Potentially toxic metals in irrigation water, soil, and vegetables and their health risks using Monte Carlo models by Muyiwa Michael Orosun, Samuel Nwabachili, Reem F. Alshehri, Maxwell Omeje, Ibtehaj F. Alshdoukhi, Hussein K. Okoro, Clement O. Ogunkunle, Hitler Louis, Fakoya A. Abdulhamid, Stephen Erhonmonsele Osahon, Adamu Usman Mohammed, Emmanuel Olusegun Ehinlafa, Sodiq Omotayo Yunus, Oluwatobi Ife-Adediran

“…Expectedly, the hazard index (HI),and carcinogenic risk values of spinach were higher than that of cabbage. …”
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Identification of Marigold(Calendula officinalis L.) Essence Compositions and Comparison of It’s Antioxidant Effects with Butyl Hydroxy Toluene in the Stability of Canola Edible Oi... by M Agha Alikhani, N Mirazi, M Agha Alikhani

“…Since synthetic compounds are limited for their toxicity and carcinogenicity, as a result today, essential oils of medicinal and aromatic plants are considered as alternatives to synthetic antioxidants in food products due to their antioxidant properties.Calendula officinalis L. is a species of chicory that has many applications in food and pharmaceutical industries. …”
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Bioinformatic analysis identifies HPV-related tumor microenvironment remodeling prognostic biomarkers in head and neck squamous cell carcinoma by Qimin Zhou, Ouyang Yuan, Hongtu Cui, Tao Hu, Gary Guishan Xiao, Jiao Wei, Honglei Zhang, Chengjun Wu

“…Human papillomavirus (HPV) infection has been identified as one of the most important carcinogens for HNSCC. As an early event in HNSCC, infection with HPV leads to altered immune profiles in the tumor microenvironment (TME). …”
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Comparison of Helicobacter pylori positive and negative gastric cancer via multi-omics analysis by Fumei Shang, Yinghao Cao, Lixin Wan, Zhonghai Ren, Xinghao Wang, Mudan Huang, Yingyun Guo

“…ABSTRACTHelicobacter pylori (H. pylori) has been regarded as a definite carcinogenic bacterium for gastric cancer (GC). This multi-omics research was designed to investigate the genetic, microbial, and metabolic changes of GC patients when they are infected with H. pylori. …”
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A Study on Heavy Metals in the Surface Soil of the Region around the Qinghai Lake in Tibet Plateau: Pollution Risk Evaluation and Pollution Source Analysis by Peiru Wei, Tianjie Shao, Ruojin Wang, Zongyan Chen, Zhongdi Zhang, Zhiping Xu, Yadi Zhu, Dongze Li, Lijuan Fu, Feier Wang

“…In fact, the heavy metals in the soil of the study area produce no noncarcinogenic and carcinogenic health risks to human health, and children and adults may be exposed to these risks by the mouth. …”
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Resveratrol improves the prognosis of rats after spinal cord injury by inhibiting mitogen-activated protein kinases signaling pathway by Shunli Kan, Chengjiang Liu, Xinyan Zhao, Sa Feng, Haoqiang Zhu, Boyuan Ma, Mengmeng Zhou, Xuanhao Fu, Wei Hu, Rusen Zhu

“…Resveratrol (3,4′,5-trihy- droxystilbene) is a naturally occurring plant-based polyphenol that has demonstrated powerful antioxidative, anti-inflammatory, and anti-carcinogenic pharmaceutical properties in previous studies. …”
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Unraveling the Structural Changes in the DNA-Binding Region of Tumor Protein p53 (<i>TP53</i>) upon Hotspot Mutation p53 Arg248 by Comparative Computational Approach by Ambritha Balasundaram, C. George Priya Doss

