The Emerging Role of E3 Ubiquitin Ligase SMURF2 in the Regulation of Transcriptional Co-Repressor KAP1 in Untransformed and Cancer Cells and Tissues by Pooja Anil Shah, Sandy Boutros-Suleiman, Andrea Emanuelli, Biagio Paolini, Gal Levy-Cohen, Michael Blank

“…The conducted immunohistochemical studies showed that the reciprocal relationship between the expression of SMURF2 and KAP1 also exists in human normal and breast cancer tissues and suggested that this relationship may be disrupted by the carcinogenic process. Finally, through stratifying KAP1 interactome in cells expressing either SMURF2 wild-type or its E3 ligase-dead form, we demonstrate that SMURF2 has a profound impact on KAP1 protein–protein interactions and the associated functions, adding an additional layer in the SMURF2-mediated regulation of KAP1. …”
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Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance by Long Jiegen, Zhu Bin, Tian Tao, Ren Linfei, Tao Yong, Zhu Haitao, Li Dengwei, Xu Yonghong

“…Ubiquitin-conjugating enzyme E2 C (UBE2C) plays a carcinogenic role in gastric cancer (GC); yet, its role in cisplatin (DDP) resistance in GC is enigmatic. …”
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Long non-coding RNA SNHG17 may function as a competitive endogenous RNA in diffuse large B-cell lymphoma progression by sponging miR-34a-5p. by Shengjuan Lu, Lin Zeng, Guojun Mo, Danqing Lei, Yuanhong Li, Guodi Ou, Hailian Wu, Jie Sun, Chao Rong, Sha He, Dani Zhong, Qing Ke, Qingmei Zhang, Xiaohong Tan, Hong Cen, Xiaoxun Xie, Chengcheng Liao

“…SNHG17, miR-34a-5p, and ZESTE gene enhancer homolog 2 (EZH2) had common hypothetical binding sites, and the luciferase reporter assay verified that miR-34a-5p was the direct target of SNHG17, and EZH2 was the direct target of miR-34a-5p. The carcinogenic function of SNHG17 in the proliferation and apoptosis of DLBCL cells was partially reversed by a miR-34a-5p inhibitor. …”
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Screening and prioritising persistent, mobile and toxic chemicals: development and application of a robust scoring system by Julia Hartmann, Emiel Rorije, Pim N. H. Wassenaar, Eric Verbruggen

“…The T score was based on the indicators for five human health endpoints: carcinogenicity (c), mutaganicity (m), reprotoxicity (r), endocrine disruption (ED) and general repeated dose systemic toxicity. …”
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Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 1–agin... by Albert Stuart Reece, Albert Stuart Reece, Gary Kenneth Hulse, Gary Kenneth Hulse

“…This pattern of widespread interference with developmental programs and relative cellular dedifferentiation (which is pro-oncogenic) is reinforced by cannabinoid impairment of intermediate metabolism (which locks in the stem cell-like hyper-replicative state) and cannabinoid immune stimulation (which perpetuates and increases aging and senescence programs, DNA damage, DNA hypomethylation, genomic instability, and oncogenesis), which together account for the diverse pattern of teratologic and carcinogenic outcomes reported in recent large epidemiologic studies in Europe, the USA, and elsewhere. …”
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Descriptive, analytical and molecular epidemiology of pancreatic cancer by O. V. Shangina, D. M. Maximovich, D. G. Zaridze

“…A signifcant disadvantage of our understanding of the process of carcinogenesis is the lack of information about carcinogenic factors that cause specifc mutations, i.e. the formation of mutational signatures. …”
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An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity by Tajai, Preechaya, Fedeles, Bogdan I, Suriyo, Tawit, Navasumrit, Panida, Kanitwithayanun, Jantamas, Essigmann, John M, Satayavivad, Jutamaad

“…Epidemiological data suggest that PQ is also mutagenic and carcinogenic, especially in high doses. The toxic and mutagenic properties of PQ are attributed to the ability of the molecule to redox-cycle, which generates reactive oxygen species (ROS) and subsequent oxidative stress. …”
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Using the HepaCometChip Assay for Broad‐Spectrum DNA Damage Analysis by Owiti, Norah A, Kaushal, Simran, Martin, Lincoln, Sly, Jamie, Swartz, Carol D, Fowler, Jasmine, Corrigan, Joshua J, Recio, Les, Engelward, Bevin P

