Short term temporal variability of selected organophosphate esters among healthy adults living in the National Capital Region of Canada by Shabana Siddique, Gong Zhang, Rocio Aranda-Rodriguez, Leonora Marro, Cariton Kubwabo

“…Potential adverse impacts on human health, including carcinogenicity, neurotoxicity, developmental and reproductive toxicity have been well documented. …”
Get full text

A simple approach to assess the cancer risk of occupational exposure to genotoxic drugs in healthcare settings by Johannes Gerding, Lea Anhäuser, Udo Eickmann, Albert Nienhaus

“…The risk model underlying ICH guideline M7 (R1): “assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk” was used as a starting point for our model. …”
Get full text

Human health risk assessment of cyanide levels in water and tuber crops from Kenyasi, a mining community in the Brong Ahafo Region of Ghana by Edward Ebow Kwaansa-Ansah, Leticia Peace Amenorfe, Edward Kwaku Armah, Francis Opoku

“…This signifies adverse non-carcinogenic risk. The persistent intake of cassava and cocoyam can probably induce adverse health effects. …”
Get full text

MODEL OF ORGANIZATION OF KIDNEY CANCER EARLY DIAGNOSIS by V. G. Moreva, G. N. Alekseeva, P. F. Kiku, L. I. Gurina, K. M. Sabirova, V. N. Rasskazova

“…The first group of factors (65.0 %) is caused by smoking, excessive alcohol consumption, overweight, unbalanced nutrition, and the influence of carcinogens. The second group of factors (35.0 %) is caused by problems of a medical and social nature: the low material and technical base of primary care medical organizations, the insufficient professional training of medical workers on the issues of cancer prevention and treatment, including kidney cancer.Conclusion. …”
Get full text

Promotion of breast cancer by β-Hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice by Matsumura Fumio, Wong Patrick S

“…Previous studies, have demonstrated the role of these markers as evidence of malignant transformations, and further illustrate the ability of β-HCH to be carcinogenic. To demonstrate β-HCH's tumorigenic properties in an <it>in vivo </it>system, we used an MMTV-Neu mouse model.…”
Get full text

Flow and temporal effects on the sonolytic defluorination of perfluorooctane sulfonic acid by Tim Sidnell, Angel J. Caceres Cobos, Jake Hurst, Judy Lee, Madeleine J. Bussemaker

“…The removal of per- and polyfluoroalkyl substance (PFAS) pollution from the environment is a globally pressing issue, due to some PFAS’ recalcitrant, bioaccumulative, and carcinogenic nature. Destruction via ultrasonic waves (sonolysis) is a promising contender for industrialisation due to; moderate power consumption, applicability to several PFAS and sample types, and limited by-products. …”
Get full text

Implications of Lifestyle and Occupational Factors on the Risk of Breast Cancer in Shiftwork Nurses by Javier Fagundo-Rivera, Regina Allande-Cussó, Mónica Ortega-Moreno, Juan Jesús García-Iglesias, Adolfo Romero, Carlos Ruiz-Frutos, Juan Gómez-Salgado

“…Shift work that involves circadian disruption has been highlighted as a likely carcinogenic factor for breast cancer in humans. Also, unhealthy lifestyle habits observed in night work nurses could be causally related to an increase in the incidence of estrogen-positive breast tumours in this population. …”
Get full text

Analysis of physicochemical attributes, contamination level of trace metals and assessment of health risk in mango fruits from Southern region Ethiopia by Dessie Ezez, Mitiku Belew

“…Except Damot Gale sample in moderate range, the values of total carcinogenic risks (TCR) in all metals were less than 1 × 10−6, which is considered to be safe. …”
Get full text

Re‐evaluation of neohesperidine dihydrochalcone (E 959) as a food additive by EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria José Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Wim Mennes, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Monika Batke, Polly Boon, Ellen Bruzell, James Chipman, Riccardo Crebelli, Rex FitzGerald, Cristina Fortes, Thorhallur Halldorsson, Jean‐Charles LeBlanc, Oliver Lindtner, Alicja Mortensen, Evangelia Ntzani, Heather Wallace, Claudia Cascio, Consuelo Civitella, Zsuzsanna Horvath, Federica Lodi, Agnieszka Mech, Alexandra Tard, Giorgia Vianello

“…The Panel also considered that a carcinogenicity study was not warranted and that the lack of human data did not affect the overall confidence in the body of evidence. …”
Get full text

Photocatalytic Degradation of Polycyclic Aromatic Hydrocarbons in Fine Particulate Matter (PM_2.5) Collected on TiO₂-Supporting Quartz Fibre Filters by Koki Sohara, Katsuya Yamauchi, Xu Sun, Kazuhiro Misawa, Yoshika Sekine

“…Airborne fine particulate matter (PM_2.5) pollution is known to have adverse effects on human health, and owing to their carcinogenic and mutagenic nature, polycyclic aromatic hydrocarbons (PAHs) are of particular concern. …”
Get full text

