The proliferation of atypical hepatocytes and CDT1 expression in noncancerous tissue are associated with the postoperative recurrence of hepatocellular carcinoma by Mitsuhiko Moriyama, Tatsuo Kanda, Yutaka Midorikawa, Hiroshi Matsumura, Ryota Masuzaki, Hitomi Nakamura, Masahiro Ogawa, Shunichi Matsuoka, Toshikatu Shibata, Motomi Yamazaki, Kazumichi Kuroda, Hisashi Nakayama, Tokio Higaki, Kazunori Kanemaru, Toshio Miki, Masahiko Sugitani, Tadatoshi Takayama

“…We found that the strong degree of atypical hepatocytes and high CDT1 mRNA expression represent a high carcinogenic state of the liver. Thus, we consider the evaluation of degree of these could support the personalized medicine.…”
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Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung adenocarc... by Ana Patiño-García, Elizabeth Guruceaga, Maria Pilar Andueza, Marimar Ocón, Jafait Junior Fodop Sokoudjou, Nicolás de Villalonga Zornoza, Gorka Alkorta-Aranburu, Ibon Tamayo Uria, Alfonso Gurpide, Carlos Camps, Eloísa Jantus-Lewintre, Maria Navamuel-Andueza, Miguel F. Sanmamed, Ignacio Melero, Mohamed Elgendy, Juan Pablo Fusco, Javier J. Zulueta, Juan P. de-Torres, Gorka Bastarrika, Luis Seijo, Ruben Pio, Luis M. Montuenga, Mikel Hernáez, Idoia Ochoa, Jose Luis Perez-Gracia

“…Yet, while some heavy smokers develop lung cancer at a young age, other heavy smokers never develop it, even at an advanced age, suggesting a remarkable variability in the individual susceptibility to the carcinogenic effects of tobacco. We characterized the germline profile of subjects presenting these extreme phenotypes with Whole Exome Sequencing (WES) and Machine Learning (ML). …”
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Prevalence, knowledge and attitude toward electronic cigarette use among male health colleges students in Saudi Arabia—A cross-sectional study by Sary Alsanea, Ziyad Alrabiah, Sana Samreen, Wajid Syed, Rawan M. Bin Khunayn, Nasser M. Al-Arifi, Miteb Alenazi, Sultan Alghadeer, Abdulaziz Alhossan, Abdulrahman Alwhaibi, Mohamed N. Al-Arifi

“…Many students had misconceptions and a low level of knowledge about ECs, such as recognizing them as smoking-cessation tools and not knowing whether toxic and carcinogenic components levels in ECs are similar to conventional cigarettes, respectively. …”
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Mobile phone use and brain tumour risk – COSMOS, a prospective cohort study by Maria Feychting, Joachim Schüz, Mireille B. Toledano, Roel Vermeulen, Anssi Auvinen, Aslak Harbo Poulsen, Isabelle Deltour, Rachel B. Smith, Joel Heller, Hans Kromhout, Anke Huss, Christoffer Johansen, Giorgio Tettamanti, Paul Elliott

“…Background: Each new generation of mobile phone technology has triggered discussions about potential carcinogenicity from exposure to radiofrequency electromagnetic fields (RF-EMF). …”
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Benzo[a]pyrene exposure affects colorectal cancer susceptibility by regulating ERβ-mediated LINC02977 transcription by Shuai Ben, Shuwei Li, Dongying Gu, Lingyan Zhao, Shenya Xu, Zhutao Ding, Silu Chen, Yifei Cheng, Junyi Xin, Mulong Du, Meilin Wang

“…The study also revealed that BaP and estradiol (E2) had different carcinogenic effects, with BaP promoting cell proliferation and inhibiting apoptosis, while E2 had the opposite effects. …”
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Implications of oral dysbiosis and HPV infection in head and neck cancer: from molecular and cellular mechanisms to early diagnosis and therapy by Marian Constantin, Marian Constantin, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Mariana Carmen Chifiriuc, Grigore Mihaescu, Corneliu Ovidiu Vrancianu, Corneliu Ovidiu Vrancianu, Corneliu Ovidiu Vrancianu, Elena-Georgiana Dobre, Elena-Georgiana Dobre, Roxana-Elena Cristian, Roxana-Elena Cristian, Roxana-Elena Cristian, Coralia Bleotu, Coralia Bleotu, Serban Vifor Bertesteanu, Raluca Grigore, Bogdan Serban, Catalin Cirstoiu

