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5681
Short term temporal variability of selected organophosphate esters among healthy adults living in the National Capital Region of Canada
Published 2024-09-01“…Potential adverse impacts on human health, including carcinogenicity, neurotoxicity, developmental and reproductive toxicity have been well documented. …”
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5682
A simple approach to assess the cancer risk of occupational exposure to genotoxic drugs in healthcare settings
Published 2022-04-01“…The risk model underlying ICH guideline M7 (R1): “assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk” was used as a starting point for our model. …”
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5683
Human health risk assessment of cyanide levels in water and tuber crops from Kenyasi, a mining community in the Brong Ahafo Region of Ghana
Published 2017-10-01“…This signifies adverse non-carcinogenic risk. The persistent intake of cassava and cocoyam can probably induce adverse health effects. …”
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5684
MODEL OF ORGANIZATION OF KIDNEY CANCER EARLY DIAGNOSIS
Published 2021-05-01“…The first group of factors (65.0 %) is caused by smoking, excessive alcohol consumption, overweight, unbalanced nutrition, and the influence of carcinogens. The second group of factors (35.0 %) is caused by problems of a medical and social nature: the low material and technical base of primary care medical organizations, the insufficient professional training of medical workers on the issues of cancer prevention and treatment, including kidney cancer.Conclusion. …”
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5685
Promotion of breast cancer by β-Hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice
Published 2007-07-01“…Previous studies, have demonstrated the role of these markers as evidence of malignant transformations, and further illustrate the ability of β-HCH to be carcinogenic. To demonstrate β-HCH's tumorigenic properties in an <it>in vivo </it>system, we used an MMTV-Neu mouse model.…”
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5686
Flow and temporal effects on the sonolytic defluorination of perfluorooctane sulfonic acid
Published 2023-12-01“…The removal of per- and polyfluoroalkyl substance (PFAS) pollution from the environment is a globally pressing issue, due to some PFAS’ recalcitrant, bioaccumulative, and carcinogenic nature. Destruction via ultrasonic waves (sonolysis) is a promising contender for industrialisation due to; moderate power consumption, applicability to several PFAS and sample types, and limited by-products. …”
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5687
Implications of Lifestyle and Occupational Factors on the Risk of Breast Cancer in Shiftwork Nurses
Published 2021-05-01“…Shift work that involves circadian disruption has been highlighted as a likely carcinogenic factor for breast cancer in humans. Also, unhealthy lifestyle habits observed in night work nurses could be causally related to an increase in the incidence of estrogen-positive breast tumours in this population. …”
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5688
Analysis of physicochemical attributes, contamination level of trace metals and assessment of health risk in mango fruits from Southern region Ethiopia
Published 2023-01-01“…Except Damot Gale sample in moderate range, the values of total carcinogenic risks (TCR) in all metals were less than 1 × 10−6, which is considered to be safe. …”
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5689
Re‐evaluation of neohesperidine dihydrochalcone (E 959) as a food additive
Published 2022-11-01“…The Panel also considered that a carcinogenicity study was not warranted and that the lack of human data did not affect the overall confidence in the body of evidence. …”
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5690
Photocatalytic Degradation of Polycyclic Aromatic Hydrocarbons in Fine Particulate Matter (PM<sub>2.5</sub>) Collected on TiO<sub>2</sub>-Supporting Quartz Fibre Filters
Published 2021-03-01“…Airborne fine particulate matter (PM<sub>2.5</sub>) pollution is known to have adverse effects on human health, and owing to their carcinogenic and mutagenic nature, polycyclic aromatic hydrocarbons (PAHs) are of particular concern. …”
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5691
A Framework for Early Detection of Acute Lymphoblastic Leukemia and Its Subtypes From Peripheral Blood Smear Images Using Deep Ensemble Learning Technique
Published 2024-01-01“…Acute lymphoblastic leukemia (ALL), one of the prevalent types of carcinogenic disease, has been seen a deadly illness exposing numerous patients across the world to potential threats of lives. …”
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5692
一种新兴的1型糖尿病治疗策略:靶向胰腺β细胞中的PI3K/Akt信号通路以增强其存活和功能
Published 2022-04-01“…An important consideration is the identification of the specific PI3K/Akt pathway modulators that enhance β‐cell function and prevent β‐cell death without inducing excessive β‐cell proliferation, which may carry carcinogenic side effects. Among potential PI3K/Akt pathway agonists, we have identified a novel parasite‐derived protein, termed FhHDM‐1 (Fasciola hepatica helminth defense molecule 1), which efficiently stimulates the PI3K/Akt pathway in β‐cells to enhance function and prevent death without concomitantly inducing proliferation unlike several other identified stimulators of PI3K/Akt signaling . …”
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5693
Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study)
Published 2023-09-01“…Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. …”
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5694
Modeling of senescent cell dynamics predicts a late‐life decrease in cancer incidence
Published 2023-03-01“…Abstract Current oncogenic theories state that tumors arise from cell lineages that sequentially accumulate (epi)mutations, progressively turning healthy cells into carcinogenic ones. While those models found some empirical support, they are little predictive of intraspecies age‐specific cancer incidence and of interspecies cancer prevalence. …”
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5695
Assessment of potentially toxic and mineral elements in paddy soils and their uptake by rice (Oryza sativa L.) with associated health hazards in district Malakand, Pakistan
Published 2024-04-01“…Monte Carlo simulations of hazard index >1 for Cr, Zn, As, and Cu with certainties of 89.93% and 90.17%, indicated significant noncarcinogenic risks for children and adults from rice consumption. The total carcinogenic risk (TCR) for adults and children exceeded the USEPA acceptable limits of 1×10−6 to 1×10−4, respectively. …”
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5696
Polymorphism of E6 and E7 Genes in Human Papillomavirus Types 31 and 33 in Northeast China
Published 2023-01-01“…Genetic polymorphism may lead to differences in the virus’ carcinogenic potential, the immune reaction of the host, and the potencies of vaccines. …”
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5697
Most commonly prescribed blood pressure lowering drug linked with increased risk of skin cancer.
Published 2022-05-01“…Moreover, HCTZ is now classified as a carcinogenic agent for humans by the International Agency for Research on Cancer and the U.S. …”
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5698
Resveratrol Modulates Chemosensitisation to 5-FU via β1-Integrin/HIF-1α Axis in CRC Tumor Microenvironment
Published 2023-03-01“…Resveratrol is able to utilize β1-integrin receptors, strongly expressed in CRC cells, to transmit and exert anti-carcinogenic signals, but whether it can also utilize these receptors to overcome 5-FU chemoresistance in CRC cells has not yet been investigated. …”
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5699
Identification and Determination of Impurities in a New Therapeutic Agent for Fatty Liver Disease
Published 2023-01-01“…Toxicity prediction revealed potential carcinogenicity of impurity V containing an N-oxygen fragment. …”
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5700
Silver nanoparticles from Saudi and syrian black cumin seed extracts: Green synthesis, ADME, toxicity, comparative research, and biological appraisal
Published 2023-01-01“…Except for molecule 11, no organ damage (hepatotoxicity) or endpoint toxicity (mutagenicity, immunotoxicity, carcinogenicity, and cytotoxicity) was identified in ProTox-II. …”
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