Facilitation of hERG Activation by Its Blocker: A Mechanism to Reduce Drug-Induced Proarrhythmic Risk by Kazuharu Furutani

“…Modulation of the human Ether-à-go-go-Related Gene (hERG) channel, a crucial voltage-gated potassium channel in the repolarization of action potentials in ventricular myocytes of the heart, has significant implications on cardiac electrophysiology and can be either antiarrhythmic or proarrhythmic. …”
Get full text

Editorial: Risk Stratification Strategies for Cardiac Rhythm Abnormalities by Gary Tse, Gary Tse, Gary Tse, Nan Zhang, Wenhua Song, Konstantinos P. Letsas, Tachapong Ngarmukos, Kamalan Jeevaratnam, Tong Liu

Get full text

Complications following cardiac pacemaker insertions by Kelechukwu UK, Shah RA

“…Settings and Design: This study was carried out in the Cardiac Electrophysiology department, of the Institute of Cardiovascular diseases, Madras Medical Mission, India. …”
Get full text

Multiscale modelling of β-adrenergic stimulation in cardiac electromechanical function by Doste, R, Bueno Orovio, A

“…In this review, we describe the main existing multiscale frameworks to equip cellular models of cardiac electrophysiology with a β-ARS response. We also outline various applications of these multiscale frameworks in the study of cardiac pathology. …”

Cellular Open Resource (COR): A public CellML based environment for modeling biological function by Garny, A, Kohl, P, Noble, D

“…Computer models have proved to be invaluable to experimental and theoretical research in cardiac electrophysiology, and several environments have been designed to aim at easing the development of such models. …”

An evaluation of some assumptions underpinning the bidomain equations of electrophysiology by Whiteley, JP

“…Tissue level cardiac electrophysiology is usually modelled by the bidomain equations, or the monodomain simplification of the bidomain equations. …”

Models of the cardiac L-type calcium current: a quantitative review by Agrawal, A, Wang, K, Polonchuk, L, Cooper, J, Hendrix, M, Gavaghan, DJ, Mirams, GR, Clerx, M

“…The L-type calcium current ( ICaL$$ {I}_{\mathrm{CaL}} $$ ) plays a critical role in cardiac electrophysiology, and models of ICaL$$ {I}_{\mathrm{CaL}} $$ are vital tools to predict arrhythmogenicity of drugs and mutations. …”

Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice by Shi Ling, Jin Xuexin, Li Zheng, Gong Rui, Guo Yang, Ma Jiudong, Zhang Yang, Cai Benzhi, Yang Baofeng, Gong Dongmei, Pan Zhenwei

“…This study highlights the role of m⁶A modification in the regulation of cardiac electrophysiology.…”
Get full text

shRNAs Targeting a Common <i>KCNQ1</i> Variant Could Alleviate Long-QT1 Disease Severity by Inhibiting a Mutant Allele by Lucía Cócera-Ortega, Ronald Wilders, Selina C. Kamps, Benedetta Fabrizi, Irit Huber, Ingeborg van der Made, Anouk van den Bout, Dylan K. de Vries, Lior Gepstein, Arie O. Verkerk, Yigal M. Pinto, Anke J. Tijsen

Get full text

Useful Electrocardiographic Signs to Support the Prediction of Favorable Response to Cardiac Resynchronization Therapy by Andras Simon, David Pilecky, Loretta Zsuzsa Kiss, Mate Vamos

Get full text

Thirty years of blackouts: a case report of swallow syncope by Irene Lambiris, Ivan Mendoza, Marcelo Helguera, Jose Baez Escudero, Cesar Bonilla

“…Referral to the cardiac electrophysiology department with tilt-table testing accompanied by swallow evaluation was then recommended. …”
Get full text

Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation by Barry O’Brien, John Reilly, Ken Coffey, Ana González-Suárez, Leo Quinlan, Martin van Zyl

Get full text

Open source model for generating RR intervals in atrial fibrillation and beyond by Lian, Jie, Clifford, Gari D., Muessig, Dirk, Lang, Volker

“…Abstract Background Realistic modeling of cardiac inter-beat (RR) intervals is highly desirable for basic research in cardiac electrophysiology, clinical management of heart diseases, and developing signal processing tools for ECG analysis. …”
Get full text

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models? by Johnstone, R, Chang, E, Bardenet, R, de Boer, T, Gavaghan, D, Pathmanathan, P, Clayton, R, Mirams, G

“…Cardiac electrophysiology models have been developed for over 50 years, and now include detailed descriptions of individual ion currents and sub-cellular calcium handling. …”

Integrated heart - coupled multiscale and multiphysics models for the simulation of the cardiac function by Ruiz Baier, R, Quarteroni, A, Lassila, T, Rossi, S

“…This article addresses the numerical modelling of many aspects of heart function, including the interaction of the cardiac electrophysiology system with contractile muscle tissue, the sub-cellular activation-contraction mechanisms, as well as the hemodynamics inside the heart chambers. …”

Multichannel mapping of fetal magnetocardiogram in an unshielded hospital setting. by Brisinda, D, Comani, S, Meloni, A, Alleva, G, Mantini, D, Fenici, R

“…CONCLUSIONS: A first demonstration has been given that multichannel mapping of FMCG can be performed in unshielded clinical environments, with resolution good enough for contactless assessment of fetal cardiac electrophysiology. FastICA processing on unshielded FMCG, recorded after the 32nd week, provided beat-to-beat analysis and heart rate variability assessment. …”

Left Atrial Appendage Occlusion: British Cardiovascular Intervention Society and British Heart Rhythm Society Position Statement by Tim R Betts, Patrick A Calvert, Lee N Graham, Gerald J Clesham, Ashan Gunarathne, Brian Clapp, Dhiraj Gupta, Jan Kovac, James D Newton, David Hildick-Smith

Get full text

An ensemble of parameters from a robust Markov-based model reproduces L-type calcium currents from different human cardiac myocytes. by Gustavo Montes Novaes, Enrique Alvarez-Lacalle, Sergio Alonso Muñoz, Rodrigo Weber Dos Santos

“…The development of modeling structures at the channel level that can integrate subcellular and cell models and properly reproduce different experimental data is of utmost importance in cardiac electrophysiology. In contrast to gate-based models, Markov Chain models are well suited to promote the integration of the subcellular level of the cardiomyocyte to the whole cell. …”
Get full text

Left Atrial Appendage Occlusion: British Cardiovascular Intervention Society and British Heart Rhythm Society Position Statement by Tim R Betts, Patrick A Calvert, Lee N Graham, Gerald J Clesham, Ashan Gunarathne, Brian Clapp, Dhiraj Gupta, Jan Kovac, James D Newton, David Hildick-Smith

Get full text

Multimodal cardiovascular model for hemodynamic analysis: Simulation study on mitral valve disorders. by Dibyendu Roy, Oishee Mazumder, Aniruddha Sinha, Sundeep Khandelwal

“…The developed model integrates cardiac electrophysiology with hemodynamic modeling, thus giving a broader and holistic understanding of the effect of disease progression on various parameters like ejection fraction, cardiac output, blood pressure, etc., to assess the severity of mitral valve disorders, naming Mitral Stenosis and Mitral Regurgitation. …”
Get full text