IL-1 receptor–associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy by Gürcan Tunalı, Marta Rúbies Bedós, Divya Nagarajan, Patrik Fridh, Irineos Papakyriacou, Yumeng Mao

“…IRAK3 deficiency delayed the growth of carcinogen-induced and oncogene-driven murine cancer cells and induced enhanced activation in myeloid cells and T cells. …”
Get full text

Primary Peritoneal Mesothelioma: Diagnostic Challenges of This Lethal Imposter by Sonya K. Dusseault, Okelue Edwards Okobi, Nimish Thakral, Vignesh Sankar, Ishan Gunawardene, Bryan Dawkins, Yaw Abu, Barry Davis

“…The pathogenesis of all forms of mesothelioma is strongly associated with industrial pollutants, of which asbestos is the principal carcinogen. Characteristically, asbestos exposure has a strong relationship with mesothelioma of the pleura, but the peritoneal cavity is the second most commonly affected site. …”
Get full text

A Novel, Simple, and Reliable Spectrophotometric Determination of Total Hexavalent Chromium by Complexation with a New Reagent of Thiazole Linked to 2H-Chromen-2-One by Abdullah Akhdhar

“…Hexavalent chromium is a known environmental contaminant and carcinogen. In the current work, a simple, rapid, and reliable direct spectrophotometric method was used for the determination of total Cr (VI) in environmental samples. …”
Get full text

Design of a Prototype Photoreactor UV-LEDs for Radiation Vulcanization of Natural Rubber Latex by Cahya Widiyati, Herry Poernomo

“…The UV-LED photoreactor prototype design results show that the UV-LED photoreactor prototype is ready to test the VNRLI process function that can produce NRL- irradiated free carcinogen and protein allergens.…”
Get full text

Risk Factors for Breast Cancer, Including Occupational Exposures by Elisabete Weiderpass, Margrethe Meo, Harri Vainio

“…Ethylene oxide is also classified as a Group 1 carcinogen, although the evidence for carcinogenicity in epidemiologic studies, and specifically for the human breast, is limited. …”
Get full text

Crises in Antimicrobial Stewardship: Misuse of Clarithromycin for <i>Helicobacter pylori</i> Therapy by David Y. Graham

“…<i>Helicobacter pylori</i> is a class I carcinogen that infects more than 100 million individuals in the United States. …”
Get full text

Morphological and chemical variations of sweet flag (Acorus calamus L.) in the Czech and Finnish gene bank collection by K. Dušek, B. Galambosi, E. B. Hethelyi, K. Korany, K. Karlová

“…This amount is not sufficient according to the Czech norm for Radix calami quality (minimal amount is 2%) but the content of carcinogen β-asarone, which was established at 9-21% in the essential oil in all the analyzed sweet flags, did not exceed the maximal recommended value 0.5% of dry drug mass.…”
Get full text

Fucoxanthin Is a Potential Therapeutic Agent for the Treatment of Breast Cancer by Tsz-Ying Lau, Hiu-Yee Kwan

“…Other signaling molecules such as MAPK, MMP2/9, CYP and ROS are also involved in the anti-cancer effects by regulating the tumor microenvironment, cancer metastasis, carcinogen metabolism and oxidation. Besides, Fx also possesses anti-obesity effects by regulating UCP1 levels and lipid metabolism, which may help to reduce BC risk. …”
Get full text

REVIEW ON AFLATOXIN IN INDONESIAN FOOD- AND FEEDSTUFFS AND THEIR PRODUCTS by OKKY SETYAWATI DHARMAPUTRA

“… Aflatoxin is a human carcinogen that  could contaminate food- and feedstuffs, and hence is a major food quality problem throughout the world. …”
Get full text

Crosstalk between cancer stem cells and the tumor microenvironment drives progression of premalignant oral epithelium by Peter J. Polverini, Felipe Nör, Jacques E. Nör

“…There is mounting evidence that carcinogen-initiated mucosal epithelial stem cells acquire the CSC phenotype following exposure to environmental or infectious mutagens and are responsible for promoting the malignant transformation of premalignant (dysplastic) epithelium. …”
Get full text

