Using in silico tools to predict flame retardant metabolites for more informative exposomics-based approaches by Breanne Kincaid, Przemyslaw Piechota, Emily Golden, Mikhail Maertens, Thomas Hartung, Thomas Hartung, Alexandra Maertens

“…The population is ubiquitously exposed to flame retardants, and evidence implicates some of these compounds as developmental neurotoxicants, endocrine disruptors, reproductive toxicants, immunotoxicants, and carcinogens. However, many flame retardants are poorly characterized, have not been linked to a definitive mode of toxic action, and are known to share metabolic breakdown products which may themselves harbor toxicity. …”
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Addition effect of pineapple, orange and beet juices on the mitochondrial membrane potential of ram sperm by Alexandre da Rocha Bozzi, Ricardo Lopes Dias da Costa, Luiz Henrique Particelli, Célia Raquel Quirino, André Furugen Cesar de Andrade, Flávia Vieira de Freitas, Marina da Silva Passarelli

“…Plants have thousands of phytochemical compounds in their roots, leaves, fruits, flowers and stems, which have several biological effects, such as anti-oxidant, anti-inflammatory, anti-carcinogenic and anti-inflammatory action. The objective of this work was to evaluate the effects of adding pineapple, beetroot, and orange juices individually and in different combinations at concentration of 10% in the cryopreserved semen extender of rams, through the mitochondrial membrane potential of sperm cells. …”
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AL360181.1 promotes proliferation and invasion in colon cancer and is one of ten m6A-related lncRNAs that predict overall survival by Yi Luo, Yayun Xie, Dejun Wu, Bingyi Wang, Helei Lu, Zhiqiang Wang, Yingjun Quan, Bo Han

“…Biological enrichment analysis indicated that the high-risk patients had a higher activity of multiple carcinogenic pathways, including glycolysis. The previously unreported lncRNA, AL360181.1, displayed a connection to glycolytic activity and diminished survival rates, warranting further investigation. …”
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Risk Alleles for Multiple Myeloma Susceptibility in ADME Genes by Francesca Scionti, Giuseppe Agapito, Daniele Caracciolo, Caterina Riillo, Katia Grillone, Mario Cannataro, Maria Teresa Di Martino, Pierosandro Tagliaferri, Pierfrancesco Tassone, Mariamena Arbitrio

“…The inter-individual variability in the bioactivation, detoxification, and clearance of chemical carcinogens such as asbestos, benzene, and pesticides might increase the MM risk. …”
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Decolorization of the azo dye Reactive Violet 5 by UV-A-Fenton and Ultrasound-Fenton Processes by Nuno Jorge, Ana R. Teixeira, José R. Fernandes, Marco S. Lucas, José A. Peres

“…The textile dye Reactive Violet 5 (RV5) is mutagenic and teratogenic as well as carcinogenic and must be degraded before the release of textile wastewater into the environment. …”
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The bZIP Transcription Factor AflRsmA Regulates Aflatoxin B₁ Biosynthesis, Oxidative Stress Response and Sclerotium Formation in <i>Aspergillus flavus</i> by Xiuna Wang, Wenjie Zha, Linlin Liang, Opemipo Esther Fasoyin, Lihan Wu, Shihua Wang

“…In this study, a connection between a bZIP TF and oxidative stress induction of secondary metabolism is uncovered in an opportunistic pathogen <i>Aspergillus flavus</i>, which produces carcinogenic and mutagenic aflatoxins. The bZIP transcription factor AflRsmA was identified by a homology research of <i>A</i>. …”
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Screening and Prioritization of Pesticide Application for Potential Human Health and Environmental Risks in Largescale Farms in Western Kenya by Zedekiah Odira Onyando, Elizabeth Omukunda, Patrick Okoth, Sandra Khatiebi, Solomon Omwoma, Peter Otieno, Odipo Osano, Joseph Lalah

