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5801
The Emerging Role of E3 Ubiquitin Ligase SMURF2 in the Regulation of Transcriptional Co-Repressor KAP1 in Untransformed and Cancer Cells and Tissues
Published 2022-03-01“…The conducted immunohistochemical studies showed that the reciprocal relationship between the expression of SMURF2 and KAP1 also exists in human normal and breast cancer tissues and suggested that this relationship may be disrupted by the carcinogenic process. Finally, through stratifying KAP1 interactome in cells expressing either SMURF2 wild-type or its E3 ligase-dead form, we demonstrate that SMURF2 has a profound impact on KAP1 protein–protein interactions and the associated functions, adding an additional layer in the SMURF2-mediated regulation of KAP1. …”
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5802
Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance
Published 2023-10-01“…Ubiquitin-conjugating enzyme E2 C (UBE2C) plays a carcinogenic role in gastric cancer (GC); yet, its role in cisplatin (DDP) resistance in GC is enigmatic. …”
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5803
Long non-coding RNA SNHG17 may function as a competitive endogenous RNA in diffuse large B-cell lymphoma progression by sponging miR-34a-5p.
Published 2023-01-01“…SNHG17, miR-34a-5p, and ZESTE gene enhancer homolog 2 (EZH2) had common hypothetical binding sites, and the luciferase reporter assay verified that miR-34a-5p was the direct target of SNHG17, and EZH2 was the direct target of miR-34a-5p. The carcinogenic function of SNHG17 in the proliferation and apoptosis of DLBCL cells was partially reversed by a miR-34a-5p inhibitor. …”
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5804
Screening and prioritising persistent, mobile and toxic chemicals: development and application of a robust scoring system
Published 2023-06-01“…The T score was based on the indicators for five human health endpoints: carcinogenicity (c), mutaganicity (m), reprotoxicity (r), endocrine disruption (ED) and general repeated dose systemic toxicity. …”
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5805
Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 1–agin...
Published 2023-09-01“…This pattern of widespread interference with developmental programs and relative cellular dedifferentiation (which is pro-oncogenic) is reinforced by cannabinoid impairment of intermediate metabolism (which locks in the stem cell-like hyper-replicative state) and cannabinoid immune stimulation (which perpetuates and increases aging and senescence programs, DNA damage, DNA hypomethylation, genomic instability, and oncogenesis), which together account for the diverse pattern of teratologic and carcinogenic outcomes reported in recent large epidemiologic studies in Europe, the USA, and elsewhere. …”
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5806
Descriptive, analytical and molecular epidemiology of pancreatic cancer
Published 2022-06-01“…A signifcant disadvantage of our understanding of the process of carcinogenesis is the lack of information about carcinogenic factors that cause specifc mutations, i.e. the formation of mutational signatures. …”
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5807
An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity
Published 2021“…Epidemiological data suggest that PQ is also mutagenic and carcinogenic, especially in high doses. The toxic and mutagenic properties of PQ are attributed to the ability of the molecule to redox-cycle, which generates reactive oxygen species (ROS) and subsequent oxidative stress. …”
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5808
Using the HepaCometChip Assay for Broad‐Spectrum DNA Damage Analysis
Published 2023“…The liver is particularly vulnerable because it contains high levels of Cytochrome P450 enzymes that can convert xenobiotics into DNA reactive metabolites that form potentially carcinogenic bulky DNA adducts. As such, current requirements for preclinical testing include in vivo testing for DNA damage in the liver, which often requires many animals. …”
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5809
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5810
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5811
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5812
Development of high-performance polydimethylsiloxane-based nanofibrous composite membranes for phenol removal from wastewater
Published 2018“…Among the major pollutants, phenol has become a rising concern due to its high toxicity and carcinogenicity. On the other hand, phenol is recognized as a valuable chemical for industrial application such as production of phenolic resins. …”
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5813
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5814
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5815
Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries.
Published 1995“…These analyses were undertaken to obtain a more precise direct assessment of the carcinogenic effects of protracted low-level exposure to external, predominantly gamma, radiation. …”
Journal article -
5816
Night shift work and breast cancer incidence: Three prospective studies and meta-analysis of published studies.
Published 2016“…A 2007 WHO review concluded, mainly from animal evidence, that shift work involving circadian disruption is probably carcinogenic to humans. We therefore aimed to generate prospective epidemiological evidence on night-shift work and breast cancer incidence.…”
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5817
Polyurethane membrane as an adsorbent for methyl orange and ethyl violet dyes(Membran poliuretana sebagai penjerap untuk pewarna metil oren dan etil ungu lembayung)
Published 2018“…Due to their complex chemical structures and synthetic nature, these dyes are highly stable to light and oxidation, making them non-biodegradable, highly toxic, carcinogenic and mutagenic in nature. Among all techniques, adsorption continues to attract considerable attention due to its simplistic approach and numerous benefits such as greater efficiency, capacity to remove dyes on a large scale, ease of recovery, and recyclability of adsorbents. …”
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5818
Effect of the oxidation process on the molecular interaction of polyaromatic hydrocarbons (PAH) with carbon nanotubes: Adsorption kinetic and isotherm study
Published 2019“…The results of this study indicate the high potential of the developed MWCNT-OH adsorbent as an efficient and successful material for the removal of carcinogenic PAHs from the water body. © 2019 Elsevier B.V.…”
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5819
Characterization and Concentration and source identification of Polycyclic aromatic Hydrocarbons in selected sites of Kota Kinabalu Port, Sabah
Published 2014“…Toxic PAHs were more abundant than carcinogenic PAHs in studied area. Stations near the main loading area of the port, deep depository sedimentary environment and near busy human activities were significant and ranging from 400-600 nglg d.w. …”
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Research Report -
5820
Assessment of heavy metals in Amaranthus viridis L. from Peninsular Malaysia
Published 2021“…Concerning HHR, the target hazard quotients (THQ) for Cd, Cu, Fe, Pb and Zn in the leaves of A. viridis were all below 1.00, indicating there were no non-carcinogenic risks four metals to consumers, including children and adults. …”
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Thesis