Can yesterday’s smoking research inform today’s shiftwork research? Epistemological consequences for exposures and doses due to circadian disruption at and off work by Thomas C. Erren, Philip Lewis

“…Abstract In 1950, landmark epidemiology studies by Wynder & Graham and Doll & Hill contributed to identifying smoking as a potent carcinogen. In 2007, IARC classified shiftwork involving circadian disruption (CD) as probably carcinogenic; however, epidemiological evidence in regards to the carcinogenicity of shiftwork that involves nightwork is conflicting. …”
Get full text

<i>Helicobacter pylori</i> Biofilm Confers Antibiotic Tolerance in Part via A Protein-Dependent Mechanism by Skander Hathroubi, Julia Zerebinski, Aaron Clarke, Karen M. Ottemann

“…<i>Helicobacter pylori</i>, a WHO class I carcinogen, is one of the most successful human pathogens colonizing the stomach of over 4.4 billion of the world’s population. …”
Get full text

Melatonin and Cancer: A Polyhedral Network Where the Source Matters by Maria-Angeles Bonmati-Carrion, Antonia Tomas-Loba

“…In 2007, the World Health Organization classified night shift work as a probable carcinogen due to circadian disruption, where melatonin plays a central role. …”
Get full text

Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review by Vasiliki Panou, Oluf Dimitri Røe

“…Furthermore, we identified several single nucleotide polymorphisms (SNPs) that may promote MM tumorigenesis as a result of an asbestos–gene interaction, including SNPs in DNA repair, carcinogen detoxification and other genes previously associated with other malignancies. …”
Get full text

Chemopreventive Effect of <i>Cratoxylum formosum</i> (Jack) ssp. <i>pruniflorum</i> on Initial Stage Hepatocarcinogenesis in Rats by Piman Pocasap, Natthida Weerapreeyakul, Rawiwan Wongpoomchai

“…This study investigated the effect of CP on early-stage hepatocarcinogenesis in rat liver when using diethylnitrosamine (DEN) as a carcinogen. Immunohistochemistry was used to detect (a) upregulation of glutathione <i>S</i>-transferase placental (GST-P) positive foci, (b) the proliferating cell nuclear antigen PCNA, and (c) apoptotic cells in the liver as indicators of early-stage carcinogenesis. …”
Get full text

Bacterial infection and microbiota in carcinogenesis and tumor development by Qiao Li

“…Infection of Helicobacter pylori in gastric cancer carcinogenesis is recognized as class I carcinogen by the World Health Organization (WHO) decades ago. …”
Get full text

The Cytolethal Distending Toxin Effects on Mammalian Cells: A DNA Damage Perspective by Elisabeth Bezine, Julien Vignard, Gladys Mirey

“…In vivo, CDT has been shown to induce the development of dysplastic nodules and to lead to genetic instability, defining CDT as a potential carcinogen. It is therefore important to characterize the outcome of the CDT-induced DNA damage and the consequences for intoxicated cells and organisms. …”
Get full text

Occupational Burden of Cancer in Korea by Eun-A Kim, Hye-Eun Lee, Seong-Kyu Kang

“…Methods: Nine kinds of Group 1 carcinogens addressed by the International Agency for Research on Cancer (IARC) and 7 kinds of cancer were selected for the target carcinogens and diseases, respectively. …”
Get full text

Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer by Huizeng Wang, Bingchun Liu, Hong Chen, Peixin Xu, Huiting Xue, Jianlong Yuan

“…Abstract Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. …”
Get full text

Analysis of Polycyclic Aromatic Hydrocarbons (PAHs) in Household Dusts of the City of Khorramabad, Iran by N. Dalvand, S. Sobhan Ardakani, M. Kiani Sadr, M. Cheraghi, B. Lorestani

“…Individuals spend a lot of time indoors, thus they can generally be exposed to polycyclic aromatic hydrocarbons (PAHs) as a teratogen, mutagen, and carcinogen pollutants with the potential for environmental and also human health risks. …”
Get full text