“…The ranked-order human toxicity potential associated with the used pesticides were teratogenicity (31.58%), neurotoxicity (28.95%), endocrine disruption (7.9%), carcinogenicity (7.9%), and mutagenicity (2.63%). However, 10.53% of the pesticides possess multiple toxicity potentials. …”
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An evaluation of an innovative screening program based on risk criteria for early diagnosis of head and neck cancers by Aitor Zabala, Aitor Zabala, Francisco Javier Martín-Arregui, Francisco Javier Martín-Arregui, Jon Sagazola, Francisco Javier Santaolalla, Francisco Santaolalla, Francisco Santaolalla

“…There did exist a statistically significant ratio between the detection of pre-neoplastic lesions and occupational exposure to carcinogenic agents (p = 0.006), poor oral hygiene (p = 0.01) and gastroesophageal reflux disease (p = 0.007). …”
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Integrated multi-omics analyses and functional validation reveal TTK as a novel EMT activator for endometrial cancer by Yu Miao, Yosuke Konno, Baojin Wang, Lin Zhu, Tianyue Zhai, Kei Ihira, Noriko Kobayashi, Hidemichi Watari, Xin Jin, Junming Yue, Peixin Dong, Mingyan Fang

“…Conclusion Our findings establish the clinical significance of TTK as a new biomarker for EC and an as-yet-unknown carcinogenic function. This present study proposes that the therapeutic targeting of TTK might provide a viable approach for the treatment of EC.…”
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Characteristic Variation of Particulate Matter-Bound Polycyclic Aromatic Hydrocarbons (PAHs) during Asian Dust Events, Based on Observations at a Japanese Background Site, Wajima,... by Pengchu Bai, Yan Wang, Hao Zhang, Xuan Zhang, Lulu Zhang, Atsushi Matsuki, Seiya Nagao, Bin Chen, Ning Tang

“…Moreover, the health risks of PAHs were calculated with the inhalation lifetime cancer risk, which ranged from 10⁻⁶ to 10⁻⁵ ng/m³, indicating a potential carcinogenic risk at the KUWAMS during the East Asian winter monsoon periods.…”
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Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deac... by Yu Zhang, Linhu Du, Jinhua Yan, Qianxiang Bai, Qiao Niu, Yiqun Mo, Qunwei Zhang, Jisheng Nie

“…Benzo[a]pyrene (B[a]P) is a widespread carcinogenic pollutant in the environment. Although previous studies have demonstrated the neurodevelopmental toxicity of B[a]P, the precise mechanisms underlying the neurotoxic effects induced by prenatal B[a]P exposure remain largely unknown. …”
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Dimethylpolysulfides production as the major mechanism behind wheat fungal pathogen biocontrol, by Arthrobacter and Microbacterium actinomycetes by Aline Ballot, Jeanne Dore, Marjolaine Rey, Guillaume Meiffren, Thierry Langin, Pierre Joly, Assia Dreux-Zigha, Ahmed Taibi, Claire Prigent-Combaret

“…Finally, we demonstrated that F. graminearum growth inhibition leads to a complete depletion of DON (deoxynivalenol) carcinogenic mycotoxins, highlighting a significant modulation of fungal metabolism. …”
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Chemical assessment of mycotoxin contaminants and veterinary residues in Costa Rican animal feed by Astrid Leiva, Geovanna Méndez, César Rodríguez, Andrea Molina, Fabio Granados-Chinchilla

“…Abstract Background When present in animal feedstuff, mycotoxins contaminants and antibiotic residues can have negative implications for animal production and Public Health, including the transmission of carcinogenic compounds and the selection of antibiotic resistant bacteria, respectively. …”
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PUS1 May Be a Potential Prognostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma by Lan C, Huang X, Liao X, Zhou X, Peng K, Wei Y, Han C, Peng T, Wang J, Zhu G