“…Oral dysbiosis is associated with the evolution of HNCs, through multiple mechanisms such as inflammation, genotoxins release, modulation of the innate and acquired immune response, carcinogens and anticarcinogens production, generation of oxidative stress, induction of mutations. …”
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Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters by Bela Barros, Ana Margarida Paiva, Marta Oliveira, Sara Alves, Filipa Esteves, Filipa Esteves, Filipa Esteves, Adília Fernandes, Josiana Vaz, Josiana Vaz, Klara Slezakova, Solange Costa, Solange Costa, João Paulo Teixeira, João Paulo Teixeira, Simone Morais

“…Firefighters who smoke presented 3-times higher total concentration of OHPAHs than non-smokers (p < 0.001); non-smoker females presented 2-fold lower total OHPAHs (p = 0.049) than males. 1-hydroxypyrene was below the recommended occupational biological exposure value (2.5 μg/L), and the metabolite of carcinogenic PAH (benzo(a)pyrene) was not detected. Blood pressure was above 120/80 mmHg in 71% of subjects. …”
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Histidine-rich glycoprotein in metabolic dysfunction-associated steatohepatitis-related disease progression and liver carcinogenesis by Beatrice Foglia, Salvatore Sutti, Stefania Cannito, Chiara Rosso, Marina Maggiora, Alice Casalino, Claudia Bocca, Erica Novo, Francesca Protopapa, Naresh Naik Ramavath, Alessia Provera, Alessandro Gambella, Elisabetta Bugianesi, Frank Tacke, Emanuele Albano, Maurizio Parola

“…When submitted to the pro-carcinogenic protocol, HRG−/− mice showed a significant decrease in the volume and number of HCC nodules in relation to decreased infiltration of macrophages producing pro-inflammatory mediators, including IL-1β, IL-6, IL-12, IL-10, and VEGF as well as impaired angiogenesis. …”
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Hydrochemical Appraisal and Driving Forces of Groundwater Quality and Potential Health Risks of Nitrate in Typical Agricultural Area of Southwestern China by Jiawei Liu, Chang Yang, Si Chen, Yangshuang Wang, Xingjun Zhang, Wulue Kang, Junyi Li, Ying Wang, Qili Hu, Xingcheng Yuan

“…The entropy-weighted water quality index ranged from 15 to 94, suggesting that the groundwater samples were suitable for drinking purposes. Non-carcinogenic human health risks followed the order of children > adult females > adult males, within the average values of 0.30, 0.21, and 0.18, respectively. …”
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Prevalence and Risk Factors of Infection with High Risk Human Papilloma Viruses among HIV-Positive Women with Clinical Manifestations of Tuberculosis in a Middle-Income Country by Maria Isaguliants, Marina Nosik, Anastasia Karlsen, Natalia Petrakova, Marina Enaeva, Natalia Lebedeva, Daria Podchufarova, Vita Laga, Konstantin Gromov, Anatoly Nazarov, Sona Chowdhury, Mikhail Sinitsyn, Alexander Sobkin, Natalya Chistyakova, Svetlana Aleshina, Alexei Grabarnik, Joel M. Palefsky

“…Women living with HIV-1 are at high risk of infection with human papillomavirus of high carcinogenic risk (HR HPVs). <i>M. tuberculosis</i> (TB) promotes HPV infection and increases the risk to develop HPV-associated cancer. …”
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Comparison of Different Self-Sampling Devices for Molecular Detection of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs): A Pilot Study by Illari Sechi, Clementina Elvezia Cocuzza, Marianna Martinelli, Narcisa Muresu, Santina Castriciano, Giovanni Sotgiu, Andrea Piana

“…Background: Cervical cancer is the fourth most common cancer in women, and it is well known that high-risk human papillomavirus (hrHPV) infections are the necessary carcinogenic factors for the development of cervical tumors. …”
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A novel anoikis-related prognostic signature associated with prognosis and immune infiltration landscape in clear cell renal cell carcinoma by Zhuo Chen, Xiao Liu, Zhengjie Zhu, Jinchao Chen, Chen Wang, Xi Chen, Shaoxing Zhu, Aiqin Zhang

“…TIDE score showed a promising immunotherapy response of ccRCC patients in different risk subgroups and cluster subgroups.Conclusion: Our study revealed that ARGs play a carcinogenic role in ccRCC. Additionally, we firstly integrated multiple ARGs to establish a risk-predictive model. …”
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Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study by Jennifer A. Rusiecki, Jordan McAdam, Hristina Denic-Roberts, Andreas Sjodin, Mark Davis, Richard Jones, Thanh D. Hoang, Mary H. Ward, Shuangge Ma, Yawei Zhang

