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6161
Using in silico tools to predict flame retardant metabolites for more informative exposomics-based approaches
Published 2023-10-01“…The population is ubiquitously exposed to flame retardants, and evidence implicates some of these compounds as developmental neurotoxicants, endocrine disruptors, reproductive toxicants, immunotoxicants, and carcinogens. However, many flame retardants are poorly characterized, have not been linked to a definitive mode of toxic action, and are known to share metabolic breakdown products which may themselves harbor toxicity. …”
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6162
Addition effect of pineapple, orange and beet juices on the mitochondrial membrane potential of ram sperm
Published 2019-04-01“…Plants have thousands of phytochemical compounds in their roots, leaves, fruits, flowers and stems, which have several biological effects, such as anti-oxidant, anti-inflammatory, anti-carcinogenic and anti-inflammatory action. The objective of this work was to evaluate the effects of adding pineapple, beetroot, and orange juices individually and in different combinations at concentration of 10% in the cryopreserved semen extender of rams, through the mitochondrial membrane potential of sperm cells. …”
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6163
AL360181.1 promotes proliferation and invasion in colon cancer and is one of ten m6A-related lncRNAs that predict overall survival
Published 2023-11-01“…Biological enrichment analysis indicated that the high-risk patients had a higher activity of multiple carcinogenic pathways, including glycolysis. The previously unreported lncRNA, AL360181.1, displayed a connection to glycolytic activity and diminished survival rates, warranting further investigation. …”
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6164
Risk Alleles for Multiple Myeloma Susceptibility in ADME Genes
Published 2022-01-01“…The inter-individual variability in the bioactivation, detoxification, and clearance of chemical carcinogens such as asbestos, benzene, and pesticides might increase the MM risk. …”
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6165
Decolorization of the azo dye Reactive Violet 5 by UV-A-Fenton and Ultrasound-Fenton Processes
Published 2022-12-01“…The textile dye Reactive Violet 5 (RV5) is mutagenic and teratogenic as well as carcinogenic and must be degraded before the release of textile wastewater into the environment. …”
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6166
The bZIP Transcription Factor AflRsmA Regulates Aflatoxin B<sub>1</sub> Biosynthesis, Oxidative Stress Response and Sclerotium Formation in <i>Aspergillus flavus</i>
Published 2020-04-01“…In this study, a connection between a bZIP TF and oxidative stress induction of secondary metabolism is uncovered in an opportunistic pathogen <i>Aspergillus flavus</i>, which produces carcinogenic and mutagenic aflatoxins. The bZIP transcription factor AflRsmA was identified by a homology research of <i>A</i>. …”
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6167
Screening and Prioritization of Pesticide Application for Potential Human Health and Environmental Risks in Largescale Farms in Western Kenya
Published 2023-05-01“…The ranked-order human toxicity potential associated with the used pesticides were teratogenicity (31.58%), neurotoxicity (28.95%), endocrine disruption (7.9%), carcinogenicity (7.9%), and mutagenicity (2.63%). However, 10.53% of the pesticides possess multiple toxicity potentials. …”
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6168
An evaluation of an innovative screening program based on risk criteria for early diagnosis of head and neck cancers
Published 2023-01-01“…There did exist a statistically significant ratio between the detection of pre-neoplastic lesions and occupational exposure to carcinogenic agents (p = 0.006), poor oral hygiene (p = 0.01) and gastroesophageal reflux disease (p = 0.007). …”
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6169
Integrated multi-omics analyses and functional validation reveal TTK as a novel EMT activator for endometrial cancer
Published 2023-02-01“…Conclusion Our findings establish the clinical significance of TTK as a new biomarker for EC and an as-yet-unknown carcinogenic function. This present study proposes that the therapeutic targeting of TTK might provide a viable approach for the treatment of EC.…”
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6170
Characteristic Variation of Particulate Matter-Bound Polycyclic Aromatic Hydrocarbons (PAHs) during Asian Dust Events, Based on Observations at a Japanese Background Site, Wajima,...