“…Missense mutations in the core DNA-binding domain (109–292) simultaneously cause the loss of <i>p53</i> tumor suppressor function and accumulation of the mutant p53 proteins that are carcinogenic. The most common <i>p53</i> hotspot mutation at codon 248 in the DNA-binding region, where arginine (R) is substituted by tryptophan (W), glycine (G), leucine (L), proline (P), and glutamine (Q), is reported in various cancers. …”
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Hydrochemical Characteristics and Risk Assessment of Tongzi River, Guizhou Province, Southwest China by Jiemei Lü, Yanling An

“…Additionally, the non-carcinogenic health risk of riverine ions for infants and children in the Tongzi River was very noteworthy, especially in the tributaries.…”
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Effects of ranitidine and nizatidine on the risk of gastrointestinal cancer by Hyejung Kang, Chung Mo Nam, Dong-Woo Choi, Sohee Park

“…However, in 2019, the US Food and Drug Administration announced that the drugs ranitidine and nizatidine, which are used for digestive disorders, contain carcinogens. In this study, we investigated the effects of ranitidine and nizatidine on the development of GI cancer.Materials and methodsIn this study, using National Health Insurance Service–National Sample Cohort (NHIS-NSC) version 2.5 (updated from 2002 to 2019), subjects who developed GI cancer were enrolled in the case group, and those who were at risk of, but did not develop, cancer were enrolled in the control group. …”
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CYP1A2 mRNA Expression Rather than Genetic Variants Indicate Hepatic CYP1A2 Activity by Ferenc Fekete, Katalin Mangó, Annamária Minus, Katalin Tóth, Katalin Monostory

“…CYP1A2, one of the most abundant hepatic cytochrome P450 enzymes, is involved in metabolism of several drugs and carcinogenic compounds. Data on the significance of <i>CYP1A2</i> genetic polymorphisms in enzyme activity are highly inconsistent; therefore, the impact of <i>CYP1A2</i> genetic variants (−3860G>A, −2467delT, −739T>G, −163C>A, 2159G>A) on mRNA expression and phenacetin <i>O</i>-dealkylation selective for CYP1A2 was investigated in human liver tissues and in psychiatric patients belonging to Caucasian populations. …”
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A Comparative Study of Cerium- and Ytterbium-Based GO/g-C₃N₄/Fe₂O₃ Composites for Electrochemical and Photocatalytic Applications by Nosheen Farooq, Rafael Luque, Mahmoud M. Hessien, Ashfaq Mahmood Qureshi, Farzana Sahiba, Muhammad Altaf Nazir, Aziz ur Rehman

“…For this purpose, cerium- and ytterbium-based GO/g-C₃N₄/Fe₂O₃ composites have been synthesized to explore their properties, especially in charge storage devices such as supercapacitors, and also as photocatalysts for the degradation of carcinogenic dyes from the environment. Physicochemical studies have been carried out using XRD, FTIR, SEM, and BET techniques. …”
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The effect of resveratrol and quercetin intervention on azoxymethane-induced colon cancer in Rats model by Sajjad Tezerji, Hamid abdolazimi, Azadeh Fallah, Behrouz Talaei

“…At the fourth week animals received azoxymethane (AOM) (15 mg/kg) subcutaneous as a carcinogenic agent weekly for two consecutive weeks except for healthy group. …”
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Development and Validation of the Epidemiological Tattoo Assessment Tool to Assess Ink Exposure and Related Factors in Tattooed Populations for Medical Research: Cross-sectional Va... by Milena Foerster, Lucas Dufour, Wolfgang Bäumler, Ines Schreiver, Marcel Goldberg, Marie Zins, Khaled Ezzedine, Joachim Schüz

“…Although these inks may contain environmental toxins, including known human carcinogens, their long-term health effects are poorly studied. …”
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Chemical composition, antioxidant and antibacterial activity of Piper chaba stem extracts with preservative effects on storage of raw beef patties by Mohammad Mahfuzur Rahman, Tyeaba Tasnim Dipti, M. Nazrul Islam, Abu Tareq Mohammad Abdullah, Sharmin Jahan, Md. Morshedul Alam, M. Rezaul Karim

