Association between sulfur microbial diet and the risk of colorectal cancer precursors in older adults by Yi Xiao, Hongmei He, Ling Xiang, Haitao Gu, Zhiquan Xu, Haoyun Luo, Xiaorui Ren, Bo Li, Qi Wei, Zhiyong Zhu, He Zhou, He Zhou, Yunhao Tang, Zhihang Zhou, Linglong Peng, Yaxu Wang, Yahui Jiang

“…This positive association between SMD score and adenoma risk was more evident in participants who were current or former smokers (p = 0.029 for interaction).ConclusionIn this study, our results support a role for the SMD in the carcinogenicity of colorectal cancer precursors among older adults. …”
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Regulation of Alcohol and Acetaldehyde Metabolism by a Mixture of <i>Lactobacillus</i> and <i>Bifidobacterium</i> Species in Human by Su-Jin Jung, Ji-Hyun Hwang, Eun-Ock Park, Seung-Ok Lee, Yun-Jo Chung, Myung-Jun Chung, Sanghyun Lim, Tae-Joong Lim, Yunhi Ha, Byung-Hyun Park, Soo-Wan Chae

“…Alcohol is oxidized to toxic and carcinogenic acetaldehyde by alcohol dehydrogenase (ADH) and further oxidized to a non-toxic acetate by aldehyde dehydrogenase (ALDH). …”
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Gas Chromatography–Mass Spectrometry Detection of Thymoquinone in Oil and Serum for Clinical Pharmacokinetic Studies by A. Tekbaş, S. Bremer-Streck, D. K. Wissenbach, F. T. Peters, M. von Lilienfeld-Toal, Z. Soonawalla, F. Rauchfuß, U. Settmacher, U. Dahmen

“…(NS) oil, which is renowned for its potent hepatoprotective effects attributed to its antioxidant, anti-fibrotic, anti-inflammatory, anti-carcinogenic, and both anti- and pro-apoptotic properties. …”
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A Retrospective Cohort Study of the 2018 Angiotensin Receptor Blocker Recalls and Subsequent Drug Shortages in Patients With Hypertension by Joshua W. Devine, Mina Tadrous, Inmaculada Hernandez, Katherine Callaway Kim, Scott D. Rothenberger, Nandita Mukhopadhyay, Walid F. Gellad, Katie J. Suda

“…Background Valsartan was recalled by the US Food and Drug Administration in July 2018 for carcinogenic impurities, resulting in a drug shortage and management challenges for valsartan users. …”
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Activity to Breast Cancer Cell Lines of Different Malignancy and Predicted Interaction with Protein Kinase C Isoforms of Royleanones by Vera M. S. Isca, Milan Sencanski, Nenad Filipovic, Daniel J. V. A. Dos Santos, Ana Čipak Gašparović, Lucília Saraíva, Carlos A. M. Afonso, Patrícia Rijo, Alfonso T. García-Sosa

“…Protein kinases C (PKCs) are involved in several carcinogenic processes. Thus, PKCs are potential targets for cancer therapy. …”
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Human Health Risk Assessment of Air Pollution in the Regions of Unsustainable Heating Sources. Case Study—The Tourist Areas of Southern Poland by Agnieszka Gruszecka-Kosowska, Jacek Dajda, Ewa Adamiec, Edeltrauda Helios-Rybicka, Marek Kisiel-Dorohinicki, Radosław Klimek, Dariusz Pałka, Jarosław Wąs

“…The risk to tourists was lower than that to inhabitants due to shorter exposure times. The target non-carcinogenic value of 1, calculated for PM₁₀, PM_2.5, and NO₂, was significantly exceeded in total risk, under the residential exposure scenario, in reference to all the local subpopulations. …”
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Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition by Giuseppe Mazza, Andrea Telese, Walid Al-Akkad, Luca Frenguelli, Ana Levi, Martina Marrali, Lisa Longato, Kessarin Thanapirom, Maria Giovanna Vilia, Benedetta Lombardi, Claire Crowley, Mark Crawford, Morten A. Karsdal, Diana J. Leeming, Giusi Marrone, Katrin Bottcher, Benjamin Robinson, Armando Del Rio Hernandez, Domenico Tamburrino, Gabriele Spoletini, Massimo Malago, Andrew R. Hall, Jasminka Godovac-Zimmermann, Tu Vinh Luong, Paolo De Coppi, Massimo Pinzani, Krista Rombouts