“…Functional enrichment analysis implied that PUS1 may be involved in metabolic pathways, mitochondrial function, non-alcoholic fatty liver disease (NAFLD), and some important carcinogenic pathways. Cell assays revealed that knockdown of PUS1 significantly constrained the migration, proliferation, invasion and improved the ROS level of HCC cells.Conclusion: PUS1 may be a prognostic biomarker and a underlying treatment target for HCC.Keywords: PUS1, pseudouridine synthase, poor prognosis, gene knockout, HCC…”
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In Vitro Cytotoxicity and Spectral Analysis-Based Phytochemical Profiling of Methanol Extract of <i>Barleria hochstetteri,</i> and Molecular Mechanisms Underlying Its Apoptosis-Ind... by Saad Ahmed Alkahtani, Ali Mohamed Alshabi, Ibrahim Ahmed Shaikh, Mohamed A. A. Orabi, Basel A. Abdel-Wahab, Ismail A. Walbi, Mohammed Shafiuddin Habeeb, Masood Medleri Khateeb, Arun K. Shettar, Joy H. Hoskeri

“…In this study, we first examined the cytotoxicity of the plant extract on non-malignant L929 cells and on the carcinogenic MCF-7 and A549 cell lines. Then, we studied the underlying molecular pathways by means of Anti-Bcl-2, caspase-3, and DNA fragmentation (TUNEL) assays, using flow cytometry. …”
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Measurement of polychlorinated biphenyls in different high consumption canned foods, using the QuEChERS/GC-MS method by Faezeh Vali Mohammadi, Peyman Qajarbeygi, Nabi Shariatifar, Razzagh Mahmoudi, Majid Arabameri

“…Polychlorinated biphenyls (PCBs) are organic pollutants containing chlorine, which can be carcinogenic to humans. The current research focused on the heart risk and determination of PCBs levels in canned foods using the modified QuEChERS (fast, easy, cheap, effective, resistant and safe) method and gas chromatograph/mass spectrometer (GC-MS) technique. …”
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Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. by Charlotte Debras, Eloi Chazelas, Bernard Srour, Nathalie Druesne-Pecollo, Younes Esseddik, Fabien Szabo de Edelenyi, Cédric Agaësse, Alexandre De Sa, Rebecca Lutchia, Stéphane Gigandet, Inge Huybrechts, Chantal Julia, Emmanuelle Kesse-Guyot, Benjamin Allès, Valentina A Andreeva, Pilar Galan, Serge Hercberg, Mélanie Deschasaux-Tanguy, Mathilde Touvier

“…In particular, their carcinogenicity has been suggested by several experimental studies, but robust epidemiological evidence is lacking. …”
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Synergistic Effects of New Curcumin Analog (PAC) and Cisplatin on Oral Cancer Therapy by Abdelhabib Semlali, Sarra Beji, Ikram Ajala, Mohammed Al-Zharani, Mahmoud Rouabhia

“…Additionally, a Western Blot analysis was performed to assess the influence of this combination on pro-carcinogenic proteins involved in various signaling pathways. …”
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Distinct Prostate Cancer Survival Outcomes in Firefighters: A Population-Based Study by Paulo S. Pinheiro, Tulay Koru-Sengul, Wei Zhao, Diana R. Hernandez, Monique N. Hernandez, Erin N. Kobetz, Alberto J. Caban-Martinez, David J. Lee

“…For firefighters, a demographic subject to rigorous medical evaluations, possessing above-average medical expertise, and exposed to specific carcinogens of interest, prostate cancer survival in the US has never been studied. …”
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Synthesis of Metakaolin Based Alkali Activated Materials as an Adsorbent at Different Na₂SiO₃/NaOH Ratios and Exposing Temperatures for Cu²⁺ Remova... by Masdiyana Ibrahim, Wan Mastura Wan Ibrahim, Mohd Mustafa Al Bakri Abdullah, Marcin Nabialek, Ramadhansyah Putra Jaya, Monthian Setkit, Romisuhani Ahmad, Bartłomiej Jeż

“…Copper ions are among the most dangerous heavy metals owing to their carcinogenicity and harmful effects on the environment and human health. …”
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