“…Practical Applications: Natural preservatives are becoming more popular as a result of the different carcinogenic and toxic side effects of conventional preservatives. …”
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Molecular genetic and clinical characteristic analysis of primary signet ring cell carcinoma of urinary bladder identified by a novel OR2L5 mutation by Mohammed Alradhi, Shuang Wen, Mohammed Safi, Abdullah Al‐danakh, Honglong Wang, Abdullah Shopit, Min Sun, Bo Fan, Xiancheng Li

“…The most frequently mutated pathway was RTK‐RAS which has 85 genes involved in carcinogenic signaling. Final screening on predisposing genes is performed after filtering based on ACMG. …”
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Oxidative Products of Curcumin Rather Than Curcumin Bind to <i>Helicobacter Pylori</i> Virulence Factor VacA and Are Required to Inhibit Its Vacuolation Activity by Maya Chaturvedi, Mohit Mishra, Achyut Pandey, Jyoti Gupta, Jyoti Pandey, Shilpi Gupta, Md. Zubbair Malik, Pallavi Somvanshi, Rupesh Chaturvedi

“…Curcumin is a hydrophobic polyphenol derived from turmeric with potent anti-oxidant, anti-microbial, anti-inflammatory and anti-carcinogenic effects. Curcumin is degraded into various derivatives under in vitro and in vivo conditions, and it appears that its degradation may be responsible for the pharmacological effects of curcumin. …”
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Identification of DLL3-related genes affecting the prognosis of patients with colon adenocarcinoma by Jinyu Xiang, Wenjing Gong, Jiannan Liu, Huijuan Zhang, Ming Li, Rujian Wang, Yaodong Lv, Ping Sun

“…Background: Delta-like ligand 3 (DLL3) is one of the NOTCH family of ligands, which plays a pro- or anti-carcinogenic role in some cancers. But the role of DLL3 in colon adenocarcinoma (COAD) has not been studied in depth.Materials and methods: First, we used Kaplan-Meier (K-M) curve to evaluate the effect of DLL3 on the prognosis of COAD in The Cancer Genome Atlas (TCGA), which was further validated in clinical samples for immunohistochemistry. …”
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Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors by Benjamin J. Buckley, Ashna Kumar, Ashraf Aboelela, Richard S. Bujaroski, Xiuju Li, Hiwa Majed, Larry Fliegel, Marie Ranson, Michael J. Kelso

“…These effects arise from the inhibition of two distinct cancer targets: the trypsin-like serine protease urokinase-type plasminogen activator (uPA), a cell-surface mediator of matrix degradation and tumor cell invasiveness, and the sodium-hydrogen exchanger isoform-1 (NHE1), a central regulator of transmembrane <i>p</i>H that supports carcinogenic progression. In this study, we co-screened our library of 5- and 6-substituted amilorides against these two targets, aiming to identify single-target selective and dual-targeting inhibitors for use as complementary pharmacological probes. …”
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Effects of 1,3,7-tribromodibenzo-p-dioxin, a natural dioxin on chicken embryos: Comparison with effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin by Jae Gon Park, Hisato Iwata, Nguyen Minh Tue, Tatsuya Kunisue, Eun-Young Kim

“…Pathway and network analyses with DEGs suggested that 1,3,7-TriBDD may induce carcinogenic effects and metabolic alterations. These results were similar to the effects on TCDD-treated embryos. …”
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Two-Dimensional MXene as a Promising Adsorbent for Trihalomethanes Removal: A Density-Functional Theory Study by Islam Gomaa, Nasser Mohammed Hosny, Hanan Elhaes, Hend A. Ezzat, Maryam G. Elmahgary, Medhat A. Ibrahim

“…Trihalomethanes are common carcinogenic chlorination byproducts found in water sanitation systems. …”
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