“…The liver is particularly vulnerable because it contains high levels of Cytochrome P450 enzymes that can convert xenobiotics into DNA reactive metabolites that form potentially carcinogenic bulky DNA adducts. As such, current requirements for preclinical testing include in vivo testing for DNA damage in the liver, which often requires many animals. …”
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Point mutations in normal lungs of smokers and non-smokers by Sudo, Hiroko, 1977-

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Enhanced polymeric nanoparticles for gene delivery by Green, Jordan Jamieson

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Nitrogen oxide delivery systems for biological media by Skinn, Brian Thomas

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Development of high-performance polydimethylsiloxane-based nanofibrous composite membranes for phenol removal from wastewater by Jin, Meng-Yi

“…Among the major pollutants, phenol has become a rising concern due to its high toxicity and carcinogenicity. On the other hand, phenol is recognized as a valuable chemical for industrial application such as production of phenolic resins. …”
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Computer-aided modelling for flavonoid solubility prediction using combined cosmo-RS and UNIFAC by Mat Nor, Mohd. Shukri

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Assessment of emerging pollutants in Skudai river and its treatability at downstream water treatment plant by Talib @ Harun, Juhaizah

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Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. by Cardis, E, Gilbert, E, Carpenter, L, Howe, G, Kato, I, Armstrong, B, Beral, V, Cowper, G, Douglas, A, Fix, J

“…These analyses were undertaken to obtain a more precise direct assessment of the carcinogenic effects of protracted low-level exposure to external, predominantly gamma, radiation. …”

Night shift work and breast cancer incidence: Three prospective studies and meta-analysis of published studies. by Travis, R, Balkwill, A, Fensom, G, Appleby, P, Reeves, G, Wang, X, Roddam, A, Gathani, T, Peto, R, Green, J, Key, T, Beral, V

“…A 2007 WHO review concluded, mainly from animal evidence, that shift work involving circadian disruption is probably carcinogenic to humans. We therefore aimed to generate prospective epidemiological evidence on night-shift work and breast cancer incidence.…”

Polyurethane membrane as an adsorbent for methyl orange and ethyl violet dyes(Membran poliuretana sebagai penjerap untuk pewarna metil oren dan etil ungu lembayung) by Badri, Khairiah, Ismail, Fatem Hamimie, Shakir, Amira Shakim Abdul, Mohamad, Sharifah, Hamuzan, Hawa Aqilah, Hassan, Nurul Syakilla

“…Due to their complex chemical structures and synthetic nature, these dyes are highly stable to light and oxidation, making them non-biodegradable, highly toxic, carcinogenic and mutagenic in nature. Among all techniques, adsorption continues to attract considerable attention due to its simplistic approach and numerous benefits such as greater efficiency, capacity to remove dyes on a large scale, ease of recovery, and recyclability of adsorbents. …”

Effect of the oxidation process on the molecular interaction of polyaromatic hydrocarbons (PAH) with carbon nanotubes: Adsorption kinetic and isotherm study by Akinpelu, Adeola Akeem, Ali, Md. Eaqub, Johan, Mohd Rafie, Saidur, Rahman, Chowdhury, Zaira Zaman, Shemsi, Ahsan Mushir, Saleh, Tawfik A.

“…The results of this study indicate the high potential of the developed MWCNT-OH adsorbent as an efficient and successful material for the removal of carcinogenic PAHs from the water body. © 2019 Elsevier B.V.…”

Characterization and Concentration and source identification of Polycyclic aromatic Hydrocarbons in selected sites of Kota Kinabalu Port, Sabah by Mahyar Sakari

“…Toxic PAHs were more abundant than carcinogenic PAHs in studied area. Stations near the main loading area of the port, deep depository sedimentary environment and near busy human activities were significant and ranging from 400-600 nglg d.w. …”
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Assessment of heavy metals in Amaranthus viridis L. from Peninsular Malaysia by Yaacob, Aziran

“…Concerning HHR, the target hazard quotients (THQ) for Cd, Cu, Fe, Pb and Zn in the leaves of A. viridis were all below 1.00, indicating there were no non-carcinogenic risks four metals to consumers, including children and adults. …”
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