicology and carcinogenicity. Recently, Ni also can impair the male reproductive system, however, its precious mechanism still has not been clarified. …”
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5639
Bigel formulations of St. John’s wort extract in wound healing: toxicological aspects
Published 2023-12-01“…The former analysis predicted low toxicity because of HP’s inability to bind DNA or proteins, but structural alerts for skin irritation/corrosion, carcinogenicity, and mutagenicity were found. Animal studies involved the treatment of excision wounds in Wistar rats with poloxamer 407/borage oil formulations (bigels; Bs) containing HP-rich SJW extract previously developed by us. …”
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5640
Levels and Potential Health Hazards of Chlorinated Pesticides in Surface Water Samples of Charsadda Area of Pakistan Using SPME-GC-ECD Technique
Published 2021-09-01“…For adults and children, the cancer risk from water due to contamination by various pesticides ranged from 0 to 33.29 × 10<sup>−6</sup>. The non-carcinogenic risk from each pollutant in the water samples of the Charsadda district was found to be in the order of heptachlor > aldrin > dieldrin > γ-BHC. …”
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