“…In conclusion, the inherent features of cirrhotic human liver ECM micro-environment were dissected and characterized for the first time as key pro-carcinogenic components in HCC development.…”
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Clinical and genomic features of non‐small cell lung cancer occurring in families by Shingo Miyabe, Shin Ito, Ikuro Sato, Jiro Abe, Keiichi Tamai, Mai Mochizuki, Haruna Fujimori, Kazunori Yamaguchi, Norihisa Shindo, Hiroshi Shima, Tomoko Yamazaki, Makoto Abue, Yoshinori Okada, Jun Yasuda

“…Abstract Background Exposure to environmental carcinogens, such as through smoking, is a major factor in the carcinogenesis of non‐small cell lung cancer (NSCLC). …”
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Wood smoke exposure affects lung aging, quality of life, and all-cause mortality in New Mexican smokers by Shuguang Leng, Maria A. Picchi, Paula M. Meek, Menghui Jiang, Samuel H. Bayliss, Ting Zhai, Ruslan I. Bayliyev, Yohannes Tesfaigzi, Matthew J. Campen, Huining Kang, Yiliang Zhu, Qing Lan, Akshay Sood, Steven A. Belinsky

“…Time-to-event analyses of LC incidence and cancer-specific mortality provide human evidence supporting the carcinogenicity of WS exposure.…”
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In Vitro and In Vivo Effects of Ulvan Polysaccharides from <i>Ulva rigida</i> by Jorge García-Márquez, Bruna Rodrigues Moreira, Piedad Valverde-Guillén, Sofía Latorre-Redoli, Candela T. Caneda-Santiago, Gabriel Acién, Eduardo Martínez-Manzanares, Manuel Marí-Beffa, Roberto T. Abdala-Díaz

“…This study investigated the cytotoxic activity of ulvan polysaccharides obtained from <i>Ulva rigida</i> in the following scenarios: (i) in vitro against healthy and carcinogenic cell lines (1064sk (human fibroblasts), HACAT (immortalized human keratinocytes), U-937 (a human leukemia cell line), G-361 (a human malignant melanoma), and HCT-116 (a colon cancer cell line)) and (ii) in vivo against zebrafish embryos. …”
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Cholangiocarcinoma: Recent Advances in Molecular Pathobiology and Therapeutic Approaches by Divya Khosla, Shagun Misra, Pek Lim Chu, Peiyong Guan, Ritambhra Nada, Rajesh Gupta, Khwanta Kaewnarin, Tun Kiat Ko, Hong Lee Heng, Vijay Kumar Srinivasalu, Rakesh Kapoor, Deepika Singh, Poramate Klanrit, Somponnat Sampattavanich, Jing Tan, Sarinya Kongpetch, Apinya Jusakul, Bin Tean Teh, Jason Yongsheng Chan, Jing Han Hong

“…CCA are driven by an intricate landscape of genetic mutations, epigenetic dysregulation, and post-transcriptional modification, which differs based on geography (e.g., for liver fluke versus non-liver fluke-driven CCA) and exposure to environmental carcinogens (e.g., exposure to aristolochic acid). Liquid biopsy, including circulating cell-free DNA, is a potential diagnostic tool for CCA, which warrants further investigations. …”
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The Potential of Colonic Tumor Tissue <i>Fusobacterium nucleatum</i> to Predict Staging and Its Interplay with Oral Abundance in Colon Cancer Patients by Pamela Pignatelli, Lorena Iezzi, Martina Pennese, Paolo Raimondi, Anna Cichella, Danilo Bondi, Rossella Grande, Roberto Cotellese, Nicola Di Bartolomeo, Paolo Innocenti, Adriano Piattelli, Maria Cristina Curia

“…Intestinal microbiota dysbiosis may enhance the carcinogenicity of colon cancer (CC) by the proliferation and differentiation of epithelial cells. …”
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Editor’s Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver by Egner, Patricia A., Groopman, John D., Satayavivad, Jutamaad, Sriwattanapong, Kanokwan, Slocum, Stephen L., Chawanthayatham, Supawadee, Fedeles, Bogdan I, Croy, Robert G, Essigmann, John M