“…Environmental Protection Agency has classified HCB and other OCPs we studied here as probable human carcinogens. Our findings of increased risks for classical PTC associated with increased concentrations of HCB and β-HCCH, which were stronger among females, should be replicated in future studies of other populations.…”
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PM_2.5-Related Health Risk during Chinese Spring Festival in Taizhou, Zhejiang: The Health Impacts of COVID-19 Lockdown by Quanquan Wu, Xianglian Wang, Kai Ji, Haibing Qiu, Weiwei Feng, Shan Huang, Ting Huang, Jianlong Li, Daishe Wu

“…The noncarcinogenic risk posed by As, Co, Mn, and Ti in 2018 and As and Mn in 2020 was significant. The carcinogenic risk posed by As, Cr(VI), and Pb exceeded the accepted precautionary limit (1 × 10⁻⁶) in both years. …”
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The Inhibitory Effect of Early Pregnancy Factor on Red Meat Neu5Gc-Mediated Antibody Production in CMAH^−/− Mice by Cong Wang, Honglin Ren, Han Wang, Haosong Li, Jian Guo, Yiran Xiao, Yuxi Guo, Mengdi Liu, Fuchun Duan, Pan Hu, Yansong Li, Zengshan Liu, Shiying Lu

“…This is due to the presence of a potential carcinogenic compound in red meat called <i>N</i>-ethanol neuraminic acid (Neu5Gc). …”
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Efficiency of a novel nitrogen-doped Fe3O4 impregnated biochar (N/Fe3O4@BC) for arsenic (III and V) removal from aqueous solution: Insight into mechanistic understanding and reusab... by Hamid Ali, Saeed Ahmed, Abdelghani Hsini, Simon Kizito, Yassine Naciri, Ridha Djellabi, Muhammad Abid, Waseem Raza, Noor Hassan, Muhammad Saif Ur Rehman, Asif Jamal Khan, Muhammad Khan, Muhammad Zia Ul Haq, Dominic Aboagye, Muhammad Kashif Irshad, Munawar Hassan, Asif Hayat, Bo. Wu, Abdul Qadeer, Zeeshan Ajmal

“…Worldwide, arsenic contamination has become a matter of extreme importance owing to its potential toxic, carcinogenic and mutagenic impact on human health and the environment. …”
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A computational approach to evaluate caffeoylquinic acids and flavonoids in Pluchea indica Less. leaves as potential anti-HIV agents by Ni Putu Ermi Hikmawanti, Fadlina Chany Saputri, Arry Yanuar, Ibrahim Jantan, Yeni Yeni, Abdul Mun’im

“…Most test compounds did not cause hepatotoxicity, carcinogenicity, or mutagenicity. All test compounds have no cytotoxic potential. …”
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Abundance, Source Apportionment and Health Risk Assessment of Polycyclic Aromatic Hydrocarbons and Nitro-Polycyclic Aromatic Hydrocarbons in PM_2.5 in the Urban Atmospher... by Yan Wang, Hao Zhang, Xuan Zhang, Pengchu Bai, Lulu Zhang, Sim Joo Huang, Stephen Brian Pointing, Seiya Nagao, Bin Chen, Akira Toriba, Ning Tang

“…The results of the total incremental lifetime cancer risk (ILCR) via three exposure routes (ingestion, inhalation and dermal absorption) for males and females during the four seasons indicated a low long-term potential carcinogenic risk, with values ranging from 10⁻¹⁰ to 10⁻⁷. …”
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miR-624 accelerates the growth of liver cancer cells by inhibiting EMC3 by Xiaoxue Jiang, Yi Lu, Sijie Xie, Yingji Chen, Xinlei Liu, Shujie Li, Shuting Song, Liyan Wang, Dongdong Lu

“…Strikingly, excessive MEC3 abrogates the carcinogenic functions of miR-624. Importantly, our findings indicate that miR-624 affects some signaling pathway in liver cancer, including Wnt signaling pathway，Hippo signaling pathway，mTOR signaling pathway, Ras signaling pathway，MAPK signaling pathway，PI3K-Akt signaling pathway, erbB signaling pathway. …”
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Synthesis of Electrospun TiO₂ Nanofibers and Characterization of Their Antibacterial and Antibiofilm Potential against Gram-Positive and Gram-Negative Bacteria by Mohammad Azam Ansari, Hani Manssor Albetran, Muidh Hamed Alheshibri, Abdelmajid Timoumi, Norah Abdullah Algarou, Sultan Akhtar, Yassine Slimani, Munirah Abdullah Almessiere, Fatimah Saad Alahmari, Abdulhadi Baykal, It-Meng Low

“…Recently, titanium dioxide (TiO₂) nanomaterials have gained increased attention because of their cost-effective, safe, stable, non-toxic, non-carcinogenic, photocatalytic, bactericidal, biomedical, industrial and waste-water treatment applications. …”
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