A Framework for Early Detection of Acute Lymphoblastic Leukemia and Its Subtypes From Peripheral Blood Smear Images Using Deep Ensemble Learning Technique by Sajida Perveen, Abdullah Alourani, Muhammad Shahbaz, M. Usman Ashraf, Isma Hamid

“…Acute lymphoblastic leukemia (ALL), one of the prevalent types of carcinogenic disease, has been seen a deadly illness exposing numerous patients across the world to potential threats of lives. …”
Get full text

一种新兴的1型糖尿病治疗策略:靶向胰腺β细胞中的PI3K/Akt信号通路以增强其存活和功能 by Inah Camaya, Sheila Donnelly, Bronwyn O'Brien

“…An important consideration is the identification of the specific PI3K/Akt pathway modulators that enhance β‐cell function and prevent β‐cell death without inducing excessive β‐cell proliferation, which may carry carcinogenic side effects. Among potential PI3K/Akt pathway agonists, we have identified a novel parasite‐derived protein, termed FhHDM‐1 (Fasciola hepatica helminth defense molecule 1), which efficiently stimulates the PI3K/Akt pathway in β‐cells to enhance function and prevent death without concomitantly inducing proliferation unlike several other identified stimulators of PI3K/Akt signaling . …”
Get full text

Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study) by Margot Guth, Marie Lefevre, Corinne Pilorget, Astrid Coste, Shukrullah Ahmadi, Aurélie Danjou, Brigitte Dananché, Delphine Praud, Isabelle Koscinski, Aline Papaxanthos, Oxana Blagosklonov, Patricia Fauque, Olivia Pérol, Joachim Schüz, Louis Bujan, Ann Olsson, Béatrice Fervers, Barbara Charbotel, The TESTIS study group

“…Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. …”
Get full text

Modeling of senescent cell dynamics predicts a late‐life decrease in cancer incidence by Margaux Bieuville, Tazzio Tissot, Alexandre Robert, Pierre‐Yves Henry, Samuel Pavard

“…Abstract Current oncogenic theories state that tumors arise from cell lineages that sequentially accumulate (epi)mutations, progressively turning healthy cells into carcinogenic ones. While those models found some empirical support, they are little predictive of intraspecies age‐specific cancer incidence and of interspecies cancer prevalence. …”
Get full text

Assessment of potentially toxic and mineral elements in paddy soils and their uptake by rice (Oryza sativa L.) with associated health hazards in district Malakand, Pakistan by Asghar Khan, Muhammad Saleem Khan, Munib Ahmed Shafique, Qaisar Khan, Ghulam Saddiq

“…Monte Carlo simulations of hazard index >1 for Cr, Zn, As, and Cu with certainties of 89.93% and 90.17%, indicated significant noncarcinogenic risks for children and adults from rice consumption. The total carcinogenic risk (TCR) for adults and children exceeded the USEPA acceptable limits of 1×10−6 to 1×10−4, respectively. …”
Get full text

Polymorphism of E6 and E7 Genes in Human Papillomavirus Types 31 and 33 in Northeast China by Miao Yu, Si Wu, Shuang Wang, Changwan Cui, Yiping Lu, Zhengrong Sun

“…Genetic polymorphism may lead to differences in the virus’ carcinogenic potential, the immune reaction of the host, and the potencies of vaccines. …”
Get full text

Most commonly prescribed blood pressure lowering drug linked with increased risk of skin cancer. by Soha Alam Rehmani, Maha Alam Rehmani, Navaira Shoaib

“…Moreover, HCTZ is now classified as a carcinogenic agent for humans by the International Agency for Research on Cancer and the U.S. …”
Get full text

Resveratrol Modulates Chemosensitisation to 5-FU via β1-Integrin/HIF-1α Axis in CRC Tumor Microenvironment by Aranka Brockmueller, Sosmitha Girisa, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei

“…Resveratrol is able to utilize β1-integrin receptors, strongly expressed in CRC cells, to transmit and exert anti-carcinogenic signals, but whether it can also utilize these receptors to overcome 5-FU chemoresistance in CRC cells has not yet been investigated. …”
Get full text

Identification and Determination of Impurities in a New Therapeutic Agent for Fatty Liver Disease by Huihui Shao, Jing Feng, Hanyilan Zhang, Yuanyuan Zhang, Tong Qin, Yuhua Hu, Wenxuan Zhang, Tiesong Wang, Song Wu, Qingyun Yang

“…Toxicity prediction revealed potential carcinogenicity of impurity V containing an N-oxygen fragment. …”
Get full text

Silver nanoparticles from Saudi and syrian black cumin seed extracts: Green synthesis, ADME, toxicity, comparative research, and biological appraisal by Mohammad Rashid, Md Tanwir Athar, Mohammed Abdelmageed, Mohammed Hilal M Al-Harbi, Asif Husain, Dheeraj Bisht, Rajeshwar Kamal Kant Arya

“…Except for molecule 11, no organ damage (hepatotoxicity) or endpoint toxicity (mutagenicity, immunotoxicity, carcinogenicity, and cytotoxicity) was identified in ProTox-II. …”
Get full text