Acute perchloroethylene intoxication in an elderly woman: a case report by Alessandro Tarditi, Leda Montalbano, Stefano Spina, Francesco Marrazzo, Giampaolo Casella, Paolo Schenardi, Tommaso Conti, Ilaria Angeli, Mauro Minoli, Roberto Fumagalli, Thomas Langer

“…Liver and kidney toxicities and carcinogenicity are well-known occupational hazards caused by chronic perchloroethylene exposure. …”
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In vivo mutagenicity assessment of orally treated tert-butyl hydroperoxide in the liver and glandular stomach of MutaMouse by Yasumasa Murata, Kenichiro Suzuki, Yoshiyuki Shigeta, Takako Iso, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura, Mariko Matsumoto

“…In contrast, there is little information about in vivo mutagenicity and no information about carcinogenicity by oral exposure. Results We conducted in vivo gene mutation assay using MutaMice according to the OECD Guidelines for the Testing of Chemicals No. 488 to investigate in vivo mutagenicity of TBHP through oral exposure. …”
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Preliminary Assessment of Occurrence, Potential Origin, and Human Health Risk of Volatile Organic Compounds in Uncontrolled Springs, North Morocco by Wafae Lechhab, Fabrizio Cincotta, Touria Lechhab, Concetta Condurso, Farida Salmoun, Francesco Cacciola, Antonella Verzera

“…A heatmap clustered the provinces based on their degree of pollution, while a dendrogram was used to classify the studied springs into six main groups. Regarding carcinogenic risk, all the samples were safe for consumption as well as for dermal contact, except for S17, S18, and S8, and S19, which might present a severe threat to inhabitants due to their contents of, respectively, naphthalene (2.1 × 10⁻³), chloroform (2.5 × 10⁻⁴), and cis and trans-dichlropropene (1.61 × 10⁻⁴ and 1.11 × 10⁻⁴). …”
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Pollution Characteristics and Health Risk Assessment of VOCs in Jinghong by Jianwu Shi, Yuzhai Bao, Feng Xiang, Zhijun Wang, Liang Ren, Xiaochen Pang, Jian Wang, Xinyu Han, Ping Ning

“…However, the value of the benzene cancer risk to the human body was higher than the safety threshold of 1 × 10⁻⁶, showing that benzene has carcinogenic risk. This study provides effective support for local governments formulating air pollution control policies.…”
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The Curcumin Analogue, EF-24, Triggers p38 MAPK-Mediated Apoptotic Cell Death via Inducing PP2A-Modulated ERK Deactivation in Human Acute Myeloid Leukemia Cells by Pei-Ching Hsiao, Jer-Hwa Chang, Wei-Jiunn Lee, Chia-Chi Ku, Meng-Ying Tsai, Shun-Fa Yang, Ming-Hsien Chien

“…Demethoxycurcumin (DMC) and diphenyl difluoroketone (EF-24) are natural and synthetic curcumin analogues, respectively, with better solubilities and higher anti-carcinogenic activities in various solid tumors than CUR. …”
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Glyphosate and AMPA in Human Urine of HBM4EU Aligned Studies: Part A Children by Jurgen Buekers, Sylvie Remy, Jos Bessems, Eva Govarts, Loïc Rambaud, Margaux Riou, Janja Snoj Tratnik, Anja Stajnko, Andromachi Katsonouri, Konstantinos C. Makris, Annelies De Decker, Bert Morrens, Nina Vogel, Marike Kolossa-Gehring, Marta Esteban-López, Argelia Castaño, Helle Raun Andersen, Greet Schoeters

“…However, the absence of a group ADI for Gly+AMPA and ongoing discussions on e.g., endocrine disrupting effects cast some uncertainty in relation to the current single substance ADI for Gly. The carcinogenic effects of Gly are still debated in the scientific community. …”
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Ecological and health risks from heavy metal sources surrounding an abandoned mercury mine in the island paradise of Palawan, Philippines by Reymar R. Diwa, Custer C. Deocaris, Lhevy D. Geraldo, Lawrence P. Belo

