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5881
Association between sulfur microbial diet and the risk of colorectal cancer precursors in older adults
Published 2023-08-01“…This positive association between SMD score and adenoma risk was more evident in participants who were current or former smokers (p = 0.029 for interaction).ConclusionIn this study, our results support a role for the SMD in the carcinogenicity of colorectal cancer precursors among older adults. …”
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5882
Regulation of Alcohol and Acetaldehyde Metabolism by a Mixture of <i>Lactobacillus</i> and <i>Bifidobacterium</i> Species in Human
Published 2021-05-01“…Alcohol is oxidized to toxic and carcinogenic acetaldehyde by alcohol dehydrogenase (ADH) and further oxidized to a non-toxic acetate by aldehyde dehydrogenase (ALDH). …”
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5883
Gas Chromatography–Mass Spectrometry Detection of Thymoquinone in Oil and Serum for Clinical Pharmacokinetic Studies
Published 2023-11-01“…(NS) oil, which is renowned for its potent hepatoprotective effects attributed to its antioxidant, anti-fibrotic, anti-inflammatory, anti-carcinogenic, and both anti- and pro-apoptotic properties. …”
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5884
A Retrospective Cohort Study of the 2018 Angiotensin Receptor Blocker Recalls and Subsequent Drug Shortages in Patients With Hypertension
Published 2024-01-01“…Background Valsartan was recalled by the US Food and Drug Administration in July 2018 for carcinogenic impurities, resulting in a drug shortage and management challenges for valsartan users. …”
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5885
Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones
Published 2020-05-01“…Protein kinases C (PKCs) are involved in several carcinogenic processes. Thus, PKCs are potential targets for cancer therapy. …”
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5886
Human Health Risk Assessment of Air Pollution in the Regions of Unsustainable Heating Sources. Case Study—The Tourist Areas of Southern Poland
Published 2021-05-01“…The risk to tourists was lower than that to inhabitants due to shorter exposure times. The target non-carcinogenic value of 1, calculated for PM<sub>10</sub>, PM<sub>2.5</sub>, and NO<sub>2</sub>, was significantly exceeded in total risk, under the residential exposure scenario, in reference to all the local subpopulations. …”
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5887
Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition
Published 2019-12-01“…In conclusion, the inherent features of cirrhotic human liver ECM micro-environment were dissected and characterized for the first time as key pro-carcinogenic components in HCC development.…”
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5888
Clinical and genomic features of non‐small cell lung cancer occurring in families
Published 2023-04-01“…Abstract Background Exposure to environmental carcinogens, such as through smoking, is a major factor in the carcinogenesis of non‐small cell lung cancer (NSCLC). …”
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5889
Wood smoke exposure affects lung aging, quality of life, and all-cause mortality in New Mexican smokers
Published 2022-09-01“…Time-to-event analyses of LC incidence and cancer-specific mortality provide human evidence supporting the carcinogenicity of WS exposure.…”
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Article -
5890
In Vitro and In Vivo Effects of Ulvan Polysaccharides from <i>Ulva rigida</i>
Published 2023-04-01“…This study investigated the cytotoxic activity of ulvan polysaccharides obtained from <i>Ulva rigida</i> in the following scenarios: (i) in vitro against healthy and carcinogenic cell lines (1064sk (human fibroblasts), HACAT (immortalized human keratinocytes), U-937 (a human leukemia cell line), G-361 (a human malignant melanoma), and HCT-116 (a colon cancer cell line)) and (ii) in vivo against zebrafish embryos. …”
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5891
Cholangiocarcinoma: Recent Advances in Molecular Pathobiology and Therapeutic Approaches
Published 2024-02-01“…CCA are driven by an intricate landscape of genetic mutations, epigenetic dysregulation, and post-transcriptional modification, which differs based on geography (e.g., for liver fluke versus non-liver fluke-driven CCA) and exposure to environmental carcinogens (e.g., exposure to aristolochic acid). Liquid biopsy, including circulating cell-free DNA, is a potential diagnostic tool for CCA, which warrants further investigations. …”
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5892
The Potential of Colonic Tumor Tissue <i>Fusobacterium nucleatum</i> to Predict Staging and Its Interplay with Oral Abundance in Colon Cancer Patients
Published 2021-03-01“…Intestinal microbiota dysbiosis may enhance the carcinogenicity of colon cancer (CC) by the proliferation and differentiation of epithelial cells. …”
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5893
Editor’s Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver
Published 2018“…One exogenous agent of concern is the hepatocarcinogen aflatoxin B1(AFB1), a foodborne fungal toxin, that requires phase I metabolic oxidation for conversion to its toxic and carcinogenic form, the AFB1-8,9-exo-epoxide. The epoxide interacts with cellular targets causing toxicity and cell death; these targets include the covalent modification of DNA leading to mutations that can initiate malignant transformation. …”
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5894
Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human ...
Published 2020“…We monitored liver regeneration after hepatocyte ablation and HCC development after administration of chemical carcinogens (dimethylbenzanthrazene). Proliferation of human hepatocytes was measured in a coculture system. …”
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5895
Integrated Molecular Analysis Indicates Undetectable Change in DNA Damage in Mice after Continuous Irradiation at ~ 400-fold Natural Background Radiation
Published 2012“…Objectives: DNA damage and mutations are well established for their carcinogenic effects. We assessed several key markers of DNA damage and DNA damage responses in mice exposed to low dose-rate radiation to reveal potential genotoxic effects associated with low dose-rate radiation. …”
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5896
Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice
Published 2023“…The colonic tumor load and number were recorded at the endpoint in two carcinogenic models. The gut microbiota composition and colonic transcriptome were assessed by metagenomic sequencing and RNA sequencing, respectively. …”
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Journal Article -
5897
Synthesis of graphene by pullulan-assisted exfoliation of graphite using ultrasonic bath
Published 2021“…Since most of the organic solvents used in the graphene synthesis like N-methyl-2-pyrrolidone (NMP) and Dimethylformamide are toxic and carcinogenic, an environment-friendly solvent was used to counter the problem. …”
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Thesis -
5898
Exfoliation of few-layer graphene in red spinach solution : the fabrication of smart “sticky note” sensor
Published 2024“…However, the majority of exfoliation of graphene using the LPE method has been accomplished by utilising an organic solvent such as dimethylformamide (DMF) and N, N-methyl pyrrolidone (NMP), which is known to be carcinogenic, and a longer exposure to this substance may risk the user to the development of major health issues in the future. …”
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Thesis -
5899
In situ Self-transforming Membrane as Solid Phase Microextraction Coating Extraction of PAHs in Environmental Water Samples
Published 2020-05-01“…BACKGROUND Polycyclic aromatic hydrocarbons (PAHs) are one of the persistent organic pollutants which are carcinogenic and difficult to degrade, and are widespread in the environment. …”
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5900
Integrated Metabolomics and Lipidomics Analysis Reveals Lipid Metabolic Disorder in NCM460 Cells Caused by Aflatoxin B1 and Aflatoxin M1 Alone and in Combination
Published 2023-03-01“…AFB1 and AFM1 are group 1 human carcinogens. Previous sufficient toxicological data show that they pose a health risk. …”
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