Nonlinear analysis of beat-to-beat variability of action potential time series data identifies dynamic re-entrant substrates in a hypokalaemic mouse model of acquired long QT syndr... by Gary Tse, Jiandong Zhou, Xiuming Dong, Guoliang Hao, Sharen Lee, Keith Sai Kit Leung, Fung Ping Leung, Tong Liu, Yimei Du, Shuk Han Cheng, Wing Tak Wong

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Sex-related differences in incidence, phenotype and risk of sudden cardiac death in inherited arrhythmia syndromes by Babken Asatryan, Andreas S. Barth

“…In this review, we highlight current knowledge of sex-related biological differences in normal cardiac electrophysiology and sex-associated factors that influence IAS phenotypes.…”
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Zero x-rays radiofrequency catheter ablation for ventricular premature contraction originating from the left coronary cusp during pregnancy: a case report by Changjin Li, Haoyu Gu, Chao Liu, Ke Li, Xianbu Gao, Manli Yu, Zhifu Guo

“…Since the 2000s, 3D mapping technique has rapidly developed, laying the foundation for cardiac electrophysiology examination free from x-rays. Ventricular arrhythmia originating from the left coronary cusp (LCC) is not common in clinic. …”
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A rare case of primary adult cardiac rhabdomyosarcoma with lower extremity metastasis by Roozbeh Tarighati Rasekhi, MD, Nastaran Hosseini, Savalan Babapoor-Farrokhran, MD, Ali Babapour Farrokhran, MD, Barzin Behzad, MD

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Editorial: Developments in cardiac implantable electronic device therapy: how can we improve clinical implementation? by Mate Vamos, Julia W. Erath, Alexander P. Benz, Alexander P. Benz, Gabor Z. Duray

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Nonapeptide Hormones Oxytocin and Vasopressin Distinctly Regulate Cav1.2 L-type Calcium Channel Expression in Cardiomyocytes by Masaki Morishima, PhD, Shintaro Tahara, Yan Wang, MD, Toshihiko Kaku, MD, Katsushige Ono, MD

“…Conclusion: OT but not AVP down-regulates L-type Ca2+ channel expression through the inhibition of CREB transcriptional, suggesting a novel mechanism of OT action in the cardiac electrophysiology.…”
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The Intrinsic Cardiac Nervous System and Its Role in Cardiac Pacemaking and Conduction by Laura Fedele, Thomas Brand

“…The cardiac ganglia contribute to the tight modulation of cardiac electrophysiology, working as a local hub integrating the inputs of the extrinsic innervation and the ICNS. …”
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Extraction of morphological QRS-based biomarkers in hypertrophic cardiomyopathy for risk stratification using L1 regularized logistic regression by Lyon, A, Minchole, A, Ariga, R, Laguna, P, Dei Freitas, N, Neubauer, S, Watkins, H, Rodriguez, B

“…Classification between control and HCM patients reached 95.7% of accuracy (sensitivity of 94.96% for HCM and specificity of 96.90%) using only two main features: the percentage of negative regions of the QRS complex with respect to the isoelectric level and the 3rd coefficient of its Hermite fitting showing interesting connections to cardiac electrophysiology.…”

Markov models for ion channels: versatility versus identifiability and speed. by Fink, M, Noble, D

“…This paper uses examples from cardiac electrophysiology to discuss aspects related to parameter estimation. …”

Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block by Tomek, J, Bueno-Orovio, A, Passini, E, Zhou, X, Minchole, A, Britton, O, Bartolucci, C, Severi, S, Shrier, A, Virag, L, Varro, A, Rodriguez, B

“…Human-based modelling and simulations are becoming ubiquitous in biomedical science due to their ability to augment experimental and clinical investigations. Cardiac electrophysiology is one of the most advanced areas, with cardiac modelling and simulation being considered for virtual testing of pharmacological therapies and medical devices. …”

In situ optical mapping of voltage and calcium in the heart. by Lee, P, Taghavi, F, Yan, P, Ewart, P, Ashley, E, Loew, L, Kohl, P, Bollensdorff, C, Woods, C

“…Optical mapping of cardiac electrophysiology combines high spatiotemporal resolution of anatomy and physiological function with fast and simultaneous data acquisition. …”

Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia. by Gemmell, P, Burrage, K, Rodríguez, B, Quinn, T

“…Computational modelling, combined with experimental investigations, is a powerful method for investigating complex cardiac electrophysiological behaviour. The use of rabbit-specific models, due to the similarities of cardiac electrophysiology in this species with human, is especially prevalent. …”

Model reduction for initial value ODEs by Ambuehl, A, Whiteley, J

“…These extensions are illustrated using examples drawn from enzyme kinetics and cardiac electrophysiology.…”

Homogenisation for the monodomain model in the presence of microscopic fibrotic structures by Lawson, B, Weber dos Santos, R, Turner, I, Bueno-Orovio, A, Burrage, P, Burrage, K

“…Computational models in cardiac electrophysiology are notorious for long runtimes, restricting the numbers of nodes and mesh elements in the numerical discretisations used for their solution. …”

Intra-Cardiac versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion with a Watchman FLX Device by Luigi Emilio Pastormerlo, Claudio Tondo, Gaetano Fassini, Antonino Nicosia, Federico Ronco, Marco Contarini, Giuseppe Giacchi, Carmelo Grasso, Gavino Casu, Maria Rita Romeo, Patrizio Mazzone, Luca Limite, Giuseppe Caramanno, Salvatore Geraci, Paolo Pagnotta, Mauro Chiarito, Corrado Tamburino, Sergio Berti

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Robotic-Assisted Epicardial Hybrid Ablation and Left Appendage Closure in Persistent Atrial Fibrillation: First European Experience by Alfonso Agnino, Laura Giroletti, Ascanio Graniero, Piersilvio Gerometta, Matteo Parrinello, Giovanni Albano, Eduardo Celentano, Ernesto Cristiano, Giuseppe Nasso, Natasja M. S. de Groot

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Enhancing convolutional neural network predictions of electrocardiograms with left ventricular dysfunction using a novel sub-waveform representation by Hossein Honarvar, PhD, Chirag Agarwal, PhD, Sulaiman Somani, MD, Akhil Vaid, MD, Joshua Lampert, MD, Tingyi Wanyan, PhD, Vivek Y. Reddy, MD, Girish N. Nadkarni, MD, Riccardo Miotto, PhD, Marinka Zitnik, PhD, Fei Wang, PhD, Benjamin S. Glicksberg, PhD

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Assessing the outcomes of prescribing angiotensin converting enzyme inhibitors and angiotensin receptor blockers for COVID-19 patients by Wissam Mekary, Souha Fares, Farah Abdulhai, Gaelle Massoud, Marwan Refaat, Mathias Mericskay, George W. Booz, Fouad A. Zouein

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NT‐proBNP as a Mediator of the Racial Difference in Incident Atrial Fibrillation and Heart Failure by Isaac R. Whitman, Eric Vittinghoff, Christopher R. DeFilippi, John S. Gottdiener, Alvaro Alonso, Bruce M. Psaty, Susan R. Heckbert, Ron C. Hoogeveen, Dan E. Arking, Elizabeth Selvin, Lin Y. Chen, Thomas A. Dewland, Gregory M. Marcus

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Brugada-like ECG Changes After Conducted Electrical Weapon Exposure: A Case Report by Christopher Trumbetta, Michael Galuska

“…Conclusion: Review of the literature surrounding the safety profile associated with CEW exposure shows few if any documented concerning cardiac electrophysiology changes and suggests that routine electrocardiographic studies or monitoring is not required. …”
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