Published 2023-09-01“…Moreover, the health risks of PAHs were calculated with the inhalation lifetime cancer risk, which ranged from 10<sup>−6</sup> to 10<sup>−5</sup> ng/m<sup>3</sup>, indicating a potential carcinogenic risk at the KUWAMS during the East Asian winter monsoon periods.…”
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6171
Prenatal benzo[a]pyrene exposure impairs hippocampal synaptic plasticity and cognitive function in SD rat offspring during adolescence and adulthood via HDAC2-mediated histone deac...
Published 2022-11-01“…Benzo[a]pyrene (B[a]P) is a widespread carcinogenic pollutant in the environment. Although previous studies have demonstrated the neurodevelopmental toxicity of B[a]P, the precise mechanisms underlying the neurotoxic effects induced by prenatal B[a]P exposure remain largely unknown. …”
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6172
Dimethylpolysulfides production as the major mechanism behind wheat fungal pathogen biocontrol, by Arthrobacter and Microbacterium actinomycetes
Published 2023-12-01“…Finally, we demonstrated that F. graminearum growth inhibition leads to a complete depletion of DON (deoxynivalenol) carcinogenic mycotoxins, highlighting a significant modulation of fungal metabolism. …”
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6173
Chemical assessment of mycotoxin contaminants and veterinary residues in Costa Rican animal feed
Published 2019-06-01“…Abstract Background When present in animal feedstuff, mycotoxins contaminants and antibiotic residues can have negative implications for animal production and Public Health, including the transmission of carcinogenic compounds and the selection of antibiotic resistant bacteria, respectively. …”
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6174
PUS1 May Be a Potential Prognostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma
Published 2023-04-01“…Functional enrichment analysis implied that PUS1 may be involved in metabolic pathways, mitochondrial function, non-alcoholic fatty liver disease (NAFLD), and some important carcinogenic pathways. Cell assays revealed that knockdown of PUS1 significantly constrained the migration, proliferation, invasion and improved the ROS level of HCC cells.Conclusion: PUS1 may be a prognostic biomarker and a underlying treatment target for HCC.Keywords: PUS1, pseudouridine synthase, poor prognosis, gene knockout, HCC…”
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6175
In Vitro Cytotoxicity and Spectral Analysis-Based Phytochemical Profiling of Methanol Extract of <i>Barleria hochstetteri,</i> and Molecular Mechanisms Underlying Its Apoptosis-Ind...
Published 2022-10-01“…In this study, we first examined the cytotoxicity of the plant extract on non-malignant L929 cells and on the carcinogenic MCF-7 and A549 cell lines. Then, we studied the underlying molecular pathways by means of Anti-Bcl-2, caspase-3, and DNA fragmentation (TUNEL) assays, using flow cytometry. …”
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6176
Measurement of polychlorinated biphenyls in different high consumption canned foods, using the QuEChERS/GC-MS method
Published 2023-12-01“…Polychlorinated biphenyls (PCBs) are organic pollutants containing chlorine, which can be carcinogenic to humans. The current research focused on the heart risk and determination of PCBs levels in canned foods using the modified QuEChERS (fast, easy, cheap, effective, resistant and safe) method and gas chromatograph/mass spectrometer (GC-MS) technique. …”
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6177
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Published 2022-03-01“…In particular, their carcinogenicity has been suggested by several experimental studies, but robust epidemiological evidence is lacking. …”
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6178
Synergistic Effects of New Curcumin Analog (PAC) and Cisplatin on Oral Cancer Therapy
Published 2023-06-01“…Additionally, a Western Blot analysis was performed to assess the influence of this combination on pro-carcinogenic proteins involved in various signaling pathways. …”
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6179
Distinct Prostate Cancer Survival Outcomes in Firefighters: A Population-Based Study
Published 2024-03-01“…For firefighters, a demographic subject to rigorous medical evaluations, possessing above-average medical expertise, and exposed to specific carcinogens of interest, prostate cancer survival in the US has never been studied. …”
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6180
Synthesis of Metakaolin Based Alkali Activated Materials as an Adsorbent at Different Na<sub>2</sub>SiO<sub>3</sub>/NaOH Ratios and Exposing Temperatures for Cu<sup>2+</sup> Remova...
Published 2023-01-01“…Copper ions are among the most dangerous heavy metals owing to their carcinogenicity and harmful effects on the environment and human health. …”
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