“…Hazard index (HI) exceeded 1 for both adults and children in all the sampling locations, implying non-carcinogenic adverse effects. The total cancer risk over a lifetime (LCR) also exceeded the threshold limit of 10−4 for both adults and children, contributed mainly by Cr (91.8%) and As (8.1%). …”
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GPR39-mediated ERK1/2 signaling reduces permethrin-induced proliferation of estrogen receptor α-negative cells by Ming-Hui Shi, Yi Yan, Xi Niu, Jia-Fu Wang, Sheng Li

“…However, it is unclear if estrogen receptor-dependent pathways are the only way in which these compounds induce carcinogenic effects. The objective of this study was to determine the impact of the pyrethroid insecticide permethrin on the growth of estrogen receptor negative breast cancer cells MDA-MB-231. …”
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The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk? by Achille Aveta, Crescenzo Cacciapuoti, Biagio Barone, Erika Di Zazzo, Francesco Del Giudice, Martina Maggi, Matteo Ferro, Daniela Terracciano, Gian Maria Busetto, Giuseppe Lucarelli, Octavian Sabin Tataru, Emanuele Montanari, Benito Fabio Mirto, Alfonso Falcone, Gaetano Giampaglia, Enrico Sicignano, Federico Capone, Gianluca Villano, Pasquale Angellotto, Celeste Manfredi, Luigi Napolitano, Ciro Imbimbo, Savio Domenico Pandolfo, Felice Crocetto

“…The most accepted mechanism proposed for explaining the correlation between meat intake and BC involves the generation of carcinogens, such as heterocyclic amines and polycyclic aromatic hydrocarbons by high-temperature cooking. …”
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Geographical distribution of radon and associated health risks in drinking water samples collected from the Mulazai area of Peshawar, Pakistan by Syed Samran Ali Shah, Abdul Rahim Asif, Manzoor Ilahi, Haseeb Haroon, Ihtisham Islam, Adnan Qadir, Irfan Nisar, Malik Muhammad Usman Sani, Rashid Iqbal, Muhammed Habib ur Rahman, Muhammad Arslan, Mona S. Alwahibi, Mohamed S. Elshikh, Allah Ditta

“…There is a formidable threat to human well-being posed by the naturally occurring carcinogenic radon (222Rn) gas due to high solubility in water. …”
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NF‐κB1 promotes miR‐27a‐5p upregulation in acrylamide‐induced toxicity in rats by Lujia Zhang, Liuqing Yang, Jianwei Gao, Li Dong, Yinghua Luo, Fang Chen

“…Abstract Acrylamide (AA) is a neurotoxic and potentially carcinogenic contaminant, usually generated during food processing. …”
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Comparative genomic analysis of esophageal squamous cell carcinoma among different geographic regions by Ruixiang Zhang, Canjun Li, Zhiyi Wan, Jianjun Qin, Yong Li, Zhen Wang, Qingfeng Zheng, Xiaozheng Kang, Xiankai Chen, Yun Li, Jie He, Yin Li

“…These differences may be related to differences in environmental carcinogens, incidence, and survival.…”
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Risk Assessment and Evaluation of Analytical Method of Polycyclic Aromatic Hydrocarbons (PAHs) for Deep-Fat Fried Pork Products in Korea by Seo Yeon Kim, Hye Won Shin, Geon Hee Kim, Yong-Yeon Kim, Min-Jae Kang, Han-Seung Shin

“…Many of them are likely to be carcinogenic and cause mutations. In this study, the PAH4 (benzo[a]pyrene (BaP), benz[a]anthracene (BaA), chrysene (CHR), benzo[b]fluoranthene (BbF)) content in deep-fat fried pork was evaluated according to temperature and time, and a risk assessment was conducted. …”
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TRPS1 regulates the opposite effect of progesterone via RANKL in endometrial carcinoma and breast carcinoma by Linlin Yang, Qiong Fan, Jing Wang, Xiaoming Yang, Jiangjing Yuan, Yuhong Li, Xiao Sun, Yudong Wang