“…One exogenous agent of concern is the hepatocarcinogen aflatoxin B1(AFB1), a foodborne fungal toxin, that requires phase I metabolic oxidation for conversion to its toxic and carcinogenic form, the AFB1-8,9-exo-epoxide. The epoxide interacts with cellular targets causing toxicity and cell death; these targets include the covalent modification of DNA leading to mutations that can initiate malignant transformation. …”
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Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human ... by Chaturantabut, Saireudee, Shwartz, Arkadi, Evason, Kimberley J., Cox, Andrew G., Labella, Kyle, Schepers, Arnout, Yang, Song, Acuña, Mariana, Houvras, Yariv, Mancio Silva, Liliana, Romano, Shannon, Gorelick, Daniel A., Cohen, David E., Zon, Leonard I., Bhatia, Sangeeta N., North, Trista E., Goessling, Wolfram, Bhatia, Sangeeta N

“…We monitored liver regeneration after hepatocyte ablation and HCC development after administration of chemical carcinogens (dimethylbenzanthrazene). Proliferation of human hepatocytes was measured in a coculture system. …”
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Integrated Molecular Analysis Indicates Undetectable Change in DNA Damage in Mice after Continuous Irradiation at ~ 400-fold Natural Background Radiation by Olipitz, Werner, Shuga, Joe, Pang, Bo, McFaline, Jose Luis, Lonkar, Pallavi, Thomas, Aline, Mutamba, James Tendai, Greenberger, Joel S., Samson, Leona D., Dedon, Peter C., Yanch, Jacquelyn C., Engelward, Bevin P., Wiktor-Brown, Dominika

“…Objectives: DNA damage and mutations are well established for their carcinogenic effects. We assessed several key markers of DNA damage and DNA damage responses in mice exposed to low dose-rate radiation to reveal potential genotoxic effects associated with low dose-rate radiation. …”
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Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice by Kang, Xing, Ng, Siu-Kin, Liu, Changan, Lin, Yufeng, Zhou, Yunfei, Kwong, Thomas N. Y., Ni, Yunbi, Lam, Thomas Y. T., Wu, William K. K., Wei, Hong, Sung, Joseph Jao Yiu, Yu, Jun, Wong, Sunny Hei

“…The colonic tumor load and number were recorded at the endpoint in two carcinogenic models. The gut microbiota composition and colonic transcriptome were assessed by metagenomic sequencing and RNA sequencing, respectively. …”
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Synthesis of graphene by pullulan-assisted exfoliation of graphite using ultrasonic bath by Nurul Farhana, Abu Kasim

“…Since most of the organic solvents used in the graphene synthesis like N-methyl-2-pyrrolidone (NMP) and Dimethylformamide are toxic and carcinogenic, an environment-friendly solvent was used to counter the problem. …”
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Exfoliation of few-layer graphene in red spinach solution : the fabrication of smart “sticky note” sensor by Wan Farhana, W Idris

“…However, the majority of exfoliation of graphene using the LPE method has been accomplished by utilising an organic solvent such as dimethylformamide (DMF) and N, N-methyl pyrrolidone (NMP), which is known to be carcinogenic, and a longer exposure to this substance may risk the user to the development of major health issues in the future. …”
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In situ Self-transforming Membrane as Solid Phase Microextraction Coating Extraction of PAHs in Environmental Water Samples by SUN Shu-tang, YAN Qian, LI Ning, HUANG Li-jin, SHUAI Qin

“…BACKGROUND Polycyclic aromatic hydrocarbons (PAHs) are one of the persistent organic pollutants which are carcinogenic and difficult to degrade, and are widespread in the environment. …”
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Integrated Metabolomics and Lipidomics Analysis Reveals Lipid Metabolic Disorder in NCM460 Cells Caused by Aflatoxin B1 and Aflatoxin M1 Alone and in Combination by Xue Yang, Xue Li, Yanan Gao, Jiaqi Wang, Nan Zheng

“…AFB1 and AFM1 are group 1 human carcinogens. Previous sufficient toxicological data show that they pose a health risk. …”
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