“…Therefore, TRPS1, the coregulator recruited by PR played a critical role in the selective mechanism of progesterone in EC and BC and could become a potential candidate for targeted therapy to improve the anticancer effect of MPA on EC and avoid its carcinogenic effect on BC.…”
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The correlation between Trichomonas vaginalis infection and reproductive system cancer: a systematic review and meta-analysis by Zhenchao Zhang, Dongxian Li, Yuhua Li, Rui Zhang, Xianghuan Xie, Yi Yao, Linfei Zhao, Xiaowei Tian, Zhenke Yang, Shuai Wang, Xuejing Yue, Xuefang Mei

“…Conclusions Our study confirmed that there was a correlation between the infection of T. vaginalis and reproductive system cancer, and provided some possible research directions for clarifying the carcinogenic mechanisms caused by T. vaginalis infection.…”
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Response of Foraminifera to Anthropogenic Nicotine Pollution of Cigarette Butts: An Experimental Approach by Anna Sabbatini, Francesca Caridi, Giovanni Birarda, Elisa Costanzi, Adolfo Amici, Giovanna Mobbili, Carla Buosi, Giovanni De Giudici, Daniela Medas, Alessandra Negri

“…Toxicants such as nicotine, dangerous metals, total particulate matter, and recognized carcinogens can be introduced and transported via CBs into aquatic ecosystems. …”
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Small RNA-Seq Transcriptome Profiling of Mesothelial and Mesothelioma Cell Lines Revealed microRNA Dysregulation after Exposure to Asbestos-like Fibers by Veronica Filetti, Claudia Lombardo, Carla Loreto, George Dounias, Massimo Bracci, Serena Matera, Lucia Rapisarda, Venerando Rapisarda, Caterina Ledda, Ermanno Vitale

“…Experimental evidence has revealed that a variety of fibers, including fluoro-edenite, can develop chronic respiratory diseases and elicit carcinogenic effects in humans. Fluoro-edenite (FE) is a silicate mineral first found in Biancavilla (Sicily, Italy) in 1997. …”
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Apoptosis and DNA damage mediated by ROS involved in male reproductive toxicity in mice induced by Nickel by Hongrui Guo, Yue Yang, Yanbing Lou, Zhicai Zuo, Hengmin Cui, Huidan Deng, Yanqiu Zhu, Jing Fang

“…Ni has been confirmed to have multi-organ toxicology and carcinogenicity. Recently, Ni also can impair the male reproductive system, however, its precious mechanism still has not been clarified. …”
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Bigel formulations of St. John’s wort extract in wound healing: toxicological aspects by Yoana Sotirova, Deyana Vankova, Oskan Tasinov, Stefka Stoeva, Minka Hristova, Ivelin Iliev, Svetlana Georgieva, Yoana Kiselova-Kaneva, Velichka Andonova

“…The former analysis predicted low toxicity because of HP’s inability to bind DNA or proteins, but structural alerts for skin irritation/corrosion, carcinogenicity, and mutagenicity were found. Animal studies involved the treatment of excision wounds in Wistar rats with poloxamer 407/borage oil formulations (bigels; Bs) containing HP-rich SJW extract previously developed by us. …”
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Levels and Potential Health Hazards of Chlorinated Pesticides in Surface Water Samples of Charsadda Area of Pakistan Using SPME-GC-ECD Technique by Muhammad Ismail, Sultan Alam, Muhammad Sufaid Khan, Luqman Ali Shah, S. M. Mukaram Shah, Muhammad Wahab, Gul Rukh, Najeeb ur Rahman, Noor Rehman, Noor ul Amin, Juris Burlakovs, Anna Kallistova, Nikolai Pimenov, Zane Vincevica-Gaile, Yahya Jani, Muhammad Zahoor, Ivar Zekker

“…For adults and children, the cancer risk from water due to contamination by various pesticides ranged from 0 to 33.29 × 10⁻⁶. The non-carcinogenic risk from each pollutant in the water samples of the Charsadda district was found to be in the order of heptachlor > aldrin > dieldrin > γ-BHC. …”
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